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Phenotypic Information (metabolism pathway, cancer, disease, phenome) | |
Gene-Gene Network Information: Co-Expression Network, Interacting Genes & KEGG | |
Gene Summary for DAK |
Basic gene info. | Gene symbol | DAK |
Gene name | dihydroxyacetone kinase 2 homolog (S. cerevisiae) | |
Synonyms | NET45 | |
Cytomap | UCSC genome browser: 11q12.2 | |
Genomic location | chr11 :61100653-61116231 | |
Type of gene | protein-coding | |
RefGenes | NM_015533.3, | |
Ensembl id | ENSG00000149476 | |
Description | ATP-dependent dihydroxyacetone kinaseDHA kinaseDha kinase/FMN cyclaseFAD-AMP lyase cyclic FMN formingFAD-AMP lyase cyclizingbifunctional ATP-dependent dihydroxyacetone kinase/FAD-AMP lyase (cyclizing)glycerone kinase | |
Modification date | 20141207 | |
dbXrefs | MIM : 615844 | |
HGNC : HGNC | ||
Ensembl : ENSG00000149476 | ||
HPRD : 13180 | ||
Vega : OTTHUMG00000168076 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_DAK | |
BioGPS: 26007 | ||
Gene Expression Atlas: ENSG00000149476 | ||
The Human Protein Atlas: ENSG00000149476 | ||
Pathway | NCI Pathway Interaction Database: DAK | |
KEGG: DAK | ||
REACTOME: DAK | ||
ConsensusPathDB | ||
Pathway Commons: DAK | ||
Metabolism | MetaCyc: DAK | |
HUMANCyc: DAK | ||
Regulation | Ensembl's Regulation: ENSG00000149476 | |
miRBase: chr11 :61,100,653-61,116,231 | ||
TargetScan: NM_015533 | ||
cisRED: ENSG00000149476 | ||
Context | iHOP: DAK | |
cancer metabolism search in PubMed: DAK | ||
UCL Cancer Institute: DAK | ||
Assigned class in ccmGDB | C |
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Phenotypic Information for DAK(metabolism pathway, cancer, disease, phenome) |
Cancer Description | |
Cancer | CGAP: DAK |
Familial Cancer Database: DAK |
* This gene is included in those cancer gene databases. |
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Oncogene 1 | Significant driver gene in |
cf) number; DB name 1 Oncogene; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long, 2 Tumor Suppressor gene; https://bioinfo.uth.edu/TSGene/, 3 Cancer Gene Census; http://www.nature.com/nrc/journal/v4/n3/abs/nrc1299.html, 4 CancerGenes; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long, 5 Network of Cancer Gene; http://ncg.kcl.ac.uk/index.php, 1Therapeutic Vulnerabilities in Cancer; http://cbio.mskcc.org/cancergenomics/statius/ |
Metabolic Pathway Description | |
KEGG_GLYCEROLIPID_METABOLISM |
Others | |
OMIM | |
Orphanet | |
Disease | KEGG Disease: DAK |
MedGen: DAK (Human Medical Genetics with Condition) | |
ClinVar: DAK | |
Phenotype | MGI: DAK (International Mouse Phenotyping Consortium) |
PhenomicDB: DAK |
Mutations for DAK |
* Under tables are showing count per each tissue to give us broad intuition about tissue specific mutation patterns.You can go to the detailed page for each mutation database's web site. |
Structural Variants in COSMIC: go to COSMIC mutation histogram |
- Statistics for Tissue and Mutation type | Top |
- For Inter-chromosomal Variations |
There's no inter-chromosomal structural variation. |
- For Intra-chromosomal Variations |
* Intra-chromosomal variantions includes 'intrachromosomal amplicon to amplicon', 'intrachromosomal amplicon to non-amplified dna', 'intrachromosomal deletion', 'intrachromosomal fold-back inversion', 'intrachromosomal inversion', 'intrachromosomal tandem duplication', 'Intrachromosomal unknown type', 'intrachromosomal with inverted orientation', 'intrachromosomal with non-inverted orientation'. |
Sample | Symbol_a | Chr_a | Start_a | End_a | Symbol_b | Chr_b | Start_b | End_b |
pancreas | DAK | chr11 | 61107790 | 61107810 | DAK | chr11 | 61108130 | 61108150 |
cf) Tissue number; Tissue name (1;Breast, 2;Central_nervous_system, 3;Haematopoietic_and_lymphoid_tissue, 4;Large_intestine, 5;Liver, 6;Lung, 7;Ovary, 8;Pancreas, 9;Prostate, 10;Skin, 11;Soft_tissue, 12;Upper_aerodigestive_tract) |
Related fusion transcripts : go to Chitars2.0 |
* From mRNA Sanger sequences, Chitars2.0 arranged chimeric transcripts. This table shows DAK related fusion information. |
ID | Head Gene | Tail Gene | Accession | Gene_a | qStart_a | qEnd_a | Chromosome_a | tStart_a | tEnd_a | Gene_a | qStart_a | qEnd_a | Chromosome_a | tStart_a | tEnd_a |
BF821140 | DAK | 4 | 96 | 11 | 61113913 | 61114007 | FTX | 97 | 217 | X | 73443839 | 73443958 |
Other DBs for Structural Variants |
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Copy Number Variations in COSMIC: go to COSMIC mutation CNV/Expr |
There's no copy number variation information in COSMIC data for this gene. |
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SNV Counts per Each Loci in COSMIC data: go to COSMIC point mutation |
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Somatic Mutation Counts per Tissue in COSMIC data |
Stat. for Non-Synonymous SNVs (# total SNVs=46) | (# total SNVs=15) |
(# total SNVs=0) | (# total SNVs=0) |
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Top 10 SNVs Having the Most Samples in COSMIC data |
* When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site,primary_histology,mutation(aa),pubmedID. |
GRCh37 position | Mutation(aa) | Unique sampleID count |
chr11:61111695-61111695 | p.R397Q | 3 |
chr11:61110107-61110107 | p.A251V | 3 |
chr11:61106818-61106818 | p.E133Q | 2 |
chr11:61110838-61110838 | p.R297H | 2 |
chr11:61113373-61113373 | p.K510K | 2 |
chr11:61106612-61106612 | p.L90L | 2 |
chr11:61110055-61110055 | p.A234S | 2 |
chr11:61111349-61111349 | p.A335V | 2 |
chr11:61113829-61113829 | p.E528* | 2 |
chr11:61109342-61109342 | p.P205S | 2 |
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SNV Counts per Each Loci in TCGA data |
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Point Mutation/ Tissue ID | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | 18 | 19 | 20 |
# sample | 1 | 4 |   | 10 |   |   | 3 |   | 2 |   |   | 6 | 1 |   |   | 1 | 7 | 6 |   | 7 |
# mutation | 1 | 4 |   | 9 |   |   | 3 |   | 2 |   |   | 6 | 1 |   |   | 1 | 7 | 7 |   | 7 |
nonsynonymous SNV | 1 | 3 |   | 7 |   |   | 3 |   | 1 |   |   | 2 | 1 |   |   |   | 2 | 5 |   | 3 |
synonymous SNV |   | 1 |   | 2 |   |   |   |   | 1 |   |   | 4 |   |   |   | 1 | 5 | 2 |   | 4 |
cf) Tissue ID; Tissue type (1; BLCA[Bladder Urothelial Carcinoma], 2; BRCA[Breast invasive carcinoma], 3; CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], 4; COAD[Colon adenocarcinoma], 5; GBM[Glioblastoma multiforme], 6; Glioma Low Grade, 7; HNSC[Head and Neck squamous cell carcinoma], 8; KICH[Kidney Chromophobe], 9; KIRC[Kidney renal clear cell carcinoma], 10; KIRP[Kidney renal papillary cell carcinoma], 11; LAML[Acute Myeloid Leukemia], 12; LUAD[Lung adenocarcinoma], 13; LUSC[Lung squamous cell carcinoma], 14; OV[Ovarian serous cystadenocarcinoma ], 15; PAAD[Pancreatic adenocarcinoma], 16; PRAD[Prostate adenocarcinoma], 17; SKCM[Skin Cutaneous Melanoma], 18:STAD[Stomach adenocarcinoma], 19:THCA[Thyroid carcinoma], 20:UCEC[Uterine Corpus Endometrial Carcinoma]) |
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Top 10 SNVs Having the Most Samples in TCGA data |
* We represented just top 10 SNVs. When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site, primary_histology, mutation(aa), pubmedID. |
Genomic Position | Mutation(aa) | Unique sampleID count |
chr11:61111695 | p.S371S | 2 |
chr11:61106612 | p.H221H | 2 |
chr11:61109940 | p.R397Q | 2 |
chr11:61110055 | p.A234T | 2 |
chr11:61111618 | p.A251V | 2 |
chr11:61110107 | p.L90L | 2 |
chr11:61111640 | p.L191M | 1 |
chr11:61105416 | p.T206N | 1 |
chr11:61106796 | p.E379Q | 1 |
chr11:61113877 | p.S3T | 1 |
Other DBs for Point Mutations |
Copy Number for DAK in TCGA |
* Copy number data were extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered on Jan-05-2015. Function ProcessCNAData in TCGA-Assembler package was used to obtain gene-level copy number value which is calculated as the average copy number of the genomic region of a gene. |
cf) Tissue ID[Tissue type]: BLCA[Bladder Urothelial Carcinoma], BRCA[Breast invasive carcinoma], CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], COAD[Colon adenocarcinoma], GBM[Glioblastoma multiforme], Glioma Low Grade, HNSC[Head and Neck squamous cell carcinoma], KICH[Kidney Chromophobe], KIRC[Kidney renal clear cell carcinoma], KIRP[Kidney renal papillary cell carcinoma], LAML[Acute Myeloid Leukemia], LUAD[Lung adenocarcinoma], LUSC[Lung squamous cell carcinoma], OV[Ovarian serous cystadenocarcinoma ], PAAD[Pancreatic adenocarcinoma], PRAD[Prostate adenocarcinoma], SKCM[Skin Cutaneous Melanoma], STAD[Stomach adenocarcinoma], THCA[Thyroid carcinoma], UCEC[Uterine Corpus Endometrial Carcinoma] |
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Gene Expression for DAK |
Gene Expression in Cancer Cell-lines (CCLE) |
* CCLE gene expression data were extracted from CCLE_Expression_Entrez_2012-10-18.res: Gene-centric RMA-normalized mRNA expression data. |
Differential Gene Expression in Primary Tumors (TCGA) |
* Normalized gene expression data of RNASeqV2 was extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered at Jan-05-2015. Only eight cancer types have enough normal control samples for differential expression analysis. (t test, adjusted p<0.05 (using Benjamini-Hochberg FDR)) |
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CNV vs Gene Expression Plot |
* This plots show the correlation between CNV and gene expression. |
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Gene-Gene Network Information |
Co-Expressed gene's network Plot |
* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown. Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene |
LMNTD2,C12orf10,CCDC24,CHCHD5,COQ4,DAK,DNAJC17, ELMO3,MZT2B,GAMT,GPR137,HEXIM2,MYL5,NUDT22, PIGQ,RAB17,RNF208,SDHAF2,STK16,SURF1,WBP1 | ARRDC1,SYNE4,EMC10,CACFD1,COQ4,DAK,FBXW9, HMG20B,IGSF8,LPAR2,LSR,MBOAT7,NDOR1,PAFAH1B3, PAK4,PICK1,PRPF19,PRRG2,SCAMP4,STXBP2,YIPF2 |
ABCC6,CDK2AP2,CLDN15,DAK,DGKZ,ELMO3,FAM86C1, GLYCTK,HNF1A,KHK,METTL7B,MFSD3,MTTP,NLRP6, NOC4L,PLCB3,PNPO,REEP6,SLC25A1,SLC7A9,TUT1 | ABCC2,ABCG8,ACE,ALDOB,C17orf78,ERICH4,CCL25, CYP2D6,DAK,DPEP1,ENPP7,FBP1,GSTA2,NR0B2, PRODH,REEP6,SLC10A2,SLC5A9,SLC7A9,SULT2A1,TTC36 |
Co-Expressed gene's Protein-protein interaction Network Plot |
* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown. Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene |
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Interacting Genes (from Pathway Commons) |
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Pharmacological Information for DAK |
There's no related Drug. |
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Cross referenced IDs for DAK |
* We obtained these cross-references from Uniprot database. It covers 150 different DBs, 18 categories. http://www.uniprot.org/help/cross_references_section |
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