Cancer Cell Metabolism Gene Database

  Cancer Cell Metabolism Gene DB

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Bioinformatics and Systems Medicine Laboratory Bioinformatics and Systems Medicine Laboratory

Gene Summary

Phenotypic Information (metabolism pathway, cancer, disease, phenome)

Mutations: SVs, CNVs, SNVs

Gene expression: GE, Protein, DEGE, CNV vs GE

Gene-Gene Network Information: Co-Expression Network, Interacting Genes & KEGG

Pharmacological Information: Drug-Gene Network

Cross referenced IDs

Gene Summary for FMO2
Basic gene info.Gene symbolFMO2
Gene nameflavin containing monooxygenase 2 (non-functional)
SynonymsFMO1B1
CytomapUCSC genome browser: 1q24.3
Genomic locationchr1 :171154387-171181822
Type of geneprotein-coding
RefGenesNM_001301347.1,
NM_001460.4,
Ensembl idENSG00000094963
DescriptionFMO, pulmonarydimethylaniline monooxygenase [N-oxide-forming] 2dimethylaniline oxidase 2pulmonary flavin-containing monooxygenase 2
Modification date20141207
dbXrefs MIM : 603955
HGNC : HGNC
HPRD : 04903
ProteinUniProt:
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_FMO2
BioGPS: 2327
Gene Expression Atlas: ENSG00000094963
The Human Protein Atlas: ENSG00000094963
PathwayNCI Pathway Interaction Database: FMO2
KEGG: FMO2
REACTOME: FMO2
ConsensusPathDB
Pathway Commons: FMO2
MetabolismMetaCyc: FMO2
HUMANCyc: FMO2
RegulationEnsembl's Regulation: ENSG00000094963
miRBase: chr1 :171,154,387-171,181,822
TargetScan: NM_001301347
cisRED: ENSG00000094963
ContextiHOP: FMO2
cancer metabolism search in PubMed: FMO2
UCL Cancer Institute: FMO2
Assigned class in ccmGDBC

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Phenotypic Information for FMO2(metabolism pathway, cancer, disease, phenome)
check002.gifCancer Description
Cancer CGAP: FMO2
Familial Cancer Database: FMO2
* This gene is included in those cancer gene databases.

Oncogene 1

Tumor Suppressor gene 2

Cancer Gene Census 3

CancerGenes 4

Network of Cancer Gene 5

Significant driver gene in

Therapeutic Vulnerabilities in Cancer1

cf) number; DB name
1 Oncogene; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long,
2 Tumor Suppressor gene; https://bioinfo.uth.edu/TSGene/,
3 Cancer Gene Census; http://www.nature.com/nrc/journal/v4/n3/abs/nrc1299.html,
4 CancerGenes; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long,
5 Network of Cancer Gene; http://ncg.kcl.ac.uk/index.php,
1Therapeutic Vulnerabilities in Cancer; http://cbio.mskcc.org/cancergenomics/statius/

check002.gifMetabolic Pathway Description
KEGG_DRUG_METABOLISM_CYTOCHROME_P450

check002.gifOthers
OMIM
Orphanet
DiseaseKEGG Disease: FMO2
MedGen: FMO2 (Human Medical Genetics with Condition)
ClinVar: FMO2
PhenotypeMGI: FMO2 (International Mouse Phenotyping Consortium)
PhenomicDB: FMO2

Mutations for FMO2
* Under tables are showing count per each tissue to give us broad intuition about tissue specific mutation patterns.You can go to the detailed page for each mutation database's web site.

check002.gifStructural Variants in COSMIC: go to COSMIC mutation histogram

- Statistics for Tissue and Mutation typeTop
- For Inter-chromosomal Variations
There's no inter-chromosomal structural variation.
- For Intra-chromosomal Variations
* Intra-chromosomal variantions includes 'intrachromosomal amplicon to amplicon', 'intrachromosomal amplicon to non-amplified dna', 'intrachromosomal deletion', 'intrachromosomal fold-back inversion', 'intrachromosomal inversion', 'intrachromosomal tandem duplication', 'Intrachromosomal unknown type', 'intrachromosomal with inverted orientation', 'intrachromosomal with non-inverted orientation'.
SampleSymbol_aChr_aStart_aEnd_aSymbol_bChr_bStart_bEnd_b
ovaryFMO2chr1171168726171168746chr1171133352171133372
ovaryFMO2chr1171168726171168746chr1171133354171133374
cf) Tissue number; Tissue name (1;Breast, 2;Central_nervous_system, 3;Haematopoietic_and_lymphoid_tissue, 4;Large_intestine, 5;Liver, 6;Lung, 7;Ovary, 8;Pancreas, 9;Prostate, 10;Skin, 11;Soft_tissue, 12;Upper_aerodigestive_tract)

check002.gifRelated fusion transcripts : go to Chitars2.0
* From mRNA Sanger sequences, Chitars2.0 arranged chimeric transcripts. This table shows FMO2 related fusion information.
IDHead GeneTail Gene
AccessionGene_aqStart_aqEnd_aChromosome_atStart_atEnd_aGene_aqStart_aqEnd_aChromosome_atStart_atEnd_a
AI452615FMO211811171174640171176903FMO21784941171173038171174568

check002.gifOther DBs for Structural Variants
Structural Variants in Ensembl: go to Ensembl Structural variation
Structural Variants in dbVar: go to dbVar

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check002.gifCopy Number Variations in COSMIC: go to COSMIC mutation CNV/Expr
There's no copy number variation information in COSMIC data for this gene.

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check002.gifSNV Counts per Each Loci in COSMIC data: go to COSMIC point mutation

 : Non-synonymous mutation, : Synonymous mutation, Circle size denotes number of samples.
Maximum mutation count=8

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check002.gifSomatic Mutation Counts per Tissue in COSMIC data
Stat. for Non-Synonymous SNVs
(# total SNVs=58)
Stat. for Synonymous SNVs
(# total SNVs=10)
Stat. for Deletions
(# total SNVs=1)
Stat. for Insertions
(# total SNVs=1)

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check002.gifTop 10 SNVs Having the Most Samples in COSMIC data
* When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site,primary_histology,mutation(aa),pubmedID.
GRCh37 positionMutation(aa)Unique sampleID count
chr1:171168584-171168584p.S195L5
chr1:171173094-171173094p.R240C4
chr1:171168585-171168585p.S195S3
chr1:171168604-171168604p.E202K3
chr1:171178045-171178045p.P457S3
chr1:171168578-171168578p.G193E2
chr1:171174531-171174531p.E314G2
chr1:171162520-171162520p.T60N2
chr1:171165909-171165909p.G148D2
chr1:171173095-171173095p.R240H2

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check002.gifSNV Counts per Each Loci in TCGA data

 : non-synonymous mutation, : synonymous mutation, Circle size denotes number of samples.
maximum mutation count=2

Point Mutation/ Tissue ID1234567891011121314151617181920
# sample5316  4 11 93 1 185 8
# mutation5318  4 11 93 1 225 9
nonsynonymous SNV5216  3 11 83 1 124 7
synonymous SNV 1 2  1    1    101 2
cf) Tissue ID; Tissue type (1; BLCA[Bladder Urothelial Carcinoma], 2; BRCA[Breast invasive carcinoma], 3; CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], 4; COAD[Colon adenocarcinoma], 5; GBM[Glioblastoma multiforme], 6; Glioma Low Grade, 7; HNSC[Head and Neck squamous cell carcinoma], 8; KICH[Kidney Chromophobe], 9; KIRC[Kidney renal clear cell carcinoma], 10; KIRP[Kidney renal papillary cell carcinoma], 11; LAML[Acute Myeloid Leukemia], 12; LUAD[Lung adenocarcinoma], 13; LUSC[Lung squamous cell carcinoma], 14; OV[Ovarian serous cystadenocarcinoma ], 15; PAAD[Pancreatic adenocarcinoma], 16; PRAD[Prostate adenocarcinoma], 17; SKCM[Skin Cutaneous Melanoma], 18:STAD[Stomach adenocarcinoma], 19:THCA[Thyroid carcinoma], 20:UCEC[Uterine Corpus Endometrial Carcinoma])

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check002.gifTop 10 SNVs Having the Most Samples in TCGA data
* We represented just top 10 SNVs. When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site, primary_histology, mutation(aa), pubmedID.
Genomic PositionMutation(aa)Unique sampleID count
chr1:171165890p.P457S2
chr1:171178045p.A142T2
chr1:171154965p.G38E2
chr1:171173094p.R240C2
chr1:171173122p.R249Q2
chr1:171168578p.G193E2
chr1:171162565p.F333L1
chr1:171173168p.L18L1
chr1:171174688p.K97N1
chr1:171154906p.A208S1

check002.gifOther DBs for Point Mutations
Point Mutation Table of Ensembl: go to Ensembl variation table
Mutation of cBioPortal: go to cBioPortal's Cross-cancer alteration summary

check002.gifCopy Number for FMO2 in TCGA
* Copy number data were extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered on Jan-05-2015. Function ProcessCNAData in TCGA-Assembler package was used to obtain gene-level copy number value which is calculated as the average copy number of the genomic region of a gene.
cf) Tissue ID[Tissue type]: BLCA[Bladder Urothelial Carcinoma], BRCA[Breast invasive carcinoma], CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], COAD[Colon adenocarcinoma], GBM[Glioblastoma multiforme], Glioma Low Grade, HNSC[Head and Neck squamous cell carcinoma], KICH[Kidney Chromophobe], KIRC[Kidney renal clear cell carcinoma], KIRP[Kidney renal papillary cell carcinoma], LAML[Acute Myeloid Leukemia], LUAD[Lung adenocarcinoma], LUSC[Lung squamous cell carcinoma], OV[Ovarian serous cystadenocarcinoma ], PAAD[Pancreatic adenocarcinoma], PRAD[Prostate adenocarcinoma], SKCM[Skin Cutaneous Melanoma], STAD[Stomach adenocarcinoma], THCA[Thyroid carcinoma], UCEC[Uterine Corpus Endometrial Carcinoma]

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Gene Expression for FMO2

check002.gifGene Expression in Cancer Cell-lines (CCLE)
* CCLE gene expression data were extracted from CCLE_Expression_Entrez_2012-10-18.res: Gene-centric RMA-normalized mRNA expression data.

check002.gifDifferential Gene Expression in Primary Tumors (TCGA)
* Normalized gene expression data of RNASeqV2 was extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered at Jan-05-2015. Only eight cancer types have enough normal control samples for differential expression analysis.
(t test, adjusted p<0.05 (using Benjamini-Hochberg FDR))
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check002.gifCNV vs Gene Expression Plot
* This plots show the correlation between CNV and gene expression.

: Open all plots for all cancer types


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Gene-Gene Network Information
check002.gifCo-Expressed gene's network Plot
* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown.
Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene

: Open all plots for all cancer types

C21orf62,CD58,CSF2RB,CXCL16,CYYR1,FCAMR,FMO2,
HTR3D,HTR3E,IDO2,KCNJ10,LRGUK,MRAS,LINC00200,
OVCH2,RARB,SFRP1,SLC43A3,TANK,TBX19,VTCN1
ADIPOQ,ANO6,CD302,CDC14B,CPM,EHHADH,EIF4EBP2,
FAM13A,FIGN,FMO2,FOXN2,GHR,JAK1,MESTIT1,
NR3C1,PLSCR4,PVRL3,RBMS3,SAMD8,SBF2,SLC16A7

ACSM5,ADH1B,ADIPOQ,CD300LG,CD36,EPB42,FABP4,
FMO2,HEPACAM,LBP,LEP,LGALS12,LIPE,LOC339524,
MRAP,PLIN1,PLIN4,SGCG,THRSP,TTTY9B,TUSC5
ADH1B,AGTR1,AMPH,C11orf70,CRISPLD1,FGF1,FMO2,
GPR176,KERA,LHFP,LRFN5,LYVE1,NXPH3,PPAPDC1A,
RBP7,RFTN2,SGCA,SNCG,TG,TMIE,TPH2
check002.gifCo-Expressed gene's Protein-protein interaction Network Plot
* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown.
Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene

: Open all plots for all cancer types

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check002.gifInteracting Genes (from Pathway Commons)

: Open all interacting genes' information including KEGG pathway for all interacting genes from DAVID

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Pharmacological Information for FMO2
check002.gifCross-referenced pharmacological DB IDs from Uniprot
DB CategoryDB NameDB's ID and Url link

check002.gifDrug-Gene Interaction Network
* Gene Centered Interaction Network.
* Drug Centered Interaction Network.
DrugBank IDTarget NameDrug GroupsGeneric NameDrug Centered NetworkDrug Structure
DB00675flavin containing monooxygenase 2 (non-functional)approvedTamoxifen


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Cross referenced IDs for FMO2
* We obtained these cross-references from Uniprot database. It covers 150 different DBs, 18 categories. http://www.uniprot.org/help/cross_references_section

: Open all cross reference information



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