|
Phenotypic Information (metabolism pathway, cancer, disease, phenome) | |
Gene-Gene Network Information: Co-Expression Network, Interacting Genes & KEGG | |
Gene Summary for ESRRA |
Top |
Phenotypic Information for ESRRA(metabolism pathway, cancer, disease, phenome) |
![]() | |
Cancer | CGAP: ESRRA |
Familial Cancer Database: ESRRA |
* This gene is included in those cancer gene databases. |
. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Oncogene 1 | Significant driver gene in |
cf) number; DB name 1 Oncogene; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long, 2 Tumor Suppressor gene; https://bioinfo.uth.edu/TSGene/, 3 Cancer Gene Census; http://www.nature.com/nrc/journal/v4/n3/abs/nrc1299.html, 4 CancerGenes; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long, 5 Network of Cancer Gene; http://ncg.kcl.ac.uk/index.php, 1Therapeutic Vulnerabilities in Cancer; http://cbio.mskcc.org/cancergenomics/statius/ |
![]() | |
REACTOME_METABOLISM_OF_LIPIDS_AND_LIPOPROTEINS |
![]() | |
OMIM | |
Orphanet | |
Disease | KEGG Disease: ESRRA |
MedGen: ESRRA (Human Medical Genetics with Condition) | |
ClinVar: ESRRA | |
Phenotype | MGI: ESRRA (International Mouse Phenotyping Consortium) |
PhenomicDB: ESRRA |
Mutations for ESRRA |
* Under tables are showing count per each tissue to give us broad intuition about tissue specific mutation patterns.You can go to the detailed page for each mutation database's web site. |
![]() |
There's no structural variation information in COSMIC data for this gene. |
![]() |
* From mRNA Sanger sequences, Chitars2.0 arranged chimeric transcripts. This table shows ESRRA related fusion information. |
ID | Head Gene | Tail Gene | Accession | Gene_a | qStart_a | qEnd_a | Chromosome_a | tStart_a | tEnd_a | Gene_a | qStart_a | qEnd_a | Chromosome_a | tStart_a | tEnd_a |
![]() |
Top |
![]() |
Mutation type/ Tissue ID | brca | cns | cerv | endome | haematopo | kidn | Lintest | liver | lung | ns | ovary | pancre | prost | skin | stoma | thyro | urina | |||
Total # sample |   |   |   |   |   |   |   |   |   |   | 1 |   |   |   |   |   |   | |||
GAIN (# sample) |   |   |   |   |   |   |   |   |   |   | 1 |   |   |   |   |   |   | |||
LOSS (# sample) |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |
cf) Tissue ID; Tissue type (1; Breast, 2; Central_nervous_system, 3; Cervix, 4; Endometrium, 5; Haematopoietic_and_lymphoid_tissue, 6; Kidney, 7; Large_intestine, 8; Liver, 9; Lung, 10; NS, 11; Ovary, 12; Pancreas, 13; Prostate, 14; Skin, 15; Stomach, 16; Thyroid, 17; Urinary_tract) |
Top |
![]() |
|
![]() |
Top |
![]() |
Stat. for Non-Synonymous SNVs (# total SNVs=27) | (# total SNVs=10) |
![]() | ![]() |
(# total SNVs=0) | (# total SNVs=0) |
Top |
![]() |
* When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site,primary_histology,mutation(aa),pubmedID. |
GRCh37 position | Mutation(aa) | Unique sampleID count |
chr11:64083296-64083298 | p.R377_A378>P | 32 |
chr11:64083221-64083221 | p.R352P | 8 |
chr11:64083293-64083293 | p.R376L | 4 |
chr11:64083300-64083300 | p.A378A | 4 |
chr11:64083331-64083331 | p.R389C | 4 |
chr11:64082556-64082556 | p.R276C | 3 |
chr11:64083252-64083252 | p.Y362Y | 2 |
chr11:64083290-64083290 | p.R375Q | 2 |
chr11:64083328-64083328 | p.L388F | 2 |
chr11:64074903-64074903 | p.D84D | 2 |
Top |
![]() |
|
![]() |
Point Mutation/ Tissue ID | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | 18 | 19 | 20 |
# sample | 1 |   | 1 | 6 |   |   | 4 |   | 1 | 1 |   | 2 | 2 |   |   |   | 4 |   |   | 2 |
# mutation | 1 |   | 1 | 6 |   |   | 3 |   | 1 | 1 |   | 2 | 2 |   |   |   | 4 |   |   | 2 |
nonsynonymous SNV | 1 |   | 1 | 5 |   |   | 3 |   |   | 1 |   | 1 |   |   |   |   | 3 |   |   | 2 |
synonymous SNV |   |   |   | 1 |   |   |   |   | 1 |   |   | 1 | 2 |   |   |   | 1 |   |   |   |
cf) Tissue ID; Tissue type (1; BLCA[Bladder Urothelial Carcinoma], 2; BRCA[Breast invasive carcinoma], 3; CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], 4; COAD[Colon adenocarcinoma], 5; GBM[Glioblastoma multiforme], 6; Glioma Low Grade, 7; HNSC[Head and Neck squamous cell carcinoma], 8; KICH[Kidney Chromophobe], 9; KIRC[Kidney renal clear cell carcinoma], 10; KIRP[Kidney renal papillary cell carcinoma], 11; LAML[Acute Myeloid Leukemia], 12; LUAD[Lung adenocarcinoma], 13; LUSC[Lung squamous cell carcinoma], 14; OV[Ovarian serous cystadenocarcinoma ], 15; PAAD[Pancreatic adenocarcinoma], 16; PRAD[Prostate adenocarcinoma], 17; SKCM[Skin Cutaneous Melanoma], 18:STAD[Stomach adenocarcinoma], 19:THCA[Thyroid carcinoma], 20:UCEC[Uterine Corpus Endometrial Carcinoma]) |
Top |
![]() |
* We represented just top 10 SNVs. When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site, primary_histology, mutation(aa), pubmedID. |
Genomic Position | Mutation(aa) | Unique sampleID count |
chr11:64082296 | p.D219N,ESRRA | 2 |
chr11:64082666 | p.T227A,ESRRA | 1 |
chr11:64081786 | p.A243A,ESRRA | 1 |
chr11:64083221 | p.V6M,ESRRA | 1 |
chr11:64074667 | p.S259P,ESRRA | 1 |
chr11:64081797 | p.E16A,ESRRA | 1 |
chr11:64083327 | p.E288Q,ESRRA | 1 |
chr11:64074698 | p.D21N,ESRRA | 1 |
chr11:64082235 | p.E295Q,ESRRA | 1 |
chr11:64083421 | p.P23L,ESRRA | 1 |
![]() |
![]() |
* Copy number data were extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered on Jan-05-2015. Function ProcessCNAData in TCGA-Assembler package was used to obtain gene-level copy number value which is calculated as the average copy number of the genomic region of a gene. |
![]() |
cf) Tissue ID[Tissue type]: BLCA[Bladder Urothelial Carcinoma], BRCA[Breast invasive carcinoma], CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], COAD[Colon adenocarcinoma], GBM[Glioblastoma multiforme], Glioma Low Grade, HNSC[Head and Neck squamous cell carcinoma], KICH[Kidney Chromophobe], KIRC[Kidney renal clear cell carcinoma], KIRP[Kidney renal papillary cell carcinoma], LAML[Acute Myeloid Leukemia], LUAD[Lung adenocarcinoma], LUSC[Lung squamous cell carcinoma], OV[Ovarian serous cystadenocarcinoma ], PAAD[Pancreatic adenocarcinoma], PRAD[Prostate adenocarcinoma], SKCM[Skin Cutaneous Melanoma], STAD[Stomach adenocarcinoma], THCA[Thyroid carcinoma], UCEC[Uterine Corpus Endometrial Carcinoma] |
Top |
Gene Expression for ESRRA |
![]() |
* CCLE gene expression data were extracted from CCLE_Expression_Entrez_2012-10-18.res: Gene-centric RMA-normalized mRNA expression data. |
![]() |
![]() |
* Normalized gene expression data of RNASeqV2 was extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered at Jan-05-2015. Only eight cancer types have enough normal control samples for differential expression analysis. (t test, adjusted p<0.05 (using Benjamini-Hochberg FDR)) |
![]() |
Top |
![]() |
* This plots show the correlation between CNV and gene expression. |
![]() | |
![]() |
Top |
Gene-Gene Network Information |
![]() |
* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown. Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene |
![]() | |||||
B3GAT3,UQCC3,CCDC124,CDC37,ESRRA,FAU,GET4, GIPC1,GUK1,MAP3K11,NUDT22,PPAN,PPP1R14B,PRDX5, PTGES2,PUS1,RPS6KA4,SART1,SCYL1,TIMM44,UBXN1 | ATP5D,DVL1,ESRRA,FAM195A,FASTK,FLII,CPTP, KEAP1,MACROD1,NTMT1,MRPL12,MRPL38,NDUFS7,NDUFV1, PANK4,PTGES2,SPAG7,STK11,STK25,TIMM44,UQCRC1 | ||||
![]() | |||||
ANO9,ASCL2,VPS51___IFT46,CDX1,CLCN2,COMTD1,COX5B, DAGLA,DNAJA3,ESRRA,FAM195A,IFRD2,MGAT4B,NDUFV1, NECAB3,OVOL1,PRDX5,TBRG4,TIMM44,TPRN,WDR74 | ACADS,ACSF2,ACSF3,AP1M2,KDF1,C6orf136,CBLC, CMBL,COQ4,ESRRA,GPR35,HDHD3,KLC4,MGAT4B, PAFAH2,PFKL,PLEKHJ1,PXMP2,RAB20,RPS6KA1,STAP2 |
![]() |
* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown. Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene |
Top |
![]() |
Top |
Pharmacological Information for ESRRA |
![]() |
DB Category | DB Name | DB's ID and Url link |
![]() |
* Gene Centered Interaction Network. |
![]() |
* Drug Centered Interaction Network. |
DrugBank ID | Target Name | Drug Groups | Generic Name | Drug Centered Network | Drug Structure |
DB00197 | estrogen-related receptor alpha | withdrawn | Troglitazone | ![]() | ![]() |
DB06833 | estrogen-related receptor alpha | experimental | 1-CYCLOHEXYL-N-{[1-(4-METHYLPHENYL)-1H-INDOL-3-YL]METHYL}METHANAMINE | ![]() | ![]() |
DB01241 | estrogen-related receptor alpha | approved | Gemfibrozil | ![]() | ![]() |
Top |
Cross referenced IDs for ESRRA |
* We obtained these cross-references from Uniprot database. It covers 150 different DBs, 18 categories. http://www.uniprot.org/help/cross_references_section |
Copyright © 2016-Present - The Univsersity of Texas Health Science Center at Houston @ |