|
Phenotypic Information (metabolism pathway, cancer, disease, phenome) | |
Gene-Gene Network Information: Co-Expression Network, Interacting Genes & KEGG | |
Gene Summary for EPHX2 |
Top |
Phenotypic Information for EPHX2(metabolism pathway, cancer, disease, phenome) |
![]() | |
Cancer | CGAP: EPHX2 |
Familial Cancer Database: EPHX2 |
* This gene is included in those cancer gene databases. |
. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Oncogene 1 | Significant driver gene in |
cf) number; DB name 1 Oncogene; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long, 2 Tumor Suppressor gene; https://bioinfo.uth.edu/TSGene/, 3 Cancer Gene Census; http://www.nature.com/nrc/journal/v4/n3/abs/nrc1299.html, 4 CancerGenes; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long, 5 Network of Cancer Gene; http://ncg.kcl.ac.uk/index.php, 1Therapeutic Vulnerabilities in Cancer; http://cbio.mskcc.org/cancergenomics/statius/ |
![]() | |
KEGG_ARACHIDONIC_ACID_METABOLISM |
![]() | |
OMIM | |
Orphanet | |
Disease | KEGG Disease: EPHX2 |
MedGen: EPHX2 (Human Medical Genetics with Condition) | |
ClinVar: EPHX2 | |
Phenotype | MGI: EPHX2 (International Mouse Phenotyping Consortium) |
PhenomicDB: EPHX2 |
Mutations for EPHX2 |
* Under tables are showing count per each tissue to give us broad intuition about tissue specific mutation patterns.You can go to the detailed page for each mutation database's web site. |
![]() |
- Statistics for Tissue and Mutation type | Top |
![]() |
- For Inter-chromosomal Variations |
* Inter-chromosomal variantions includes 'interchromosomal amplicon to amplicon', 'interchromosomal amplicon to non-amplified dna', 'interchromosomal insertion', 'Interchromosomal unknown type'. |
![]() |
- For Intra-chromosomal Variations |
* Intra-chromosomal variantions includes 'intrachromosomal amplicon to amplicon', 'intrachromosomal amplicon to non-amplified dna', 'intrachromosomal deletion', 'intrachromosomal fold-back inversion', 'intrachromosomal inversion', 'intrachromosomal tandem duplication', 'Intrachromosomal unknown type', 'intrachromosomal with inverted orientation', 'intrachromosomal with non-inverted orientation'. |
![]() |
Sample | Symbol_a | Chr_a | Start_a | End_a | Symbol_b | Chr_b | Start_b | End_b |
liver | EPHX2 | chr8 | 27389859 | 27389859 | SCARA5 | chr8 | 27830910 | 27830910 |
cf) Tissue number; Tissue name (1;Breast, 2;Central_nervous_system, 3;Haematopoietic_and_lymphoid_tissue, 4;Large_intestine, 5;Liver, 6;Lung, 7;Ovary, 8;Pancreas, 9;Prostate, 10;Skin, 11;Soft_tissue, 12;Upper_aerodigestive_tract) |
![]() |
* From mRNA Sanger sequences, Chitars2.0 arranged chimeric transcripts. This table shows EPHX2 related fusion information. |
ID | Head Gene | Tail Gene | Accession | Gene_a | qStart_a | qEnd_a | Chromosome_a | tStart_a | tEnd_a | Gene_a | qStart_a | qEnd_a | Chromosome_a | tStart_a | tEnd_a |
![]() |
Top |
![]() |
Mutation type/ Tissue ID | brca | cns | cerv | endome | haematopo | kidn | Lintest | liver | lung | ns | ovary | pancre | prost | skin | stoma | thyro | urina | |||
Total # sample | 1 |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   | |||
GAIN (# sample) | 1 |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   | |||
LOSS (# sample) |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |
cf) Tissue ID; Tissue type (1; Breast, 2; Central_nervous_system, 3; Cervix, 4; Endometrium, 5; Haematopoietic_and_lymphoid_tissue, 6; Kidney, 7; Large_intestine, 8; Liver, 9; Lung, 10; NS, 11; Ovary, 12; Pancreas, 13; Prostate, 14; Skin, 15; Stomach, 16; Thyroid, 17; Urinary_tract) |
Top |
![]() |
|
![]() |
Top |
![]() |
Stat. for Non-Synonymous SNVs (# total SNVs=41) | (# total SNVs=19) |
![]() | ![]() |
(# total SNVs=2) | (# total SNVs=0) |
![]() |
Top |
![]() |
* When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site,primary_histology,mutation(aa),pubmedID. |
GRCh37 position | Mutation(aa) | Unique sampleID count |
chr8:27382971-27382971 | p.Q384L | 3 |
chr8:27382881-27382881 | p.A354V | 3 |
chr8:27382957-27382957 | p.P379P | 3 |
chr8:27398124-27398124 | p.E444K | 2 |
chr8:27364474-27364474 | p.T208M | 2 |
chr8:27358512-27358512 | p.E57E | 2 |
chr8:27362584-27362584 | p.S153L | 2 |
chr8:27369368-27369368 | p.A226T | 2 |
chr8:27396186-27396186 | p.S418F | 2 |
chr8:27379945-27379945 | p.L326L | 2 |
Top |
![]() |
|
![]() |
Point Mutation/ Tissue ID | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | 18 | 19 | 20 |
# sample | 3 | 1 | 1 | 2 | 1 |   | 4 |   | 1 |   |   | 4 | 4 | 3 |   |   | 9 | 5 |   | 12 |
# mutation | 3 | 1 | 1 | 2 | 1 |   | 4 |   | 1 |   |   | 4 | 4 | 3 |   |   | 9 | 5 |   | 13 |
nonsynonymous SNV | 2 |   | 1 | 2 |   |   | 4 |   | 1 |   |   | 1 | 3 | 3 |   |   | 5 | 4 |   | 8 |
synonymous SNV | 1 | 1 |   |   | 1 |   |   |   |   |   |   | 3 | 1 |   |   |   | 4 | 1 |   | 5 |
cf) Tissue ID; Tissue type (1; BLCA[Bladder Urothelial Carcinoma], 2; BRCA[Breast invasive carcinoma], 3; CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], 4; COAD[Colon adenocarcinoma], 5; GBM[Glioblastoma multiforme], 6; Glioma Low Grade, 7; HNSC[Head and Neck squamous cell carcinoma], 8; KICH[Kidney Chromophobe], 9; KIRC[Kidney renal clear cell carcinoma], 10; KIRP[Kidney renal papillary cell carcinoma], 11; LAML[Acute Myeloid Leukemia], 12; LUAD[Lung adenocarcinoma], 13; LUSC[Lung squamous cell carcinoma], 14; OV[Ovarian serous cystadenocarcinoma ], 15; PAAD[Pancreatic adenocarcinoma], 16; PRAD[Prostate adenocarcinoma], 17; SKCM[Skin Cutaneous Melanoma], 18:STAD[Stomach adenocarcinoma], 19:THCA[Thyroid carcinoma], 20:UCEC[Uterine Corpus Endometrial Carcinoma]) |
Top |
![]() |
* We represented just top 10 SNVs. When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site, primary_histology, mutation(aa), pubmedID. |
Genomic Position | Mutation(aa) | Unique sampleID count |
chr8:27364474 | p.T142M,EPHX2 | 2 |
chr8:27396186 | p.S352F,EPHX2 | 2 |
chr8:27373267 | p.A29V,EPHX2 | 1 |
chr8:27361194 | p.S172T,EPHX2 | 1 |
chr8:27396187 | p.N365D,EPHX2 | 1 |
chr8:27364405 | p.L40L,EPHX2 | 1 |
chr8:27401308 | p.G174G,EPHX2 | 1 |
chr8:27373843 | p.P370H,EPHX2 | 1 |
chr8:27361207 | p.R47S,EPHX2 | 1 |
chr8:27398071 | p.V176M,EPHX2 | 1 |
![]() |
![]() |
* Copy number data were extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered on Jan-05-2015. Function ProcessCNAData in TCGA-Assembler package was used to obtain gene-level copy number value which is calculated as the average copy number of the genomic region of a gene. |
![]() |
cf) Tissue ID[Tissue type]: BLCA[Bladder Urothelial Carcinoma], BRCA[Breast invasive carcinoma], CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], COAD[Colon adenocarcinoma], GBM[Glioblastoma multiforme], Glioma Low Grade, HNSC[Head and Neck squamous cell carcinoma], KICH[Kidney Chromophobe], KIRC[Kidney renal clear cell carcinoma], KIRP[Kidney renal papillary cell carcinoma], LAML[Acute Myeloid Leukemia], LUAD[Lung adenocarcinoma], LUSC[Lung squamous cell carcinoma], OV[Ovarian serous cystadenocarcinoma ], PAAD[Pancreatic adenocarcinoma], PRAD[Prostate adenocarcinoma], SKCM[Skin Cutaneous Melanoma], STAD[Stomach adenocarcinoma], THCA[Thyroid carcinoma], UCEC[Uterine Corpus Endometrial Carcinoma] |
Top |
Gene Expression for EPHX2 |
![]() |
* CCLE gene expression data were extracted from CCLE_Expression_Entrez_2012-10-18.res: Gene-centric RMA-normalized mRNA expression data. |
![]() |
![]() |
* Normalized gene expression data of RNASeqV2 was extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered at Jan-05-2015. Only eight cancer types have enough normal control samples for differential expression analysis. (t test, adjusted p<0.05 (using Benjamini-Hochberg FDR)) |
![]() |
Top |
![]() |
* This plots show the correlation between CNV and gene expression. |
![]() | |
![]() |
Top |
Gene-Gene Network Information |
![]() |
* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown. Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene |
![]() | |||||
ALDH6A1,BNIP3L,CCDC25,ELP3,EPHX2,FBXO16,FBXO25, HMGCL,INTS9,CCAR2,KIF13B,NEK11,NOSTRIN,NUDT18, PHYHD1,RORC,SH2D4A,SIAE,TMEM25,UBXN8,ZNF395 | AGBL5,CIRBP,EPHX2,GNG7,HSD17B8,IL17RC,ING5, LGTN,LOC100286793,MKS1,POLR1E,RPL3,RPL4,RPL5, RPL7A,RPS18,RPS6,SNHG8,TMCO4,VIPR1,ZNF821 | ||||
![]() | |||||
AGPAT5,BIN3,CCDC25,CNOT7,ELP3,DMTN,EPHX2, ERICH1,FBXO25,INTS10,INTS9,KBTBD11,CCAR2,LONRF1, MCPH1,NAT1,NAT2,TRIM35,TTC38,VPS37A,XPO7 | ACY1,CCDC108,CHN2,CLDN15,CYP2J2,DAK,DDC, DEGS2,DGAT1,EPHX2,FBP1,IYD,MACC1,MMEL1, MARC2,MYO1A,PCK2,PKLR,SLC37A4,SLC39A5,TM4SF5 |
![]() |
* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown. Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene |
Top |
![]() |
Top |
Pharmacological Information for EPHX2 |
![]() |
DB Category | DB Name | DB's ID and Url link |
![]() |
* Gene Centered Interaction Network. |
![]() |
* Drug Centered Interaction Network. |
DrugBank ID | Target Name | Drug Groups | Generic Name | Drug Centered Network | Drug Structure |
DB01248 | epoxide hydrolase 2, cytoplasmic | approved; investigational | Docetaxel | ![]() | ![]() |
Top |
Cross referenced IDs for EPHX2 |
* We obtained these cross-references from Uniprot database. It covers 150 different DBs, 18 categories. http://www.uniprot.org/help/cross_references_section |
Copyright © 2016-Present - The Univsersity of Texas Health Science Center at Houston @ |