Cancer Cell Metabolism Gene Database

  Cancer Cell Metabolism Gene DB

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Gene Summary

Phenotypic Information (metabolism pathway, cancer, disease, phenome)

Mutations: SVs, CNVs, SNVs

Gene expression: GE, Protein, DEGE, CNV vs GE

Gene-Gene Network Information: Co-Expression Network, Interacting Genes & KEGG

Pharmacological Information: Drug-Gene Network

Cross referenced IDs

Gene Summary for CES5A
Basic gene info.Gene symbolCES5A
Gene namecarboxylesterase 5A
SynonymsCAUXIN|CES4C1|CES5|CES7|HEL126
CytomapUCSC genome browser: 16q12.2
Genomic locationchr16 :55880065-55909282
Type of geneprotein-coding
RefGenesNM_001143685.1,
NM_001190158.1,NM_145024.2,
Ensembl idENSG00000261972
Descriptioncarboxylesterase 5carboxylesterase 7carboxylesterase-like urinary excreted protein homologepididymis luminal protein 126
Modification date20141207
dbXrefs HGNC : HGNC
Ensembl : ENSG00000159398
HPRD : 07016
Vega : OTTHUMG00000133236
ProteinUniProt:
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_CES5A
BioGPS: 221223
Gene Expression Atlas: ENSG00000261972
The Human Protein Atlas: ENSG00000261972
PathwayNCI Pathway Interaction Database: CES5A
KEGG: CES5A
REACTOME: CES5A
ConsensusPathDB
Pathway Commons: CES5A
MetabolismMetaCyc: CES5A
HUMANCyc: CES5A
RegulationEnsembl's Regulation: ENSG00000261972
miRBase: chr16 :55,880,065-55,909,282
TargetScan: NM_001143685
cisRED: ENSG00000261972
ContextiHOP: CES5A
cancer metabolism search in PubMed: CES5A
UCL Cancer Institute: CES5A
Assigned class in ccmGDBC

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Phenotypic Information for CES5A(metabolism pathway, cancer, disease, phenome)
check002.gifCancer Description
Cancer CGAP: CES5A
Familial Cancer Database: CES5A
* This gene is included in those cancer gene databases.

Oncogene 1

Tumor Suppressor gene 2

Cancer Gene Census 3

CancerGenes 4

Network of Cancer Gene 5

Significant driver gene in

Therapeutic Vulnerabilities in Cancer1

cf) number; DB name
1 Oncogene; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long,
2 Tumor Suppressor gene; https://bioinfo.uth.edu/TSGene/,
3 Cancer Gene Census; http://www.nature.com/nrc/journal/v4/n3/abs/nrc1299.html,
4 CancerGenes; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long,
5 Network of Cancer Gene; http://ncg.kcl.ac.uk/index.php,
1Therapeutic Vulnerabilities in Cancer; http://cbio.mskcc.org/cancergenomics/statius/

check002.gifMetabolic Pathway Description
KEGG_DRUG_METABOLISM_OTHER_ENZYMES

check002.gifOthers
OMIM
Orphanet
DiseaseKEGG Disease: CES5A
MedGen: CES5A (Human Medical Genetics with Condition)
ClinVar: CES5A
PhenotypeMGI: CES5A (International Mouse Phenotyping Consortium)
PhenomicDB: CES5A

Mutations for CES5A
* Under tables are showing count per each tissue to give us broad intuition about tissue specific mutation patterns.You can go to the detailed page for each mutation database's web site.

check002.gifStructural Variants in COSMIC: go to COSMIC mutation histogram
There's no structural variation information in COSMIC data for this gene.

check002.gifRelated fusion transcripts : go to Chitars2.0
* From mRNA Sanger sequences, Chitars2.0 arranged chimeric transcripts. This table shows CES5A related fusion information.
IDHead GeneTail Gene
AccessionGene_aqStart_aqEnd_aChromosome_atStart_atEnd_aGene_aqStart_aqEnd_aChromosome_atStart_atEnd_a

check002.gifOther DBs for Structural Variants
Structural Variants in Ensembl: go to Ensembl Structural variation
Structural Variants in dbVar: go to dbVar

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check002.gifCopy Number Variations in COSMIC: go to COSMIC mutation CNV/Expr
 
Mutation type/ Tissue IDbrcacnscervendomehaematopokidnLintestliverlungnsovarypancreprostskinstomathyrourina
Total # sample 1 1  1 1        
GAIN (# sample)      1 1        
LOSS (# sample) 1 1             
cf) Tissue ID; Tissue type (1; Breast, 2; Central_nervous_system, 3; Cervix, 4; Endometrium, 5; Haematopoietic_and_lymphoid_tissue, 6; Kidney, 7; Large_intestine, 8; Liver, 9; Lung, 10; NS, 11; Ovary, 12; Pancreas, 13; Prostate, 14; Skin, 15; Stomach, 16; Thyroid, 17; Urinary_tract)

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check002.gifSNV Counts per Each Loci in COSMIC data: go to COSMIC point mutation

 : Non-synonymous mutation, : Synonymous mutation, Circle size denotes number of samples.
Maximum mutation count=7

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check002.gifSomatic Mutation Counts per Tissue in COSMIC data
Stat. for Non-Synonymous SNVs
(# total SNVs=70)
Stat. for Synonymous SNVs
(# total SNVs=40)
Stat. for Deletions
(# total SNVs=0)
Stat. for Insertions
(# total SNVs=0)
There's no deleted snv.There's no inserted snv.

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check002.gifTop 10 SNVs Having the Most Samples in COSMIC data
* When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site,primary_histology,mutation(aa),pubmedID.
GRCh37 positionMutation(aa)Unique sampleID count
chr16:55899902-55899902p.S226S6
chr16:55880572-55880572p.S457P4
chr16:55886932-55886932p.P378P3
chr16:55907786-55907786p.S79S3
chr16:55907857-55907857p.V56M2
chr16:55903558-55903558p.V172V2
chr16:55907868-55907868p.V52A2
chr16:55895427-55895427p.L271P2
chr16:55907805-55907805p.T73M2
chr16:55880534-55880534p.L469L2

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check002.gifSNV Counts per Each Loci in TCGA data

 : non-synonymous mutation, : synonymous mutation, Circle size denotes number of samples.
maximum mutation count=4

Point Mutation/ Tissue ID1234567891011121314151617181920
# sample 31221 3 2  1943  1014 8
# mutation 31191 3 2  1943  1418 8
nonsynonymous SNV 2114  2 1  1423  119 5
synonymous SNV 1 51 1 1  52   39 3
cf) Tissue ID; Tissue type (1; BLCA[Bladder Urothelial Carcinoma], 2; BRCA[Breast invasive carcinoma], 3; CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], 4; COAD[Colon adenocarcinoma], 5; GBM[Glioblastoma multiforme], 6; Glioma Low Grade, 7; HNSC[Head and Neck squamous cell carcinoma], 8; KICH[Kidney Chromophobe], 9; KIRC[Kidney renal clear cell carcinoma], 10; KIRP[Kidney renal papillary cell carcinoma], 11; LAML[Acute Myeloid Leukemia], 12; LUAD[Lung adenocarcinoma], 13; LUSC[Lung squamous cell carcinoma], 14; OV[Ovarian serous cystadenocarcinoma ], 15; PAAD[Pancreatic adenocarcinoma], 16; PRAD[Prostate adenocarcinoma], 17; SKCM[Skin Cutaneous Melanoma], 18:STAD[Stomach adenocarcinoma], 19:THCA[Thyroid carcinoma], 20:UCEC[Uterine Corpus Endometrial Carcinoma])

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check002.gifTop 10 SNVs Having the Most Samples in TCGA data
* We represented just top 10 SNVs. When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site, primary_histology, mutation(aa), pubmedID.
Genomic PositionMutation(aa)Unique sampleID count
chr16:55880572p.S457P,CES5A4
chr16:55895427p.V52A,CES5A2
chr16:55907805p.L350L,CES5A2
chr16:55903558p.I339I,CES5A2
chr16:55893467p.V172V,CES5A2
chr16:55893498p.S457Y,CES5A2
chr16:55903594p.L271P,CES5A2
chr16:55880571p.T73M,CES5A2
chr16:55907868p.S160S,CES5A2
chr16:55907910p.G147D,CES5A1

check002.gifOther DBs for Point Mutations
Point Mutation Table of Ensembl: go to Ensembl variation table
Mutation of cBioPortal: go to cBioPortal's Cross-cancer alteration summary

check002.gifCopy Number for CES5A in TCGA
* Copy number data were extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered on Jan-05-2015. Function ProcessCNAData in TCGA-Assembler package was used to obtain gene-level copy number value which is calculated as the average copy number of the genomic region of a gene.
cf) Tissue ID[Tissue type]: BLCA[Bladder Urothelial Carcinoma], BRCA[Breast invasive carcinoma], CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], COAD[Colon adenocarcinoma], GBM[Glioblastoma multiforme], Glioma Low Grade, HNSC[Head and Neck squamous cell carcinoma], KICH[Kidney Chromophobe], KIRC[Kidney renal clear cell carcinoma], KIRP[Kidney renal papillary cell carcinoma], LAML[Acute Myeloid Leukemia], LUAD[Lung adenocarcinoma], LUSC[Lung squamous cell carcinoma], OV[Ovarian serous cystadenocarcinoma ], PAAD[Pancreatic adenocarcinoma], PRAD[Prostate adenocarcinoma], SKCM[Skin Cutaneous Melanoma], STAD[Stomach adenocarcinoma], THCA[Thyroid carcinoma], UCEC[Uterine Corpus Endometrial Carcinoma]

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Gene Expression for CES5A

check002.gifGene Expression in Cancer Cell-lines (CCLE)
* CCLE gene expression data were extracted from CCLE_Expression_Entrez_2012-10-18.res: Gene-centric RMA-normalized mRNA expression data.

check002.gifDifferential Gene Expression in Primary Tumors (TCGA)
* Normalized gene expression data of RNASeqV2 was extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered at Jan-05-2015. Only eight cancer types have enough normal control samples for differential expression analysis.
(t test, adjusted p<0.05 (using Benjamini-Hochberg FDR))
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check002.gifCNV vs Gene Expression Plot
* This plots show the correlation between CNV and gene expression.

: Open all plots for all cancer types


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Gene-Gene Network Information
check002.gifCo-Expressed gene's network Plot
* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown.
Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene

: Open all plots for all cancer types

AWAT1,BCO1,CCDC129,CES5A,CLEC3A,HABP2,HNF1A,
LRRK2,MGLL,MIA2,OR10H4,PCDHGA1,PCDHGA5,PCTP,
POTED,RGS5,SCN11A,SLC5A5,SNPH,SPANXN1,STS
ABCC4,ACER1,AMBP,B4GALNT2,CES5A,CFHR2,CFHR5,
CPB2,GSTM1,HES3,HIST1H2AE,HIST1H4G,ISX,LOC145837,
LOC360030,NOTO,OR2J2,OR7D4,PPEF1,SNAP91,UGT2B28

CES5A,SPATA31A5,FMR1NB,HHATL,IGDCC3,KRT33A,KRT34,
KRTAP1-1,KRTAP19-3,KRTAP3-1,KRTAP3-3,MAGEB6,OC90,OR5AR1,
RHOXF2B,TEX13A,UPK2,VCX2,VCX,V
ALDH8A1,ARPP21,CACNA1B,CES5A,CHD5,CRABP1,CTNNA2,
EGFL8,FAM106CP,GDI1,H2BFXP,HEPN1,HRH3,JPH3,
KIF5A,LRRC55,MAB21L1,MYT1,PCDHA9,RNF182,SYT9
check002.gifCo-Expressed gene's Protein-protein interaction Network Plot
* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown.
Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene

: Open all plots for all cancer types

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check002.gifInteracting Genes (from Pathway Commons)

: Open all interacting genes' information including KEGG pathway for all interacting genes from DAVID

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Pharmacological Information for CES5A


There's no related Drug.
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Cross referenced IDs for CES5A
* We obtained these cross-references from Uniprot database. It covers 150 different DBs, 18 categories. http://www.uniprot.org/help/cross_references_section

: Open all cross reference information



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