Cancer Cell Metabolism Gene Database

  Cancer Cell Metabolism Gene DB

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Gene Summary

Phenotypic Information (metabolism pathway, cancer, disease, phenome)

Mutations: SVs, CNVs, SNVs

Gene expression: GE, Protein, DEGE, CNV vs GE

Gene-Gene Network Information: Co-Expression Network, Interacting Genes & KEGG

Pharmacological Information: Drug-Gene Network

Cross referenced IDs

Gene Summary for ENO3
Basic gene info.Gene symbolENO3
Gene nameenolase 3 (beta, muscle)
SynonymsGSD13|MSE
CytomapUCSC genome browser: 17p13.2
Genomic locationchr17 :4854383-4860426
Type of geneprotein-coding
RefGenesNM_001193503.1,
NM_001976.4,NM_053013.3,
Ensembl idENSG00000108515
Description2-phospho-D-glycerate hydrolyasebeta-enolasemuscle-specific enolaseskeletal muscle enolase
Modification date20141207
dbXrefs MIM : 131370
HGNC : HGNC
Ensembl : ENSG00000108515
HPRD : 11746
Vega : OTTHUMG00000099394
ProteinUniProt: P13929
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_ENO3
BioGPS: 2027
Gene Expression Atlas: ENSG00000108515
The Human Protein Atlas: ENSG00000108515
PathwayNCI Pathway Interaction Database: ENO3
KEGG: ENO3
REACTOME: ENO3
ConsensusPathDB
Pathway Commons: ENO3
MetabolismMetaCyc: ENO3
HUMANCyc: ENO3
RegulationEnsembl's Regulation: ENSG00000108515
miRBase: chr17 :4,854,383-4,860,426
TargetScan: NM_001193503
cisRED: ENSG00000108515
ContextiHOP: ENO3
cancer metabolism search in PubMed: ENO3
UCL Cancer Institute: ENO3
Assigned class in ccmGDBA - This gene has a literature evidence and it belongs to cancer gene.
References showing role of ENO3 in cancer cell metabolism1. Li JL, Fei Q, Yu J, Zhang HY, Wang P, et al. (2004) Correlation between methylation profile of promoter cpg islands of seven metastasis-associated genes and their expression states in six cell lines of liver origin. Ai Zheng 23: 985-991. go to article

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Phenotypic Information for ENO3(metabolism pathway, cancer, disease, phenome)
check002.gifCancer Description
Cancer CGAP: ENO3
Familial Cancer Database: ENO3
* This gene is included in those cancer gene databases.

Oncogene 1

Tumor Suppressor gene 2

Cancer Gene Census 3

CancerGenes 4

Network of Cancer Gene 5

Significant driver gene in

Therapeutic Vulnerabilities in Cancer1

cf) number; DB name
1 Oncogene; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long,
2 Tumor Suppressor gene; https://bioinfo.uth.edu/TSGene/,
3 Cancer Gene Census; http://www.nature.com/nrc/journal/v4/n3/abs/nrc1299.html,
4 CancerGenes; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long,
5 Network of Cancer Gene; http://ncg.kcl.ac.uk/index.php,
1Therapeutic Vulnerabilities in Cancer; http://cbio.mskcc.org/cancergenomics/statius/

check002.gifMetabolic Pathway Description
KEGG_GLYCOLYSIS_GLUCONEOGENESIS
REACTOME_METABOLISM_OF_CARBOHYDRATES
REACTOME_GLUCOSE_METABOLISM

check002.gifOthers
OMIM 131370; gene.
612932; phenotype.
Orphanet 99849; Glycogen storage disease due to muscle beta-enolase deficiency.
DiseaseKEGG Disease: ENO3
MedGen: ENO3 (Human Medical Genetics with Condition)
ClinVar: ENO3
PhenotypeMGI: ENO3 (International Mouse Phenotyping Consortium)
PhenomicDB: ENO3

Mutations for ENO3
* Under tables are showing count per each tissue to give us broad intuition about tissue specific mutation patterns.You can go to the detailed page for each mutation database's web site.

check002.gifStructural Variants in COSMIC: go to COSMIC mutation histogram
There's no structural variation information in COSMIC data for this gene.

check002.gifRelated fusion transcripts : go to Chitars2.0
* From mRNA Sanger sequences, Chitars2.0 arranged chimeric transcripts. This table shows ENO3 related fusion information.
IDHead GeneTail Gene
AccessionGene_aqStart_aqEnd_aChromosome_atStart_atEnd_aGene_aqStart_aqEnd_aChromosome_atStart_atEnd_a
CV314769ENO3172731748573624857622VIM258433101727758017277755

check002.gifOther DBs for Structural Variants
Structural Variants in Ensembl: go to Ensembl Structural variation
Structural Variants in dbVar: go to dbVar

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check002.gifCopy Number Variations in COSMIC: go to COSMIC mutation CNV/Expr
There's no copy number variation information in COSMIC data for this gene.

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check002.gifSNV Counts per Each Loci in COSMIC data: go to COSMIC point mutation

 : Non-synonymous mutation, : Synonymous mutation, Circle size denotes number of samples.
Maximum mutation count=3

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check002.gifSomatic Mutation Counts per Tissue in COSMIC data
Stat. for Non-Synonymous SNVs
(# total SNVs=26)
Stat. for Synonymous SNVs
(# total SNVs=11)
Stat. for Deletions
(# total SNVs=2)
Stat. for Insertions
(# total SNVs=0)
There's no inserted snv.

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check002.gifTop 10 SNVs Having the Most Samples in COSMIC data
* When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site,primary_histology,mutation(aa),pubmedID.
GRCh37 positionMutation(aa)Unique sampleID count
chr17:4860152-4860152p.S401S3
chr17:4860277-4860277p.E414K2
chr17:4856580-4856580p.V85A2
chr17:4858465-4858465p.E180D2
chr17:4859292-4859292p.F307F2
chr17:4858564-4858564p.F213F1
chr17:4859297-4859297p.S309L1
chr17:4856127-4856127p.T41T1
chr17:4860186-4860186p.?1
chr17:4857038-4857038p.V114V1

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check002.gifSNV Counts per Each Loci in TCGA data

 : non-synonymous mutation, : synonymous mutation, Circle size denotes number of samples.
maximum mutation count=3

Point Mutation/ Tissue ID1234567891011121314151617181920
# sample22 61      721  55 5
# mutation22 61      721  55 5
nonsynonymous SNV12 41      31   33 4
synonymous SNV1  2       411  22 1
cf) Tissue ID; Tissue type (1; BLCA[Bladder Urothelial Carcinoma], 2; BRCA[Breast invasive carcinoma], 3; CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], 4; COAD[Colon adenocarcinoma], 5; GBM[Glioblastoma multiforme], 6; Glioma Low Grade, 7; HNSC[Head and Neck squamous cell carcinoma], 8; KICH[Kidney Chromophobe], 9; KIRC[Kidney renal clear cell carcinoma], 10; KIRP[Kidney renal papillary cell carcinoma], 11; LAML[Acute Myeloid Leukemia], 12; LUAD[Lung adenocarcinoma], 13; LUSC[Lung squamous cell carcinoma], 14; OV[Ovarian serous cystadenocarcinoma ], 15; PAAD[Pancreatic adenocarcinoma], 16; PRAD[Prostate adenocarcinoma], 17; SKCM[Skin Cutaneous Melanoma], 18:STAD[Stomach adenocarcinoma], 19:THCA[Thyroid carcinoma], 20:UCEC[Uterine Corpus Endometrial Carcinoma])

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check002.gifTop 10 SNVs Having the Most Samples in TCGA data
* We represented just top 10 SNVs. When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site, primary_histology, mutation(aa), pubmedID.
Genomic PositionMutation(aa)Unique sampleID count
chr17:4860152p.S358S,ENO33
chr17:4858806p.D215N,ENO32
chr17:4859297p.L216V,ENO31
chr17:4856180p.G59E,ENO31
chr17:4858519p.P224P,ENO31
chr17:4859299p.N71I,ENO31
chr17:4856376p.A225T,ENO31
chr17:4858527p.V85V,ENO31
chr17:4859385p.L233L,ENO31
chr17:4856581p.F93C,ENO31

check002.gifOther DBs for Point Mutations
Point Mutation Table of Ensembl: go to Ensembl variation table
Mutation of cBioPortal: go to cBioPortal's Cross-cancer alteration summary

check002.gifCopy Number for ENO3 in TCGA
* Copy number data were extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered on Jan-05-2015. Function ProcessCNAData in TCGA-Assembler package was used to obtain gene-level copy number value which is calculated as the average copy number of the genomic region of a gene.
cf) Tissue ID[Tissue type]: BLCA[Bladder Urothelial Carcinoma], BRCA[Breast invasive carcinoma], CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], COAD[Colon adenocarcinoma], GBM[Glioblastoma multiforme], Glioma Low Grade, HNSC[Head and Neck squamous cell carcinoma], KICH[Kidney Chromophobe], KIRC[Kidney renal clear cell carcinoma], KIRP[Kidney renal papillary cell carcinoma], LAML[Acute Myeloid Leukemia], LUAD[Lung adenocarcinoma], LUSC[Lung squamous cell carcinoma], OV[Ovarian serous cystadenocarcinoma ], PAAD[Pancreatic adenocarcinoma], PRAD[Prostate adenocarcinoma], SKCM[Skin Cutaneous Melanoma], STAD[Stomach adenocarcinoma], THCA[Thyroid carcinoma], UCEC[Uterine Corpus Endometrial Carcinoma]

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Gene Expression for ENO3

check002.gifGene Expression in Cancer Cell-lines (CCLE)
* CCLE gene expression data were extracted from CCLE_Expression_Entrez_2012-10-18.res: Gene-centric RMA-normalized mRNA expression data.

check002.gifDifferential Gene Expression in Primary Tumors (TCGA)
* Normalized gene expression data of RNASeqV2 was extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered at Jan-05-2015. Only eight cancer types have enough normal control samples for differential expression analysis.
(t test, adjusted p<0.05 (using Benjamini-Hochberg FDR))
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check002.gifCNV vs Gene Expression Plot
* This plots show the correlation between CNV and gene expression.

: Open all plots for all cancer types


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Gene-Gene Network Information
check002.gifCo-Expressed gene's network Plot
* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown.
Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene

: Open all plots for all cancer types

ASB10,ATP1B4,ATP2A1,C10orf71,MIR1-1HG,CACNA1S,CKM,
COX6A2,DHRS7C,PPP1R27,ENO3,KLHL41,LRRC30,MYH6,
MYH7,MYLK2,MYLPF,NEB,TECRL,TMOD4,TNNC2
ATP2A1,MIR1-1HG,CKM,COX6A2,CSRP3,PPP1R27,ENO3,
HFE2,LMOD2,LOC151300,MYH2,MYH6,MYH7,MYL1,
MYL2,MYLPF,NRAP,OR5H15,P2RX6P,PPP1R3A,TCAP,
T

ADAMTS13,AGAP4,APBB3,DDX39B,BRICD5,CENPT,CHKB-CPT1B,
CLK2,CPT1B,CSAD,EGFL8,ENO3,FAM193B,LTB4R,
MDM4,PRR22,SGK494,SPRN,TAF1C,ZGLP1,ZNF692
AGAP11,AQP3,TMEM74B,CCDC108,DNASE1,DSG3,ENO3,
GGN,MLXIPL,MST1,MUC17,NEB,PIK3C2G,PLB1,
PRODH,RHOBTB2,SEC14L2,SLC5A2,TH,WNT9B,ZNF488
check002.gifCo-Expressed gene's Protein-protein interaction Network Plot
* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown.
Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene

: Open all plots for all cancer types

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check002.gifInteracting Genes (from Pathway Commons)

: Open all interacting genes' information including KEGG pathway for all interacting genes from DAVID

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Pharmacological Information for ENO3


There's no related Drug.
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Cross referenced IDs for ENO3
* We obtained these cross-references from Uniprot database. It covers 150 different DBs, 18 categories. http://www.uniprot.org/help/cross_references_section

: Open all cross reference information



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