Cancer Cell Metabolism Gene Database

  Cancer Cell Metabolism Gene DB

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Bioinformatics and Systems Medicine Laboratory Bioinformatics and Systems Medicine Laboratory

Gene Summary

Phenotypic Information (metabolism pathway, cancer, disease, phenome)

Mutations: SVs, CNVs, SNVs

Gene expression: GE, Protein, DEGE, CNV vs GE

Gene-Gene Network Information: Co-Expression Network, Interacting Genes & KEGG

Pharmacological Information: Drug-Gene Network

Cross referenced IDs

Gene Summary for FAU
Basic gene info.Gene symbolFAU
Gene nameFinkel-Biskis-Reilly murine sarcoma virus (FBR-MuSV) ubiquitously expressed
SynonymsFAU1|Fub1|Fubi|MNSFbeta|RPS30|S30|asr1
CytomapUCSC genome browser: 11q13
Genomic locationchr11 :64888098-64889672
Type of geneprotein-coding
RefGenesNM_001997.4,
Ensembl idENSG00000149806
Description40S ribosomal protein S30FAU-encoded ubiquitin-like proteinFBR-MuSV-associated ubiquitously expressedFinkel-Biskis-Reilly murine sarcoma virus (FBR-MuSV) ubiquitously expressed (fox derived)monoclonal nonspecific suppressor factor betaribosomal prote
Modification date20141207
dbXrefs MIM : 134690
HGNC : HGNC
HPRD : 00002
ProteinUniProt: P35544
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_FAU
BioGPS: 2197
Gene Expression Atlas: ENSG00000149806
The Human Protein Atlas: ENSG00000149806
PathwayNCI Pathway Interaction Database: FAU
KEGG: FAU
REACTOME: FAU
ConsensusPathDB
Pathway Commons: FAU
MetabolismMetaCyc: FAU
HUMANCyc: FAU
RegulationEnsembl's Regulation: ENSG00000149806
miRBase: chr11 :64,888,098-64,889,672
TargetScan: NM_001997
cisRED: ENSG00000149806
ContextiHOP: FAU
cancer metabolism search in PubMed: FAU
UCL Cancer Institute: FAU
Assigned class in ccmGDBB - This gene belongs to cancer gene.

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Phenotypic Information for FAU(metabolism pathway, cancer, disease, phenome)
check002.gifCancer Description
Cancer CGAP: FAU
Familial Cancer Database: FAU
* This gene is included in those cancer gene databases.

.

Oncogene 1

Tumor Suppressor gene 2

Cancer Gene Census 3

CancerGenes 4

Network of Cancer Gene 5

Significant driver gene in

Therapeutic Vulnerabilities in Cancer1

cf) number; DB name
1 Oncogene; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long,
2 Tumor Suppressor gene; https://bioinfo.uth.edu/TSGene/,
3 Cancer Gene Census; http://www.nature.com/nrc/journal/v4/n3/abs/nrc1299.html,
4 CancerGenes; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long,
5 Network of Cancer Gene; http://ncg.kcl.ac.uk/index.php,
1Therapeutic Vulnerabilities in Cancer; http://cbio.mskcc.org/cancergenomics/statius/

check002.gifMetabolic Pathway Description
REACTOME_METABOLISM_OF_PROTEINS
REACTOME_METABOLISM_OF_MRNA
REACTOME_METABOLISM_OF_RNA

check002.gifOthers
OMIM 134690; gene.
Orphanet
DiseaseKEGG Disease: FAU
MedGen: FAU (Human Medical Genetics with Condition)
ClinVar: FAU
PhenotypeMGI: FAU (International Mouse Phenotyping Consortium)
PhenomicDB: FAU

Mutations for FAU
* Under tables are showing count per each tissue to give us broad intuition about tissue specific mutation patterns.You can go to the detailed page for each mutation database's web site.

check002.gifStructural Variants in COSMIC: go to COSMIC mutation histogram
There's no structural variation information in COSMIC data for this gene.

check002.gifRelated fusion transcripts : go to Chitars2.0
* From mRNA Sanger sequences, Chitars2.0 arranged chimeric transcripts. This table shows FAU related fusion information.
IDHead GeneTail Gene
AccessionGene_aqStart_aqEnd_aChromosome_atStart_atEnd_aGene_aqStart_aqEnd_aChromosome_atStart_atEnd_a
BG251227APOL6198223605844736058545FAU98543116488810664889283
X75315FAU164116488817164888234MIR5095571434205596672055983642
BG472330FAU20163116488816164888479BAD164768116403765264052162
AJ712941FAU974116488825764888496PLIN3643351948389474839219
BG479472FAU21165116488816164888479BAD166617116403908564052162
AA071465FAU2274116488810264888154CNOT266491127074771570748140
AA469444PRKDC143984879239648792421FAU37427116488810264889225
BG491927FAU20101116488817864888260CALR98950191305032813054606
BM990847FAU1886116488810264888170MRPL1678563115957382159574306
DR979128PTPRD189983160518316140FAU78152116488810664888180
CN275873ANKRD116646168934835289348995FAU633799116488810864888275

check002.gifOther DBs for Structural Variants
Structural Variants in Ensembl: go to Ensembl Structural variation
Structural Variants in dbVar: go to dbVar

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check002.gifCopy Number Variations in COSMIC: go to COSMIC mutation CNV/Expr
There's no copy number variation information in COSMIC data for this gene.

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check002.gifSNV Counts per Each Loci in COSMIC data: go to COSMIC point mutation

 : Non-synonymous mutation, : Synonymous mutation, Circle size denotes number of samples.
Maximum mutation count=2

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check002.gifSomatic Mutation Counts per Tissue in COSMIC data
Stat. for Non-Synonymous SNVs
(# total SNVs=12)
Stat. for Synonymous SNVs
(# total SNVs=5)
Stat. for Deletions
(# total SNVs=0)
Stat. for Insertions
(# total SNVs=0)
There's no deleted snv.There's no inserted snv.

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check002.gifTop 10 SNVs Having the Most Samples in COSMIC data
* When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site,primary_histology,mutation(aa),pubmedID.
GRCh37 positionMutation(aa)Unique sampleID count
chr11:64888518-64888518p.?2
chr11:64888169-64888169p.P129H2
chr11:64888248-64888250p.K102delK2
chr11:64888164-64888164p.A131T1
chr11:64889010-64889010p.A61V1
chr11:64888175-64888175p.K127M1
chr11:64889081-64889081p.E37D1
chr11:64888211-64888211p.R115H1
chr11:64889083-64889083p.E37*1
chr11:64888220-64888220p.Y112C1

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check002.gifSNV Counts per Each Loci in TCGA data

 : non-synonymous mutation, : synonymous mutation, Circle size denotes number of samples.
maximum mutation count=1

Point Mutation/ Tissue ID1234567891011121314151617181920
# sample2  21   11 1     1 2
# mutation2  21   11 1     1 2
nonsynonymous SNV2  21   11 1       1
synonymous SNV                 1 1
cf) Tissue ID; Tissue type (1; BLCA[Bladder Urothelial Carcinoma], 2; BRCA[Breast invasive carcinoma], 3; CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], 4; COAD[Colon adenocarcinoma], 5; GBM[Glioblastoma multiforme], 6; Glioma Low Grade, 7; HNSC[Head and Neck squamous cell carcinoma], 8; KICH[Kidney Chromophobe], 9; KIRC[Kidney renal clear cell carcinoma], 10; KIRP[Kidney renal papillary cell carcinoma], 11; LAML[Acute Myeloid Leukemia], 12; LUAD[Lung adenocarcinoma], 13; LUSC[Lung squamous cell carcinoma], 14; OV[Ovarian serous cystadenocarcinoma ], 15; PAAD[Pancreatic adenocarcinoma], 16; PRAD[Prostate adenocarcinoma], 17; SKCM[Skin Cutaneous Melanoma], 18:STAD[Stomach adenocarcinoma], 19:THCA[Thyroid carcinoma], 20:UCEC[Uterine Corpus Endometrial Carcinoma])

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check002.gifTop 10 SNVs Having the Most Samples in TCGA data
* We represented just top 10 SNVs. When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site, primary_histology, mutation(aa), pubmedID.
Genomic PositionMutation(aa)Unique sampleID count
chr11:64888164p.A131T1
chr11:64888175p.K127M1
chr11:64888201p.N118N1
chr11:64888220p.Y112C1
chr11:64888258p.K99N1
chr11:64888455p.K92E1
chr11:64889007p.L62P1
chr11:64889081p.E37D1
chr11:64889086p.P36S1
chr11:64889260p.E9V1

check002.gifOther DBs for Point Mutations
Point Mutation Table of Ensembl: go to Ensembl variation table
Mutation of cBioPortal: go to cBioPortal's Cross-cancer alteration summary

check002.gifCopy Number for FAU in TCGA
* Copy number data were extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered on Jan-05-2015. Function ProcessCNAData in TCGA-Assembler package was used to obtain gene-level copy number value which is calculated as the average copy number of the genomic region of a gene.
cf) Tissue ID[Tissue type]: BLCA[Bladder Urothelial Carcinoma], BRCA[Breast invasive carcinoma], CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], COAD[Colon adenocarcinoma], GBM[Glioblastoma multiforme], Glioma Low Grade, HNSC[Head and Neck squamous cell carcinoma], KICH[Kidney Chromophobe], KIRC[Kidney renal clear cell carcinoma], KIRP[Kidney renal papillary cell carcinoma], LAML[Acute Myeloid Leukemia], LUAD[Lung adenocarcinoma], LUSC[Lung squamous cell carcinoma], OV[Ovarian serous cystadenocarcinoma ], PAAD[Pancreatic adenocarcinoma], PRAD[Prostate adenocarcinoma], SKCM[Skin Cutaneous Melanoma], STAD[Stomach adenocarcinoma], THCA[Thyroid carcinoma], UCEC[Uterine Corpus Endometrial Carcinoma]

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Gene Expression for FAU

check002.gifGene Expression in Cancer Cell-lines (CCLE)
* CCLE gene expression data were extracted from CCLE_Expression_Entrez_2012-10-18.res: Gene-centric RMA-normalized mRNA expression data.

check002.gifDifferential Gene Expression in Primary Tumors (TCGA)
* Normalized gene expression data of RNASeqV2 was extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered at Jan-05-2015. Only eight cancer types have enough normal control samples for differential expression analysis.
(t test, adjusted p<0.05 (using Benjamini-Hochberg FDR))
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check002.gifCNV vs Gene Expression Plot
* This plots show the correlation between CNV and gene expression.

: Open all plots for all cancer types


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Gene-Gene Network Information
check002.gifCo-Expressed gene's network Plot
* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown.
Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene

: Open all plots for all cancer types

ATP5D,UQCC3,C19orf43,FAU,FKBP2,GADD45GIP1,PRDX5,
RPL13,RPL18,RPL28,RPL35,RPL36,RPL37A,RPLP2,
RPS15,RPS19,RPS9,TRMT112,UBXN1,ZFPL1,ZNHIT2
C12orf10,EDF1,EEF1D,EIF3G,FAU,NME2,POLR2F,
PQBP1,PRDX5,RFXANK,RPL13,RPL18,RPL19,RPL35,
RPL36,RPL8,RPS15,RPS16,RPS9,SNRPD2,SURF2

ATP5L,BANF1,C11orf31,UQCC3,C19orf53,COA4,FAU,
GADD45GIP1,MRPL11,MRPL21,NDUFA13,NDUFB7,NDUFS3,PFDN5,
RPL24,RPS25,RPS3,RPS9,SSSCA1,PAM16,TMEM223
ALKBH2,ANAPC11,C12orf57,C19orf53,FAU,FIS1,HAX1,
MRPL40,MRPL43,OST4,PFDN5,RPL24,RPL35,RPL35A,
RPL41,RPL5,RPS10,RPS11,RPS13,RPS5,SNRPD2
check002.gifCo-Expressed gene's Protein-protein interaction Network Plot
* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown.
Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene

: Open all plots for all cancer types

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check002.gifInteracting Genes (from Pathway Commons)

: Open all interacting genes' information including KEGG pathway for all interacting genes from DAVID

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Pharmacological Information for FAU


There's no related Drug.
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Cross referenced IDs for FAU
* We obtained these cross-references from Uniprot database. It covers 150 different DBs, 18 categories. http://www.uniprot.org/help/cross_references_section

: Open all cross reference information



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