Cancer Cell Metabolism Database ~~ Bioinformatics and Systems Medicine Laboratory ~~

Cancer Cell Metabolism Gene Database

Cancer Cell Metabolism Gene DB

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	Gene Summary
	Phenotypic Information (metabolism pathway, cancer, disease, phenome)
	Mutations : SVs, CNVs, SNVs
	Gene expression: GE, Protein, DEGE, CNV vs GE
	Gene-Gene Network Information: Co-Expression Network, Interacting Genes & KEGG
	Pharmacological Information: Drug-Gene Network
	Cross referenced IDs

Gene Summary for PLA2G15

Basic gene info.	Gene symbol	PLA2G15
	Gene name	phospholipase A2, group XV
	Synonyms	ACS\|GXVPLA2\|LLPL\|LPLA2\|LYPLA3
	Cytomap	UCSC genome browser: 16q22.1
	Genomic location	chr16 :68279246-68294961
	Type of gene	protein-coding
	RefGenes	NM_012320.3,
	Ensembl id	ENSG00000103066
	Description	1-O-acylceramide synthaseLCAT-like lysophospholipasegroup XV phospholipase A2lysophospholipase 3 (lysosomal phospholipase A2)lysosomal phospholipase A2
	Modification date	20141207
dbXrefs	MIM : 609362
	HGNC : HGNC
	Ensembl : ENSG00000103066
	HPRD : 07128
	Vega : OTTHUMG00000137554
Protein	UniProt: go to UniProt's Cross Reference DB Table
Expression	CleanEX: HS_PLA2G15
	BioGPS: 23659
	Gene Expression Atlas: ENSG00000103066
	The Human Protein Atlas: ENSG00000103066
Pathway	NCI Pathway Interaction Database: PLA2G15
	KEGG: PLA2G15
	REACTOME: PLA2G15
	ConsensusPathDB
	Pathway Commons: PLA2G15
Metabolism	MetaCyc: PLA2G15
	HUMANCyc: PLA2G15
Regulation	Ensembl's Regulation: ENSG00000103066
	miRBase: chr16 :68,279,246-68,294,961
	TargetScan: NM_012320
	cisRED: ENSG00000103066
Context	iHOP: PLA2G15
	cancer metabolism search in PubMed: PLA2G15
	UCL Cancer Institute: PLA2G15
Assigned class in ccmGDB	C

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Phenotypic Information for PLA2G15(metabolism pathway, cancer, disease, phenome)

Cancer Description
Cancer	CGAP: PLA2G15
	Familial Cancer Database: PLA2G15

* This gene is included in those cancer gene databases.

						.
Oncogene ¹	Tumor Suppressor gene ²	Cancer Gene Census ³	CancerGenes ⁴	Network of Cancer Gene ⁵	Significant driver gene in	Therapeutic Vulnerabilities in Cancer¹

cf) number; DB name
1 Oncogene; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long,
2 Tumor Suppressor gene; https://bioinfo.uth.edu/TSGene/,
3 Cancer Gene Census; http://www.nature.com/nrc/journal/v4/n3/abs/nrc1299.html,
4 CancerGenes; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long,
5 Network of Cancer Gene; http://ncg.kcl.ac.uk/index.php,
1Therapeutic Vulnerabilities in Cancer; http://cbio.mskcc.org/cancergenomics/statius/

Metabolic Pathway Description
KEGG_GLYCEROPHOSPHOLIPID_METABOLISM

Others
OMIM
Orphanet
Disease	KEGG Disease: PLA2G15
	MedGen: PLA2G15 (Human Medical Genetics with Condition)
	ClinVar: PLA2G15
Phenotype	MGI: PLA2G15 (International Mouse Phenotyping Consortium)
Phenotype	PhenomicDB: PLA2G15

Mutations for PLA2G15

* Under tables are showing count per each tissue to give us broad intuition about tissue specific mutation patterns.You can go to the detailed page for each mutation database's web site.

Structural Variants in COSMIC : go to COSMIC mutation histogram

There's no structural variation information in COSMIC data for this gene.

Related fusion transcripts : go to Chitars2.0

* From mRNA Sanger sequences, Chitars2.0 arranged chimeric transcripts. This table shows PLA2G15 related fusion information.

ID	Head Gene						Tail Gene
Accession	Gene_a	qStart_a	qEnd_a	Chromosome_a	tStart_a	tEnd_a	Gene_a	qStart_a	qEnd_a	Chromosome_a	tStart_a	tEnd_a
BQ000365	PLA2G15	19	278	16	68294707	68294965	APBB2	274	673	4	41015813	41016213
T11609	SDF4	4	84	1	1159256	1159336	PLA2G15	70	198	16	68294264	68294391
CN480826	PLA2G15	17	564	16	68294413	68294961	CD82	559	676	11	44638251	44638370

Other DBs for Structural Variants

Structural Variants in Ensembl: go to Ensembl Structural variation

Structural Variants in dbVar: go to dbVar

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Copy Number Variations in COSMIC : go to COSMIC mutation CNV/Expr

There's no copy number variation information in COSMIC data for this gene.

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SNV Counts per Each Loci in COSMIC data : go to COSMIC point mutation

: Non-synonymous mutation, : Synonymous mutation, Circle size denotes number of samples.
Maximum mutation count=4

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Somatic Mutation Counts per Tissue in COSMIC data

Stat. for Non-Synonymous SNVs (# total SNVs=27)	Stat. for Synonymous SNVs (# total SNVs=13)

Stat. for Deletions (# total SNVs=1)	Stat. for Insertions (# total SNVs=2)

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Top 10 SNVs Having the Most Samples in COSMIC data

* When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site,primary_histology,mutation(aa),pubmedID.

GRCh37 position	Mutation(aa)	Unique sampleID count
chr16:68283280-68283280	p.Y72C	3
chr16:68288909-68288909	p.L124L	2
chr16:68293167-68293167	p.F282F	2
chr16:68293320-68293320	p.G333G	2
chr16:68293463-68293463	p.Q381R	1
chr16:68293549-68293549	p.L410I	1
chr16:68289850-68289850	p.A228A	1
chr16:68279354-68279354	p.R9G	1
chr16:68293349-68293349	p.Y343C	1
chr16:68293464-68293464	p.Q381Q	1

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SNV Counts per Each Loci in TCGA data

: non-synonymous mutation, : synonymous mutation, Circle size denotes number of samples.
maximum mutation count=4

Point Mutation/ Tissue ID	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20
# sample		2		7	1		3		2			1	1	2		1		8		2
# mutation		2		5	1		3		2			1	1	2		1		8		2
nonsynonymous SNV		1		4			3		1			1	1	1				5
synonymous SNV		1		1	1				1					1		1		3		2

cf) Tissue ID; Tissue type (1; BLCA[Bladder Urothelial Carcinoma], 2; BRCA[Breast invasive carcinoma], 3; CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], 4; COAD[Colon adenocarcinoma], 5; GBM[Glioblastoma multiforme], 6; Glioma Low Grade, 7; HNSC[Head and Neck squamous cell carcinoma], 8; KICH[Kidney Chromophobe], 9; KIRC[Kidney renal clear cell carcinoma], 10; KIRP[Kidney renal papillary cell carcinoma], 11; LAML[Acute Myeloid Leukemia], 12; LUAD[Lung adenocarcinoma], 13; LUSC[Lung squamous cell carcinoma], 14; OV[Ovarian serous cystadenocarcinoma ], 15; PAAD[Pancreatic adenocarcinoma], 16; PRAD[Prostate adenocarcinoma], 17; SKCM[Skin Cutaneous Melanoma], 18:STAD[Stomach adenocarcinoma], 19:THCA[Thyroid carcinoma], 20:UCEC[Uterine Corpus Endometrial Carcinoma])

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Top 10 SNVs Having the Most Samples in TCGA data

* We represented just top 10 SNVs. When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site, primary_histology, mutation(aa), pubmedID.

Genomic Position	Mutation(aa)	Unique sampleID count
chr16:68283280	p.Y72C	3
chr16:68289217	p.S136F	1
chr16:68293320	p.I393I	1
chr16:68279354	p.V146M	1
chr16:68289275	p.L405L	1
chr16:68293349	p.R165Q	1
chr16:68283194	p.R407C	1
chr16:68289682	p.P172P	1
chr16:68293405	p.L410I	1
chr16:68283257	p.R178C	1

Other DBs for Point Mutations

Point Mutation Table of Ensembl: go to Ensembl variation table

Mutation of cBioPortal: go to cBioPortal's Cross-cancer alteration summary

Copy Number for PLA2G15 in TCGA

* Copy number data were extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered on Jan-05-2015. Function ProcessCNAData in TCGA-Assembler package was used to obtain gene-level copy number value which is calculated as the average copy number of the genomic region of a gene.

cf) Tissue ID[Tissue type]: BLCA[Bladder Urothelial Carcinoma], BRCA[Breast invasive carcinoma], CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], COAD[Colon adenocarcinoma], GBM[Glioblastoma multiforme], Glioma Low Grade, HNSC[Head and Neck squamous cell carcinoma], KICH[Kidney Chromophobe], KIRC[Kidney renal clear cell carcinoma], KIRP[Kidney renal papillary cell carcinoma], LAML[Acute Myeloid Leukemia], LUAD[Lung adenocarcinoma], LUSC[Lung squamous cell carcinoma], OV[Ovarian serous cystadenocarcinoma ], PAAD[Pancreatic adenocarcinoma], PRAD[Prostate adenocarcinoma], SKCM[Skin Cutaneous Melanoma], STAD[Stomach adenocarcinoma], THCA[Thyroid carcinoma], UCEC[Uterine Corpus Endometrial Carcinoma]

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Gene Expression for PLA2G15

Gene Expression in Cancer Cell-lines (CCLE)

* CCLE gene expression data were extracted from CCLE_Expression_Entrez_2012-10-18.res: Gene-centric RMA-normalized mRNA expression data.

Differential Gene Expression in Primary Tumors (TCGA)

* Normalized gene expression data of RNASeqV2 was extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered at Jan-05-2015. Only eight cancer types have enough normal control samples for differential expression analysis.
(t test, adjusted p<0.05 (using Benjamini-Hochberg FDR))

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CNV vs Gene Expression Plot

* This plots show the correlation between CNV and gene expression.

: Open all plots for all cancer types

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Gene-Gene Network Information

Co-Expressed gene's network Plot

* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown.
Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene

: Open all plots for all cancer types


APOE,ATP6V0D1,CCM2,CHPF,CLEC11A,CRYBB1,CTSB, DUS2,EMP3,FHOD1,GPX1,GRN,MGAT1,NAGK, PLA2G15,PRMT7,TMEM208,TRADD,TYROBP,VAC14,VPS4A	ARRB2,C1QC,CD300C,CD68,CTSB,DOK2,DPEP2, FERMT3,HK3,IFI30,ITGB2,LRRC25,NRROS,NFAM1, PILRA,PLA2G15,PLD3,SLC15A3,SPI1,TRPV2,TYROBP

AEBP1,ARAP1,C16orf86,CMTM3,COL8A2,CTSZ,EFEMP2, GLIS2,ISLR,ITGB5,MRAS,MXRA8,PLA2G15,PSAP, RAB3IL1,RARRES2,RUSC2,SFRP4,THBS2,TNS3,VEGFB	C1QA,C2,M1AP,C3AR1,CD4,CMKLR1,CSF1R, CYTH4,DISC1,GGTA1P,GIMAP1,LAIR1,NRROS,MAFB, NFAM1,NPL,PLA2G15,RASGRP4,SIGLEC1,TMEM86A,TRIM50

Co-Expressed gene's Protein-protein interaction Network Plot

: Open all plots for all cancer types

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Interacting Genes (from Pathway Commons)

: Open all interacting genes' information including KEGG pathway for all interacting genes from DAVID

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Pharmacological Information for PLA2G15

Cross-referenced pharmacological DB IDs from Uniprot

DB Category

DB Name

DB's ID and Url link

Drug-Gene Interaction Network

* Gene Centered Interaction Network.

* Drug Centered Interaction Network.

DrugBank ID	Target Name	Drug Groups	Generic Name	Drug Centered Network	Drug Structure
DB01992	phospholipase A2, group XV	experimental	Coenzyme A
DB03230	phospholipase A2, group XV	experimental	Adenosine-5'-Propylphosphate

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Cross referenced IDs for PLA2G15

* We obtained these cross-references from Uniprot database. It covers 150 different DBs, 18 categories. http://www.uniprot.org/help/cross_references_section

: Open all cross reference information