Cancer Cell Metabolism Database ~~ Bioinformatics and Systems Medicine Laboratory ~~

Cancer Cell Metabolism Gene Database

Cancer Cell Metabolism Gene DB

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	Gene Summary
	Phenotypic Information (metabolism pathway, cancer, disease, phenome)
	Mutations : SVs, CNVs, SNVs
	Gene expression: GE, Protein, DEGE, CNV vs GE
	Gene-Gene Network Information: Co-Expression Network, Interacting Genes & KEGG
	Pharmacological Information: Drug-Gene Network
	Cross referenced IDs

Gene Summary for AKT1

Basic gene info.	Gene symbol	AKT1
	Gene name	v-akt murine thymoma viral oncogene homolog 1
	Synonyms	AKT\|CWS6\|PKB\|PKB-ALPHA\|PRKBA\|RAC\|RAC-ALPHA
	Cytomap	UCSC genome browser: 14q32.32
	Genomic location	chr14 :105235686-105262080
	Type of gene	protein-coding
	RefGenes	NM_001014431.1, NM_001014432.1,NM_005163.2,
	Ensembl id	ENSG00000142208
	Description	AKT1mPKB alphaRAC-PK-alphaRAC-alpha serine/threonine-protein kinaseprotein kinase B alphaproto-oncogene c-Aktrac protein kinase alpha
	Modification date	20141222
dbXrefs	MIM : 164730
	HGNC : HGNC
	Ensembl : ENSG00000142208
	HPRD : 01261
	Vega : OTTHUMG00000170795
Protein	UniProt: P31749 go to UniProt's Cross Reference DB Table
Expression	CleanEX: HS_AKT1
	BioGPS: 207
	Gene Expression Atlas: ENSG00000142208
	The Human Protein Atlas: ENSG00000142208
Pathway	NCI Pathway Interaction Database: AKT1
	KEGG: AKT1
	REACTOME: AKT1
	ConsensusPathDB
	Pathway Commons: AKT1
Metabolism	MetaCyc: AKT1
	HUMANCyc: AKT1
Regulation	Ensembl's Regulation: ENSG00000142208
	miRBase: chr14 :105,235,686-105,262,080
	TargetScan: NM_001014431
	cisRED: ENSG00000142208
Context	iHOP: AKT1
	cancer metabolism search in PubMed: AKT1
	UCL Cancer Institute: AKT1
Assigned class in ccmGDB	A - This gene has a literature evidence and it belongs to cancer gene.
References showing role of AKT1 in cancer cell metabolism	1. Tenkerian C, Krishnamoorthy J, Mounir Z, Kazimierczak U, Khoutorsky A, et al. (2015) mTORC2 balances Akt activation and eIF2alpha serine 51 phosphorylation to promote survival under stress. Mol Cancer Res. doi: 10.1158/1541-7786.MCR-15-0184-T. go to article 2. Zhang Y, Guo X, Xiong L, Yu L, Li Z, et al. (2014) Comprehensive analysis of microRNA-regulated protein interaction network reveals the tumor suppressive role of microRNA-149 in human hepatocellular carcinoma via targeting AKT-mTOR pathway. Mol Cancer 13: 253. doi: 10.1186/1476-4598-13-253. pmid: 4255446. go to article 3. Maurya AK, Vinayak M (2015) Quercetin regresses Dalton's lymphoma growth via suppression of PI3K/AKT signaling leading to upregulation of p53 and decrease in energy metabolism. Nutr Cancer 67: 354-363. doi: 10.1080/01635581.2015.990574. go to article 4. Villar VH, Merhi F, Djavaheri-Mergny M, Duran RV (2015) Glutaminolysis and autophagy in cancer. Autophagy: 0. doi: 10.1080/15548627.2015.1053680. go to article

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Phenotypic Information for AKT1(metabolism pathway, cancer, disease, phenome)

Cancer Description
Cancer	CGAP: AKT1
	Familial Cancer Database: AKT1

* This gene is included in those cancer gene databases.

						.
Oncogene ¹	Tumor Suppressor gene ²	Cancer Gene Census ³	CancerGenes ⁴	Network of Cancer Gene ⁵	Significant driver gene in BRCA ⁶, UCEC ⁷,	Therapeutic Vulnerabilities in Cancer⁸

cf) number; DB name
1 Oncogene; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long,
2 Tumor Suppressor gene; https://bioinfo.uth.edu/TSGene/,
3 Cancer Gene Census; http://www.nature.com/nrc/journal/v4/n3/abs/nrc1299.html,
4 CancerGenes; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long,
5 Network of Cancer Gene; http://ncg.kcl.ac.uk/index.php,
6 http://www.nature.com/nature/journal/v490/n7418/full/nature11412.html,
7 http://www.nature.com/nature/journal/v497/n7447/full/nature12113.html,
8Therapeutic Vulnerabilities in Cancer; http://cbio.mskcc.org/cancergenomics/statius/

Metabolic Pathway Description
KEGG_FC_GAMMA_R_MEDIATED_PHAGOCYTOSIS REACTOME_METABOLISM_OF_MRNA REACTOME_METABOLISM_OF_RNA

Others
OMIM	114480; phenotype. 114500; phenotype. 164730; gene. 176920; phenotype. 615109; phenotype.
Orphanet	201; Cowden syndrome. 744; Proteus syndrome.
Disease	KEGG Disease: AKT1
	MedGen: AKT1 (Human Medical Genetics with Condition)
	ClinVar: AKT1
Phenotype	MGI: AKT1 (International Mouse Phenotyping Consortium)
Phenotype	PhenomicDB: AKT1

Mutations for AKT1

* Under tables are showing count per each tissue to give us broad intuition about tissue specific mutation patterns.You can go to the detailed page for each mutation database's web site.

Structural Variants in COSMIC : go to COSMIC mutation histogram

There's no structural variation information in COSMIC data for this gene.

Related fusion transcripts : go to Chitars2.0

* From mRNA Sanger sequences, Chitars2.0 arranged chimeric transcripts. This table shows AKT1 related fusion information.

Head Gene

Tail Gene

Accession

Gene_a

qStart_a

qEnd_a

Chromosome_a

tStart_a

tEnd_a

Gene_a

qStart_a

qEnd_a

Chromosome_a

tStart_a

tEnd_a

BC063408

AKT1

157

105258934

105261851

PPP3R1

154

268

68405988

68406102

Other DBs for Structural Variants

Structural Variants in Ensembl: go to Ensembl Structural variation

Structural Variants in dbVar: go to dbVar

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Copy Number Variations in COSMIC : go to COSMIC mutation CNV/Expr

There's no copy number variation information in COSMIC data for this gene.

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SNV Counts per Each Loci in COSMIC data : go to COSMIC point mutation

: Non-synonymous mutation, : Synonymous mutation, Circle size denotes number of samples.
Maximum mutation count=435

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Somatic Mutation Counts per Tissue in COSMIC data

Stat. for Non-Synonymous SNVs (# total SNVs=359)	Stat. for Synonymous SNVs (# total SNVs=10)

Stat. for Deletions (# total SNVs=0)	Stat. for Insertions (# total SNVs=0)
There's no deleted snv.	There's no inserted snv.

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Top 10 SNVs Having the Most Samples in COSMIC data

* When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site,primary_histology,mutation(aa),pubmedID.

GRCh37 position	Mutation(aa)	Unique sampleID count
chr14:105246551-105246551	p.E17K	283
chr14:105246445-105246445	p.L52R	5
chr14:105243048-105243048	p.Q79K	2
chr14:105239878-105239878	p.D248H	2
chr14:105239419-105239419	p.D323G	2
chr14:105239894-105239894	p.E242E	2
chr14:105242063-105242063	p.R121W	2
chr14:105242100-105242100	p.D108D	2
chr14:105241437-105241437	p.L181L	2
chr14:105239693-105239693	p.K284K	1

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SNV Counts per Each Loci in TCGA data

: non-synonymous mutation, : synonymous mutation, Circle size denotes number of samples.
maximum mutation count=23

Point Mutation/ Tissue ID	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20
# sample	2	20		9	1		3		2			1	1	1		1	5	5	1	8
# mutation	2	3		9	1		3		2			1	1	1		1	5	5	1	8
nonsynonymous SNV		2		7	1		2		2			1	1			1	1	3		4
synonymous SNV	2	1		2			1							1			4	2	1	4

cf) Tissue ID; Tissue type (1; BLCA[Bladder Urothelial Carcinoma], 2; BRCA[Breast invasive carcinoma], 3; CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], 4; COAD[Colon adenocarcinoma], 5; GBM[Glioblastoma multiforme], 6; Glioma Low Grade, 7; HNSC[Head and Neck squamous cell carcinoma], 8; KICH[Kidney Chromophobe], 9; KIRC[Kidney renal clear cell carcinoma], 10; KIRP[Kidney renal papillary cell carcinoma], 11; LAML[Acute Myeloid Leukemia], 12; LUAD[Lung adenocarcinoma], 13; LUSC[Lung squamous cell carcinoma], 14; OV[Ovarian serous cystadenocarcinoma ], 15; PAAD[Pancreatic adenocarcinoma], 16; PRAD[Prostate adenocarcinoma], 17; SKCM[Skin Cutaneous Melanoma], 18:STAD[Stomach adenocarcinoma], 19:THCA[Thyroid carcinoma], 20:UCEC[Uterine Corpus Endometrial Carcinoma])

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Top 10 SNVs Having the Most Samples in TCGA data

* We represented just top 10 SNVs. When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site, primary_histology, mutation(aa), pubmedID.

Genomic Position	Mutation(aa)	Unique sampleID count
chr14:105246551	p.E17K,AKT1	23
chr14:105246445	p.D108D,AKT1	2
chr14:105242100	p.L52R,AKT1	2
chr14:105241276	p.Y417C,AKT1	1
chr14:105243045	p.R144R,AKT1	1
chr14:105238712	p.F35S,AKT1	1
chr14:105246496	p.V416V,AKT1	1
chr14:105241278	p.S122S,AKT1	1
chr14:105243048	p.R25R,AKT1	1
chr14:105238714	p.T371T,AKT1	1

Other DBs for Point Mutations

Point Mutation Table of Ensembl: go to Ensembl variation table

Mutation of cBioPortal: go to cBioPortal's Cross-cancer alteration summary

Copy Number for AKT1 in TCGA

* Copy number data were extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered on Jan-05-2015. Function ProcessCNAData in TCGA-Assembler package was used to obtain gene-level copy number value which is calculated as the average copy number of the genomic region of a gene.

cf) Tissue ID[Tissue type]: BLCA[Bladder Urothelial Carcinoma], BRCA[Breast invasive carcinoma], CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], COAD[Colon adenocarcinoma], GBM[Glioblastoma multiforme], Glioma Low Grade, HNSC[Head and Neck squamous cell carcinoma], KICH[Kidney Chromophobe], KIRC[Kidney renal clear cell carcinoma], KIRP[Kidney renal papillary cell carcinoma], LAML[Acute Myeloid Leukemia], LUAD[Lung adenocarcinoma], LUSC[Lung squamous cell carcinoma], OV[Ovarian serous cystadenocarcinoma ], PAAD[Pancreatic adenocarcinoma], PRAD[Prostate adenocarcinoma], SKCM[Skin Cutaneous Melanoma], STAD[Stomach adenocarcinoma], THCA[Thyroid carcinoma], UCEC[Uterine Corpus Endometrial Carcinoma]

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Gene Expression for AKT1

Gene Expression in Cancer Cell-lines (CCLE)

* CCLE gene expression data were extracted from CCLE_Expression_Entrez_2012-10-18.res: Gene-centric RMA-normalized mRNA expression data.

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Protein Expression Plot (RPPA)

*RPPA protein expression data were extracted from TCPA (The Cancer Proteome Atlas). Normalized data based on replicated based normalization (RBN) was used to draw following figures.

Differential Gene Expression in Primary Tumors (TCGA)

* Normalized gene expression data of RNASeqV2 was extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered at Jan-05-2015. Only eight cancer types have enough normal control samples for differential expression analysis.
(t test, adjusted p<0.05 (using Benjamini-Hochberg FDR))

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CNV vs Gene Expression Plot

* This plots show the correlation between CNV and gene expression.

: Open all plots for all cancer types

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Gene-Gene Network Information

Co-Expressed gene's network Plot

* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown.
Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene

: Open all plots for all cancer types


ADSSL1,AKT1,BRF1,BTBD6,APOPT1,CCDC85C,CRIP2, DOLPP1,GALE,INF2,CEP170B,MARK3,MTA1,PACS2, PAK4,PPP2R4,SIVA1,SPDEF,XRCC3,ZBTB42,ZFYVE21	AAMP,ABCB8,AKT1,ASNA1,B4GALT7,C9orf69,CENPB, DRAP1,GIPC1,IMP4,LRPAP1,MXD4,NCLN,PFKL, PIN1,RAB1B,SDF4,SLC4A2,SNF8,STRN4,TMEM129

AKT1,BAG5,BRF1,BTBD6,C14orf80,CCDC85C,FNTB, GLRX5,INF2,CEP170B,MARK3,MTA1,PACS2,POMT2, PPP1R13B,RCOR1,VTI1B,WDR20,XRCC3,ZBTB42,ZFYVE21	AKT1,ANKRD13B,DBN1,DLGAP4,EVI5L,JMJD8,KLC2, LOXL1,LPPR2,MAP4,NACC2,NCDN,NDE1,NFIX, PIP5K1C,PKN1,RANBP3,RBM38,SLC4A2,SPRYD3,ST5

Co-Expressed gene's Protein-protein interaction Network Plot

: Open all plots for all cancer types

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Interacting Genes (from Pathway Commons)

: Open all interacting genes' information including KEGG pathway for all interacting genes from DAVID

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Pharmacological Information for AKT1

Cross-referenced pharmacological DB IDs from Uniprot

DB Category	DB Name	DB's ID and Url link
Chemistry	BindingDB	P31749; -.
Chemistry	ChEMBL	CHEMBL3038463; -.
Chemistry	GuidetoPHARMACOLOGY	1479; -.
Organism-specific databases	PharmGKB	PA24684; -.
Organism-specific databases	CTD	207; -.

Drug-Gene Interaction Network

* Gene Centered Interaction Network.

* Drug Centered Interaction Network.

DrugBank ID	Target Name	Drug Groups	Generic Name	Drug Centered Network	Drug Structure
DB00171	v-akt murine thymoma viral oncogene homolog 1	approved; nutraceutical	Adenosine triphosphate
DB01169	v-akt murine thymoma viral oncogene homolog 1	approved; investigational	Arsenic trioxide
DB01863	v-akt murine thymoma viral oncogene homolog 1	experimental	Inositol 1,3,4,5-Tetrakisphosphate
DB07584	v-akt murine thymoma viral oncogene homolog 1	experimental	N-[2-(5-methyl-4H-1,2,4-triazol-3-yl)phenyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine
DB07585	v-akt murine thymoma viral oncogene homolog 1	experimental	5-(5-chloro-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine
DB00398	v-akt murine thymoma viral oncogene homolog 1	approved; investigational	Sorafenib
DB00864	v-akt murine thymoma viral oncogene homolog 1	approved; investigational	Tacrolimus
DB00675	v-akt murine thymoma viral oncogene homolog 1	approved	Tamoxifen
DB00734	v-akt murine thymoma viral oncogene homolog 1	approved; investigational	Risperidone
DB00997	v-akt murine thymoma viral oncogene homolog 1	approved; investigational	Doxorubicin
DB00317	v-akt murine thymoma viral oncogene homolog 1	approved; investigational	Gefitinib
DB01259	v-akt murine thymoma viral oncogene homolog 1	approved; investigational	Lapatinib
DB00360	v-akt murine thymoma viral oncogene homolog 1	approved; investigational	Tetrahydrobiopterin
DB00394	v-akt murine thymoma viral oncogene homolog 1	approved	Beclomethasone
DB00443	v-akt murine thymoma viral oncogene homolog 1	approved	Betamethasone
DB01222	v-akt murine thymoma viral oncogene homolog 1	approved; investigational	Budesonide
DB01410	v-akt murine thymoma viral oncogene homolog 1	approved; investigational	Ciclesonide
DB01260	v-akt murine thymoma viral oncogene homolog 1	approved; investigational	Desonide
DB01234	v-akt murine thymoma viral oncogene homolog 1	approved; investigational	Dexamethasone
DB00180	v-akt murine thymoma viral oncogene homolog 1	approved; investigational	Flunisolide
DB00588	v-akt murine thymoma viral oncogene homolog 1	approved; investigational	Fluticasone Propionate
DB00741	v-akt murine thymoma viral oncogene homolog 1	approved	Hydrocortisone
DB00959	v-akt murine thymoma viral oncogene homolog 1	approved	Methylprednisolone
DB00764	v-akt murine thymoma viral oncogene homolog 1	approved	Mometasone
DB01384	v-akt murine thymoma viral oncogene homolog 1	approved	Paramethasone
DB00860	v-akt murine thymoma viral oncogene homolog 1	approved	Prednisolone
DB00635	v-akt murine thymoma viral oncogene homolog 1	approved	Prednisone
DB00896	v-akt murine thymoma viral oncogene homolog 1	approved	Rimexolone
DB00620	v-akt murine thymoma viral oncogene homolog 1	approved	Triamcinolone
DB00877	v-akt murine thymoma viral oncogene homolog 1	approved; investigational	Sirolimus
DB00143	v-akt murine thymoma viral oncogene homolog 1	approved; nutraceutical	Glutathione
DB00122	v-akt murine thymoma viral oncogene homolog 1	approved; nutraceutical	Choline
DB00125	v-akt murine thymoma viral oncogene homolog 1	approved; nutraceutical	L-Arginine
DB00155	v-akt murine thymoma viral oncogene homolog 1	approved; nutraceutical	L-Citrulline
DB00435	v-akt murine thymoma viral oncogene homolog 1	approved	Nitric Oxide
DB00131	v-akt murine thymoma viral oncogene homolog 1	approved; nutraceutical	Adenosine monophosphate
DB00619	v-akt murine thymoma viral oncogene homolog 1	approved	Imatinib
DB00515	v-akt murine thymoma viral oncogene homolog 1	approved	Cisplatin
DB00441	v-akt murine thymoma viral oncogene homolog 1	approved	Gemcitabine
DB00482	v-akt murine thymoma viral oncogene homolog 1	approved; investigational	Celecoxib
DB00184	v-akt murine thymoma viral oncogene homolog 1	approved	Nicotine
DB01132	v-akt murine thymoma viral oncogene homolog 1	approved; investigational	Pioglitazone
DB00412	v-akt murine thymoma viral oncogene homolog 1	approved; investigational	Rosiglitazone

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Cross referenced IDs for AKT1

* We obtained these cross-references from Uniprot database. It covers 150 different DBs, 18 categories. http://www.uniprot.org/help/cross_references_section

: Open all cross reference information