Cancer Cell Metabolism Gene Database

  Cancer Cell Metabolism Gene DB

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Gene Summary

Phenotypic Information (metabolism pathway, cancer, disease, phenome)

Mutations: SVs, CNVs, SNVs

Gene expression: GE, Protein, DEGE, CNV vs GE

Gene-Gene Network Information: Co-Expression Network, Interacting Genes & KEGG

Pharmacological Information: Drug-Gene Network

Cross referenced IDs

Gene Summary for ALOX15B
Basic gene info.Gene symbolALOX15B
Gene namearachidonate 15-lipoxygenase, type B
Synonyms15-LOX-2
CytomapUCSC genome browser: 17p13.1
Genomic locationchr17 :7942357-7952451
Type of geneprotein-coding
RefGenesNM_001039130.1,
NM_001039131.1,NM_001141.2,
Ensembl idENSG00000179593
Description15-LOX-B15S-lipoxygenasearachidonate 15-lipoxygenase 2arachidonate 15-lipoxygenase Barachidonate 15-lipoxygenase type IIarachidonate 15-lipoxygenase, second typearachidonate omega(6) lipoxygenaselinoleate 13-lipoxygenase 15-LOb
Modification date20141207
dbXrefs MIM : 603697
HGNC : HGNC
Ensembl : ENSG00000179593
HPRD : 04739
Vega : OTTHUMG00000108181
ProteinUniProt: O15296
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_ALOX15B
BioGPS: 247
Gene Expression Atlas: ENSG00000179593
The Human Protein Atlas: ENSG00000179593
PathwayNCI Pathway Interaction Database: ALOX15B
KEGG: ALOX15B
REACTOME: ALOX15B
ConsensusPathDB
Pathway Commons: ALOX15B
MetabolismMetaCyc: ALOX15B
HUMANCyc: ALOX15B
RegulationEnsembl's Regulation: ENSG00000179593
miRBase: chr17 :7,942,357-7,952,451
TargetScan: NM_001039130
cisRED: ENSG00000179593
ContextiHOP: ALOX15B
cancer metabolism search in PubMed: ALOX15B
UCL Cancer Institute: ALOX15B
Assigned class in ccmGDBA - This gene has a literature evidence and it belongs to cancer gene.
References showing role of ALOX15B in cancer cell metabolism1. Suraneni MV, Moore JR, Zhang D, Badeaux M, Macaluso MD, et al. (2014) Tumor-suppressive functions of 15-Lipoxygenase-2 and RB1CC1 in prostate cancer. Cell Cycle 13: 1798-1810. doi: 10.4161/cc.28757. pmid: 4111726. go to article

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Phenotypic Information for ALOX15B(metabolism pathway, cancer, disease, phenome)
check002.gifCancer Description
Cancer CGAP: ALOX15B
Familial Cancer Database: ALOX15B
* This gene is included in those cancer gene databases.

Oncogene 1

Tumor Suppressor gene 2

Cancer Gene Census 3

CancerGenes 4

Network of Cancer Gene 5

Significant driver gene in

Therapeutic Vulnerabilities in Cancer1

cf) number; DB name
1 Oncogene; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long,
2 Tumor Suppressor gene; https://bioinfo.uth.edu/TSGene/,
3 Cancer Gene Census; http://www.nature.com/nrc/journal/v4/n3/abs/nrc1299.html,
4 CancerGenes; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long,
5 Network of Cancer Gene; http://ncg.kcl.ac.uk/index.php,
1Therapeutic Vulnerabilities in Cancer; http://cbio.mskcc.org/cancergenomics/statius/

check002.gifMetabolic Pathway Description
KEGG_ARACHIDONIC_ACID_METABOLISM

check002.gifOthers
OMIM 603697; gene.
Orphanet
DiseaseKEGG Disease: ALOX15B
MedGen: ALOX15B (Human Medical Genetics with Condition)
ClinVar: ALOX15B
PhenotypeMGI: ALOX15B (International Mouse Phenotyping Consortium)
PhenomicDB: ALOX15B

Mutations for ALOX15B
* Under tables are showing count per each tissue to give us broad intuition about tissue specific mutation patterns.You can go to the detailed page for each mutation database's web site.

check002.gifStructural Variants in COSMIC: go to COSMIC mutation histogram
There's no structural variation information in COSMIC data for this gene.

check002.gifRelated fusion transcripts : go to Chitars2.0
* From mRNA Sanger sequences, Chitars2.0 arranged chimeric transcripts. This table shows ALOX15B related fusion information.
IDHead GeneTail Gene
AccessionGene_aqStart_aqEnd_aChromosome_atStart_atEnd_aGene_aqStart_aqEnd_aChromosome_atStart_atEnd_a
BF737723ALOX15B81191779519277952039CAPNS1114355193664099636641237

check002.gifOther DBs for Structural Variants
Structural Variants in Ensembl: go to Ensembl Structural variation
Structural Variants in dbVar: go to dbVar

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check002.gifCopy Number Variations in COSMIC: go to COSMIC mutation CNV/Expr
There's no copy number variation information in COSMIC data for this gene.

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check002.gifSNV Counts per Each Loci in COSMIC data: go to COSMIC point mutation

 : Non-synonymous mutation, : Synonymous mutation, Circle size denotes number of samples.
Maximum mutation count=8

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check002.gifSomatic Mutation Counts per Tissue in COSMIC data
Stat. for Non-Synonymous SNVs
(# total SNVs=41)
Stat. for Synonymous SNVs
(# total SNVs=23)
Stat. for Deletions
(# total SNVs=1)
Stat. for Insertions
(# total SNVs=0)
There's no inserted snv.

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check002.gifTop 10 SNVs Having the Most Samples in COSMIC data
* When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site,primary_histology,mutation(aa),pubmedID.
GRCh37 positionMutation(aa)Unique sampleID count
chr17:7942901-7942901p.T115T8
chr17:7950952-7950952p.S550S2
chr17:7942557-7942557p.G28G2
chr17:7948939-7948939p.L379V2
chr17:7942596-7942596p.L41L2
chr17:7942706-7942706p.E50D2
chr17:7951740-7951740p.E630K2
chr17:7948175-7948175p.D235D2
chr17:7948185-7948185p.A239T2
chr17:7950292-7950292p.S452F2

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check002.gifSNV Counts per Each Loci in TCGA data

 : non-synonymous mutation, : synonymous mutation, Circle size denotes number of samples.
maximum mutation count=1

Point Mutation/ Tissue ID1234567891011121314151617181920
# sample 31123 1 3  3241 123 10
# mutation 31113 1 3  3241 123 11
nonsynonymous SNV 2181 1 3  312  73 6
synonymous SNV 1 52       121 5  5
cf) Tissue ID; Tissue type (1; BLCA[Bladder Urothelial Carcinoma], 2; BRCA[Breast invasive carcinoma], 3; CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], 4; COAD[Colon adenocarcinoma], 5; GBM[Glioblastoma multiforme], 6; Glioma Low Grade, 7; HNSC[Head and Neck squamous cell carcinoma], 8; KICH[Kidney Chromophobe], 9; KIRC[Kidney renal clear cell carcinoma], 10; KIRP[Kidney renal papillary cell carcinoma], 11; LAML[Acute Myeloid Leukemia], 12; LUAD[Lung adenocarcinoma], 13; LUSC[Lung squamous cell carcinoma], 14; OV[Ovarian serous cystadenocarcinoma ], 15; PAAD[Pancreatic adenocarcinoma], 16; PRAD[Prostate adenocarcinoma], 17; SKCM[Skin Cutaneous Melanoma], 18:STAD[Stomach adenocarcinoma], 19:THCA[Thyroid carcinoma], 20:UCEC[Uterine Corpus Endometrial Carcinoma])

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check002.gifTop 10 SNVs Having the Most Samples in TCGA data
* We represented just top 10 SNVs. When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site, primary_histology, mutation(aa), pubmedID.
Genomic PositionMutation(aa)Unique sampleID count
chr17:7942706p.E50E,ALOX15B2
chr17:7948181p.F237F,ALOX15B2
chr17:7942501p.T10A,ALOX15B2
chr17:7945743p.F367F,ALOX15B1
chr17:7950374p.E556K,ALOX15B1
chr17:7948220p.R68R,ALOX15B1
chr17:7948893p.A239T,ALOX15B1
chr17:7942594p.L402L1
chr17:7945753p.I577I,ALOX15B1
chr17:7950393p.V69M,ALOX15B1

check002.gifOther DBs for Point Mutations
Point Mutation Table of Ensembl: go to Ensembl variation table
Mutation of cBioPortal: go to cBioPortal's Cross-cancer alteration summary

check002.gifCopy Number for ALOX15B in TCGA
* Copy number data were extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered on Jan-05-2015. Function ProcessCNAData in TCGA-Assembler package was used to obtain gene-level copy number value which is calculated as the average copy number of the genomic region of a gene.
cf) Tissue ID[Tissue type]: BLCA[Bladder Urothelial Carcinoma], BRCA[Breast invasive carcinoma], CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], COAD[Colon adenocarcinoma], GBM[Glioblastoma multiforme], Glioma Low Grade, HNSC[Head and Neck squamous cell carcinoma], KICH[Kidney Chromophobe], KIRC[Kidney renal clear cell carcinoma], KIRP[Kidney renal papillary cell carcinoma], LAML[Acute Myeloid Leukemia], LUAD[Lung adenocarcinoma], LUSC[Lung squamous cell carcinoma], OV[Ovarian serous cystadenocarcinoma ], PAAD[Pancreatic adenocarcinoma], PRAD[Prostate adenocarcinoma], SKCM[Skin Cutaneous Melanoma], STAD[Stomach adenocarcinoma], THCA[Thyroid carcinoma], UCEC[Uterine Corpus Endometrial Carcinoma]

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Gene Expression for ALOX15B

check002.gifGene Expression in Cancer Cell-lines (CCLE)
* CCLE gene expression data were extracted from CCLE_Expression_Entrez_2012-10-18.res: Gene-centric RMA-normalized mRNA expression data.

check002.gifDifferential Gene Expression in Primary Tumors (TCGA)
* Normalized gene expression data of RNASeqV2 was extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered at Jan-05-2015. Only eight cancer types have enough normal control samples for differential expression analysis.
(t test, adjusted p<0.05 (using Benjamini-Hochberg FDR))
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check002.gifCNV vs Gene Expression Plot
* This plots show the correlation between CNV and gene expression.

: Open all plots for all cancer types


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Gene-Gene Network Information
check002.gifCo-Expressed gene's network Plot
* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown.
Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene

: Open all plots for all cancer types

ACADL,ALOX15B,APOD,C15orf43,CLDN8,FKBP5,GGT1,
GGT3P,HAAO,LST-3TM12,MPV17L,MVK,OXER1,PNLIPRP3,
RLN3,SERHL2,SERHL,SLCO1B1,SPINK8,SULT1C3,UGT2B28
ABCC11,ACSL3,ADAM2,ALOX15B,APOD,B3GAT1,C15orf43,
DHRS2,DMRTC2,GGT1,HPGD,IDI1,LST-3TM12,MPV17L,
PNLIPRP3,SERHL2,SERHL,SRD5A1,TARP,TMPRSS11F,UGT2B10

ALOX15B,CRISP2,EPYC,FGL1,FOLH1,FOXE1,GABBR2,
GPR37L1,GSTTP1,GSTTP2,HIST1H4A,HSPA2,HTR1B,ITLN1,
ITLN2,LOC29034,LYZL6,GRIK1-AS1,SHISA3,UGT2B4,UMOD
ALOX15B,ANTXRL,C15orf43,CA5A,PTGDR2,HIST1H1A,ITGA10,
KCNS2,LOC731789,LY6K,MC3R,MERTK,MYH13,OR10J3,
OR1L6,PSCA,SDHAP2,SIGLEC8,SNORA71D,SP9,TRPC3
check002.gifCo-Expressed gene's Protein-protein interaction Network Plot
* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown.
Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene

: Open all plots for all cancer types

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check002.gifInteracting Genes (from Pathway Commons)

: Open all interacting genes' information including KEGG pathway for all interacting genes from DAVID

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Pharmacological Information for ALOX15B


There's no related Drug.
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Cross referenced IDs for ALOX15B
* We obtained these cross-references from Uniprot database. It covers 150 different DBs, 18 categories. http://www.uniprot.org/help/cross_references_section

: Open all cross reference information



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