Cancer Cell Metabolism Gene Database

  Cancer Cell Metabolism Gene DB

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Gene Summary

Phenotypic Information (metabolism pathway, cancer, disease, phenome)

Mutations: SVs, CNVs, SNVs

Gene expression: GE, Protein, DEGE, CNV vs GE

Gene-Gene Network Information: Co-Expression Network, Interacting Genes & KEGG

Pharmacological Information: Drug-Gene Network

Cross referenced IDs

Gene Summary for AKR1B1
Basic gene info.Gene symbolAKR1B1
Gene namealdo-keto reductase family 1, member B1 (aldose reductase)
SynonymsADR|ALDR1|ALR2|AR
CytomapUCSC genome browser: 7q35
Genomic locationchr7 :134127106-134143888
Type of geneprotein-coding
RefGenesNM_001628.2,
Ensembl idENSG00000085662
DescriptionLii5-2 CTCL tumor antigenaldehyde reductase 1aldo-keto reductase family 1 member B1aldose reductaselow Km aldose reductase
Modification date20141207
dbXrefs MIM : 103880
HGNC : HGNC
Ensembl : ENSG00000085662
HPRD : 00071
Vega : OTTHUMG00000155322
ProteinUniProt: P15121
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_AKR1B1
BioGPS: 231
Gene Expression Atlas: ENSG00000085662
The Human Protein Atlas: ENSG00000085662
PathwayNCI Pathway Interaction Database: AKR1B1
KEGG: AKR1B1
REACTOME: AKR1B1
ConsensusPathDB
Pathway Commons: AKR1B1
MetabolismMetaCyc: AKR1B1
HUMANCyc: AKR1B1
RegulationEnsembl's Regulation: ENSG00000085662
miRBase: chr7 :134,127,106-134,143,888
TargetScan: NM_001628
cisRED: ENSG00000085662
ContextiHOP: AKR1B1
cancer metabolism search in PubMed: AKR1B1
UCL Cancer Institute: AKR1B1
Assigned class in ccmGDBA - This gene has a literature evidence and it belongs to cancer gene.
References showing role of AKR1B1 in cancer cell metabolism1. Uzozie A, Nanni P, Staiano T, Grossmann J, Barkow-Oesterreicher S, et al. (2014) Sorbitol dehydrogenase overexpression and other aspects of dysregulated protein expression in human precancerous colorectal neoplasms: a quantitative proteomics study. Mol Cell Proteomics 13: 1198-1218. doi: 10.1074/mcp.M113.035105. pmid: 4014279 go to article
2. Balendiran GK, Martin HJ, El-Hawari Y, Maser E (2009) Cancer biomarker AKR1B10 and carbonyl metabolism. Chem Biol Interact 178: 134-137. doi: 10.1016/j.cbi.2008.10.044. go to article

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Phenotypic Information for AKR1B1(metabolism pathway, cancer, disease, phenome)
check002.gifCancer Description
Cancer CGAP: AKR1B1
Familial Cancer Database: AKR1B1
* This gene is included in those cancer gene databases.

Oncogene 1

Tumor Suppressor gene 2

Cancer Gene Census 3

CancerGenes 4

Network of Cancer Gene 5

Significant driver gene in

Therapeutic Vulnerabilities in Cancer1

cf) number; DB name
1 Oncogene; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long,
2 Tumor Suppressor gene; https://bioinfo.uth.edu/TSGene/,
3 Cancer Gene Census; http://www.nature.com/nrc/journal/v4/n3/abs/nrc1299.html,
4 CancerGenes; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long,
5 Network of Cancer Gene; http://ncg.kcl.ac.uk/index.php,
1Therapeutic Vulnerabilities in Cancer; http://cbio.mskcc.org/cancergenomics/statius/

check002.gifMetabolic Pathway Description
KEGG_FRUCTOSE_AND_MANNOSE_METABOLISM
KEGG_GALACTOSE_METABOLISM
KEGG_GLYCEROLIPID_METABOLISM
KEGG_PYRUVATE_METABOLISM
REACTOME_METABOLISM_OF_STEROID_HORMONES_AND_VITAMINS_A_AND_D
REACTOME_METABOLISM_OF_LIPIDS_AND_LIPOPROTEINS

check002.gifOthers
OMIM 103880; gene.
Orphanet
DiseaseKEGG Disease: AKR1B1
MedGen: AKR1B1 (Human Medical Genetics with Condition)
ClinVar: AKR1B1
PhenotypeMGI: AKR1B1 (International Mouse Phenotyping Consortium)
PhenomicDB: AKR1B1

Mutations for AKR1B1
* Under tables are showing count per each tissue to give us broad intuition about tissue specific mutation patterns.You can go to the detailed page for each mutation database's web site.

check002.gifStructural Variants in COSMIC: go to COSMIC mutation histogram
There's no structural variation information in COSMIC data for this gene.

check002.gifRelated fusion transcripts : go to Chitars2.0
* From mRNA Sanger sequences, Chitars2.0 arranged chimeric transcripts. This table shows AKR1B1 related fusion information.
IDHead GeneTail Gene
AccessionGene_aqStart_aqEnd_aChromosome_atStart_atEnd_aGene_aqStart_aqEnd_aChromosome_atStart_atEnd_a
BG009392TBCD61156178079009680790191AKR1B11483407134134452134135632
AV708454KDM4A19214416611844166263AKR1B1873917134134330134135623
AV701562PHF151865133860064133871576AKR1B1816497134127108134132119
AI654627AKR1B172387134127108134127339PPP1R2122850124871819148725693
AV705293AKR1B1486887134130004134135656ITK6726955156679776156679822

check002.gifOther DBs for Structural Variants
Structural Variants in Ensembl: go to Ensembl Structural variation
Structural Variants in dbVar: go to dbVar

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check002.gifCopy Number Variations in COSMIC: go to COSMIC mutation CNV/Expr
There's no copy number variation information in COSMIC data for this gene.

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check002.gifSNV Counts per Each Loci in COSMIC data: go to COSMIC point mutation

 : Non-synonymous mutation, : Synonymous mutation, Circle size denotes number of samples.
Maximum mutation count=5

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check002.gifSomatic Mutation Counts per Tissue in COSMIC data
Stat. for Non-Synonymous SNVs
(# total SNVs=21)
Stat. for Synonymous SNVs
(# total SNVs=10)
Stat. for Deletions
(# total SNVs=1)
Stat. for Insertions
(# total SNVs=0)
There's no inserted snv.

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check002.gifTop 10 SNVs Having the Most Samples in COSMIC data
* When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site,primary_histology,mutation(aa),pubmedID.
GRCh37 positionMutation(aa)Unique sampleID count
chr7:134134532-134134532p.F123F5
chr7:134133183-134133183p.I205I3
chr7:134132761-134132761p.A238T2
chr7:134134517-134134517p.S128S2
chr7:134132069-134132069p.R269H2
chr7:134135550-134135550p.P113P1
chr7:134136454-134136454p.Y40H1
chr7:134132082-134132082p.V265M1
chr7:134135551-134135551p.P113L1
chr7:134136460-134136460p.V38I1

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check002.gifSNV Counts per Each Loci in TCGA data

 : non-synonymous mutation, : synonymous mutation, Circle size denotes number of samples.
maximum mutation count=6

Point Mutation/ Tissue ID1234567891011121314151617181920
# sample1  9  2 21 615  97  
# mutation1  7  2 21 615  49  
nonsynonymous SNV1  5  2 1  514  16  
synonymous SNV   2    11 1 1  33  
cf) Tissue ID; Tissue type (1; BLCA[Bladder Urothelial Carcinoma], 2; BRCA[Breast invasive carcinoma], 3; CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], 4; COAD[Colon adenocarcinoma], 5; GBM[Glioblastoma multiforme], 6; Glioma Low Grade, 7; HNSC[Head and Neck squamous cell carcinoma], 8; KICH[Kidney Chromophobe], 9; KIRC[Kidney renal clear cell carcinoma], 10; KIRP[Kidney renal papillary cell carcinoma], 11; LAML[Acute Myeloid Leukemia], 12; LUAD[Lung adenocarcinoma], 13; LUSC[Lung squamous cell carcinoma], 14; OV[Ovarian serous cystadenocarcinoma ], 15; PAAD[Pancreatic adenocarcinoma], 16; PRAD[Prostate adenocarcinoma], 17; SKCM[Skin Cutaneous Melanoma], 18:STAD[Stomach adenocarcinoma], 19:THCA[Thyroid carcinoma], 20:UCEC[Uterine Corpus Endometrial Carcinoma])

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check002.gifTop 10 SNVs Having the Most Samples in TCGA data
* We represented just top 10 SNVs. When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site, primary_histology, mutation(aa), pubmedID.
Genomic PositionMutation(aa)Unique sampleID count
chr7:134134532p.F123F6
chr7:134132069p.R269H3
chr7:134132761p.A238T2
chr7:134136347p.K86K1
chr7:134132119p.K86R1
chr7:134134473p.P219L1
chr7:134136399p.E85K1
chr7:134132123p.T208T1
chr7:134134495p.I75I1
chr7:134136430p.V206V1

check002.gifOther DBs for Point Mutations
Point Mutation Table of Ensembl: go to Ensembl variation table
Mutation of cBioPortal: go to cBioPortal's Cross-cancer alteration summary

check002.gifCopy Number for AKR1B1 in TCGA
* Copy number data were extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered on Jan-05-2015. Function ProcessCNAData in TCGA-Assembler package was used to obtain gene-level copy number value which is calculated as the average copy number of the genomic region of a gene.
cf) Tissue ID[Tissue type]: BLCA[Bladder Urothelial Carcinoma], BRCA[Breast invasive carcinoma], CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], COAD[Colon adenocarcinoma], GBM[Glioblastoma multiforme], Glioma Low Grade, HNSC[Head and Neck squamous cell carcinoma], KICH[Kidney Chromophobe], KIRC[Kidney renal clear cell carcinoma], KIRP[Kidney renal papillary cell carcinoma], LAML[Acute Myeloid Leukemia], LUAD[Lung adenocarcinoma], LUSC[Lung squamous cell carcinoma], OV[Ovarian serous cystadenocarcinoma ], PAAD[Pancreatic adenocarcinoma], PRAD[Prostate adenocarcinoma], SKCM[Skin Cutaneous Melanoma], STAD[Stomach adenocarcinoma], THCA[Thyroid carcinoma], UCEC[Uterine Corpus Endometrial Carcinoma]

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Gene Expression for AKR1B1

check002.gifGene Expression in Cancer Cell-lines (CCLE)
* CCLE gene expression data were extracted from CCLE_Expression_Entrez_2012-10-18.res: Gene-centric RMA-normalized mRNA expression data.

check002.gifDifferential Gene Expression in Primary Tumors (TCGA)
* Normalized gene expression data of RNASeqV2 was extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered at Jan-05-2015. Only eight cancer types have enough normal control samples for differential expression analysis.
(t test, adjusted p<0.05 (using Benjamini-Hochberg FDR))
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check002.gifCNV vs Gene Expression Plot
* This plots show the correlation between CNV and gene expression.

: Open all plots for all cancer types


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Gene-Gene Network Information
check002.gifCo-Expressed gene's network Plot
* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown.
Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene

: Open all plots for all cancer types

AKR1B10,AKR1C1,AKR1C3,ALDH3A1,BCL2L10,C10orf99,FOXE1,
GAGE12J,GAGE2B,GAGE8,GPX2,IQCF2,KRT13,KRT74,
LOC285629,NKX2-4,RBMXL2,UGT1A5,VCX,VCX3A,VCY
ADH7,AKR1B10,ALDH3A1,C10orf99,CAPNS2,CYP4F3,GJB6,
KRT13,KRT4,KRT6A,KRT78,KRTDAP,SOX2,SPRR1A,
SPRR1B,SPRR2A,SPRR2D,SPRR3,TMPRSS11D,UGT1A7,UPK1B

AKR1B10,AKR1B15,BTNL3,C11orf86,MIEN1,AXDND1,DHRS9,
ERBB2,KRT20,MALL,MMP28,MSL1,PPP1R1B,RAPGEFL1,
TCAP,TMEM54,TMEM82,TSPAN1,UGT1A1,UGT1A8,WIPF2
ABCD3,AKR1B10,AP1AR,CROT,CRYL1,CTAGE5,ETFDH,
FAM73B,FLVCR2,HADHB,KALRN,NCOA4,OCIAD2,PDXP,
PRR13,RBKS,RRAS2,STK17B,TMEM139,SLC35G1,UGT1A9
check002.gifCo-Expressed gene's Protein-protein interaction Network Plot
* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown.
Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene

: Open all plots for all cancer types

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check002.gifInteracting Genes (from Pathway Commons)

: Open all interacting genes' information including KEGG pathway for all interacting genes from DAVID

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Pharmacological Information for AKR1B1
check002.gifCross-referenced pharmacological DB IDs from Uniprot
DB CategoryDB NameDB's ID and Url link
ChemistryBindingDB P15121; -.
ChemistryChEMBL CHEMBL1900; -.
ChemistryGuidetoPHARMACOLOGY 2768; -.
Organism-specific databasesPharmGKB PA24675; -.
Organism-specific databasesCTD 231; -.

check002.gifDrug-Gene Interaction Network
* Gene Centered Interaction Network.
* Drug Centered Interaction Network.
DrugBank IDTarget NameDrug GroupsGeneric NameDrug Centered NetworkDrug Structure
DB00157aldo-keto reductase family 1, member B1 (aldose reductase)approved; nutraceuticalNADH
DB00605aldo-keto reductase family 1, member B1 (aldose reductase)approvedSulindac
DB01689aldo-keto reductase family 1, member B1 (aldose reductase)experimentalInhibitor Idd 384
DB02007aldo-keto reductase family 1, member B1 (aldose reductase)experimentalAlpha-D-Glucose-6-Phosphate
DB02020aldo-keto reductase family 1, member B1 (aldose reductase)experimentalAlrestatin
DB02021aldo-keto reductase family 1, member B1 (aldose reductase)experimentalFidarestat
DB02101aldo-keto reductase family 1, member B1 (aldose reductase)experimentalFidarestat(Stereoisomer)
DB02132aldo-keto reductase family 1, member B1 (aldose reductase)experimental[3-(4-Bromo-2-Fluoro-Benzyl)-7-Chloro-2,4-Dioxo-3,4-Dihydro-2h-Quinazolin-1-Yl]-Acetic Acid
DB02383aldo-keto reductase family 1, member B1 (aldose reductase)experimentalTolrestat
DB02518aldo-keto reductase family 1, member B1 (aldose reductase)experimentalN-Acetylalanine
DB02712aldo-keto reductase family 1, member B1 (aldose reductase)experimentalSorbinil
DB02834aldo-keto reductase family 1, member B1 (aldose reductase)experimentalIDD552
DB02994aldo-keto reductase family 1, member B1 (aldose reductase)experimentalHydroxydimethylarsine Oxide
DB03461aldo-keto reductase family 1, member B1 (aldose reductase)experimental2'-Monophosphoadenosine 5'-Diphosphoribose
DB04272aldo-keto reductase family 1, member B1 (aldose reductase)experimentalCitric Acid
DB07028aldo-keto reductase family 1, member B1 (aldose reductase)experimental(2-{[(4-BROMO-2-FLUOROBENZYL)AMINO]CARBONYL}-5-CHLOROPHENOXY)ACETIC ACID
DB07030aldo-keto reductase family 1, member B1 (aldose reductase)experimental(5-CHLORO-2-{[(3-NITROBENZYL)AMINO]CARBONYL}PHENOXY)ACETIC ACID
DB07063aldo-keto reductase family 1, member B1 (aldose reductase)experimental{3-[(4,5,7-TRIFLUORO-1,3-BENZOTHIAZOL-2-YL)METHYL]-1H-INDOL-1-YL}ACETIC ACID
DB07093aldo-keto reductase family 1, member B1 (aldose reductase)experimental{3-[(5-CHLORO-1,3-BENZOTHIAZOL-2-YL)METHYL]-2,4-DIOXO-3,4-DIHYDROPYRIMIDIN-1(2H)-YL}ACETIC ACID
DB07139aldo-keto reductase family 1, member B1 (aldose reductase)experimental3-[5-(3-nitrophenyl)thiophen-2-yl]propanoic acid
DB07187aldo-keto reductase family 1, member B1 (aldose reductase)experimental6-[(5-CHLORO-3-METHYL-1-BENZOFURAN-2-YL)SULFONYL]PYRIDAZIN-3(2H)-ONE
DB07450aldo-keto reductase family 1, member B1 (aldose reductase)experimental2[4-BROMO-2-FLUOROPHENYL)METHYL]-6-FLUOROSPIRO[ISOQUINOLINE-4-(1H),3'-PYRROLIDINE]-1,2',3,5'(2H)-TETRONE
DB07498aldo-keto reductase family 1, member B1 (aldose reductase)experimental4-[3-(3-NITROPHENYL)-1,2,4-OXADIAZOL-5-YL]BUTANOIC ACID
DB07999aldo-keto reductase family 1, member B1 (aldose reductase)experimental{4-[(CARBOXYMETHOXY)CARBONYL]-3,3-DIOXIDO-1-OXONAPHTHO[1,2-D]ISOTHIAZOL-2(1H)-YL}ACETIC ACID
DB08000aldo-keto reductase family 1, member B1 (aldose reductase)experimental2-(CARBOXYMETHYL)-1-OXO-1,2-DIHYDRONAPHTHO[1,2-D]ISOTHIAZOLE-4-CARBOXYLIC ACID 3,3-DIOXIDE
DB08084aldo-keto reductase family 1, member B1 (aldose reductase)experimentalIDD594
DB08098aldo-keto reductase family 1, member B1 (aldose reductase)experimental{[5-(5-NITRO-2-FURYL)-1,3,4-OXADIAZOL-2-YL]THIO}ACETIC ACID
DB08449aldo-keto reductase family 1, member B1 (aldose reductase)experimental2-(3-((4,5,7-trifluorobenzo[d]thiazol-2-yl)methyl)-1H-pyrrolo[2,3-b]pyridin-1-yl)acetic acid
DB08772aldo-keto reductase family 1, member B1 (aldose reductase)experimental3,4-DIHYDRO-4-OXO-3-((5-TRIFLUOROMETHYL-2-BENZOTHIAZOLYL)METHYL)-1-PHTHALAZINE ACETIC ACID


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Cross referenced IDs for AKR1B1
* We obtained these cross-references from Uniprot database. It covers 150 different DBs, 18 categories. http://www.uniprot.org/help/cross_references_section

: Open all cross reference information



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