Cancer Cell Metabolism Gene Database

  Cancer Cell Metabolism Gene DB

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Bioinformatics and Systems Medicine Laboratory Bioinformatics and Systems Medicine Laboratory

Gene Summary

Phenotypic Information (metabolism pathway, cancer, disease, phenome)

Mutations: SVs, CNVs, SNVs

Gene expression: GE, Protein, DEGE, CNV vs GE

Gene-Gene Network Information: Co-Expression Network, Interacting Genes & KEGG

Pharmacological Information: Drug-Gene Network

Cross referenced IDs

Gene Summary for F2
Basic gene info.Gene symbolF2
Gene namecoagulation factor II (thrombin)
SynonymsPT|RPRGL2|THPH1
CytomapUCSC genome browser: 11p11
Genomic locationchr11 :46740742-46761056
Type of geneprotein-coding
RefGenesNM_000506.3,
Ensembl idENSG00000180210
Descriptionprepro-coagulation factor IIprothrombinprothrombin B-chainserine protease
Modification date20141222
dbXrefs MIM : 176930
HGNC : HGNC
Ensembl : ENSG00000180210
HPRD : 01488
Vega : OTTHUMG00000150344
ProteinUniProt: P00734
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_F2
BioGPS: 2147
Gene Expression Atlas: ENSG00000180210
The Human Protein Atlas: ENSG00000180210
PathwayNCI Pathway Interaction Database: F2
KEGG: F2
REACTOME: F2
ConsensusPathDB
Pathway Commons: F2
MetabolismMetaCyc: F2
HUMANCyc: F2
RegulationEnsembl's Regulation: ENSG00000180210
miRBase: chr11 :46,740,742-46,761,056
TargetScan: NM_000506
cisRED: ENSG00000180210
ContextiHOP: F2
cancer metabolism search in PubMed: F2
UCL Cancer Institute: F2
Assigned class in ccmGDBB - This gene belongs to cancer gene.

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Phenotypic Information for F2(metabolism pathway, cancer, disease, phenome)
check002.gifCancer Description
Cancer CGAP: F2
Familial Cancer Database: F2
* This gene is included in those cancer gene databases.

.

Oncogene 1

Tumor Suppressor gene 2

Cancer Gene Census 3

CancerGenes 4

Network of Cancer Gene 5

Significant driver gene in

Therapeutic Vulnerabilities in Cancer1

cf) number; DB name
1 Oncogene; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long,
2 Tumor Suppressor gene; https://bioinfo.uth.edu/TSGene/,
3 Cancer Gene Census; http://www.nature.com/nrc/journal/v4/n3/abs/nrc1299.html,
4 CancerGenes; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long,
5 Network of Cancer Gene; http://ncg.kcl.ac.uk/index.php,
1Therapeutic Vulnerabilities in Cancer; http://cbio.mskcc.org/cancergenomics/statius/

check002.gifMetabolic Pathway Description
REACTOME_METABOLISM_OF_PROTEINS

check002.gifOthers
OMIM 176930; gene.
176930; gene.
188050; phenotype.
188050; phenotype.
601367; phenotype.
601367; phenotype.
613679; phenotype.
613679; phenotype.
614390; phenotype.
614390; phenotype.
Orphanet 325; Congenital factor II deficiency.
325; Congenital factor II deficiency.
329217; Cerebral sinovenous thrombosis.
329217; Cerebral sinovenous thrombosis.
64738; Non rare thrombophilia.
64738; Non rare thrombophilia.
DiseaseKEGG Disease: F2
MedGen: F2 (Human Medical Genetics with Condition)
ClinVar: F2
PhenotypeMGI: F2 (International Mouse Phenotyping Consortium)
PhenomicDB: F2

Mutations for F2
* Under tables are showing count per each tissue to give us broad intuition about tissue specific mutation patterns.You can go to the detailed page for each mutation database's web site.

check002.gifStructural Variants in COSMIC: go to COSMIC mutation histogram

- Statistics for Tissue and Mutation typeTop
- For Inter-chromosomal Variations
There's no inter-chromosomal structural variation.
- For Intra-chromosomal Variations
* Intra-chromosomal variantions includes 'intrachromosomal amplicon to amplicon', 'intrachromosomal amplicon to non-amplified dna', 'intrachromosomal deletion', 'intrachromosomal fold-back inversion', 'intrachromosomal inversion', 'intrachromosomal tandem duplication', 'Intrachromosomal unknown type', 'intrachromosomal with inverted orientation', 'intrachromosomal with non-inverted orientation'.
SampleSymbol_aChr_aStart_aEnd_aSymbol_bChr_bStart_bEnd_b
ovaryF2chr114676059846760618F2chr114675633746756357
cf) Tissue number; Tissue name (1;Breast, 2;Central_nervous_system, 3;Haematopoietic_and_lymphoid_tissue, 4;Large_intestine, 5;Liver, 6;Lung, 7;Ovary, 8;Pancreas, 9;Prostate, 10;Skin, 11;Soft_tissue, 12;Upper_aerodigestive_tract)

check002.gifRelated fusion transcripts : go to Chitars2.0
* From mRNA Sanger sequences, Chitars2.0 arranged chimeric transcripts. This table shows F2 related fusion information.
IDHead GeneTail Gene
AccessionGene_aqStart_aqEnd_aChromosome_atStart_atEnd_aGene_aqStart_aqEnd_aChromosome_atStart_atEnd_a

check002.gifOther DBs for Structural Variants
Structural Variants in Ensembl: go to Ensembl Structural variation
Structural Variants in dbVar: go to dbVar

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check002.gifCopy Number Variations in COSMIC: go to COSMIC mutation CNV/Expr
There's no copy number variation information in COSMIC data for this gene.

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check002.gifSNV Counts per Each Loci in COSMIC data: go to COSMIC point mutation

 : Non-synonymous mutation, : Synonymous mutation, Circle size denotes number of samples.
Maximum mutation count=4

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check002.gifSomatic Mutation Counts per Tissue in COSMIC data
Stat. for Non-Synonymous SNVs
(# total SNVs=63)
Stat. for Synonymous SNVs
(# total SNVs=18)
Stat. for Deletions
(# total SNVs=3)
Stat. for Insertions
(# total SNVs=0)
There's no inserted snv.

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check002.gifTop 10 SNVs Having the Most Samples in COSMIC data
* When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site,primary_histology,mutation(aa),pubmedID.
GRCh37 positionMutation(aa)Unique sampleID count
chr11:46750326-46750326p.P471A4
chr11:46760817-46760817p.S576S4
chr11:46744803-46744803p.Q130H3
chr11:46747680-46747680p.A277A2
chr11:46745000-46745000p.T164I2
chr11:46745003-46745003p.T165M2
chr11:46747442-46747442p.R198L2
chr11:46748373-46748373p.I372I2
chr11:46744817-46744817p.R135H2
chr11:46750981-46750981p.K508K2

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check002.gifSNV Counts per Each Loci in TCGA data

 : non-synonymous mutation, : synonymous mutation, Circle size denotes number of samples.
maximum mutation count=3

Point Mutation/ Tissue ID1234567891011121314151617181920
# sample14 112 1 31 8 3  158 8
# mutation14 112 1 31 9 3  1510 10
nonsynonymous SNV 3 82 1 31 7 3  86 8
synonymous SNV11 3       2    74 2
cf) Tissue ID; Tissue type (1; BLCA[Bladder Urothelial Carcinoma], 2; BRCA[Breast invasive carcinoma], 3; CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], 4; COAD[Colon adenocarcinoma], 5; GBM[Glioblastoma multiforme], 6; Glioma Low Grade, 7; HNSC[Head and Neck squamous cell carcinoma], 8; KICH[Kidney Chromophobe], 9; KIRC[Kidney renal clear cell carcinoma], 10; KIRP[Kidney renal papillary cell carcinoma], 11; LAML[Acute Myeloid Leukemia], 12; LUAD[Lung adenocarcinoma], 13; LUSC[Lung squamous cell carcinoma], 14; OV[Ovarian serous cystadenocarcinoma ], 15; PAAD[Pancreatic adenocarcinoma], 16; PRAD[Prostate adenocarcinoma], 17; SKCM[Skin Cutaneous Melanoma], 18:STAD[Stomach adenocarcinoma], 19:THCA[Thyroid carcinoma], 20:UCEC[Uterine Corpus Endometrial Carcinoma])

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check002.gifTop 10 SNVs Having the Most Samples in TCGA data
* We represented just top 10 SNVs. When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site, primary_histology, mutation(aa), pubmedID.
Genomic PositionMutation(aa)Unique sampleID count
chr11:46750326p.P471A3
chr11:46749600p.A194A1
chr11:46744971p.Y290C1
chr11:46747499p.A464S1
chr11:46750931p.G598W1
chr11:46747700p.F83L1
chr11:46760879p.R198C1
chr11:46741372p.D306N1
chr11:46749618p.K469N1
chr11:46744981p.A89T1

check002.gifOther DBs for Point Mutations
Point Mutation Table of Ensembl: go to Ensembl variation table
Mutation of cBioPortal: go to cBioPortal's Cross-cancer alteration summary

check002.gifCopy Number for F2 in TCGA
* Copy number data were extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered on Jan-05-2015. Function ProcessCNAData in TCGA-Assembler package was used to obtain gene-level copy number value which is calculated as the average copy number of the genomic region of a gene.
cf) Tissue ID[Tissue type]: BLCA[Bladder Urothelial Carcinoma], BRCA[Breast invasive carcinoma], CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], COAD[Colon adenocarcinoma], GBM[Glioblastoma multiforme], Glioma Low Grade, HNSC[Head and Neck squamous cell carcinoma], KICH[Kidney Chromophobe], KIRC[Kidney renal clear cell carcinoma], KIRP[Kidney renal papillary cell carcinoma], LAML[Acute Myeloid Leukemia], LUAD[Lung adenocarcinoma], LUSC[Lung squamous cell carcinoma], OV[Ovarian serous cystadenocarcinoma ], PAAD[Pancreatic adenocarcinoma], PRAD[Prostate adenocarcinoma], SKCM[Skin Cutaneous Melanoma], STAD[Stomach adenocarcinoma], THCA[Thyroid carcinoma], UCEC[Uterine Corpus Endometrial Carcinoma]

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Gene Expression for F2

check002.gifGene Expression in Cancer Cell-lines (CCLE)
* CCLE gene expression data were extracted from CCLE_Expression_Entrez_2012-10-18.res: Gene-centric RMA-normalized mRNA expression data.

check002.gifDifferential Gene Expression in Primary Tumors (TCGA)
* Normalized gene expression data of RNASeqV2 was extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered at Jan-05-2015. Only eight cancer types have enough normal control samples for differential expression analysis.
(t test, adjusted p<0.05 (using Benjamini-Hochberg FDR))
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check002.gifCNV vs Gene Expression Plot
* This plots show the correlation between CNV and gene expression.

: Open all plots for all cancer types


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Gene-Gene Network Information
check002.gifCo-Expressed gene's network Plot
* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown.
Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene

: Open all plots for all cancer types

APCS,APOA2,APOA4,APOC3,ARG1,C8A,C9,
CREB3L3,CRP,F2,FABP1,FGF23,HP,ITIH1,
MT1B,PLG,SERPINA7,SERPINC1,SLC17A2,SULT2A1,TM4SF5
VRTN,C1QTNF8,C7orf33,CLPS,COL9A1,CPNE6,DRP2,
F2,HBG2,HSD17B6,HTR1B,ITIH3,ITLN1,KIF1A,
MLC1,NKX2-3,NOBOX,P2RX1,SOST,TGM2,WFDC1

AMBP,APOA2,ATP4A,BCAM,C1orf64,CHRND,DCT,
F2,FAM71E2,GYPB,HHATL,HIST1H4G,IGDCC3,IGF2BP1,
KLK2,MLANA,LINC00202-1,OC90,OR6C68,SNAR-F,TRIM71
APCS,C3P1,C8A,CFHR5,CPB2,CYP2E1,CYP4A22,
DNAJB8,F13B,F2,F9,KIR3DP1,KRTAP4-11,KRTAP5-3,
LECT2,LOC100129935,LINC00160,OR1N1,PAGE4,PAH,SLC17A2
check002.gifCo-Expressed gene's Protein-protein interaction Network Plot
* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown.
Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene

: Open all plots for all cancer types

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check002.gifInteracting Genes (from Pathway Commons)

: Open all interacting genes' information including KEGG pathway for all interacting genes from DAVID

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Pharmacological Information for F2
check002.gifCross-referenced pharmacological DB IDs from Uniprot
DB CategoryDB NameDB's ID and Url link
ChemistryBindingDB P00734; -.
ChemistryChEMBL CHEMBL2111379; -.
ChemistryGuidetoPHARMACOLOGY 2362; -.
ChemistryBindingDB P00734; -.
ChemistryChEMBL CHEMBL2111379; -.
ChemistryGuidetoPHARMACOLOGY 2362; -.
Organism-specific databasesPharmGKB PA157; -.
Organism-specific databasesPharmGKB PA157; -.
Organism-specific databasesCTD 2147; -.
Organism-specific databasesCTD 2147; -.

check002.gifDrug-Gene Interaction Network
* Gene Centered Interaction Network.
* Drug Centered Interaction Network.
DrugBank IDTarget NameDrug GroupsGeneric NameDrug Centered NetworkDrug Structure
DB00170coagulation factor II (thrombin)approved; nutraceuticalMenadione
DB00278coagulation factor II (thrombin)approved; investigationalArgatroban
DB01123coagulation factor II (thrombin)approvedProflavine
DB01766coagulation factor II (thrombin)experimentalBeta-(2-Naphthyl)-Alanine
DB01767coagulation factor II (thrombin)experimentalHemi-Babim
DB02193coagulation factor II (thrombin)experimental2-(2-Hydroxy-Phenyl)-1h-Benzoimidazole-5-Carboxamidine
DB02351coagulation factor II (thrombin)experimentalHirulog
DB02723coagulation factor II (thrombin)experimental4-Oxo-2-Phenylmethanesulfonyl-Octahydro-Pyrrolo[1,2-a]Pyrazine-6-Carboxylic Acid [1-(N-Hydroxycarbamimidoyl)-Piperidin-4-Ylmethyl]-Amide
DB03136coagulation factor II (thrombin)experimental4-Iodobenzo[B]Thiophene-2-Carboxamidine
DB03159coagulation factor II (thrombin)experimentalCRA_8696
DB03847coagulation factor II (thrombin)experimentalGamma-Carboxy-Glutamic Acid
DB03865coagulation factor II (thrombin)experimental6-Chloro-2-(2-Hydroxy-Biphenyl-3-Yl)-1h-Indole-5-Carboxamidine
DB04136coagulation factor II (thrombin)experimentalLysophosphotidylserine
DB04591coagulation factor II (thrombin)experimentalN-{2,2-DIFLUORO-2-[(2R)-PIPERIDIN-2-YL]ETHYL}-2-[2-(1H-1,2,4-TRIAZOL-1-YL)BENZYL][1,3]OXAZOLO[4,5-C]PYRIDIN-4-AMINE
DB04697coagulation factor II (thrombin)experimentalTRANS-4-(GUANIDINOMETHYL)-CYCLOHEXANE-L-YL-D-3-CYCLOHEXYLALANYL-L-AZETIDINE-2-YL-D-TYROSINYL-L-HOMOARGININAMIDE
DB04722coagulation factor II (thrombin)experimental2-(3-CHLORO-6-{[2,2-DIFLUORO-2-(1-OXIDOPYRIDIN-2-YL)ETHYL]AMINO}-1-OXIDOPYRIDIN-2-YL)-N-[1-(3-CHLOROPHENYL)ETHYL]ACETAMIDE
DB04771coagulation factor II (thrombin)experimental1-GUANIDINO-4-(N-NITRO-BENZOYLAMINO-L-LEUCYL-L-PROLYLAMINO)BUTANE
DB04772coagulation factor II (thrombin)experimental1-GUANIDINO-4-(N-PHENYLMETHANESULFONYL-L-LEUCYL-L-PROLYLAMINO)BUTANE
DB04786coagulation factor II (thrombin)approvedSuramin
DB04898coagulation factor II (thrombin)approved; withdrawn; investigationalXimelagatran
DB06695coagulation factor II (thrombin)approvedDabigatran etexilate
DB06838coagulation factor II (thrombin)experimentalmethyl L-phenylalaninate
DB06841coagulation factor II (thrombin)experimentalD-phenylalanyl-N-[(1S)-4-{[amino(iminio)methyl]amino}-1-(chloroacetyl)butyl]-L-prolinamide
DB06845coagulation factor II (thrombin)experimental(S)-N-(4-carbamimidoylbenzyl)-1-(2-(cyclopentylamino)ethanoyl)pyrrolidine-2-carboxamide
DB06850coagulation factor II (thrombin)experimental(S)-N-(4-carbamimidoylbenzyl)-1-(2-(cyclohexylamino)ethanoyl)pyrrolidine-2-carboxamide
DB06853coagulation factor II (thrombin)experimentalN-cycloheptylglycyl-N-(4-carbamimidoylbenzyl)-L-prolinamide
DB06854coagulation factor II (thrombin)experimental2-(2-HYDROXY-BIPHENYL)-1H-BENZOIMIDAZOLE-5-CARBOXAMIDINE
DB06858coagulation factor II (thrombin)experimentalN-cyclooctylglycyl-N-(4-carbamimidoylbenzyl)-L-prolinamide
DB06859coagulation factor II (thrombin)experimentalN-ALLYL-5-AMIDINOAMINOOXY-PROPYLOXY-3-CHLORO-N-CYCLOPENTYLBENZAMIDE
DB06861coagulation factor II (thrombin)experimental6-(2-HYDROXY-CYCLOPENTYL)-7-OXO-HEPTANAMIDINE
DB06865coagulation factor II (thrombin)experimental6-CARBAMIMIDOYL-2-[2-HYDROXY-6-(4-HYDROXY-PHENYL)-INDAN-1-YL]-HEXANOIC ACID
DB06866coagulation factor II (thrombin)experimental6-CARBAMIMIDOYL-2-[2-HYDROXY-5-(3-METHOXY-PHENYL)-INDAN-1-YL]-HEXANOIC ACID
DB06868coagulation factor II (thrombin)experimentalN-(3-chlorobenzyl)-1-(4-methylpentanoyl)-L-prolinamide
DB06869coagulation factor II (thrombin)experimental1-[2-AMINO-2-CYCLOHEXYL-ACETYL]-PYRROLIDINE-3-CARBOXYLIC ACID 5-CHLORO-2-(2-ETHYLCARBAMOYL-ETHOXY)-BENZYLAMIDE
DB06878coagulation factor II (thrombin)experimental1-[(2R)-2-aminobutanoyl]-N-(3-chlorobenzyl)-L-prolinamide
DB06911coagulation factor II (thrombin)experimentalD-leucyl-N-(3-chlorobenzyl)-L-prolinamide
DB06919coagulation factor II (thrombin)experimentalD-phenylalanyl-N-(3-chlorobenzyl)-L-prolinamide
DB06929coagulation factor II (thrombin)experimental1-butanoyl-N-(4-carbamimidoylbenzyl)-L-prolinamide
DB06936coagulation factor II (thrombin)experimentalN-(4-carbamimidoylbenzyl)-1-(4-methylpentanoyl)-L-prolinamide
DB06942coagulation factor II (thrombin)experimentalN-(4-carbamimidoylbenzyl)-1-(3-phenylpropanoyl)-L-prolinamide
DB06947coagulation factor II (thrombin)experimental1-[(2R)-2-aminobutanoyl]-N-(4-carbamimidoylbenzyl)-L-prolinamide
DB06996coagulation factor II (thrombin)experimentalD-leucyl-N-(4-carbamimidoylbenzyl)-L-prolinamide
DB07005coagulation factor II (thrombin)experimentalD-phenylalanyl-N-{4-[amino(iminio)methyl]benzyl}-L-prolinamide
DB07016coagulation factor II (thrombin)experimental(3R)-8-(dioxidosulfanyl)-3-methyl-1,2,3,4-tetrahydroquinoline
DB07027coagulation factor II (thrombin)experimentalD-phenylalanyl-N-(3-fluorobenzyl)-L-prolinamide
DB07083coagulation factor II (thrombin)experimentalbeta-phenyl-D-phenylalanyl-N-propyl-L-prolinamide
DB07088coagulation factor II (thrombin)experimental(S)-N-(4-carbamimidoylbenzyl)-1-(2-(cyclopentyloxy)ethanoyl)pyrrolidine-2-carboxamide
DB07091coagulation factor II (thrombin)experimental(S)-N-(4-carbamimidoylbenzyl)-1-(2-(cyclohexyloxy)ethanoyl)pyrrolidine-2-carboxamide
DB07095coagulation factor II (thrombin)experimental(S)-N-(4-carbamimidoylbenzyl)-1-(3-cyclopentylpropanoyl)pyrrolidine-2-carboxamide
DB07105coagulation factor II (thrombin)experimental2-[2-(4-CHLORO-PHENYLSULFANYL)-ACETYLAMINO]-3-(4-GUANIDINO-PHENYL)-PROPIONAMIDE
DB07120coagulation factor II (thrombin)experimentalN4-(N,N-DIPHENYLCARBAMOYL)-AMINOGUANIDINE
DB07128coagulation factor II (thrombin)experimentalN7-BUTYL-N2-(5-CHLORO-2-METHYLPHENYL)-5-METHYL[1,2,4]TRIAZOLO[1,5-A]PYRIMIDINE-2,7-DIAMINE
DB07131coagulation factor II (thrombin)experimental(S)-N-(4-carbamimidoylbenzyl)-1-(3-cyclohexylpropanoyl)pyrrolidine-2-carboxamide
DB07133coagulation factor II (thrombin)experimentalD-phenylalanyl-N-(3-methylbenzyl)-L-prolinamide
DB07143coagulation factor II (thrombin)experimentalD-phenylalanyl-N-benzyl-L-prolinamide
DB07165coagulation factor II (thrombin)experimentalN-(5-CHLORO-BENZO[B]THIOPHEN-3-YLMETHYL)-2-[6-CHLORO-OXO-3-(2-PYRIDIN-2-YL-ETHYLAMINO)-2H-PYRAZIN-1-YL]-ACETAMIDE
DB07190coagulation factor II (thrombin)experimental3-cyclohexyl-D-alanyl-N-(3-chlorobenzyl)-L-prolinamide
DB07211coagulation factor II (thrombin)experimental(2R)-2-(5-CHLORO-2-THIENYL)-N-{(3S)-1-[(1S)-1-METHYL-2-MORPHOLIN-4-YL-2-OXOETHYL]-2-OXOPYRROLIDIN-3-YL}PROPENE-1-SULFONAMIDE
DB07277coagulation factor II (thrombin)experimental2-(5-CHLORO-2-THIENYL)-N-{(3S)-1-[(1S)-1-METHYL-2-MORPHOLIN-4-YL-2-OXOETHYL]-2-OXOPYRROLIDIN-3-YL}ETHANESULFONAMIDE
DB07278coagulation factor II (thrombin)experimental2-(5-CHLORO-2-THIENYL)-N-{(3S)-1-[(1S)-1-METHYL-2-MORPHOLIN-4-YL-2-OXOETHYL]-2-OXOPYRROLIDIN-3-YL}ETHENESULFONAMIDE
DB07279coagulation factor II (thrombin)experimentalN-ETHYL-N-ISOPROPYL-3-METHYL-5-{[(2S)-2-(PYRIDIN-4-YLAMINO)PROPYL]OXY}BENZAMIDE
DB07353coagulation factor II (thrombin)experimental4-(2,5-DIAMINO-5-HYDROXY-PENTYL)-PHENOL
DB07366coagulation factor II (thrombin)experimental2-[N'-(4-AMINO-BUTYL)-HYDRAZINOCARBONYL]-PYRROLIDINE-1-CARBOXYLIC ACID BENZYL ESTER
DB07376coagulation factor II (thrombin)experimental5-(DIMETHYLAMINO)-1-NAPHTHALENESULFONIC ACID(DANSYL ACID)
DB07400coagulation factor II (thrombin)experimental1-ETHOXYCARBONYL-D-PHE-PRO-2(4-AMINOBUTYL)HYDRAZINE
DB07440coagulation factor II (thrombin)experimental4-TERT-BUTYLBENZENESULFONIC ACID
DB07461coagulation factor II (thrombin)experimental3-AMINO-3-BENZYL-9-CARBOXAMIDE[4.3.0]BICYCLO-1,6-DIAZANONAN-2-ONE
DB07508coagulation factor II (thrombin)experimental4-(5-BENZENESULFONYLAMINO-1-METHYL-1H-BENZOIMIDAZOL-2-YLMETHYL)-BENZAMIDINE
DB07515coagulation factor II (thrombin)experimental1-(2-{[(6-AMINO-2-METHYLPYRIDIN-3-YL)METHYL]AMINO}ETHYL)-6-CHLORO-3-[(2,2-DIFLUORO-2-PYRIDIN-2-YLETHYL)AMINO]-1,4-DIHYDROPYRAZIN-2-OL
DB07521coagulation factor II (thrombin)experimental6-CHLORO-1-(2-{[(5-CHLORO-1-BENZOTHIEN-3-YL)METHYL]AMINO}ETHYL)-3-[(2-PYRIDIN-2-YLETHYL)AMINO]-1,4-DIHYDROPYRAZIN-2-OL
DB07522coagulation factor II (thrombin)experimentalN-[(2R,3S)-3-AMINO-2-HYDROXY-4-PHENYLBUTYL]NAPHTHALENE-2-SULFONAMIDE
DB07527coagulation factor II (thrombin)experimentalN-[(2R,3S)-3-AMINO-2-HYDROXY-4-PHENYLBUTYL]-4-METHOXY-2,3,6-TRIMETHYLBENZENESULFONAMIDE
DB07548coagulation factor II (thrombin)experimental2-(6-CHLORO-3-{[2,2-DIFLUORO-2-(2-PYRIDINYL)ETHYL]AMINO}-2-OXO-1(2H)-PYRAZINYL)-N-[(2-FLUORO-6-PYRIDINYL)METHYL]ACETAMIDE
DB07549coagulation factor II (thrombin)experimental2-(6-CHLORO-3-{[2,2-DIFLUORO-2-(2-PYRIDINYL)ETHYL]AMINO}-2-OXO-1(2H)-PYRAZINYL)-N-[(2-FLUORO-3-METHYL-6-PYRIDINYL)METHYL]ACETAMIDE
DB07550coagulation factor II (thrombin)experimental2-(6-CHLORO-3-{[2,2-DIFLUORO-2-(1-OXIDO-2-PYRIDINYL)ETHYL]AMINO}-2-OXO-1(2H)-PYRAZINYL)-N-[(2-FLUOROPHENYL)METHYL]ACETAMIDE
DB07639coagulation factor II (thrombin)experimental3-(7-DIAMINOMETHYL-NAPHTHALEN-2-YL)-PROPIONIC ACID ETHYL ESTER
DB07658coagulation factor II (thrombin)experimentalAC-(D)PHE-PRO-BOROLYS-OH
DB07659coagulation factor II (thrombin)experimentalAC-(D)PHE-PRO-BOROHOMOLYS-OH
DB07660coagulation factor II (thrombin)experimentalAC-(D)PHE-PRO-BOROHOMOORNITHINE-OH
DB07665coagulation factor II (thrombin)experimentalN-[2-(carbamimidamidooxy)ethyl]-2-{6-cyano-3-[(2,2-difluoro-2-pyridin-2-ylethyl)amino]-2-fluorophenyl}acetamide
DB07718coagulation factor II (thrombin)experimental3-(4-HYDROXY-PHENYL)PYRUVIC ACID
DB07741coagulation factor II (thrombin)experimental4-(1R,3AS,4R,8AS,8BR)-[1-DIFLUOROMETHYL-2-(4-FLUOROBENZYL)-3-OXODECAHYDROPYRROLO[3,4-A]PYRROLIZIN-4-YL]BENZAMIDINE
DB07796coagulation factor II (thrombin)experimental(3ASR,4RS,8ASR,8BRS)-4-(2-(4-FLUOROBENZYL)-1,3-DIOXODEACAHYDROPYRROLO[3,4-A] PYRROLIZIN-4-YL)BENZAMIDINE
DB07809coagulation factor II (thrombin)experimental4-({[4-(3-METHYLBENZOYL)PYRIDIN-2-YL]AMINO}METHYL)BENZENECARBOXIMIDAMIDE
DB07897coagulation factor II (thrombin)experimental1-(HYDROXYMETHYLENEAMINO)-8-HYDROXY-OCTANE
DB07934coagulation factor II (thrombin)experimental[[CYCLOHEXANESULFONYL-GLYCYL]-3[PYRIDIN-4-YL-AMINOMETHYL]ALANYL]PIPERIDINE
DB07944coagulation factor II (thrombin)experimentalN-{3-METHYL-5-[2-(PYRIDIN-4-YLAMINO)-ETHOXY]-PHENYL}-BENZENESULFONAMIDE
DB07946coagulation factor II (thrombin)experimentalN-[2-({[amino(imino)methyl]amino}oxy)ethyl]-2-{6-chloro-3-[(2,2-difluoro-2-phenylethyl)amino]-2-fluorophenyl}acetamide
DB08061coagulation factor II (thrombin)experimental4-[3-(4-CHLOROPHENYL)-1H-PYRAZOL-5-YL]PIPERIDINE
DB08062coagulation factor II (thrombin)experimental3-(4-CHLOROPHENYL)-5-(METHYLTHIO)-4H-1,2,4-TRIAZOLE
DB08152coagulation factor II (thrombin)experimental{(2S)-1-[N-(tert-butoxycarbonyl)glycyl]pyrrolidin-2-yl}methyl (3-chlorophenyl)acetate
DB08187coagulation factor II (thrombin)experimentalMETHYL-PHE-PRO-AMINO-CYCLOHEXYLGLYCINE
DB08254coagulation factor II (thrombin)experimental2-NAPHTHALENESULFONIC ACID
DB08422coagulation factor II (thrombin)experimental[PHENYLALANINYL-PROLINYL]-[2-(PYRIDIN-4-YLAMINO)-ETHYL]-AMINE
DB08546coagulation factor II (thrombin)experimental4-[(3AS,4R,7R,8AS,8BR)-2-(1,3-BENZODIOXOL-5-YLMETHYL)-7-HYDROXY-1,3-DIOXODECAHYDROPYRROLO[3,4-A]PYRROLIZIN-4-YL]BENZENECARBOXIMIDAMIDE
DB08624coagulation factor II (thrombin)experimentalBENZOTHIAZOLE
DB00945coagulation factor II (thrombin)approvedAcetylsalicylic acid
DB00682coagulation factor II (thrombin)approvedWarfarin
DB00269coagulation factor II (thrombin)approvedChlorotrianisene
DB00286coagulation factor II (thrombin)approvedConjugated Estrogens
DB00890coagulation factor II (thrombin)approvedDienestrol
DB00255coagulation factor II (thrombin)approvedDiethylstilbestrol
DB00783coagulation factor II (thrombin)approved; investigationalEstradiol
DB00655coagulation factor II (thrombin)approvedEstrone
DB00977coagulation factor II (thrombin)approvedEthinyl Estradiol
DB00122coagulation factor II (thrombin)approved; nutraceuticalCholine
DB00125coagulation factor II (thrombin)approved; nutraceuticalL-Arginine
DB00435coagulation factor II (thrombin)approvedNitric Oxide
DB00668coagulation factor II (thrombin)approvedEpinephrine
DB00460coagulation factor II (thrombin)approved; investigationalVerteporfin
DB00717coagulation factor II (thrombin)approvedNorethindrone


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Cross referenced IDs for F2
* We obtained these cross-references from Uniprot database. It covers 150 different DBs, 18 categories. http://www.uniprot.org/help/cross_references_section

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