Cancer Cell Metabolism Gene Database

  Cancer Cell Metabolism Gene DB

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Gene Summary

Phenotypic Information (metabolism pathway, cancer, disease, phenome)

Mutations: SVs, CNVs, SNVs

Gene expression: GE, Protein, DEGE, CNV vs GE

Gene-Gene Network Information: Co-Expression Network, Interacting Genes & KEGG

Pharmacological Information: Drug-Gene Network

Cross referenced IDs

Gene Summary for AKT1
Basic gene info.Gene symbolAKT1
Gene namev-akt murine thymoma viral oncogene homolog 1
SynonymsAKT|CWS6|PKB|PKB-ALPHA|PRKBA|RAC|RAC-ALPHA
CytomapUCSC genome browser: 14q32.32
Genomic locationchr14 :105235686-105262080
Type of geneprotein-coding
RefGenesNM_001014431.1,
NM_001014432.1,NM_005163.2,
Ensembl idENSG00000142208
DescriptionAKT1mPKB alphaRAC-PK-alphaRAC-alpha serine/threonine-protein kinaseprotein kinase B alphaproto-oncogene c-Aktrac protein kinase alpha
Modification date20141222
dbXrefs MIM : 164730
HGNC : HGNC
Ensembl : ENSG00000142208
HPRD : 01261
Vega : OTTHUMG00000170795
ProteinUniProt: P31749
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_AKT1
BioGPS: 207
Gene Expression Atlas: ENSG00000142208
The Human Protein Atlas: ENSG00000142208
PathwayNCI Pathway Interaction Database: AKT1
KEGG: AKT1
REACTOME: AKT1
ConsensusPathDB
Pathway Commons: AKT1
MetabolismMetaCyc: AKT1
HUMANCyc: AKT1
RegulationEnsembl's Regulation: ENSG00000142208
miRBase: chr14 :105,235,686-105,262,080
TargetScan: NM_001014431
cisRED: ENSG00000142208
ContextiHOP: AKT1
cancer metabolism search in PubMed: AKT1
UCL Cancer Institute: AKT1
Assigned class in ccmGDBA - This gene has a literature evidence and it belongs to cancer gene.
References showing role of AKT1 in cancer cell metabolism1. Tenkerian C, Krishnamoorthy J, Mounir Z, Kazimierczak U, Khoutorsky A, et al. (2015) mTORC2 balances Akt activation and eIF2alpha serine 51 phosphorylation to promote survival under stress. Mol Cancer Res. doi: 10.1158/1541-7786.MCR-15-0184-T. go to article
2. Zhang Y, Guo X, Xiong L, Yu L, Li Z, et al. (2014) Comprehensive analysis of microRNA-regulated protein interaction network reveals the tumor suppressive role of microRNA-149 in human hepatocellular carcinoma via targeting AKT-mTOR pathway. Mol Cancer 13: 253. doi: 10.1186/1476-4598-13-253. pmid: 4255446. go to article
3. Maurya AK, Vinayak M (2015) Quercetin regresses Dalton's lymphoma growth via suppression of PI3K/AKT signaling leading to upregulation of p53 and decrease in energy metabolism. Nutr Cancer 67: 354-363. doi: 10.1080/01635581.2015.990574. go to article
4. Villar VH, Merhi F, Djavaheri-Mergny M, Duran RV (2015) Glutaminolysis and autophagy in cancer. Autophagy: 0. doi: 10.1080/15548627.2015.1053680. go to article

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Phenotypic Information for AKT1(metabolism pathway, cancer, disease, phenome)
check002.gifCancer Description
Cancer CGAP: AKT1
Familial Cancer Database: AKT1
* This gene is included in those cancer gene databases.

.

Oncogene 1

Tumor Suppressor gene 2

Cancer Gene Census 3

CancerGenes 4

Network of Cancer Gene 5

Significant driver gene in BRCA 6, UCEC 7,

Therapeutic Vulnerabilities in Cancer8

cf) number; DB name
1 Oncogene; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long,
2 Tumor Suppressor gene; https://bioinfo.uth.edu/TSGene/,
3 Cancer Gene Census; http://www.nature.com/nrc/journal/v4/n3/abs/nrc1299.html,
4 CancerGenes; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long,
5 Network of Cancer Gene; http://ncg.kcl.ac.uk/index.php,
6 http://www.nature.com/nature/journal/v490/n7418/full/nature11412.html,
7 http://www.nature.com/nature/journal/v497/n7447/full/nature12113.html,
8Therapeutic Vulnerabilities in Cancer; http://cbio.mskcc.org/cancergenomics/statius/

check002.gifMetabolic Pathway Description
KEGG_FC_GAMMA_R_MEDIATED_PHAGOCYTOSIS
REACTOME_METABOLISM_OF_MRNA
REACTOME_METABOLISM_OF_RNA

check002.gifOthers
OMIM 114480; phenotype.
114500; phenotype.
164730; gene.
176920; phenotype.
615109; phenotype.
Orphanet 201; Cowden syndrome.
744; Proteus syndrome.
DiseaseKEGG Disease: AKT1
MedGen: AKT1 (Human Medical Genetics with Condition)
ClinVar: AKT1
PhenotypeMGI: AKT1 (International Mouse Phenotyping Consortium)
PhenomicDB: AKT1

Mutations for AKT1
* Under tables are showing count per each tissue to give us broad intuition about tissue specific mutation patterns.You can go to the detailed page for each mutation database's web site.

check002.gifStructural Variants in COSMIC: go to COSMIC mutation histogram
There's no structural variation information in COSMIC data for this gene.

check002.gifRelated fusion transcripts : go to Chitars2.0
* From mRNA Sanger sequences, Chitars2.0 arranged chimeric transcripts. This table shows AKT1 related fusion information.
IDHead GeneTail Gene
AccessionGene_aqStart_aqEnd_aChromosome_atStart_atEnd_aGene_aqStart_aqEnd_aChromosome_atStart_atEnd_a
BC063408AKT1115714105258934105261851PPP3R115426826840598868406102

check002.gifOther DBs for Structural Variants
Structural Variants in Ensembl: go to Ensembl Structural variation
Structural Variants in dbVar: go to dbVar

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check002.gifCopy Number Variations in COSMIC: go to COSMIC mutation CNV/Expr
There's no copy number variation information in COSMIC data for this gene.

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check002.gifSNV Counts per Each Loci in COSMIC data: go to COSMIC point mutation

 : Non-synonymous mutation, : Synonymous mutation, Circle size denotes number of samples.
Maximum mutation count=435

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check002.gifSomatic Mutation Counts per Tissue in COSMIC data
Stat. for Non-Synonymous SNVs
(# total SNVs=359)
Stat. for Synonymous SNVs
(# total SNVs=10)
Stat. for Deletions
(# total SNVs=0)
Stat. for Insertions
(# total SNVs=0)
There's no deleted snv.There's no inserted snv.

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check002.gifTop 10 SNVs Having the Most Samples in COSMIC data
* When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site,primary_histology,mutation(aa),pubmedID.
GRCh37 positionMutation(aa)Unique sampleID count
chr14:105246551-105246551p.E17K283
chr14:105246445-105246445p.L52R5
chr14:105242100-105242100p.D108D2
chr14:105241437-105241437p.L181L2
chr14:105243048-105243048p.Q79K2
chr14:105239878-105239878p.D248H2
chr14:105239419-105239419p.D323G2
chr14:105239894-105239894p.E242E2
chr14:105242063-105242063p.R121W2
chr14:105239628-105239628p.M306T1

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check002.gifSNV Counts per Each Loci in TCGA data

 : non-synonymous mutation, : synonymous mutation, Circle size denotes number of samples.
maximum mutation count=23

Point Mutation/ Tissue ID1234567891011121314151617181920
# sample220 91 3 2  111 15518
# mutation23 91 3 2  111 15518
nonsynonymous SNV 2 71 2 2  11  113 4
synonymous SNV21 2  1      1  4214
cf) Tissue ID; Tissue type (1; BLCA[Bladder Urothelial Carcinoma], 2; BRCA[Breast invasive carcinoma], 3; CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], 4; COAD[Colon adenocarcinoma], 5; GBM[Glioblastoma multiforme], 6; Glioma Low Grade, 7; HNSC[Head and Neck squamous cell carcinoma], 8; KICH[Kidney Chromophobe], 9; KIRC[Kidney renal clear cell carcinoma], 10; KIRP[Kidney renal papillary cell carcinoma], 11; LAML[Acute Myeloid Leukemia], 12; LUAD[Lung adenocarcinoma], 13; LUSC[Lung squamous cell carcinoma], 14; OV[Ovarian serous cystadenocarcinoma ], 15; PAAD[Pancreatic adenocarcinoma], 16; PRAD[Prostate adenocarcinoma], 17; SKCM[Skin Cutaneous Melanoma], 18:STAD[Stomach adenocarcinoma], 19:THCA[Thyroid carcinoma], 20:UCEC[Uterine Corpus Endometrial Carcinoma])

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check002.gifTop 10 SNVs Having the Most Samples in TCGA data
* We represented just top 10 SNVs. When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site, primary_histology, mutation(aa), pubmedID.
Genomic PositionMutation(aa)Unique sampleID count
chr14:105246551p.E17K,AKT123
chr14:105246445p.L52R,AKT12
chr14:105242100p.D108D,AKT12
chr14:105241449p.K284K,AKT11
chr14:105246435p.Q79K,AKT11
chr14:105239379p.S266S,AKT11
chr14:105241522p.R69R,AKT11
chr14:105239420p.N231N,AKT11
chr14:105241992p.T65M,AKT11
chr14:105246455p.R222R,AKT11

check002.gifOther DBs for Point Mutations
Point Mutation Table of Ensembl: go to Ensembl variation table
Mutation of cBioPortal: go to cBioPortal's Cross-cancer alteration summary

check002.gifCopy Number for AKT1 in TCGA
* Copy number data were extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered on Jan-05-2015. Function ProcessCNAData in TCGA-Assembler package was used to obtain gene-level copy number value which is calculated as the average copy number of the genomic region of a gene.
cf) Tissue ID[Tissue type]: BLCA[Bladder Urothelial Carcinoma], BRCA[Breast invasive carcinoma], CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], COAD[Colon adenocarcinoma], GBM[Glioblastoma multiforme], Glioma Low Grade, HNSC[Head and Neck squamous cell carcinoma], KICH[Kidney Chromophobe], KIRC[Kidney renal clear cell carcinoma], KIRP[Kidney renal papillary cell carcinoma], LAML[Acute Myeloid Leukemia], LUAD[Lung adenocarcinoma], LUSC[Lung squamous cell carcinoma], OV[Ovarian serous cystadenocarcinoma ], PAAD[Pancreatic adenocarcinoma], PRAD[Prostate adenocarcinoma], SKCM[Skin Cutaneous Melanoma], STAD[Stomach adenocarcinoma], THCA[Thyroid carcinoma], UCEC[Uterine Corpus Endometrial Carcinoma]

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Gene Expression for AKT1

check002.gifGene Expression in Cancer Cell-lines (CCLE)
* CCLE gene expression data were extracted from CCLE_Expression_Entrez_2012-10-18.res: Gene-centric RMA-normalized mRNA expression data.
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check002.gifProtein Expression Plot (RPPA)
*RPPA protein expression data were extracted from TCPA (The Cancer Proteome Atlas). Normalized data based on replicated based normalization (RBN) was used to draw following figures.

check002.gifDifferential Gene Expression in Primary Tumors (TCGA)
* Normalized gene expression data of RNASeqV2 was extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered at Jan-05-2015. Only eight cancer types have enough normal control samples for differential expression analysis.
(t test, adjusted p<0.05 (using Benjamini-Hochberg FDR))
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check002.gifCNV vs Gene Expression Plot
* This plots show the correlation between CNV and gene expression.

: Open all plots for all cancer types


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Gene-Gene Network Information
check002.gifCo-Expressed gene's network Plot
* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown.
Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene

: Open all plots for all cancer types

ADSSL1,AKT1,BRF1,BTBD6,APOPT1,CCDC85C,CRIP2,
DOLPP1,GALE,INF2,CEP170B,MARK3,MTA1,PACS2,
PAK4,PPP2R4,SIVA1,SPDEF,XRCC3,ZBTB42,ZFYVE21
AAMP,ABCB8,AKT1,ASNA1,B4GALT7,C9orf69,CENPB,
DRAP1,GIPC1,IMP4,LRPAP1,MXD4,NCLN,PFKL,
PIN1,RAB1B,SDF4,SLC4A2,SNF8,STRN4,TMEM129

AKT1,BAG5,BRF1,BTBD6,C14orf80,CCDC85C,FNTB,
GLRX5,INF2,CEP170B,MARK3,MTA1,PACS2,POMT2,
PPP1R13B,RCOR1,VTI1B,WDR20,XRCC3,ZBTB42,ZFYVE21
AKT1,ANKRD13B,DBN1,DLGAP4,EVI5L,JMJD8,KLC2,
LOXL1,LPPR2,MAP4,NACC2,NCDN,NDE1,NFIX,
PIP5K1C,PKN1,RANBP3,RBM38,SLC4A2,SPRYD3,ST5
check002.gifCo-Expressed gene's Protein-protein interaction Network Plot
* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown.
Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene

: Open all plots for all cancer types

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check002.gifInteracting Genes (from Pathway Commons)

: Open all interacting genes' information including KEGG pathway for all interacting genes from DAVID

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Pharmacological Information for AKT1
check002.gifCross-referenced pharmacological DB IDs from Uniprot
DB CategoryDB NameDB's ID and Url link
ChemistryBindingDB P31749; -.
ChemistryChEMBL CHEMBL3038463; -.
ChemistryGuidetoPHARMACOLOGY 1479; -.
Organism-specific databasesPharmGKB PA24684; -.
Organism-specific databasesCTD 207; -.

check002.gifDrug-Gene Interaction Network
* Gene Centered Interaction Network.
* Drug Centered Interaction Network.
DrugBank IDTarget NameDrug GroupsGeneric NameDrug Centered NetworkDrug Structure
DB00171v-akt murine thymoma viral oncogene homolog 1approved; nutraceuticalAdenosine triphosphate
DB01169v-akt murine thymoma viral oncogene homolog 1approved; investigationalArsenic trioxide
DB01863v-akt murine thymoma viral oncogene homolog 1experimentalInositol 1,3,4,5-Tetrakisphosphate
DB07584v-akt murine thymoma viral oncogene homolog 1experimentalN-[2-(5-methyl-4H-1,2,4-triazol-3-yl)phenyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine
DB07585v-akt murine thymoma viral oncogene homolog 1experimental5-(5-chloro-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine
DB00398v-akt murine thymoma viral oncogene homolog 1approved; investigationalSorafenib
DB00864v-akt murine thymoma viral oncogene homolog 1approved; investigationalTacrolimus
DB00675v-akt murine thymoma viral oncogene homolog 1approvedTamoxifen
DB00734v-akt murine thymoma viral oncogene homolog 1approved; investigationalRisperidone
DB00997v-akt murine thymoma viral oncogene homolog 1approved; investigationalDoxorubicin
DB00317v-akt murine thymoma viral oncogene homolog 1approved; investigationalGefitinib
DB01259v-akt murine thymoma viral oncogene homolog 1approved; investigationalLapatinib
DB00360v-akt murine thymoma viral oncogene homolog 1approved; investigationalTetrahydrobiopterin
DB00394v-akt murine thymoma viral oncogene homolog 1approvedBeclomethasone
DB00443v-akt murine thymoma viral oncogene homolog 1approvedBetamethasone
DB01222v-akt murine thymoma viral oncogene homolog 1approved; investigationalBudesonide
DB01410v-akt murine thymoma viral oncogene homolog 1approved; investigationalCiclesonide
DB01260v-akt murine thymoma viral oncogene homolog 1approved; investigationalDesonide
DB01234v-akt murine thymoma viral oncogene homolog 1approved; investigationalDexamethasone
DB00180v-akt murine thymoma viral oncogene homolog 1approved; investigationalFlunisolide
DB00588v-akt murine thymoma viral oncogene homolog 1approved; investigationalFluticasone Propionate
DB00741v-akt murine thymoma viral oncogene homolog 1approvedHydrocortisone
DB00959v-akt murine thymoma viral oncogene homolog 1approvedMethylprednisolone
DB00764v-akt murine thymoma viral oncogene homolog 1approvedMometasone
DB01384v-akt murine thymoma viral oncogene homolog 1approvedParamethasone
DB00860v-akt murine thymoma viral oncogene homolog 1approvedPrednisolone
DB00635v-akt murine thymoma viral oncogene homolog 1approvedPrednisone
DB00896v-akt murine thymoma viral oncogene homolog 1approvedRimexolone
DB00620v-akt murine thymoma viral oncogene homolog 1approvedTriamcinolone
DB00877v-akt murine thymoma viral oncogene homolog 1approved; investigationalSirolimus
DB00143v-akt murine thymoma viral oncogene homolog 1approved; nutraceuticalGlutathione
DB00122v-akt murine thymoma viral oncogene homolog 1approved; nutraceuticalCholine
DB00125v-akt murine thymoma viral oncogene homolog 1approved; nutraceuticalL-Arginine
DB00155v-akt murine thymoma viral oncogene homolog 1approved; nutraceuticalL-Citrulline
DB00435v-akt murine thymoma viral oncogene homolog 1approvedNitric Oxide
DB00131v-akt murine thymoma viral oncogene homolog 1approved; nutraceuticalAdenosine monophosphate
DB00619v-akt murine thymoma viral oncogene homolog 1approvedImatinib
DB00515v-akt murine thymoma viral oncogene homolog 1approvedCisplatin
DB00441v-akt murine thymoma viral oncogene homolog 1approvedGemcitabine
DB00482v-akt murine thymoma viral oncogene homolog 1approved; investigationalCelecoxib
DB00184v-akt murine thymoma viral oncogene homolog 1approvedNicotine
DB01132v-akt murine thymoma viral oncogene homolog 1approved; investigationalPioglitazone
DB00412v-akt murine thymoma viral oncogene homolog 1approved; investigationalRosiglitazone


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Cross referenced IDs for AKT1
* We obtained these cross-references from Uniprot database. It covers 150 different DBs, 18 categories. http://www.uniprot.org/help/cross_references_section

: Open all cross reference information



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