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Phenotypic Information (metabolism pathway, cancer, disease, phenome) | |
Gene-Gene Network Information: Co-Expression Network, Interacting Genes & KEGG | |
Gene Summary for ACSL6 |
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Phenotypic Information for ACSL6(metabolism pathway, cancer, disease, phenome) |
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Cancer | CGAP: ACSL6 |
Familial Cancer Database: ACSL6 |
* This gene is included in those cancer gene databases. |
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Oncogene 1 | Significant driver gene in |
cf) number; DB name 1 Oncogene; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long, 2 Tumor Suppressor gene; https://bioinfo.uth.edu/TSGene/, 3 Cancer Gene Census; http://www.nature.com/nrc/journal/v4/n3/abs/nrc1299.html, 4 CancerGenes; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long, 5 Network of Cancer Gene; http://ncg.kcl.ac.uk/index.php, 1Therapeutic Vulnerabilities in Cancer; http://cbio.mskcc.org/cancergenomics/statius/ |
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KEGG_FATTY_ACID_METABOLISM REACTOME_METABOLISM_OF_LIPIDS_AND_LIPOPROTEINS |
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OMIM | 604443; gene. |
Orphanet | |
Disease | KEGG Disease: ACSL6 |
MedGen: ACSL6 (Human Medical Genetics with Condition) | |
ClinVar: ACSL6 | |
Phenotype | MGI: ACSL6 (International Mouse Phenotyping Consortium) |
PhenomicDB: ACSL6 |
Mutations for ACSL6 |
* Under tables are showing count per each tissue to give us broad intuition about tissue specific mutation patterns.You can go to the detailed page for each mutation database's web site. |
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- Statistics for Tissue and Mutation type | Top |
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- For Inter-chromosomal Variations |
There's no inter-chromosomal structural variation. |
- For Intra-chromosomal Variations |
* Intra-chromosomal variantions includes 'intrachromosomal amplicon to amplicon', 'intrachromosomal amplicon to non-amplified dna', 'intrachromosomal deletion', 'intrachromosomal fold-back inversion', 'intrachromosomal inversion', 'intrachromosomal tandem duplication', 'Intrachromosomal unknown type', 'intrachromosomal with inverted orientation', 'intrachromosomal with non-inverted orientation'. |
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Sample | Symbol_a | Chr_a | Start_a | End_a | Symbol_b | Chr_b | Start_b | End_b |
ovary | ACSL6 | chr5 | 131316780 | 131316800 | ACSL6 | chr5 | 131316936 | 131316956 |
cf) Tissue number; Tissue name (1;Breast, 2;Central_nervous_system, 3;Haematopoietic_and_lymphoid_tissue, 4;Large_intestine, 5;Liver, 6;Lung, 7;Ovary, 8;Pancreas, 9;Prostate, 10;Skin, 11;Soft_tissue, 12;Upper_aerodigestive_tract) |
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* From mRNA Sanger sequences, Chitars2.0 arranged chimeric transcripts. This table shows ACSL6 related fusion information. |
ID | Head Gene | Tail Gene | Accession | Gene_a | qStart_a | qEnd_a | Chromosome_a | tStart_a | tEnd_a | Gene_a | qStart_a | qEnd_a | Chromosome_a | tStart_a | tEnd_a |
AF102845 | ETV6 | 1 | 40 | 12 | 11803055 | 11803094 | ACSL6 | 39 | 1161 | 5 | 131308480 | 131329946 | |
BE766684 | ACSL6 | 15 | 116 | 5 | 131325100 | 131325201 | ACSL6 | 113 | 254 | 5 | 131323885 | 131324603 |
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Mutation type/ Tissue ID | brca | cns | cerv | endome | haematopo | kidn | Lintest | liver | lung | ns | ovary | pancre | prost | skin | stoma | thyro | urina | |||
Total # sample |   |   |   |   |   |   |   |   |   |   | 1 |   |   |   |   |   |   | |||
GAIN (# sample) |   |   |   |   |   |   |   |   |   |   | 1 |   |   |   |   |   |   | |||
LOSS (# sample) |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |
cf) Tissue ID; Tissue type (1; Breast, 2; Central_nervous_system, 3; Cervix, 4; Endometrium, 5; Haematopoietic_and_lymphoid_tissue, 6; Kidney, 7; Large_intestine, 8; Liver, 9; Lung, 10; NS, 11; Ovary, 12; Pancreas, 13; Prostate, 14; Skin, 15; Stomach, 16; Thyroid, 17; Urinary_tract) |
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Stat. for Non-Synonymous SNVs (# total SNVs=75) | (# total SNVs=20) |
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(# total SNVs=0) | (# total SNVs=0) |
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* When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site,primary_histology,mutation(aa),pubmedID. |
GRCh37 position | Mutation(aa) | Unique sampleID count |
chr5:131329832-131329832 | p.T54T | 4 |
chr5:131296268-131296268 | p.S635C | 3 |
chr5:131308521-131308521 | p.R412C | 2 |
chr5:131308548-131308548 | p.F403I | 2 |
chr5:131305833-131305833 | p.D499Y | 2 |
chr5:131329888-131329888 | p.R36* | 2 |
chr5:131321104-131321104 | p.T304T | 2 |
chr5:131321105-131321105 | p.T304M | 2 |
chr5:131309041-131309041 | p.R374H | 2 |
chr5:131309043-131309043 | p.I373I | 2 |
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Point Mutation/ Tissue ID | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | 18 | 19 | 20 |
# sample | 2 | 2 |   | 11 |   |   | 1 |   | 4 | 1 |   | 10 | 2 | 2 | 1 |   | 15 | 6 |   | 12 |
# mutation | 2 | 2 |   | 12 |   |   | 1 |   | 4 | 1 |   | 10 | 2 | 2 | 1 |   | 16 | 7 |   | 15 |
nonsynonymous SNV | 2 | 2 |   | 10 |   |   | 1 |   | 4 | 1 |   | 8 | 2 | 2 |   |   | 11 | 4 |   | 12 |
synonymous SNV |   |   |   | 2 |   |   |   |   |   |   |   | 2 |   |   | 1 |   | 5 | 3 |   | 3 |
cf) Tissue ID; Tissue type (1; BLCA[Bladder Urothelial Carcinoma], 2; BRCA[Breast invasive carcinoma], 3; CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], 4; COAD[Colon adenocarcinoma], 5; GBM[Glioblastoma multiforme], 6; Glioma Low Grade, 7; HNSC[Head and Neck squamous cell carcinoma], 8; KICH[Kidney Chromophobe], 9; KIRC[Kidney renal clear cell carcinoma], 10; KIRP[Kidney renal papillary cell carcinoma], 11; LAML[Acute Myeloid Leukemia], 12; LUAD[Lung adenocarcinoma], 13; LUSC[Lung squamous cell carcinoma], 14; OV[Ovarian serous cystadenocarcinoma ], 15; PAAD[Pancreatic adenocarcinoma], 16; PRAD[Prostate adenocarcinoma], 17; SKCM[Skin Cutaneous Melanoma], 18:STAD[Stomach adenocarcinoma], 19:THCA[Thyroid carcinoma], 20:UCEC[Uterine Corpus Endometrial Carcinoma]) |
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* We represented just top 10 SNVs. When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site, primary_histology, mutation(aa), pubmedID. |
Genomic Position | Mutation(aa) | Unique sampleID count |
chr5:131298258 | p.P362L,ACSL6 | 2 |
chr5:131305833 | p.I273I,ACSL6 | 2 |
chr5:131309043 | p.D399Y,ACSL6 | 2 |
chr5:131307292 | p.A509A,ACSL6 | 2 |
chr5:131302211 | p.N307D,ACSL6 | 1 |
chr5:131323840 | p.E150D,ACSL6 | 1 |
chr5:131326566 | p.E496D,ACSL6 | 1 |
chr5:131307307 | p.T304T,ACSL6 | 1 |
chr5:131296268 | p.S128P,ACSL6 | 1 |
chr5:131310506 | p.E491K,ACSL6 | 1 |
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* Copy number data were extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered on Jan-05-2015. Function ProcessCNAData in TCGA-Assembler package was used to obtain gene-level copy number value which is calculated as the average copy number of the genomic region of a gene. |
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cf) Tissue ID[Tissue type]: BLCA[Bladder Urothelial Carcinoma], BRCA[Breast invasive carcinoma], CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], COAD[Colon adenocarcinoma], GBM[Glioblastoma multiforme], Glioma Low Grade, HNSC[Head and Neck squamous cell carcinoma], KICH[Kidney Chromophobe], KIRC[Kidney renal clear cell carcinoma], KIRP[Kidney renal papillary cell carcinoma], LAML[Acute Myeloid Leukemia], LUAD[Lung adenocarcinoma], LUSC[Lung squamous cell carcinoma], OV[Ovarian serous cystadenocarcinoma ], PAAD[Pancreatic adenocarcinoma], PRAD[Prostate adenocarcinoma], SKCM[Skin Cutaneous Melanoma], STAD[Stomach adenocarcinoma], THCA[Thyroid carcinoma], UCEC[Uterine Corpus Endometrial Carcinoma] |
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Gene Expression for ACSL6 |
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* CCLE gene expression data were extracted from CCLE_Expression_Entrez_2012-10-18.res: Gene-centric RMA-normalized mRNA expression data. |
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* Normalized gene expression data of RNASeqV2 was extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered at Jan-05-2015. Only eight cancer types have enough normal control samples for differential expression analysis. (t test, adjusted p<0.05 (using Benjamini-Hochberg FDR)) |
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* This plots show the correlation between CNV and gene expression. |
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Gene-Gene Network Information |
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* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown. Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene |
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ACSL6,AKT3,APOBEC3B,CHST3,COL22A1,DNAH17,FZD9, LOC100124692,LOC121838,MFGE8,MUC16,PAPSS1,PROM1,PRSS12, RASGEF1C,SEPT3,SLC6A15,SOX6,TCF20,TP53BP2,TRPV4 | ACSL6,CD3G,CD5,CYFIP2,ERMN,GCSAM,GFI1, GPR171,IKZF3,ITK,KIF21B,SLC25A53,NLRC3,P2RY10, PLCXD2,SCML4,SLAMF1,TRAT1,UBASH3A,ZAP70,ZNF831 |
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ACOX2,ACSL6,ATP5EP2,KIAA0226L,IGBP1P1,C21orf62-AS1,FAM105A, FUNDC2P2,GPR89B,HNMT,HSPA1L,IGSF22,LOC407835,FTX, OVGP1,RPL18A,RPL29P2,RPL39,RPS10P7,SNORA67,TDGF1P3 | ACSL6,DAZL,EVX2,FAM19A2,GCG,GLYATL3,HCG4, HOXD13,ISL1,KCTD14,LHFPL1,LYPD6,PARP8,RARRES2, RFC1,RP9,SNW1,UCN3,WBP11,WDR87,WFDC2 |
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* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown. Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene |
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Pharmacological Information for ACSL6 |
There's no related Drug. |
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Cross referenced IDs for ACSL6 |
* We obtained these cross-references from Uniprot database. It covers 150 different DBs, 18 categories. http://www.uniprot.org/help/cross_references_section |
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