Cancer Cell Metabolism Database ~~ Bioinformatics and Systems Medicine Laboratory ~~

Cancer Cell Metabolism Gene Database

Cancer Cell Metabolism Gene DB

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	Gene Summary
	Phenotypic Information (metabolism pathway, cancer, disease, phenome)
	Mutations : SVs, CNVs, SNVs
	Gene expression: GE, Protein, DEGE, CNV vs GE
	Gene-Gene Network Information: Co-Expression Network, Interacting Genes & KEGG
	Pharmacological Information: Drug-Gene Network
	Cross referenced IDs

Gene Summary for RPL36

Basic gene info.	Gene symbol	RPL36
	Gene name	ribosomal protein L36
	Synonyms	L36
	Cytomap	UCSC genome browser: 19p13.3
	Genomic location	chr19 :5690271-5691678
	Type of gene	protein-coding
	RefGenes	NM_015414.3, NM_033643.2,
	Ensembl id	ENSG00000130255
	Description	60S ribosomal protein L36
	Modification date	20141207
dbXrefs	HGNC : HGNC
	Ensembl : ENSG00000130255
	HPRD : 10201
	Vega : OTTHUMG00000178585
Protein	UniProt: go to UniProt's Cross Reference DB Table
Expression	CleanEX: HS_RPL36
	BioGPS: 25873
	Gene Expression Atlas: ENSG00000130255
	The Human Protein Atlas: ENSG00000130255
Pathway	NCI Pathway Interaction Database: RPL36
	KEGG: RPL36
	REACTOME: RPL36
	ConsensusPathDB
	Pathway Commons: RPL36
Metabolism	MetaCyc: RPL36
	HUMANCyc: RPL36
Regulation	Ensembl's Regulation: ENSG00000130255
	miRBase: chr19 :5,690,271-5,691,678
	TargetScan: NM_015414
	cisRED: ENSG00000130255
Context	iHOP: RPL36
	cancer metabolism search in PubMed: RPL36
	UCL Cancer Institute: RPL36
Assigned class in ccmGDB	C

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Phenotypic Information for RPL36(metabolism pathway, cancer, disease, phenome)

Cancer Description
Cancer	CGAP: RPL36
	Familial Cancer Database: RPL36

* This gene is included in those cancer gene databases.

						.
Oncogene ¹	Tumor Suppressor gene ²	Cancer Gene Census ³	CancerGenes ⁴	Network of Cancer Gene ⁵	Significant driver gene in	Therapeutic Vulnerabilities in Cancer¹

cf) number; DB name
1 Oncogene; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long,
2 Tumor Suppressor gene; https://bioinfo.uth.edu/TSGene/,
3 Cancer Gene Census; http://www.nature.com/nrc/journal/v4/n3/abs/nrc1299.html,
4 CancerGenes; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long,
5 Network of Cancer Gene; http://ncg.kcl.ac.uk/index.php,
1Therapeutic Vulnerabilities in Cancer; http://cbio.mskcc.org/cancergenomics/statius/

Metabolic Pathway Description
REACTOME_METABOLISM_OF_PROTEINS REACTOME_METABOLISM_OF_MRNA REACTOME_METABOLISM_OF_RNA

Others
OMIM
Orphanet
Disease	KEGG Disease: RPL36
	MedGen: RPL36 (Human Medical Genetics with Condition)
	ClinVar: RPL36
Phenotype	MGI: RPL36 (International Mouse Phenotyping Consortium)
Phenotype	PhenomicDB: RPL36

Mutations for RPL36

* Under tables are showing count per each tissue to give us broad intuition about tissue specific mutation patterns.You can go to the detailed page for each mutation database's web site.

Structural Variants in COSMIC : go to COSMIC mutation histogram

There's no structural variation information in COSMIC data for this gene.

Related fusion transcripts : go to Chitars2.0

* From mRNA Sanger sequences, Chitars2.0 arranged chimeric transcripts. This table shows RPL36 related fusion information.

ID	Head Gene						Tail Gene
Accession	Gene_a	qStart_a	qEnd_a	Chromosome_a	tStart_a	tEnd_a	Gene_a	qStart_a	qEnd_a	Chromosome_a	tStart_a	tEnd_a
EC575727	FOXP2	1	54	7	113937246	113937300	RPL36	49	116	19	5691358	5691425
BG271954	ZFP36L2	1	218	2	43451136	43451353	RPL36	214	267	19	5691358	5691411
BE881501	UGGT1	1	449	2	128947371	128947822	RPL36	442	485	19	5691635	5691678
AI497618	RPL36	36	79	19	5691635	5691678	IGFBP5	75	535	2	217541449	217543759
AI497603	RPL36	24	66	19	5691636	5691678	SLC23A2	65	335	20	4833667	4833937

Other DBs for Structural Variants

Structural Variants in Ensembl: go to Ensembl Structural variation

Structural Variants in dbVar: go to dbVar

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Copy Number Variations in COSMIC : go to COSMIC mutation CNV/Expr

There's no copy number variation information in COSMIC data for this gene.

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SNV Counts per Each Loci in COSMIC data : go to COSMIC point mutation

: Non-synonymous mutation, : Synonymous mutation, Circle size denotes number of samples.
Maximum mutation count=1

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Somatic Mutation Counts per Tissue in COSMIC data

Stat. for Non-Synonymous SNVs (# total SNVs=2)	Stat. for Synonymous SNVs (# total SNVs=0)
	There's no s-snv.
Stat. for Deletions (# total SNVs=0)	Stat. for Insertions (# total SNVs=0)
There's no deleted snv.	There's no inserted snv.

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Top 10 SNVs Having the Most Samples in COSMIC data

* When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site,primary_histology,mutation(aa),pubmedID.

GRCh37 position	Mutation(aa)	Unique sampleID count
chr19:5691353-5691353	p.F39F	1
chr19:5691448-5691448	p.K71T	1
chr19:5691557-5691557	p.I81M	1
chr19:5691568-5691568	p.R85K	1
chr19:5691598-5691598	p.A95V	1

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SNV Counts per Each Loci in TCGA data

: non-synonymous mutation, : synonymous mutation, Circle size denotes number of samples.
maximum mutation count=1

Point Mutation/ Tissue ID	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20
# sample	1	1					2											1
# mutation	1	1					2											1
nonsynonymous SNV	1	1					2											1
synonymous SNV

cf) Tissue ID; Tissue type (1; BLCA[Bladder Urothelial Carcinoma], 2; BRCA[Breast invasive carcinoma], 3; CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], 4; COAD[Colon adenocarcinoma], 5; GBM[Glioblastoma multiforme], 6; Glioma Low Grade, 7; HNSC[Head and Neck squamous cell carcinoma], 8; KICH[Kidney Chromophobe], 9; KIRC[Kidney renal clear cell carcinoma], 10; KIRP[Kidney renal papillary cell carcinoma], 11; LAML[Acute Myeloid Leukemia], 12; LUAD[Lung adenocarcinoma], 13; LUSC[Lung squamous cell carcinoma], 14; OV[Ovarian serous cystadenocarcinoma ], 15; PAAD[Pancreatic adenocarcinoma], 16; PRAD[Prostate adenocarcinoma], 17; SKCM[Skin Cutaneous Melanoma], 18:STAD[Stomach adenocarcinoma], 19:THCA[Thyroid carcinoma], 20:UCEC[Uterine Corpus Endometrial Carcinoma])

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Top 10 SNVs Having the Most Samples in TCGA data

* We represented just top 10 SNVs. When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site, primary_histology, mutation(aa), pubmedID.

Genomic Position	Mutation(aa)	Unique sampleID count
chr19:5691333	p.L33V,RPL36	1
chr19:5691360	p.D42N,RPL36	1
chr19:5691434	p.D66E,RPL36	1
chr19:5691448	p.K71T,RPL36	1
chr19:5691557	p.I81M,RPL36	1
chr19:5691598	p.A95V,RPL36	1

Other DBs for Point Mutations

Point Mutation Table of Ensembl: go to Ensembl variation table

Mutation of cBioPortal: go to cBioPortal's Cross-cancer alteration summary

Copy Number for RPL36 in TCGA

* Copy number data were extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered on Jan-05-2015. Function ProcessCNAData in TCGA-Assembler package was used to obtain gene-level copy number value which is calculated as the average copy number of the genomic region of a gene.

cf) Tissue ID[Tissue type]: BLCA[Bladder Urothelial Carcinoma], BRCA[Breast invasive carcinoma], CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], COAD[Colon adenocarcinoma], GBM[Glioblastoma multiforme], Glioma Low Grade, HNSC[Head and Neck squamous cell carcinoma], KICH[Kidney Chromophobe], KIRC[Kidney renal clear cell carcinoma], KIRP[Kidney renal papillary cell carcinoma], LAML[Acute Myeloid Leukemia], LUAD[Lung adenocarcinoma], LUSC[Lung squamous cell carcinoma], OV[Ovarian serous cystadenocarcinoma ], PAAD[Pancreatic adenocarcinoma], PRAD[Prostate adenocarcinoma], SKCM[Skin Cutaneous Melanoma], STAD[Stomach adenocarcinoma], THCA[Thyroid carcinoma], UCEC[Uterine Corpus Endometrial Carcinoma]

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Gene Expression for RPL36

Gene Expression in Cancer Cell-lines (CCLE)

* CCLE gene expression data were extracted from CCLE_Expression_Entrez_2012-10-18.res: Gene-centric RMA-normalized mRNA expression data.

Differential Gene Expression in Primary Tumors (TCGA)

* Normalized gene expression data of RNASeqV2 was extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered at Jan-05-2015. Only eight cancer types have enough normal control samples for differential expression analysis.
(t test, adjusted p<0.05 (using Benjamini-Hochberg FDR))

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CNV vs Gene Expression Plot

* This plots show the correlation between CNV and gene expression.

: Open all plots for all cancer types

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Gene-Gene Network Information

Co-Expressed gene's network Plot

* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown.
Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene

: Open all plots for all cancer types


CDCA3,EIF5AL1,FAM136A,LYAR,MRPL9,NOP2,NPM3, PFDN2,PUS1,RPL35A,RPL36A,RPS24,RPS2,RPS7, SF3B14,SNHG1,SNHG3,SNRPA,TIMM8A,UCK2,UQCRH	AHCY,ZFAS1,FAM83A,GINS2,GNB2L1,IMPDH2,DANCR, NPM1,PRPS2,RPL10A,RPL12,RPL36A,RPS18,RPS24, RPS4X,S100A14,SMPDL3B,NELFCD,TPRXL,TSPAN1,WNT4

HIST1H4K,LCE2B,LOC100132247,LOC613037,FTX,OR6N2,OR8B3, POTEE,PPIAL4G,PRAMEF17,PRAMEF3,RPL13AP20,RPL13AP6,RPL21, RPL36A,RPL39,RPS26P11,RPSAP9,SNORA38,SNORD16,SNORD35B, SNORD88C,TBC1	ATAD5,BLM,BRIP1,RMI2,ZGRF1,CHAF1B,CHEK1, CSTF3,DTL,EHF,FAM111B,GPX2,JAK2,KNTC1, LOC100129066,MCM7,RPL36A,SHCBP1,TIFA,TMEM173,TYMS

Co-Expressed gene's Protein-protein interaction Network Plot

: Open all plots for all cancer types

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Interacting Genes (from Pathway Commons)

: Open all interacting genes' information including KEGG pathway for all interacting genes from DAVID

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Pharmacological Information for RPL36

There's no related Drug.

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Cross referenced IDs for RPL36

* We obtained these cross-references from Uniprot database. It covers 150 different DBs, 18 categories. http://www.uniprot.org/help/cross_references_section

: Open all cross reference information