Cancer Cell Metabolism Gene Database

  Cancer Cell Metabolism Gene DB

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Gene Summary

Phenotypic Information (metabolism pathway, cancer, disease, phenome)

Mutations: SVs, CNVs, SNVs

Gene expression: GE, Protein, DEGE, CNV vs GE

Gene-Gene Network Information: Co-Expression Network, Interacting Genes & KEGG

Pharmacological Information: Drug-Gene Network

Cross referenced IDs

Gene Summary for FBP1
Basic gene info.Gene symbolFBP1
Gene namefructose-1,6-bisphosphatase 1
SynonymsFBP
CytomapUCSC genome browser: 9q22.3
Genomic locationchr9 :97365420-97401923
Type of geneprotein-coding
RefGenesNM_000507.3,
NM_001127628.1,
Ensembl idENSG00000165140
DescriptionD-fructose-1,6-bisphosphate 1-phosphohydrolase 1FBPase 1fructose-bisphosphatase 1growth-inhibiting protein 17liver FBPase
Modification date20141207
dbXrefs MIM : 611570
HGNC : HGNC
Ensembl : ENSG00000165140
HPRD : 01973
Vega : OTTHUMG00000020268
ProteinUniProt:
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_FBP1
BioGPS: 2203
Gene Expression Atlas: ENSG00000165140
The Human Protein Atlas: ENSG00000165140
PathwayNCI Pathway Interaction Database: FBP1
KEGG: FBP1
REACTOME: FBP1
ConsensusPathDB
Pathway Commons: FBP1
MetabolismMetaCyc: FBP1
HUMANCyc: FBP1
RegulationEnsembl's Regulation: ENSG00000165140
miRBase: chr9 :97,365,420-97,401,923
TargetScan: NM_000507
cisRED: ENSG00000165140
ContextiHOP: FBP1
cancer metabolism search in PubMed: FBP1
UCL Cancer Institute: FBP1
Assigned class in ccmGDBC

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Phenotypic Information for FBP1(metabolism pathway, cancer, disease, phenome)
check002.gifCancer Description
Cancer CGAP: FBP1
Familial Cancer Database: FBP1
* This gene is included in those cancer gene databases.

Oncogene 1

Tumor Suppressor gene 2

Cancer Gene Census 3

CancerGenes 4

Network of Cancer Gene 5

Significant driver gene in

Therapeutic Vulnerabilities in Cancer1

cf) number; DB name
1 Oncogene; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long,
2 Tumor Suppressor gene; https://bioinfo.uth.edu/TSGene/,
3 Cancer Gene Census; http://www.nature.com/nrc/journal/v4/n3/abs/nrc1299.html,
4 CancerGenes; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long,
5 Network of Cancer Gene; http://ncg.kcl.ac.uk/index.php,
1Therapeutic Vulnerabilities in Cancer; http://cbio.mskcc.org/cancergenomics/statius/

check002.gifMetabolic Pathway Description
KEGG_GLYCOLYSIS_GLUCONEOGENESIS
KEGG_FRUCTOSE_AND_MANNOSE_METABOLISM
REACTOME_METABOLISM_OF_CARBOHYDRATES
REACTOME_GLUCOSE_METABOLISM

check002.gifOthers
OMIM
Orphanet
DiseaseKEGG Disease: FBP1
MedGen: FBP1 (Human Medical Genetics with Condition)
ClinVar: FBP1
PhenotypeMGI: FBP1 (International Mouse Phenotyping Consortium)
PhenomicDB: FBP1

Mutations for FBP1
* Under tables are showing count per each tissue to give us broad intuition about tissue specific mutation patterns.You can go to the detailed page for each mutation database's web site.

check002.gifStructural Variants in COSMIC: go to COSMIC mutation histogram
There's no structural variation information in COSMIC data for this gene.

check002.gifRelated fusion transcripts : go to Chitars2.0
* From mRNA Sanger sequences, Chitars2.0 arranged chimeric transcripts. This table shows FBP1 related fusion information.
IDHead GeneTail Gene
AccessionGene_aqStart_aqEnd_aChromosome_atStart_atEnd_aGene_aqStart_aqEnd_aChromosome_atStart_atEnd_a
BF806754FBP11310799736568297365780AHCTF11012831247075362247075544

check002.gifOther DBs for Structural Variants
Structural Variants in Ensembl: go to Ensembl Structural variation
Structural Variants in dbVar: go to dbVar

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check002.gifCopy Number Variations in COSMIC: go to COSMIC mutation CNV/Expr
 
Mutation type/ Tissue IDbrcacnscervendomehaematopokidnLintestliverlungnsovarypancreprostskinstomathyrourina
Total # sample11   1           
GAIN (# sample)                 
LOSS (# sample)11   1           
cf) Tissue ID; Tissue type (1; Breast, 2; Central_nervous_system, 3; Cervix, 4; Endometrium, 5; Haematopoietic_and_lymphoid_tissue, 6; Kidney, 7; Large_intestine, 8; Liver, 9; Lung, 10; NS, 11; Ovary, 12; Pancreas, 13; Prostate, 14; Skin, 15; Stomach, 16; Thyroid, 17; Urinary_tract)

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check002.gifSNV Counts per Each Loci in COSMIC data: go to COSMIC point mutation

 : Non-synonymous mutation, : Synonymous mutation, Circle size denotes number of samples.
Maximum mutation count=3

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check002.gifSomatic Mutation Counts per Tissue in COSMIC data
Stat. for Non-Synonymous SNVs
(# total SNVs=13)
Stat. for Synonymous SNVs
(# total SNVs=8)
Stat. for Deletions
(# total SNVs=0)
Stat. for Insertions
(# total SNVs=0)
There's no deleted snv.There's no inserted snv.

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check002.gifTop 10 SNVs Having the Most Samples in COSMIC data
* When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site,primary_histology,mutation(aa),pubmedID.
GRCh37 positionMutation(aa)Unique sampleID count
chr9:97369151-97369151p.A217A2
chr9:97382677-97382677p.S89S2
chr9:97365813-97365813p.M289I2
chr9:97369109-97369109p.K231K1
chr9:97382612-97382612p.R111K1
chr9:97365749-97365749p.I311V1
chr9:97369126-97369126p.E226K1
chr9:97382635-97382635p.A103A1
chr9:97365773-97365773p.V303L1
chr9:97369155-97369155p.Y216C1

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check002.gifSNV Counts per Each Loci in TCGA data

 : non-synonymous mutation, : synonymous mutation, Circle size denotes number of samples.
maximum mutation count=1

Point Mutation/ Tissue ID1234567891011121314151617181920
# sample1  14 1 3  1    45 3
# mutation1  14 1 3  1    45 3
nonsynonymous SNV1  12   1  1    22 2
synonymous SNV    2 1 2       23 1
cf) Tissue ID; Tissue type (1; BLCA[Bladder Urothelial Carcinoma], 2; BRCA[Breast invasive carcinoma], 3; CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], 4; COAD[Colon adenocarcinoma], 5; GBM[Glioblastoma multiforme], 6; Glioma Low Grade, 7; HNSC[Head and Neck squamous cell carcinoma], 8; KICH[Kidney Chromophobe], 9; KIRC[Kidney renal clear cell carcinoma], 10; KIRP[Kidney renal papillary cell carcinoma], 11; LAML[Acute Myeloid Leukemia], 12; LUAD[Lung adenocarcinoma], 13; LUSC[Lung squamous cell carcinoma], 14; OV[Ovarian serous cystadenocarcinoma ], 15; PAAD[Pancreatic adenocarcinoma], 16; PRAD[Prostate adenocarcinoma], 17; SKCM[Skin Cutaneous Melanoma], 18:STAD[Stomach adenocarcinoma], 19:THCA[Thyroid carcinoma], 20:UCEC[Uterine Corpus Endometrial Carcinoma])

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check002.gifTop 10 SNVs Having the Most Samples in TCGA data
* We represented just top 10 SNVs. When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site, primary_histology, mutation(aa), pubmedID.
Genomic PositionMutation(aa)Unique sampleID count
chr9:97369216p.S63S,FBP11
chr9:97365818p.V258F,FBP11
chr9:97380054p.E30K,FBP11
chr9:97367792p.N237I,FBP11
chr9:97380079p.T15T,FBP11
chr9:97367854p.D236D,FBP11
chr9:97380089p.F233F,FBP11
chr9:97367856p.K231N,FBP11
chr9:97382612p.A223A,FBP11
chr9:97369103p.Y216C,FBP11

check002.gifOther DBs for Point Mutations
Point Mutation Table of Ensembl: go to Ensembl variation table
Mutation of cBioPortal: go to cBioPortal's Cross-cancer alteration summary

check002.gifCopy Number for FBP1 in TCGA
* Copy number data were extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered on Jan-05-2015. Function ProcessCNAData in TCGA-Assembler package was used to obtain gene-level copy number value which is calculated as the average copy number of the genomic region of a gene.
cf) Tissue ID[Tissue type]: BLCA[Bladder Urothelial Carcinoma], BRCA[Breast invasive carcinoma], CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], COAD[Colon adenocarcinoma], GBM[Glioblastoma multiforme], Glioma Low Grade, HNSC[Head and Neck squamous cell carcinoma], KICH[Kidney Chromophobe], KIRC[Kidney renal clear cell carcinoma], KIRP[Kidney renal papillary cell carcinoma], LAML[Acute Myeloid Leukemia], LUAD[Lung adenocarcinoma], LUSC[Lung squamous cell carcinoma], OV[Ovarian serous cystadenocarcinoma ], PAAD[Pancreatic adenocarcinoma], PRAD[Prostate adenocarcinoma], SKCM[Skin Cutaneous Melanoma], STAD[Stomach adenocarcinoma], THCA[Thyroid carcinoma], UCEC[Uterine Corpus Endometrial Carcinoma]

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Gene Expression for FBP1

check002.gifGene Expression in Cancer Cell-lines (CCLE)
* CCLE gene expression data were extracted from CCLE_Expression_Entrez_2012-10-18.res: Gene-centric RMA-normalized mRNA expression data.

check002.gifDifferential Gene Expression in Primary Tumors (TCGA)
* Normalized gene expression data of RNASeqV2 was extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered at Jan-05-2015. Only eight cancer types have enough normal control samples for differential expression analysis.
(t test, adjusted p<0.05 (using Benjamini-Hochberg FDR))
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check002.gifCNV vs Gene Expression Plot
* This plots show the correlation between CNV and gene expression.

: Open all plots for all cancer types


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Gene-Gene Network Information
check002.gifCo-Expressed gene's network Plot
* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown.
Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene

: Open all plots for all cancer types

ARFIP2,COQ4,COQ6,FAAH,FBP1,G6PC3,GAMT,
GATA3,CCDC183,MDP1,MLPH,MOAP1,NECAB3,OCEL1,
P4HTM,PRR15,RAB17,SIGIRR,SPDEF,TMEM141,ZNF467
AIFM3,ATP6AP1,ATP6V0B,BIK,CCDC159,CLN3,FBP1,
GAA,NEU1,P2RX4,RAB17,RNASET2,RNPEP,RPS6KA1,
SLC26A11,STXBP2,SULT2B1,TBC1D2,TMED3,TMEM141,VAMP8

APOD,CCL17,CD1B,CXorf49B,DMRTB1,DNASE2B,FBP1,
FBXO24,SLC25A3P1,GCNT1,LOC388242,LRCH4,MARCO,psiTPTE22,
RGS17,RMST,SI,DCSTAMP,TSC22D4,WIPF3,WNT16
ABCC2,ABCG5,ABCG8,ACE,ALDOB,ERICH4,CYP2D6,
DAK,DHDH,DPEP1,FBP1,GSTA1,GSTA2,MGAM,
NAT8,NR0B2,REEP6,SHBG,SLC10A2,SLC5A4,TREH
check002.gifCo-Expressed gene's Protein-protein interaction Network Plot
* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown.
Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene

: Open all plots for all cancer types

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check002.gifInteracting Genes (from Pathway Commons)

: Open all interacting genes' information including KEGG pathway for all interacting genes from DAVID

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Pharmacological Information for FBP1
check002.gifCross-referenced pharmacological DB IDs from Uniprot
DB CategoryDB NameDB's ID and Url link

check002.gifDrug-Gene Interaction Network
* Gene Centered Interaction Network.
* Drug Centered Interaction Network.
DrugBank IDTarget NameDrug GroupsGeneric NameDrug Centered NetworkDrug Structure
DB00131fructose-1,6-bisphosphatase 1approved; nutraceuticalAdenosine monophosphate
DB02778fructose-1,6-bisphosphatase 1experimental2,5-Anhydroglucitol-1,6-Biphosphate
DB02848fructose-1,6-bisphosphatase 1experimental{4-[3-(6,7-Diethoxy-Quinazolin-4-Ylamino)-Phenyl]-Thiazol-2-Yl}-Methanol
DB04175fructose-1,6-bisphosphatase 1experimentalMdl-29951
DB04493fructose-1,6-bisphosphatase 1experimentalFructose-6-Phosphate
DB07270fructose-1,6-bisphosphatase 1experimentalN-[7-(3-AMINOPHENYL)-5-METHOXY-1,3-BENZOXAZOL-2-YL]-2,5-DICHLOROBENZENESULFONAMIDE
DB07312fructose-1,6-bisphosphatase 1experimental2,5-DICHLORO-N-(5-CHLORO-1,3-BENZOXAZOL-2-YL)BENZENESULFONAMIDE
DB07321fructose-1,6-bisphosphatase 1experimental2,5-DICHLORO-N-[5-METHOXY-7-(6-METHOXYPYRIDIN-3-YL)-1,3-BENZOXAZOL-2-YL]BENZENESULFONAMIDE
DB08484fructose-1,6-bisphosphatase 1experimental4-AMINO-N-[(2-SULFANYLETHYL)CARBAMOYL]BENZENESULFONAMIDE


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Cross referenced IDs for FBP1
* We obtained these cross-references from Uniprot database. It covers 150 different DBs, 18 categories. http://www.uniprot.org/help/cross_references_section

: Open all cross reference information



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