Cancer Cell Metabolism Database ~~ Bioinformatics and Systems Medicine Laboratory ~~

Cancer Cell Metabolism Gene Database

Cancer Cell Metabolism Gene DB

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	Gene Summary
	Phenotypic Information (metabolism pathway, cancer, disease, phenome)
	Mutations : SVs, CNVs, SNVs
	Gene expression: GE, Protein, DEGE, CNV vs GE
	Gene-Gene Network Information: Co-Expression Network, Interacting Genes & KEGG
	Pharmacological Information: Drug-Gene Network
	Cross referenced IDs

Gene Summary for FH

Basic gene info.	Gene symbol	FH
	Gene name	fumarate hydratase
	Synonyms	HLRCC\|LRCC\|MCL\|MCUL1
	Cytomap	UCSC genome browser: 1q42.1
	Genomic location	chr1 :241660856-241683085
	Type of gene	protein-coding
	RefGenes	NM_000143.3,
	Ensembl id	ENSG00000091483
	Description	fumarasefumarate hydratase, mitochondrial
	Modification date	20141222
dbXrefs	MIM : 136850
	HGNC : HGNC
	Ensembl : ENSG00000091483
	HPRD : 00652
	Vega : OTTHUMG00000039597
Protein	UniProt: P07954 go to UniProt's Cross Reference DB Table
Expression	CleanEX: HS_FH
	BioGPS: 2271
	Gene Expression Atlas: ENSG00000091483
	The Human Protein Atlas: ENSG00000091483
Pathway	NCI Pathway Interaction Database: FH
	KEGG: FH
	REACTOME: FH
	ConsensusPathDB
	Pathway Commons: FH
Metabolism	MetaCyc: FH
	HUMANCyc: FH
Regulation	Ensembl's Regulation: ENSG00000091483
	miRBase: chr1 :241,660,856-241,683,085
	TargetScan: NM_000143
	cisRED: ENSG00000091483
Context	iHOP: FH
	cancer metabolism search in PubMed: FH
	UCL Cancer Institute: FH
Assigned class in ccmGDB	A - This gene has a literature evidence and it belongs to cancer gene.
References showing role of FH in cancer cell metabolism	1. Zecchini V, Madhu B, Russell R, Pertega-Gomes N, Warren A, et al. (2014) Nuclear ARRB1 induces pseudohypoxia and cellular metabolism reprogramming in prostate cancer. EMBO J 33: 1365-1382. doi: 10.15252/embj.201386874. pmid: 4194125. go to article 2. Morin A, Letouze E, Gimenez-Roqueplo AP, Favier J (2014) Oncometabolites-driven tumorigenesis: From genetics to targeted therapy. Int J Cancer 135: 2237-2248. doi: 10.1002/ijc.29080. go to article 3. Nowicki S, Gottlieb E (2015) Oncometabolites: tailoring our genes. FEBS J. doi: 10.1111/febs.13295. go to article 4. Sourbier C, Ricketts CJ, Matsumoto S, Crooks DR, Liao PJ, et al. (2014) Targeting ABL1-mediated oxidative stress adaptation in fumarate hydratase-deficient cancer. Cancer Cell 26: 840-850. doi: 10.1016/j.ccell.2014.10.005. pmid: 4386283. go to article 5. Kaelin WG, Jr. (2014) DisABLing kidney cancers caused by fumarate hydratase mutations. Cancer Cell 26: 779-780. doi: 10.1016/j.ccell.2014.11.022. go to article

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Phenotypic Information for FH(metabolism pathway, cancer, disease, phenome)

Cancer Description
Cancer	CGAP: FH
	Familial Cancer Database: FH

* This gene is included in those cancer gene databases.

						.
Oncogene ¹	Tumor Suppressor gene ²	Cancer Gene Census ³	CancerGenes ⁴	Network of Cancer Gene ⁵	Significant driver gene in	Therapeutic Vulnerabilities in Cancer¹

cf) number; DB name
1 Oncogene; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long,
2 Tumor Suppressor gene; https://bioinfo.uth.edu/TSGene/,
3 Cancer Gene Census; http://www.nature.com/nrc/journal/v4/n3/abs/nrc1299.html,
4 CancerGenes; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long,
5 Network of Cancer Gene; http://ncg.kcl.ac.uk/index.php,
1Therapeutic Vulnerabilities in Cancer; http://cbio.mskcc.org/cancergenomics/statius/

Metabolic Pathway Description
REACTOME_PYRUVATE_METABOLISM_AND_CITRIC_ACID_TCA_CYCLE

Others
OMIM	136850; gene. 150800; phenotype. 606812; phenotype.
Orphanet	24; Fumaric aciduria. 29072; Hereditary pheochromocytoma-paraganglioma. 523; Hereditary leiomyomatosis and renal cell cancer.
Disease	KEGG Disease: FH
	MedGen: FH (Human Medical Genetics with Condition)
	ClinVar: FH
Phenotype	MGI: FH (International Mouse Phenotyping Consortium)
Phenotype	PhenomicDB: FH

Mutations for FH

* Under tables are showing count per each tissue to give us broad intuition about tissue specific mutation patterns.You can go to the detailed page for each mutation database's web site.

Structural Variants in COSMIC : go to COSMIC mutation histogram

There's no structural variation information in COSMIC data for this gene.

Related fusion transcripts : go to Chitars2.0

* From mRNA Sanger sequences, Chitars2.0 arranged chimeric transcripts. This table shows FH related fusion information.

Head Gene

Tail Gene

Accession

Gene_a

qStart_a

qEnd_a

Chromosome_a

tStart_a

tEnd_a

Gene_a

qStart_a

qEnd_a

Chromosome_a

tStart_a

tEnd_a

Other DBs for Structural Variants

Structural Variants in Ensembl: go to Ensembl Structural variation

Structural Variants in dbVar: go to dbVar

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Copy Number Variations in COSMIC : go to COSMIC mutation CNV/Expr

Mutation type/ Tissue ID

brca

cns

cerv

endome

haematopo

kidn

Lintest

liver

lung

ovary

pancre

prost

skin

stoma

thyro

urina

Total # sample

GAIN (# sample)

LOSS (# sample)

cf) Tissue ID; Tissue type (1; Breast, 2; Central_nervous_system, 3; Cervix, 4; Endometrium, 5; Haematopoietic_and_lymphoid_tissue, 6; Kidney, 7; Large_intestine, 8; Liver, 9; Lung, 10; NS, 11; Ovary, 12; Pancreas, 13; Prostate, 14; Skin, 15; Stomach, 16; Thyroid, 17; Urinary_tract)

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SNV Counts per Each Loci in COSMIC data : go to COSMIC point mutation

: Non-synonymous mutation, : Synonymous mutation, Circle size denotes number of samples.
Maximum mutation count=6

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Somatic Mutation Counts per Tissue in COSMIC data

Stat. for Non-Synonymous SNVs (# total SNVs=44)	Stat. for Synonymous SNVs (# total SNVs=18)

Stat. for Deletions (# total SNVs=0)	Stat. for Insertions (# total SNVs=0)
There's no deleted snv.	There's no inserted snv.

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Top 10 SNVs Having the Most Samples in COSMIC data

* When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site,primary_histology,mutation(aa),pubmedID.

GRCh37 position	Mutation(aa)	Unique sampleID count
chr1:241663758-241663758	p.T457A	3
chr1:241665814-241665814	p.G389W	2
chr1:241661270-241661270	p.G464V	2
chr1:241675287-241675287	p.D179N	2
chr1:241663756-241663756	p.T457T	2
chr1:241680472-241680472	p.?	2
chr1:241663880-241663880	p.V416A	2
chr1:241680522-241680522	p.T76M	2
chr1:241663881-241663881	p.V416L	2
chr1:241663802-241663802	p.T442R	1

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SNV Counts per Each Loci in TCGA data

: non-synonymous mutation, : synonymous mutation, Circle size denotes number of samples.
maximum mutation count=5

Point Mutation/ Tissue ID	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20
# sample	4			17			2		1			8	3	1			2	3	1	9
# mutation	4			15			2		1			9	3	1			2	3	1	11
nonsynonymous SNV	3			8			2		1			7	1	1			2	3	1	8
synonymous SNV	1			7								2	2							3

cf) Tissue ID; Tissue type (1; BLCA[Bladder Urothelial Carcinoma], 2; BRCA[Breast invasive carcinoma], 3; CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], 4; COAD[Colon adenocarcinoma], 5; GBM[Glioblastoma multiforme], 6; Glioma Low Grade, 7; HNSC[Head and Neck squamous cell carcinoma], 8; KICH[Kidney Chromophobe], 9; KIRC[Kidney renal clear cell carcinoma], 10; KIRP[Kidney renal papillary cell carcinoma], 11; LAML[Acute Myeloid Leukemia], 12; LUAD[Lung adenocarcinoma], 13; LUSC[Lung squamous cell carcinoma], 14; OV[Ovarian serous cystadenocarcinoma ], 15; PAAD[Pancreatic adenocarcinoma], 16; PRAD[Prostate adenocarcinoma], 17; SKCM[Skin Cutaneous Melanoma], 18:STAD[Stomach adenocarcinoma], 19:THCA[Thyroid carcinoma], 20:UCEC[Uterine Corpus Endometrial Carcinoma])

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Top 10 SNVs Having the Most Samples in TCGA data

* We represented just top 10 SNVs. When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site, primary_histology, mutation(aa), pubmedID.

Genomic Position	Mutation(aa)	Unique sampleID count
chr1:241663758	p.T457A	3
chr1:241663880	p.V416A	2
chr1:241663824	p.F497L	1
chr1:241677012	p.S399I	1
chr1:241667492	p.D179N	1
chr1:241661202	p.G69G	1
chr1:241675291	p.I487V	1
chr1:241663856	p.V396V	1
chr1:241680489	p.P177P	1
chr1:241667497	p.F50I	1

Other DBs for Point Mutations

Point Mutation Table of Ensembl: go to Ensembl variation table

Mutation of cBioPortal: go to cBioPortal's Cross-cancer alteration summary

Copy Number for FH in TCGA

* Copy number data were extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered on Jan-05-2015. Function ProcessCNAData in TCGA-Assembler package was used to obtain gene-level copy number value which is calculated as the average copy number of the genomic region of a gene.

cf) Tissue ID[Tissue type]: BLCA[Bladder Urothelial Carcinoma], BRCA[Breast invasive carcinoma], CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], COAD[Colon adenocarcinoma], GBM[Glioblastoma multiforme], Glioma Low Grade, HNSC[Head and Neck squamous cell carcinoma], KICH[Kidney Chromophobe], KIRC[Kidney renal clear cell carcinoma], KIRP[Kidney renal papillary cell carcinoma], LAML[Acute Myeloid Leukemia], LUAD[Lung adenocarcinoma], LUSC[Lung squamous cell carcinoma], OV[Ovarian serous cystadenocarcinoma ], PAAD[Pancreatic adenocarcinoma], PRAD[Prostate adenocarcinoma], SKCM[Skin Cutaneous Melanoma], STAD[Stomach adenocarcinoma], THCA[Thyroid carcinoma], UCEC[Uterine Corpus Endometrial Carcinoma]

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Gene Expression for FH

Gene Expression in Cancer Cell-lines (CCLE)

* CCLE gene expression data were extracted from CCLE_Expression_Entrez_2012-10-18.res: Gene-centric RMA-normalized mRNA expression data.

Differential Gene Expression in Primary Tumors (TCGA)

* Normalized gene expression data of RNASeqV2 was extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered at Jan-05-2015. Only eight cancer types have enough normal control samples for differential expression analysis.
(t test, adjusted p<0.05 (using Benjamini-Hochberg FDR))

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CNV vs Gene Expression Plot

* This plots show the correlation between CNV and gene expression.

: Open all plots for all cancer types

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Gene-Gene Network Information

Co-Expressed gene's network Plot

* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown.
Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene

: Open all plots for all cancer types


ATP10A,CLIC5,CLIC6,DOK7,EIF4E1B,FHL2,GADD45A, GPR26,ITPRIPL2,AJUBA,KCNS3,PGR,PLCD3,RAB31, RBBP8,SEMA3B,SUSD3,TMEM26,TUBA3D,UGDH,WT1	PIFO,FHL2,GPR87,KIF9,KLK5,KLK7,KRT14, KRT17,KRT5,KRT9,MGP,NXT1,PDLIM1,PDLIM4, SF3B4,SFN,TACSTD2,TES,TMEM51,ZNF165,ZYX

AGR2,ANG,B3GNT5,SMCO4,GSKIP,CYSTM1,MCU, DDB2,EGLN3,FHL2,FOXA3,FUT8,GMDS,FFAR4, LIMA1,MLPH,MRAP2,SEMA4B,TC2N,TRIM16,TSPAN15	ADRM1,AKIRIN2,BCL10,LURAP1L,CASP5,CD55,DGCR11, FHL2,PLAUR,PSMC4,PSMD12,RAB35,RND1,RNF19B, SEMA4B,SERPINB8,SERTAD1,TNFRSF1A,TRIM15,TRIM40,TTC39B

Co-Expressed gene's Protein-protein interaction Network Plot

: Open all plots for all cancer types

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Interacting Genes (from Pathway Commons)

: Open all interacting genes' information including KEGG pathway for all interacting genes from DAVID

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Pharmacological Information for FH

There's no related Drug.

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Cross referenced IDs for FH

* We obtained these cross-references from Uniprot database. It covers 150 different DBs, 18 categories. http://www.uniprot.org/help/cross_references_section

: Open all cross reference information