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Phenotypic Information (metabolism pathway, cancer, disease, phenome) | |
Gene-Gene Network Information: Co-Expression Network, Interacting Genes & KEGG | |
Gene Summary for ALDH1B1 |
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Phenotypic Information for ALDH1B1(metabolism pathway, cancer, disease, phenome) |
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Cancer | CGAP: ALDH1B1 |
Familial Cancer Database: ALDH1B1 |
* This gene is included in those cancer gene databases. |
Oncogene 1 | Significant driver gene in |
cf) number; DB name 1 Oncogene; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long, 2 Tumor Suppressor gene; https://bioinfo.uth.edu/TSGene/, 3 Cancer Gene Census; http://www.nature.com/nrc/journal/v4/n3/abs/nrc1299.html, 4 CancerGenes; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long, 5 Network of Cancer Gene; http://ncg.kcl.ac.uk/index.php, 1Therapeutic Vulnerabilities in Cancer; http://cbio.mskcc.org/cancergenomics/statius/ |
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KEGG_GLYCOLYSIS_GLUCONEOGENESIS KEGG_ASCORBATE_AND_ALDARATE_METABOLISM KEGG_FATTY_ACID_METABOLISM KEGG_ARGININE_AND_PROLINE_METABOLISM KEGG_HISTIDINE_METABOLISM KEGG_TRYPTOPHAN_METABOLISM KEGG_BETA_ALANINE_METABOLISM KEGG_GLYCEROLIPID_METABOLISM KEGG_PYRUVATE_METABOLISM KEGG_PROPANOATE_METABOLISM KEGG_BUTANOATE_METABOLISM |
Mutations for ALDH1B1 |
* Under tables are showing count per each tissue to give us broad intuition about tissue specific mutation patterns.You can go to the detailed page for each mutation database's web site. |
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There's no structural variation information in COSMIC data for this gene. |
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* From mRNA Sanger sequences, Chitars2.0 arranged chimeric transcripts. This table shows ALDH1B1 related fusion information. |
ID | Head Gene | Tail Gene | Accession | Gene_a | qStart_a | qEnd_a | Chromosome_a | tStart_a | tEnd_a | Gene_a | qStart_a | qEnd_a | Chromosome_a | tStart_a | tEnd_a |
BE856261 | NDUFB7 | 1 | 173 | 19 | 14676892 | 14677064 | ALDH1B1 | 174 | 474 | 9 | 38396300 | 38396600 | |
AI422203 | NDUFB7 | 1 | 173 | 19 | 14676892 | 14677064 | ALDH1B1 | 174 | 466 | 9 | 38396308 | 38396600 |
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There's no copy number variation information in COSMIC data for this gene. |
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Stat. for Non-Synonymous SNVs (# total SNVs=40) | (# total SNVs=10) |
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(# total SNVs=1) | (# total SNVs=0) |
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* When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site,primary_histology,mutation(aa),pubmedID. |
GRCh37 position | Mutation(aa) | Unique sampleID count |
chr9:38395753-38395753 | p.R3H | 4 |
chr9:38395928-38395928 | p.T61T | 3 |
chr9:38396065-38396065 | p.R107L | 3 |
chr9:38396397-38396397 | p.A218S | 3 |
chr9:38395809-38395809 | p.A22T | 2 |
chr9:38395994-38395994 | p.A83A | 2 |
chr9:38396624-38396624 | p.I293I | 2 |
chr9:38396134-38396134 | p.P130H | 2 |
chr9:38396762-38396762 | p.T339T | 2 |
chr9:38396002-38396002 | p.A86V | 2 |
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Point Mutation/ Tissue ID | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | 18 | 19 | 20 |
# sample | 1 | 1 |   | 9 |   |   | 3 |   | 1 | 1 |   | 8 | 2 | 1 |   |   | 11 | 7 | 1 | 7 |
# mutation | 1 | 1 |   | 10 |   |   | 3 |   | 1 | 1 |   | 8 | 2 | 1 |   |   | 11 | 8 | 1 | 7 |
nonsynonymous SNV |   | 1 |   | 9 |   |   | 1 |   | 1 | 1 |   | 7 | 2 | 1 |   |   | 7 | 6 |   | 6 |
synonymous SNV | 1 |   |   | 1 |   |   | 2 |   |   |   |   | 1 |   |   |   |   | 4 | 2 | 1 | 1 |
cf) Tissue ID; Tissue type (1; BLCA[Bladder Urothelial Carcinoma], 2; BRCA[Breast invasive carcinoma], 3; CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], 4; COAD[Colon adenocarcinoma], 5; GBM[Glioblastoma multiforme], 6; Glioma Low Grade, 7; HNSC[Head and Neck squamous cell carcinoma], 8; KICH[Kidney Chromophobe], 9; KIRC[Kidney renal clear cell carcinoma], 10; KIRP[Kidney renal papillary cell carcinoma], 11; LAML[Acute Myeloid Leukemia], 12; LUAD[Lung adenocarcinoma], 13; LUSC[Lung squamous cell carcinoma], 14; OV[Ovarian serous cystadenocarcinoma ], 15; PAAD[Pancreatic adenocarcinoma], 16; PRAD[Prostate adenocarcinoma], 17; SKCM[Skin Cutaneous Melanoma], 18:STAD[Stomach adenocarcinoma], 19:THCA[Thyroid carcinoma], 20:UCEC[Uterine Corpus Endometrial Carcinoma]) |
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* We represented just top 10 SNVs. When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site, primary_histology, mutation(aa), pubmedID. |
Genomic Position | Mutation(aa) | Unique sampleID count |
chr9:38395753 | p.R3H | 4 |
chr9:38396569 | p.G405G | 2 |
chr9:38396134 | p.G275V | 2 |
chr9:38396624 | p.I293I | 2 |
chr9:38396960 | p.T339T | 2 |
chr9:38396762 | p.R8Q | 2 |
chr9:38395768 | p.P130L | 2 |
chr9:38396515 | p.D47N | 1 |
chr9:38395848 | p.P198Q | 1 |
chr9:38396907 | p.R394C | 1 |
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* Copy number data were extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered on Jan-05-2015. Function ProcessCNAData in TCGA-Assembler package was used to obtain gene-level copy number value which is calculated as the average copy number of the genomic region of a gene. |
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cf) Tissue ID[Tissue type]: BLCA[Bladder Urothelial Carcinoma], BRCA[Breast invasive carcinoma], CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], COAD[Colon adenocarcinoma], GBM[Glioblastoma multiforme], Glioma Low Grade, HNSC[Head and Neck squamous cell carcinoma], KICH[Kidney Chromophobe], KIRC[Kidney renal clear cell carcinoma], KIRP[Kidney renal papillary cell carcinoma], LAML[Acute Myeloid Leukemia], LUAD[Lung adenocarcinoma], LUSC[Lung squamous cell carcinoma], OV[Ovarian serous cystadenocarcinoma ], PAAD[Pancreatic adenocarcinoma], PRAD[Prostate adenocarcinoma], SKCM[Skin Cutaneous Melanoma], STAD[Stomach adenocarcinoma], THCA[Thyroid carcinoma], UCEC[Uterine Corpus Endometrial Carcinoma] |
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Gene Expression for ALDH1B1 |
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* CCLE gene expression data were extracted from CCLE_Expression_Entrez_2012-10-18.res: Gene-centric RMA-normalized mRNA expression data. |
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* Normalized gene expression data of RNASeqV2 was extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered at Jan-05-2015. Only eight cancer types have enough normal control samples for differential expression analysis. (t test, adjusted p<0.05 (using Benjamini-Hochberg FDR)) |
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* This plots show the correlation between CNV and gene expression. |
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Gene-Gene Network Information |
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* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown. Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene |
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ACTN1,ALDH1B1,CALD1,CALU,CHST3,COL8A1,DPYSL3, FLNA,FNDC1,GLS,HEPH,MSN,MYH9,MYO1E, NEXN,NRP2,PLS3,RAB23,RAI14,TAGLN,TIMP2 | ALDH1B1,CAMK2G,CASQ2,DGKG,DMPK,FZD9,INPP5A, ITLN1,KCNA5,LGI1,LOC401093,MT3,MUSTN1,PDE4C, PKNOX2,POU4F1,RCAN2,TGM2,TYRP1,WFDC1,ZNF536 | ||||
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ALDH1B1,TMEM261,CDHR1,CDX2,DAGLA,FAM171A1,GSPT2, IFT74,KANK1,LOC151009,MAT1A,NOTCH1,PMFBP1,PRDX5, RGMB,SMTN,STK38L,TDGF1,TDGF1P3,TTLL11,WNK2 | ALDH1B1,FAM210A,DOLK,DUSP14,ERAL1,FASTKD2,FXN, G6PC3,GCDH,COLGALT1,H2AFY2,IPO11,NDUFAF4,NUFIP1, OGFOD1,PROCR,RCL1,RNMTL1,SMYD5,TIMM44,TANGO6 |
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* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown. Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene |
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Pharmacological Information for ALDH1B1 |
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DB Category | DB Name | DB's ID and Url link |
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* Gene Centered Interaction Network. |
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* Drug Centered Interaction Network. |
DrugBank ID | Target Name | Drug Groups | Generic Name | Drug Centered Network | Drug Structure |
DB00157 | aldehyde dehydrogenase 1 family, member B1 | approved; nutraceutical | NADH | ![]() | ![]() |
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Cross referenced IDs for ALDH1B1 |
* We obtained these cross-references from Uniprot database. It covers 150 different DBs, 18 categories. http://www.uniprot.org/help/cross_references_section |
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