Cancer Cell Metabolism Database ~~ Bioinformatics and Systems Medicine Laboratory ~~

Cancer Cell Metabolism Gene Database

Cancer Cell Metabolism Gene DB

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	Gene Summary
	Phenotypic Information (metabolism pathway, cancer, disease, phenome)
	Mutations : SVs, CNVs, SNVs
	Gene expression: GE, Protein, DEGE, CNV vs GE
	Gene-Gene Network Information: Co-Expression Network, Interacting Genes & KEGG
	Pharmacological Information: Drug-Gene Network
	Cross referenced IDs

Gene Summary for ALOX15

Basic gene info.	Gene symbol	ALOX15
	Gene name	arachidonate 15-lipoxygenase
	Synonyms	12-LOX\|15-LOX-1\|15LOX-1
	Cytomap	UCSC genome browser: 17p13.3
	Genomic location	chr17 :4534213-4544960
	Type of gene	protein-coding
	RefGenes	NM_001140.3,
	Ensembl id	ENSG00000161905
	Description	12/15-lipoxygenase15-LOX15-lipooxygenase-1arachidonate 12-lipoxygenase, leukocyte-typearachidonate omega-6 lipoxygenase
	Modification date	20141222
dbXrefs	MIM : 152392
	HGNC : HGNC
	Ensembl : ENSG00000161905
	HPRD : 01067
	Vega : OTTHUMG00000090746
Protein	UniProt: P16050 go to UniProt's Cross Reference DB Table
Expression	CleanEX: HS_ALOX15
	BioGPS: 246
	Gene Expression Atlas: ENSG00000161905
	The Human Protein Atlas: ENSG00000161905
Pathway	NCI Pathway Interaction Database: ALOX15
	KEGG: ALOX15
	REACTOME: ALOX15
	ConsensusPathDB
	Pathway Commons: ALOX15
Metabolism	MetaCyc: ALOX15
	HUMANCyc: ALOX15
Regulation	Ensembl's Regulation: ENSG00000161905
	miRBase: chr17 :4,534,213-4,544,960
	TargetScan: NM_001140
	cisRED: ENSG00000161905
Context	iHOP: ALOX15
	cancer metabolism search in PubMed: ALOX15
	UCL Cancer Institute: ALOX15
Assigned class in ccmGDB	A - This gene has a literature evidence and it belongs to cancer gene.
References showing role of ALOX15 in cancer cell metabolism	1. Hu Y, Sun H, O'Flaherty JT, Edwards IJ (2013) 15-Lipoxygenase-1-mediated metabolism of docosahexaenoic acid is required for syndecan-1 signaling and apoptosis in prostate cancer cells. Carcinogenesis 34: 176-182. doi: 10.1093/carcin/bgs324. pmid: 3584949. go to article 2. Suraneni MV, Moore JR, Zhang D, Badeaux M, Macaluso MD, et al. (2014) Tumor-suppressive functions of 15-Lipoxygenase-2 and RB1CC1 in prostate cancer. Cell Cycle 13: 1798-1810. doi: 10.4161/cc.28757. pmid: 4111726. go to article 3. Guo Y, Nie D (2014) Tumor-suppressing 15-lipoxygenase-2: time for prime time? Cell Cycle 13: 1836-1837. doi: 10.4161/cc.29328. pmid: 4111746. go to article

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Phenotypic Information for ALOX15(metabolism pathway, cancer, disease, phenome)

Cancer Description
Cancer	CGAP: ALOX15
	Familial Cancer Database: ALOX15

* This gene is included in those cancer gene databases.


Oncogene ¹	Tumor Suppressor gene ²	Cancer Gene Census ³	CancerGenes ⁴	Network of Cancer Gene ⁵	Significant driver gene in	Therapeutic Vulnerabilities in Cancer¹

cf) number; DB name
1 Oncogene; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long,
2 Tumor Suppressor gene; https://bioinfo.uth.edu/TSGene/,
3 Cancer Gene Census; http://www.nature.com/nrc/journal/v4/n3/abs/nrc1299.html,
4 CancerGenes; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long,
5 Network of Cancer Gene; http://ncg.kcl.ac.uk/index.php,
1Therapeutic Vulnerabilities in Cancer; http://cbio.mskcc.org/cancergenomics/statius/

Metabolic Pathway Description
KEGG_ARACHIDONIC_ACID_METABOLISM KEGG_LINOLEIC_ACID_METABOLISM

Others
OMIM	152392; gene.
Orphanet
Disease	KEGG Disease: ALOX15
	MedGen: ALOX15 (Human Medical Genetics with Condition)
	ClinVar: ALOX15
Phenotype	MGI: ALOX15 (International Mouse Phenotyping Consortium)
Phenotype	PhenomicDB: ALOX15

Mutations for ALOX15

* Under tables are showing count per each tissue to give us broad intuition about tissue specific mutation patterns.You can go to the detailed page for each mutation database's web site.

Structural Variants in COSMIC : go to COSMIC mutation histogram

There's no structural variation information in COSMIC data for this gene.

Related fusion transcripts : go to Chitars2.0

* From mRNA Sanger sequences, Chitars2.0 arranged chimeric transcripts. This table shows ALOX15 related fusion information.

Head Gene

Tail Gene

Accession

Gene_a

qStart_a

qEnd_a

Chromosome_a

tStart_a

tEnd_a

Gene_a

qStart_a

qEnd_a

Chromosome_a

tStart_a

tEnd_a

Other DBs for Structural Variants

Structural Variants in Ensembl: go to Ensembl Structural variation

Structural Variants in dbVar: go to dbVar

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Copy Number Variations in COSMIC : go to COSMIC mutation CNV/Expr

There's no copy number variation information in COSMIC data for this gene.

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SNV Counts per Each Loci in COSMIC data : go to COSMIC point mutation

: Non-synonymous mutation, : Synonymous mutation, Circle size denotes number of samples.
Maximum mutation count=3

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Somatic Mutation Counts per Tissue in COSMIC data

Stat. for Non-Synonymous SNVs (# total SNVs=41)	Stat. for Synonymous SNVs (# total SNVs=11)

Stat. for Deletions (# total SNVs=0)	Stat. for Insertions (# total SNVs=0)
There's no deleted snv.	There's no inserted snv.

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Top 10 SNVs Having the Most Samples in COSMIC data

* When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site,primary_histology,mutation(aa),pubmedID.

GRCh37 position	Mutation(aa)	Unique sampleID count
chr17:4542791-4542791	p.E91K	3
chr17:4540538-4540538	p.E275K	2
chr17:4542894-4542894	p.Y56Y	2
chr17:4536722-4536722	p.G412E	2
chr17:4542381-4542381	p.R128R	2
chr17:4541560-4541560	p.F253F	2
chr17:4536769-4536769	p.T396T	2
chr17:4541604-4541604	p.V239M	2
chr17:4536197-4536197	p.R500Q	2
chr17:4540413-4540413	p.I316M	2

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SNV Counts per Each Loci in TCGA data

: non-synonymous mutation, : synonymous mutation, Circle size denotes number of samples.
maximum mutation count=2

Point Mutation/ Tissue ID	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20
# sample	1	2		6	1		3					4	3	2		1	11	3		8
# mutation	1	2		7	1		3					4	3	2		1	11	3		8
nonsynonymous SNV	1	2		2			1					4	3	2		1	6	3		8
synonymous SNV				5	1		2										5

cf) Tissue ID; Tissue type (1; BLCA[Bladder Urothelial Carcinoma], 2; BRCA[Breast invasive carcinoma], 3; CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], 4; COAD[Colon adenocarcinoma], 5; GBM[Glioblastoma multiforme], 6; Glioma Low Grade, 7; HNSC[Head and Neck squamous cell carcinoma], 8; KICH[Kidney Chromophobe], 9; KIRC[Kidney renal clear cell carcinoma], 10; KIRP[Kidney renal papillary cell carcinoma], 11; LAML[Acute Myeloid Leukemia], 12; LUAD[Lung adenocarcinoma], 13; LUSC[Lung squamous cell carcinoma], 14; OV[Ovarian serous cystadenocarcinoma ], 15; PAAD[Pancreatic adenocarcinoma], 16; PRAD[Prostate adenocarcinoma], 17; SKCM[Skin Cutaneous Melanoma], 18:STAD[Stomach adenocarcinoma], 19:THCA[Thyroid carcinoma], 20:UCEC[Uterine Corpus Endometrial Carcinoma])

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Top 10 SNVs Having the Most Samples in TCGA data

* We represented just top 10 SNVs. When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site, primary_histology, mutation(aa), pubmedID.

Genomic Position	Mutation(aa)	Unique sampleID count
chr17:4540413	p.T396T	2
chr17:4540538	p.I316M	2
chr17:4536769	p.E275K	2
chr17:4536516	p.R599H	1
chr17:4535217	p.G406E	1
chr17:4542248	p.A186T	1
chr17:4536586	p.I592I	1
chr17:4540418	p.G147W	1
chr17:4535233	p.S587C	1
chr17:4542357	p.P380L	1

Other DBs for Point Mutations

Point Mutation Table of Ensembl: go to Ensembl variation table

Mutation of cBioPortal: go to cBioPortal's Cross-cancer alteration summary

Copy Number for ALOX15 in TCGA

* Copy number data were extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered on Jan-05-2015. Function ProcessCNAData in TCGA-Assembler package was used to obtain gene-level copy number value which is calculated as the average copy number of the genomic region of a gene.

cf) Tissue ID[Tissue type]: BLCA[Bladder Urothelial Carcinoma], BRCA[Breast invasive carcinoma], CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], COAD[Colon adenocarcinoma], GBM[Glioblastoma multiforme], Glioma Low Grade, HNSC[Head and Neck squamous cell carcinoma], KICH[Kidney Chromophobe], KIRC[Kidney renal clear cell carcinoma], KIRP[Kidney renal papillary cell carcinoma], LAML[Acute Myeloid Leukemia], LUAD[Lung adenocarcinoma], LUSC[Lung squamous cell carcinoma], OV[Ovarian serous cystadenocarcinoma ], PAAD[Pancreatic adenocarcinoma], PRAD[Prostate adenocarcinoma], SKCM[Skin Cutaneous Melanoma], STAD[Stomach adenocarcinoma], THCA[Thyroid carcinoma], UCEC[Uterine Corpus Endometrial Carcinoma]

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Gene Expression for ALOX15

Gene Expression in Cancer Cell-lines (CCLE)

* CCLE gene expression data were extracted from CCLE_Expression_Entrez_2012-10-18.res: Gene-centric RMA-normalized mRNA expression data.

Differential Gene Expression in Primary Tumors (TCGA)

* Normalized gene expression data of RNASeqV2 was extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered at Jan-05-2015. Only eight cancer types have enough normal control samples for differential expression analysis.
(t test, adjusted p<0.05 (using Benjamini-Hochberg FDR))

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CNV vs Gene Expression Plot

* This plots show the correlation between CNV and gene expression.

: Open all plots for all cancer types

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Gene-Gene Network Information

Co-Expressed gene's network Plot

* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown.
Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene

: Open all plots for all cancer types


ACADL,ALOX15B,APOD,C15orf43,CLDN8,FKBP5,GGT1, GGT3P,HAAO,LST-3TM12,MPV17L,MVK,OXER1,PNLIPRP3, RLN3,SERHL2,SERHL,SLCO1B1,SPINK8,SULT1C3,UGT2B28	ABCC11,ACSL3,ADAM2,ALOX15B,APOD,B3GAT1,C15orf43, DHRS2,DMRTC2,GGT1,HPGD,IDI1,LST-3TM12,MPV17L, PNLIPRP3,SERHL2,SERHL,SRD5A1,TARP,TMPRSS11F,UGT2B10

ALOX15B,CRISP2,EPYC,FGL1,FOLH1,FOXE1,GABBR2, GPR37L1,GSTTP1,GSTTP2,HIST1H4A,HSPA2,HTR1B,ITLN1, ITLN2,LOC29034,LYZL6,GRIK1-AS1,SHISA3,UGT2B4,UMOD	ALOX15B,ANTXRL,C15orf43,CA5A,PTGDR2,HIST1H1A,ITGA10, KCNS2,LOC731789,LY6K,MC3R,MERTK,MYH13,OR10J3, OR1L6,PSCA,SDHAP2,SIGLEC8,SNORA71D,SP9,TRPC3

Co-Expressed gene's Protein-protein interaction Network Plot

: Open all plots for all cancer types

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Interacting Genes (from Pathway Commons)

: Open all interacting genes' information including KEGG pathway for all interacting genes from DAVID

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Pharmacological Information for ALOX15

There's no related Drug.

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Cross referenced IDs for ALOX15

* We obtained these cross-references from Uniprot database. It covers 150 different DBs, 18 categories. http://www.uniprot.org/help/cross_references_section

: Open all cross reference information