Cancer Cell Metabolism Database ~~ Bioinformatics and Systems Medicine Laboratory ~~

Cancer Cell Metabolism Gene Database

Cancer Cell Metabolism Gene DB

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	Gene Summary
	Phenotypic Information (metabolism pathway, cancer, disease, phenome)
	Mutations : SVs, CNVs, SNVs
	Gene expression: GE, Protein, DEGE, CNV vs GE
	Gene-Gene Network Information: Co-Expression Network, Interacting Genes & KEGG
	Pharmacological Information: Drug-Gene Network
	Cross referenced IDs

Gene Summary for ENO2

Basic gene info.	Gene symbol	ENO2
	Gene name	enolase 2 (gamma, neuronal)
	Synonyms	HEL-S-279\|NSE
	Cytomap	UCSC genome browser: 12p13
	Genomic location	chr12 :7023613-7032859
	Type of gene	protein-coding
	RefGenes	NM_001975.2,
	Ensembl id	ENSG00000269528
	Description	2-phospho-D-glycerate hydro-lyase2-phospho-D-glycerate hydrolyaseepididymis secretory protein Li 279gamma-enolaseneural enolaseneuron specific gamma enolaseneuron-specific enolaseneurone-specific enolase
	Modification date	20141207
dbXrefs	MIM : 131360
	HGNC : HGNC
	Ensembl : ENSG00000111674
	HPRD : 00573
	Vega : OTTHUMG00000168967
Protein	UniProt: go to UniProt's Cross Reference DB Table
Expression	CleanEX: HS_ENO2
	BioGPS: 2026
	Gene Expression Atlas: ENSG00000269528
	The Human Protein Atlas: ENSG00000269528
Pathway	NCI Pathway Interaction Database: ENO2
	KEGG: ENO2
	REACTOME: ENO2
	ConsensusPathDB
	Pathway Commons: ENO2
Metabolism	MetaCyc: ENO2
	HUMANCyc: ENO2
Regulation	Ensembl's Regulation: ENSG00000269528
	miRBase: chr12 :7,023,613-7,032,859
	TargetScan: NM_001975
	cisRED: ENSG00000269528
Context	iHOP: ENO2
	cancer metabolism search in PubMed: ENO2
	UCL Cancer Institute: ENO2
Assigned class in ccmGDB	C

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Phenotypic Information for ENO2(metabolism pathway, cancer, disease, phenome)

Cancer Description
Cancer	CGAP: ENO2
	Familial Cancer Database: ENO2

* This gene is included in those cancer gene databases.


Oncogene ¹	Tumor Suppressor gene ²	Cancer Gene Census ³	CancerGenes ⁴	Network of Cancer Gene ⁵	Significant driver gene in	Therapeutic Vulnerabilities in Cancer¹

cf) number; DB name
1 Oncogene; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long,
2 Tumor Suppressor gene; https://bioinfo.uth.edu/TSGene/,
3 Cancer Gene Census; http://www.nature.com/nrc/journal/v4/n3/abs/nrc1299.html,
4 CancerGenes; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long,
5 Network of Cancer Gene; http://ncg.kcl.ac.uk/index.php,
1Therapeutic Vulnerabilities in Cancer; http://cbio.mskcc.org/cancergenomics/statius/

Metabolic Pathway Description
KEGG_GLYCOLYSIS_GLUCONEOGENESIS REACTOME_METABOLISM_OF_CARBOHYDRATES REACTOME_GLUCOSE_METABOLISM

Others
OMIM
Orphanet
Disease	KEGG Disease: ENO2
	MedGen: ENO2 (Human Medical Genetics with Condition)
	ClinVar: ENO2
Phenotype	MGI: ENO2 (International Mouse Phenotyping Consortium)
Phenotype	PhenomicDB: ENO2

Mutations for ENO2

* Under tables are showing count per each tissue to give us broad intuition about tissue specific mutation patterns.You can go to the detailed page for each mutation database's web site.

Structural Variants in COSMIC : go to COSMIC mutation histogram

- Statistics for Tissue and Mutation type

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- For Inter-chromosomal Variations

* Inter-chromosomal variantions includes 'interchromosomal amplicon to amplicon', 'interchromosomal amplicon to non-amplified dna', 'interchromosomal insertion', 'Interchromosomal unknown type'.

- For Intra-chromosomal Variations

* Intra-chromosomal variantions includes 'intrachromosomal amplicon to amplicon', 'intrachromosomal amplicon to non-amplified dna', 'intrachromosomal deletion', 'intrachromosomal fold-back inversion', 'intrachromosomal inversion', 'intrachromosomal tandem duplication', 'Intrachromosomal unknown type', 'intrachromosomal with inverted orientation', 'intrachromosomal with non-inverted orientation'.

Sample	Symbol_a	Chr_a	Start_a	End_a	Symbol_b	Chr_b	Start_b	End_b
pancreas	ENO2	chr12	7027758	7027958	ENO2	chr12	7032286	7032486

cf) Tissue number; Tissue name (1;Breast, 2;Central_nervous_system, 3;Haematopoietic_and_lymphoid_tissue, 4;Large_intestine, 5;Liver, 6;Lung, 7;Ovary, 8;Pancreas, 9;Prostate, 10;Skin, 11;Soft_tissue, 12;Upper_aerodigestive_tract)

Related fusion transcripts : go to Chitars2.0

* From mRNA Sanger sequences, Chitars2.0 arranged chimeric transcripts. This table shows ENO2 related fusion information.

ID	Head Gene						Tail Gene
Accession	Gene_a	qStart_a	qEnd_a	Chromosome_a	tStart_a	tEnd_a	Gene_a	qStart_a	qEnd_a	Chromosome_a	tStart_a	tEnd_a
AU142951	NAE1	1	511	16	66842911	66850908	ENO2	511	712	12	7023722	7025082
BQ302654	CLASRP	1	135	19	45557798	45557933	ENO2	120	587	12	7030826	7032073
BQ316184	ENO2	1	132	12	7031242	7031553	TNRC18	127	642	7	5399156	5410034
DA094244	LOC100507412	1	151	?	112029	112179	ENO2	150	563	12	7023742	7024155

Other DBs for Structural Variants

Structural Variants in Ensembl: go to Ensembl Structural variation

Structural Variants in dbVar: go to dbVar

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Copy Number Variations in COSMIC : go to COSMIC mutation CNV/Expr

Mutation type/ Tissue ID

brca

cns

cerv

endome

haematopo

kidn

Lintest

liver

lung

ovary

pancre

prost

skin

stoma

thyro

urina

Total # sample

GAIN (# sample)

LOSS (# sample)

cf) Tissue ID; Tissue type (1; Breast, 2; Central_nervous_system, 3; Cervix, 4; Endometrium, 5; Haematopoietic_and_lymphoid_tissue, 6; Kidney, 7; Large_intestine, 8; Liver, 9; Lung, 10; NS, 11; Ovary, 12; Pancreas, 13; Prostate, 14; Skin, 15; Stomach, 16; Thyroid, 17; Urinary_tract)

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SNV Counts per Each Loci in COSMIC data : go to COSMIC point mutation

: Non-synonymous mutation, : Synonymous mutation, Circle size denotes number of samples.
Maximum mutation count=7

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Somatic Mutation Counts per Tissue in COSMIC data

Stat. for Non-Synonymous SNVs (# total SNVs=22)	Stat. for Synonymous SNVs (# total SNVs=12)

Stat. for Deletions (# total SNVs=1)	Stat. for Insertions (# total SNVs=0)
	There's no inserted snv.

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Top 10 SNVs Having the Most Samples in COSMIC data

* When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site,primary_histology,mutation(aa),pubmedID.

GRCh37 position	Mutation(aa)	Unique sampleID count
chr12:7031324-7031324	p.G391G	7
chr12:7028831-7028831	p.Y257H	3
chr12:7025017-7025017	p.W7*	3
chr12:7025874-7025874	p.A74V	2
chr12:7026819-7026819	p.P129A	2
chr12:7028928-7028928	p.?	2
chr12:7031509-7031509	p.I393M	2
chr12:7030925-7030925	p.S349S	1
chr12:7025849-7025849	p.V66M	1
chr12:7028782-7028782	p.I240I	1

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SNV Counts per Each Loci in TCGA data

: non-synonymous mutation, : synonymous mutation, Circle size denotes number of samples.
maximum mutation count=3

Point Mutation/ Tissue ID	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20
# sample	1			3	1		2		1			1	1				3	4		6
# mutation	1			3	1		2		1			1	1				3	4		6
nonsynonymous SNV	1			3	1				1			1	1				2	3		6
synonymous SNV							2										1	1

cf) Tissue ID; Tissue type (1; BLCA[Bladder Urothelial Carcinoma], 2; BRCA[Breast invasive carcinoma], 3; CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], 4; COAD[Colon adenocarcinoma], 5; GBM[Glioblastoma multiforme], 6; Glioma Low Grade, 7; HNSC[Head and Neck squamous cell carcinoma], 8; KICH[Kidney Chromophobe], 9; KIRC[Kidney renal clear cell carcinoma], 10; KIRP[Kidney renal papillary cell carcinoma], 11; LAML[Acute Myeloid Leukemia], 12; LUAD[Lung adenocarcinoma], 13; LUSC[Lung squamous cell carcinoma], 14; OV[Ovarian serous cystadenocarcinoma ], 15; PAAD[Pancreatic adenocarcinoma], 16; PRAD[Prostate adenocarcinoma], 17; SKCM[Skin Cutaneous Melanoma], 18:STAD[Stomach adenocarcinoma], 19:THCA[Thyroid carcinoma], 20:UCEC[Uterine Corpus Endometrial Carcinoma])

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Top 10 SNVs Having the Most Samples in TCGA data

* We represented just top 10 SNVs. When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site, primary_histology, mutation(aa), pubmedID.

Genomic Position	Mutation(aa)	Unique sampleID count
chr12:7031310	p.G387W	2
chr12:7026819	p.W304L	1
chr12:7031312	p.E333K	1
chr12:7027203	p.M1I	1
chr12:7031509	p.A336V	1
chr12:7024999	p.K5Q	1
chr12:7027207	p.G348S	1
chr12:7031525	p.I6I	1
chr12:7025009	p.A382V	1
chr12:7028878	p.P36S	1

Other DBs for Point Mutations

Point Mutation Table of Ensembl: go to Ensembl variation table

Mutation of cBioPortal: go to cBioPortal's Cross-cancer alteration summary

Copy Number for ENO2 in TCGA

* Copy number data were extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered on Jan-05-2015. Function ProcessCNAData in TCGA-Assembler package was used to obtain gene-level copy number value which is calculated as the average copy number of the genomic region of a gene.

cf) Tissue ID[Tissue type]: BLCA[Bladder Urothelial Carcinoma], BRCA[Breast invasive carcinoma], CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], COAD[Colon adenocarcinoma], GBM[Glioblastoma multiforme], Glioma Low Grade, HNSC[Head and Neck squamous cell carcinoma], KICH[Kidney Chromophobe], KIRC[Kidney renal clear cell carcinoma], KIRP[Kidney renal papillary cell carcinoma], LAML[Acute Myeloid Leukemia], LUAD[Lung adenocarcinoma], LUSC[Lung squamous cell carcinoma], OV[Ovarian serous cystadenocarcinoma ], PAAD[Pancreatic adenocarcinoma], PRAD[Prostate adenocarcinoma], SKCM[Skin Cutaneous Melanoma], STAD[Stomach adenocarcinoma], THCA[Thyroid carcinoma], UCEC[Uterine Corpus Endometrial Carcinoma]

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Gene Expression for ENO2

Gene Expression in Cancer Cell-lines (CCLE)

* CCLE gene expression data were extracted from CCLE_Expression_Entrez_2012-10-18.res: Gene-centric RMA-normalized mRNA expression data.

Differential Gene Expression in Primary Tumors (TCGA)

* Normalized gene expression data of RNASeqV2 was extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered at Jan-05-2015. Only eight cancer types have enough normal control samples for differential expression analysis.
(t test, adjusted p<0.05 (using Benjamini-Hochberg FDR))

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CNV vs Gene Expression Plot

* This plots show the correlation between CNV and gene expression.

: Open all plots for all cancer types

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Gene-Gene Network Information

Co-Expressed gene's network Plot

* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown.
Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene

: Open all plots for all cancer types


ACTL6B,APLP1,ATCAY,LINC01548,CAMK2N2,CRMP1,DPYSL5, ENO2,FAM150A,FAM57B,GABRA4,GDAP1L1,GLS2,KCNH2, LMO3,MAPK8IP1,SCAMP5,ST18,STMN3,TIGD3,TMEM179	ACTR5,AZIN2,APOBEC3G,ATG9B,C11orf80,CABLES2,CDK2, DEF6,DGKA,DMKN,ENO2,FBXO41,FCHSD1,FER1L4, GNB5,HDAC1,LOC643008,MAPK15,RND2,SMAGP,WNT10A

ALKBH5,BNIP3L,DNAAF3,CAMK2N2,CDR2L,COQ10A,DUSP4, ENO2,GNB5,HPSE,LMF2,MAP3K6,P4HA1,PFKFB3, PFKP,PKM,SPHK1,TBC1D8,TRIB2,ULBP2,WDR54	ADCY2,APBB1,CD81,CLIP3,DTX3,ENO2,FAM127C, FGFR1,GFRA1,GPRASP1,GRIK5,HAND2,JAM3,LIX1L, MAGED4B,MAGEE1,MEIS1,PGR,PLCL1,SLC4A3,SMARCA1

Co-Expressed gene's Protein-protein interaction Network Plot

: Open all plots for all cancer types

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Interacting Genes (from Pathway Commons)

: Open all interacting genes' information including KEGG pathway for all interacting genes from DAVID

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Pharmacological Information for ENO2

There's no related Drug.

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Cross referenced IDs for ENO2

* We obtained these cross-references from Uniprot database. It covers 150 different DBs, 18 categories. http://www.uniprot.org/help/cross_references_section

: Open all cross reference information