Cancer Cell Metabolism Gene Database

  Cancer Cell Metabolism Gene DB

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Bioinformatics and Systems Medicine Laboratory Bioinformatics and Systems Medicine Laboratory

Gene Summary

Phenotypic Information (metabolism pathway, cancer, disease, phenome)

Mutations: SVs, CNVs, SNVs

Gene expression: GE, Protein, DEGE, CNV vs GE

Gene-Gene Network Information: Co-Expression Network, Interacting Genes & KEGG

Pharmacological Information: Drug-Gene Network

Cross referenced IDs

Gene Summary for ALDOC
Basic gene info.Gene symbolALDOC
Gene namealdolase C, fructose-bisphosphate
SynonymsALDC
CytomapUCSC genome browser: 17cen-q12
Genomic locationchr17 :26900132-26903951
Type of geneprotein-coding
RefGenesNM_005165.2,
Ensembl idENSG00000109107
Descriptionaldolase 3brain-type aldolasefructoaldolase Cfructose-1,6-biphosphate triosephosphate lyasefructose-bisphosphate aldolase C
Modification date20141207
dbXrefs MIM : 103870
HGNC : HGNC
Ensembl : ENSG00000109107
HPRD : 02386
Vega : OTTHUMG00000132605
ProteinUniProt:
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_ALDOC
BioGPS: 230
Gene Expression Atlas: ENSG00000109107
The Human Protein Atlas: ENSG00000109107
PathwayNCI Pathway Interaction Database: ALDOC
KEGG: ALDOC
REACTOME: ALDOC
ConsensusPathDB
Pathway Commons: ALDOC
MetabolismMetaCyc: ALDOC
HUMANCyc: ALDOC
RegulationEnsembl's Regulation: ENSG00000109107
miRBase: chr17 :26,900,132-26,903,951
TargetScan: NM_005165
cisRED: ENSG00000109107
ContextiHOP: ALDOC
cancer metabolism search in PubMed: ALDOC
UCL Cancer Institute: ALDOC
Assigned class in ccmGDBC

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Phenotypic Information for ALDOC(metabolism pathway, cancer, disease, phenome)
check002.gifCancer Description
Cancer CGAP: ALDOC
Familial Cancer Database: ALDOC
* This gene is included in those cancer gene databases.

Oncogene 1

Tumor Suppressor gene 2

Cancer Gene Census 3

CancerGenes 4

Network of Cancer Gene 5

Significant driver gene in

Therapeutic Vulnerabilities in Cancer1

cf) number; DB name
1 Oncogene; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long,
2 Tumor Suppressor gene; https://bioinfo.uth.edu/TSGene/,
3 Cancer Gene Census; http://www.nature.com/nrc/journal/v4/n3/abs/nrc1299.html,
4 CancerGenes; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long,
5 Network of Cancer Gene; http://ncg.kcl.ac.uk/index.php,
1Therapeutic Vulnerabilities in Cancer; http://cbio.mskcc.org/cancergenomics/statius/

check002.gifMetabolic Pathway Description
KEGG_GLYCOLYSIS_GLUCONEOGENESIS
KEGG_FRUCTOSE_AND_MANNOSE_METABOLISM
REACTOME_METABOLISM_OF_CARBOHYDRATES
REACTOME_GLUCOSE_METABOLISM

check002.gifOthers
OMIM
Orphanet
DiseaseKEGG Disease: ALDOC
MedGen: ALDOC (Human Medical Genetics with Condition)
ClinVar: ALDOC
PhenotypeMGI: ALDOC (International Mouse Phenotyping Consortium)
PhenomicDB: ALDOC

Mutations for ALDOC
* Under tables are showing count per each tissue to give us broad intuition about tissue specific mutation patterns.You can go to the detailed page for each mutation database's web site.

check002.gifStructural Variants in COSMIC: go to COSMIC mutation histogram
There's no structural variation information in COSMIC data for this gene.

check002.gifRelated fusion transcripts : go to Chitars2.0
* From mRNA Sanger sequences, Chitars2.0 arranged chimeric transcripts. This table shows ALDOC related fusion information.
IDHead GeneTail Gene
AccessionGene_aqStart_aqEnd_aChromosome_atStart_atEnd_aGene_aqStart_aqEnd_aChromosome_atStart_atEnd_a
DA078791GAD112742171673400171675153ALDOC274581172690197226902481
AI193580SYN11136X4744605547446190ALDOC128718172690038226901220
BE070871TRAK11714034224563842245761ALDOC126278172690027826900430
AI308067MARK21152116367689763677048ALDOC151275172690028426900408
DA088736WNK1119912971381987436ALDOC198572172690216526903883

check002.gifOther DBs for Structural Variants
Structural Variants in Ensembl: go to Ensembl Structural variation
Structural Variants in dbVar: go to dbVar

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check002.gifCopy Number Variations in COSMIC: go to COSMIC mutation CNV/Expr
There's no copy number variation information in COSMIC data for this gene.

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check002.gifSNV Counts per Each Loci in COSMIC data: go to COSMIC point mutation

 : Non-synonymous mutation, : Synonymous mutation, Circle size denotes number of samples.
Maximum mutation count=6

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check002.gifSomatic Mutation Counts per Tissue in COSMIC data
Stat. for Non-Synonymous SNVs
(# total SNVs=18)
Stat. for Synonymous SNVs
(# total SNVs=8)
Stat. for Deletions
(# total SNVs=0)
Stat. for Insertions
(# total SNVs=0)
There's no deleted snv.There's no inserted snv.

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check002.gifTop 10 SNVs Having the Most Samples in COSMIC data
* When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site,primary_histology,mutation(aa),pubmedID.
GRCh37 positionMutation(aa)Unique sampleID count
chr17:26901115-26901115p.L257L6
chr17:26901108-26901108p.R259H2
chr17:26901111-26901111p.R258H2
chr17:26902486-26902486p.R22Q2
chr17:26901545-26901545p.H197H2
chr17:26900886-26900886p.R289L1
chr17:26901737-26901737p.R173C1
chr17:26900565-26900565p.Y358Y1
chr17:26902548-26902548p.M1I1
chr17:26900951-26900951p.G267G1

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check002.gifSNV Counts per Each Loci in TCGA data

 : non-synonymous mutation, : synonymous mutation, Circle size denotes number of samples.
maximum mutation count=2

Point Mutation/ Tissue ID1234567891011121314151617181920
# sample 1 31 3    221 136 4
# mutation 1 31 3    221 136 4
nonsynonymous SNV 1 3  1    211 124 3
synonymous SNV    1 2     1   12 1
cf) Tissue ID; Tissue type (1; BLCA[Bladder Urothelial Carcinoma], 2; BRCA[Breast invasive carcinoma], 3; CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], 4; COAD[Colon adenocarcinoma], 5; GBM[Glioblastoma multiforme], 6; Glioma Low Grade, 7; HNSC[Head and Neck squamous cell carcinoma], 8; KICH[Kidney Chromophobe], 9; KIRC[Kidney renal clear cell carcinoma], 10; KIRP[Kidney renal papillary cell carcinoma], 11; LAML[Acute Myeloid Leukemia], 12; LUAD[Lung adenocarcinoma], 13; LUSC[Lung squamous cell carcinoma], 14; OV[Ovarian serous cystadenocarcinoma ], 15; PAAD[Pancreatic adenocarcinoma], 16; PRAD[Prostate adenocarcinoma], 17; SKCM[Skin Cutaneous Melanoma], 18:STAD[Stomach adenocarcinoma], 19:THCA[Thyroid carcinoma], 20:UCEC[Uterine Corpus Endometrial Carcinoma])

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check002.gifTop 10 SNVs Having the Most Samples in TCGA data
* We represented just top 10 SNVs. When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site, primary_histology, mutation(aa), pubmedID.
Genomic PositionMutation(aa)Unique sampleID count
chr17:26901108p.R259H2
chr17:26901111p.Y358Y1
chr17:26902271p.H197H1
chr17:26900565p.L311F1
chr17:26901115p.R173C1
chr17:26902293p.Q307K1
chr17:26900821p.P93P1
chr17:26901211p.R304H1
chr17:26902474p.G91V1
chr17:26900833p.R304C1

check002.gifOther DBs for Point Mutations
Point Mutation Table of Ensembl: go to Ensembl variation table
Mutation of cBioPortal: go to cBioPortal's Cross-cancer alteration summary

check002.gifCopy Number for ALDOC in TCGA
* Copy number data were extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered on Jan-05-2015. Function ProcessCNAData in TCGA-Assembler package was used to obtain gene-level copy number value which is calculated as the average copy number of the genomic region of a gene.
cf) Tissue ID[Tissue type]: BLCA[Bladder Urothelial Carcinoma], BRCA[Breast invasive carcinoma], CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], COAD[Colon adenocarcinoma], GBM[Glioblastoma multiforme], Glioma Low Grade, HNSC[Head and Neck squamous cell carcinoma], KICH[Kidney Chromophobe], KIRC[Kidney renal clear cell carcinoma], KIRP[Kidney renal papillary cell carcinoma], LAML[Acute Myeloid Leukemia], LUAD[Lung adenocarcinoma], LUSC[Lung squamous cell carcinoma], OV[Ovarian serous cystadenocarcinoma ], PAAD[Pancreatic adenocarcinoma], PRAD[Prostate adenocarcinoma], SKCM[Skin Cutaneous Melanoma], STAD[Stomach adenocarcinoma], THCA[Thyroid carcinoma], UCEC[Uterine Corpus Endometrial Carcinoma]

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Gene Expression for ALDOC

check002.gifGene Expression in Cancer Cell-lines (CCLE)
* CCLE gene expression data were extracted from CCLE_Expression_Entrez_2012-10-18.res: Gene-centric RMA-normalized mRNA expression data.

check002.gifDifferential Gene Expression in Primary Tumors (TCGA)
* Normalized gene expression data of RNASeqV2 was extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered at Jan-05-2015. Only eight cancer types have enough normal control samples for differential expression analysis.
(t test, adjusted p<0.05 (using Benjamini-Hochberg FDR))
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check002.gifCNV vs Gene Expression Plot
* This plots show the correlation between CNV and gene expression.

: Open all plots for all cancer types


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Gene-Gene Network Information
check002.gifCo-Expressed gene's network Plot
* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown.
Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene

: Open all plots for all cancer types

ALDOC,DNLZ,ERAL1,FLOT2,GAPDH,IFT20,LOC389458,
MRPS24,PIGS,PLAC8L1,POLD2,POLDIP2,RPL23A,SCT,
SDF2,SPAG4,TBRG4,TLCD1,TMEM199,TRAF4,UNC119
ABCD2,ADIPOR2,AIFM2,ALDOC,CALB2,CPA2,DGAT1,
DGAT2,EPHX1,FADS3,FMOD,GDPD5,GLYAT,GPAM,
HSPA12A,SLC25A51,MRAP,PDXK,RASGRF2,RPS2P32,TK2

ACAT2,ALDOA,ALDOC,C14orf1,C6orf223,CYP51A1,DHCR7,
GPI,HMGCS1,INSIG1,LDHA,MVD,NARF,P4HA1,
PCSK9,PLA2G3,PRR15L,MSMO1,TFRC,TMEM97,WDR45B
ALDOC,ALPI,SLC25A47,C9orf24,CCDC108,CREB3L3,CRIP1,
DNASE1,FADS6,FAM151A,MLXIPL,NAALADL1,PFKFB4,PLB1,
PNLIPRP2,PRODH,SI,SLC15A1,TM4SF5,UGT2B7,VNN1
check002.gifCo-Expressed gene's Protein-protein interaction Network Plot
* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown.
Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene

: Open all plots for all cancer types

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check002.gifInteracting Genes (from Pathway Commons)

: Open all interacting genes' information including KEGG pathway for all interacting genes from DAVID

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Pharmacological Information for ALDOC


There's no related Drug.
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Cross referenced IDs for ALDOC
* We obtained these cross-references from Uniprot database. It covers 150 different DBs, 18 categories. http://www.uniprot.org/help/cross_references_section

: Open all cross reference information



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