Cancer Cell Metabolism Gene Database

  Cancer Cell Metabolism Gene DB

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Bioinformatics and Systems Medicine Laboratory Bioinformatics and Systems Medicine Laboratory

Gene Summary

Phenotypic Information (metabolism pathway, cancer, disease, phenome)

Mutations: SVs, CNVs, SNVs

Gene expression: GE, Protein, DEGE, CNV vs GE

Gene-Gene Network Information: Co-Expression Network, Interacting Genes & KEGG

Pharmacological Information: Drug-Gene Network

Cross referenced IDs

Gene Summary for GAMT
Basic gene info.Gene symbolGAMT
Gene nameguanidinoacetate N-methyltransferase
SynonymsCCDS2|HEL-S-20|PIG2|TP53I2
CytomapUCSC genome browser: 19p13.3
Genomic locationchr19 :1397024-1401569
Type of geneprotein-coding
RefGenesNM_000156.5,
NM_138924.2,
Ensembl idENSG00000130005
Descriptionepididymis secretory protein Li 20
Modification date20141219
dbXrefs MIM : 601240
HGNC : HGNC
Ensembl : ENSG00000130005
HPRD : 03142
Vega : OTTHUMG00000180095
ProteinUniProt:
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_GAMT
BioGPS: 2593
Gene Expression Atlas: ENSG00000130005
The Human Protein Atlas: ENSG00000130005
PathwayNCI Pathway Interaction Database: GAMT
KEGG: GAMT
REACTOME: GAMT
ConsensusPathDB
Pathway Commons: GAMT
MetabolismMetaCyc: GAMT
HUMANCyc: GAMT
RegulationEnsembl's Regulation: ENSG00000130005
miRBase: chr19 :1,397,024-1,401,569
TargetScan: NM_000156
cisRED: ENSG00000130005
ContextiHOP: GAMT
cancer metabolism search in PubMed: GAMT
UCL Cancer Institute: GAMT
Assigned class in ccmGDBC

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Phenotypic Information for GAMT(metabolism pathway, cancer, disease, phenome)
check002.gifCancer Description
Cancer CGAP: GAMT
Familial Cancer Database: GAMT
* This gene is included in those cancer gene databases.

.

Oncogene 1

Tumor Suppressor gene 2

Cancer Gene Census 3

CancerGenes 4

Network of Cancer Gene 5

Significant driver gene in

Therapeutic Vulnerabilities in Cancer1

cf) number; DB name
1 Oncogene; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long,
2 Tumor Suppressor gene; https://bioinfo.uth.edu/TSGene/,
3 Cancer Gene Census; http://www.nature.com/nrc/journal/v4/n3/abs/nrc1299.html,
4 CancerGenes; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long,
5 Network of Cancer Gene; http://ncg.kcl.ac.uk/index.php,
1Therapeutic Vulnerabilities in Cancer; http://cbio.mskcc.org/cancergenomics/statius/

check002.gifMetabolic Pathway Description
KEGG_GLYCINE_SERINE_AND_THREONINE_METABOLISM
KEGG_ARGININE_AND_PROLINE_METABOLISM
REACTOME_METABOLISM_OF_AMINO_ACIDS_AND_DERIVATIVES

check002.gifOthers
OMIM
Orphanet
DiseaseKEGG Disease: GAMT
MedGen: GAMT (Human Medical Genetics with Condition)
ClinVar: GAMT
PhenotypeMGI: GAMT (International Mouse Phenotyping Consortium)
PhenomicDB: GAMT

Mutations for GAMT
* Under tables are showing count per each tissue to give us broad intuition about tissue specific mutation patterns.You can go to the detailed page for each mutation database's web site.

check002.gifStructural Variants in COSMIC: go to COSMIC mutation histogram
There's no structural variation information in COSMIC data for this gene.

check002.gifRelated fusion transcripts : go to Chitars2.0
* From mRNA Sanger sequences, Chitars2.0 arranged chimeric transcripts. This table shows GAMT related fusion information.
IDHead GeneTail Gene
AccessionGene_aqStart_aqEnd_aChromosome_atStart_atEnd_aGene_aqStart_aqEnd_aChromosome_atStart_atEnd_a

check002.gifOther DBs for Structural Variants
Structural Variants in Ensembl: go to Ensembl Structural variation
Structural Variants in dbVar: go to dbVar

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check002.gifCopy Number Variations in COSMIC: go to COSMIC mutation CNV/Expr
There's no copy number variation information in COSMIC data for this gene.

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check002.gifSNV Counts per Each Loci in COSMIC data: go to COSMIC point mutation

 : Non-synonymous mutation, : Synonymous mutation, Circle size denotes number of samples.
Maximum mutation count=4

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check002.gifSomatic Mutation Counts per Tissue in COSMIC data
Stat. for Non-Synonymous SNVs
(# total SNVs=17)
Stat. for Synonymous SNVs
(# total SNVs=4)
Stat. for Deletions
(# total SNVs=1)
Stat. for Insertions
(# total SNVs=1)

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check002.gifTop 10 SNVs Having the Most Samples in COSMIC data
* When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site,primary_histology,mutation(aa),pubmedID.
GRCh37 positionMutation(aa)Unique sampleID count
chr19:1399836-1399836p.V95I4
chr19:1397456-1397456p.E205*3
chr19:1399181-1399181p.D135E1
chr19:1398961-1398961p.G175E1
chr19:1399536-1399536p.D126D1
chr19:1398963-1398963p.W174C1
chr19:1399562-1399562p.E118K1
chr19:1398967-1398967p.S173F1
chr19:1399821-1399821p.R100W1
chr19:1397382-1397382p.I229M1

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check002.gifSNV Counts per Each Loci in TCGA data

 : non-synonymous mutation, : synonymous mutation, Circle size denotes number of samples.
maximum mutation count=1

Point Mutation/ Tissue ID1234567891011121314151617181920
# sample 1 41   1       3  4
# mutation 1 41   1       3  5
nonsynonymous SNV 1 31           3  3
synonymous SNV   1    1          2
cf) Tissue ID; Tissue type (1; BLCA[Bladder Urothelial Carcinoma], 2; BRCA[Breast invasive carcinoma], 3; CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], 4; COAD[Colon adenocarcinoma], 5; GBM[Glioblastoma multiforme], 6; Glioma Low Grade, 7; HNSC[Head and Neck squamous cell carcinoma], 8; KICH[Kidney Chromophobe], 9; KIRC[Kidney renal clear cell carcinoma], 10; KIRP[Kidney renal papillary cell carcinoma], 11; LAML[Acute Myeloid Leukemia], 12; LUAD[Lung adenocarcinoma], 13; LUSC[Lung squamous cell carcinoma], 14; OV[Ovarian serous cystadenocarcinoma ], 15; PAAD[Pancreatic adenocarcinoma], 16; PRAD[Prostate adenocarcinoma], 17; SKCM[Skin Cutaneous Melanoma], 18:STAD[Stomach adenocarcinoma], 19:THCA[Thyroid carcinoma], 20:UCEC[Uterine Corpus Endometrial Carcinoma])

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check002.gifTop 10 SNVs Having the Most Samples in TCGA data
* We represented just top 10 SNVs. When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site, primary_histology, mutation(aa), pubmedID.
Genomic PositionMutation(aa)Unique sampleID count
chr19:1399012p.A156T,GAMT1
chr19:1399019p.H155H,GAMT1
chr19:1399020p.D126D,GAMT1
chr19:1397385p.R100W,GAMT1
chr19:1399536p.V95I,GAMT1
chr19:1397401p.V78V,GAMT1
chr19:1399821p.M228I1
chr19:1397419p.Y223C1
chr19:1399836p.P217L1
chr19:1398886p.S200F1

check002.gifOther DBs for Point Mutations
Point Mutation Table of Ensembl: go to Ensembl variation table
Mutation of cBioPortal: go to cBioPortal's Cross-cancer alteration summary

check002.gifCopy Number for GAMT in TCGA
* Copy number data were extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered on Jan-05-2015. Function ProcessCNAData in TCGA-Assembler package was used to obtain gene-level copy number value which is calculated as the average copy number of the genomic region of a gene.
cf) Tissue ID[Tissue type]: BLCA[Bladder Urothelial Carcinoma], BRCA[Breast invasive carcinoma], CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], COAD[Colon adenocarcinoma], GBM[Glioblastoma multiforme], Glioma Low Grade, HNSC[Head and Neck squamous cell carcinoma], KICH[Kidney Chromophobe], KIRC[Kidney renal clear cell carcinoma], KIRP[Kidney renal papillary cell carcinoma], LAML[Acute Myeloid Leukemia], LUAD[Lung adenocarcinoma], LUSC[Lung squamous cell carcinoma], OV[Ovarian serous cystadenocarcinoma ], PAAD[Pancreatic adenocarcinoma], PRAD[Prostate adenocarcinoma], SKCM[Skin Cutaneous Melanoma], STAD[Stomach adenocarcinoma], THCA[Thyroid carcinoma], UCEC[Uterine Corpus Endometrial Carcinoma]

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Gene Expression for GAMT

check002.gifGene Expression in Cancer Cell-lines (CCLE)
* CCLE gene expression data were extracted from CCLE_Expression_Entrez_2012-10-18.res: Gene-centric RMA-normalized mRNA expression data.

check002.gifDifferential Gene Expression in Primary Tumors (TCGA)
* Normalized gene expression data of RNASeqV2 was extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered at Jan-05-2015. Only eight cancer types have enough normal control samples for differential expression analysis.
(t test, adjusted p<0.05 (using Benjamini-Hochberg FDR))
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check002.gifCNV vs Gene Expression Plot
* This plots show the correlation between CNV and gene expression.

: Open all plots for all cancer types


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Gene-Gene Network Information
check002.gifCo-Expressed gene's network Plot
* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown.
Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene

: Open all plots for all cancer types

BLOC1S1,C19orf24,C19orf25,CHCHD5,MZT2B,FAM173A,FAM195A,
GAMT,GPX4,HEXIM2,NAA38,MRPL54,NDUFA2,NDUFS7,
NME3,NPDC1,PHPT1,TEX264,TMEM219,UQCR11,ZNF688
ADPRHL1,PERM1,CHRNA10,CHRNB1,CLCN1,DYRK1B,EEF1A2,
FEM1A,FHL3,GAMT,GOT1,JSRP1,MYL6B,OBSCN,
PFKM,RTN2,SEMA6C,SHISA4,SRPK3,TPM2,WDR62

ARSB,ASTN2,COL22A1,DIRAS1,EFNB3,FAM133A,FGL1,
FOLH1,FOXE1,GABBR2,GAMT,MYO3B,NLGN2,OR10C1,
PAGE1,PNMA6A,SLC7A2,SNCA,TLL2,TPH1,TUB
ARL3,CDPF1,CCDC106,CNRIP1,CRTAP,CUEDC2,CYB5R1,
FBXO27,GAMT,GYPC,LOC158572,MAGED2,MAGEH1,OAZ2,
SMARCD3,TCEA2,TCTN1,TMEM121,TNFSF12,ZFP82,ZNF667
check002.gifCo-Expressed gene's Protein-protein interaction Network Plot
* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown.
Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene

: Open all plots for all cancer types

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check002.gifInteracting Genes (from Pathway Commons)

: Open all interacting genes' information including KEGG pathway for all interacting genes from DAVID

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Pharmacological Information for GAMT
check002.gifCross-referenced pharmacological DB IDs from Uniprot
DB CategoryDB NameDB's ID and Url link

check002.gifDrug-Gene Interaction Network
* Gene Centered Interaction Network.
* Drug Centered Interaction Network.
DrugBank IDTarget NameDrug GroupsGeneric NameDrug Centered NetworkDrug Structure
DB00148guanidinoacetate N-methyltransferaseapproved; nutraceuticalCreatine
DB00536guanidinoacetate N-methyltransferaseapprovedGuanidine
DB01752guanidinoacetate N-methyltransferaseexperimentalS-Adenosyl-L-Homocysteine
DB02751guanidinoacetate N-methyltransferaseexperimentalN-[Amino(Imino)Methyl]Glycine
DB00145guanidinoacetate N-methyltransferaseapproved; nutraceuticalGlycine
DB00125guanidinoacetate N-methyltransferaseapproved; nutraceuticalL-Arginine


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Cross referenced IDs for GAMT
* We obtained these cross-references from Uniprot database. It covers 150 different DBs, 18 categories. http://www.uniprot.org/help/cross_references_section

: Open all cross reference information



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