Cancer Cell Metabolism Database ~~ Bioinformatics and Systems Medicine Laboratory ~~

Cancer Cell Metabolism Gene Database

Cancer Cell Metabolism Gene DB

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	Gene Summary
	Phenotypic Information (metabolism pathway, cancer, disease, phenome)
	Mutations : SVs, CNVs, SNVs
	Gene expression: GE, Protein, DEGE, CNV vs GE
	Gene-Gene Network Information: Co-Expression Network, Interacting Genes & KEGG
	Pharmacological Information: Drug-Gene Network
	Cross referenced IDs

Gene Summary for AMD1

Basic gene info.	Gene symbol	AMD1
	Gene name	adenosylmethionine decarboxylase 1
	Synonyms	ADOMETDC\|AMD\|SAMDC
	Cytomap	UCSC genome browser: 6q21
	Genomic location	chr6 :111195987-111216913
	Type of gene	protein-coding
	RefGenes	NM_001287214.1, NM_001287215.1,NM_001287216.1,NM_001634.5,NR_109768.1, NM_001033059.1,
	Ensembl id	ENSG00000123505
	Description	S-adenosylmethionine decarboxylase 1S-adenosylmethionine decarboxylase proenzyme
	Modification date	20141207
dbXrefs	MIM : 180980
	HGNC : HGNC
	Ensembl : ENSG00000123505
	HPRD : 01622
	Vega : OTTHUMG00000015369
Protein	UniProt: go to UniProt's Cross Reference DB Table
Expression	CleanEX: HS_AMD1
	BioGPS: 262
	Gene Expression Atlas: ENSG00000123505
	The Human Protein Atlas: ENSG00000123505
Pathway	NCI Pathway Interaction Database: AMD1
	KEGG: AMD1
	REACTOME: AMD1
	ConsensusPathDB
	Pathway Commons: AMD1
Metabolism	MetaCyc: AMD1
	HUMANCyc: AMD1
Regulation	Ensembl's Regulation: ENSG00000123505
	miRBase: chr6 :111,195,987-111,216,913
	TargetScan: NM_001287214
	cisRED: ENSG00000123505
Context	iHOP: AMD1
	cancer metabolism search in PubMed: AMD1
	UCL Cancer Institute: AMD1
Assigned class in ccmGDB	C

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Phenotypic Information for AMD1(metabolism pathway, cancer, disease, phenome)

Cancer Description
Cancer	CGAP: AMD1
	Familial Cancer Database: AMD1

* This gene is included in those cancer gene databases.

						.
Oncogene ¹	Tumor Suppressor gene ²	Cancer Gene Census ³	CancerGenes ⁴	Network of Cancer Gene ⁵	Significant driver gene in	Therapeutic Vulnerabilities in Cancer¹

cf) number; DB name
1 Oncogene; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long,
2 Tumor Suppressor gene; https://bioinfo.uth.edu/TSGene/,
3 Cancer Gene Census; http://www.nature.com/nrc/journal/v4/n3/abs/nrc1299.html,
4 CancerGenes; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long,
5 Network of Cancer Gene; http://ncg.kcl.ac.uk/index.php,
1Therapeutic Vulnerabilities in Cancer; http://cbio.mskcc.org/cancergenomics/statius/

Metabolic Pathway Description
KEGG_CYSTEINE_AND_METHIONINE_METABOLISM KEGG_ARGININE_AND_PROLINE_METABOLISM REACTOME_METABOLISM_OF_AMINO_ACIDS_AND_DERIVATIVES REACTOME_METABOLISM_OF_POLYAMINES

Others
OMIM
Orphanet
Disease	KEGG Disease: AMD1
	MedGen: AMD1 (Human Medical Genetics with Condition)
	ClinVar: AMD1
Phenotype	MGI: AMD1 (International Mouse Phenotyping Consortium)
Phenotype	PhenomicDB: AMD1

Mutations for AMD1

* Under tables are showing count per each tissue to give us broad intuition about tissue specific mutation patterns.You can go to the detailed page for each mutation database's web site.

Structural Variants in COSMIC : go to COSMIC mutation histogram

- Statistics for Tissue and Mutation type

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- For Inter-chromosomal Variations

There's no inter-chromosomal structural variation.

- For Intra-chromosomal Variations

* Intra-chromosomal variantions includes 'intrachromosomal amplicon to amplicon', 'intrachromosomal amplicon to non-amplified dna', 'intrachromosomal deletion', 'intrachromosomal fold-back inversion', 'intrachromosomal inversion', 'intrachromosomal tandem duplication', 'Intrachromosomal unknown type', 'intrachromosomal with inverted orientation', 'intrachromosomal with non-inverted orientation'.

Sample	Symbol_a	Chr_a	Start_a	End_a	Symbol_b	Chr_b	Start_b	End_b
ovary	AMD1	chr6	111213879	111213899		chr6	111217410	111217430

cf) Tissue number; Tissue name (1;Breast, 2;Central_nervous_system, 3;Haematopoietic_and_lymphoid_tissue, 4;Large_intestine, 5;Liver, 6;Lung, 7;Ovary, 8;Pancreas, 9;Prostate, 10;Skin, 11;Soft_tissue, 12;Upper_aerodigestive_tract)

Related fusion transcripts : go to Chitars2.0

* From mRNA Sanger sequences, Chitars2.0 arranged chimeric transcripts. This table shows AMD1 related fusion information.

ID	Head Gene						Tail Gene
Accession	Gene_a	qStart_a	qEnd_a	Chromosome_a	tStart_a	tEnd_a	Gene_a	qStart_a	qEnd_a	Chromosome_a	tStart_a	tEnd_a
CN399561	AMD1	10	425	6	111196003	111196418	ECHDC1	424	693	6	127611236	127636043
CR992767	AMD1	1	416	6	111196006	111196421	TNFAIP3	412	690	6	138192348	138192626
BI770432	NAA60	1	311	16	3493725	3498540	AMD1	312	871	6	111213364	111214801
BE181974	AMD1	45	132	6	111210097	111210185	AMD1	125	192	6	111214224	111214701

Other DBs for Structural Variants

Structural Variants in Ensembl: go to Ensembl Structural variation

Structural Variants in dbVar: go to dbVar

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Copy Number Variations in COSMIC : go to COSMIC mutation CNV/Expr

Mutation type/ Tissue ID

brca

cns

cerv

endome

haematopo

kidn

Lintest

liver

lung

ovary

pancre

prost

skin

stoma

thyro

urina

Total # sample

GAIN (# sample)

LOSS (# sample)

cf) Tissue ID; Tissue type (1; Breast, 2; Central_nervous_system, 3; Cervix, 4; Endometrium, 5; Haematopoietic_and_lymphoid_tissue, 6; Kidney, 7; Large_intestine, 8; Liver, 9; Lung, 10; NS, 11; Ovary, 12; Pancreas, 13; Prostate, 14; Skin, 15; Stomach, 16; Thyroid, 17; Urinary_tract)

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SNV Counts per Each Loci in COSMIC data : go to COSMIC point mutation

: Non-synonymous mutation, : Synonymous mutation, Circle size denotes number of samples.
Maximum mutation count=2

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Somatic Mutation Counts per Tissue in COSMIC data

Stat. for Non-Synonymous SNVs (# total SNVs=26)	Stat. for Synonymous SNVs (# total SNVs=5)

Stat. for Deletions (# total SNVs=0)	Stat. for Insertions (# total SNVs=0)
There's no deleted snv.	There's no inserted snv.

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Top 10 SNVs Having the Most Samples in COSMIC data

* When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site,primary_histology,mutation(aa),pubmedID.

GRCh37 position	Mutation(aa)	Unique sampleID count
chr6:111214008-111214008	p.S229L	2
chr6:111213388-111213388	p.R151H	2
chr6:111210086-111210086	p.R75K	2
chr6:111213533-111213533	p.R168W	2
chr6:111208791-111208791	p.L65P	1
chr6:111214205-111214205	p.L267L	1
chr6:111211547-111211547	p.A139S	1
chr6:111210061-111210061	p.E67Q	1
chr6:111214224-111214224	p.V274I	1
chr6:111214017-111214017	p.G232V	1

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SNV Counts per Each Loci in TCGA data

: non-synonymous mutation, : synonymous mutation, Circle size denotes number of samples.
maximum mutation count=2

Point Mutation/ Tissue ID	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20
# sample		1	1	3	2				1	3		3		1				3		3
# mutation		1	1	4	2				1	3		3		1				3		3
nonsynonymous SNV		1	1	4	2				1	2		2		1				3		3
synonymous SNV										1		1

cf) Tissue ID; Tissue type (1; BLCA[Bladder Urothelial Carcinoma], 2; BRCA[Breast invasive carcinoma], 3; CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], 4; COAD[Colon adenocarcinoma], 5; GBM[Glioblastoma multiforme], 6; Glioma Low Grade, 7; HNSC[Head and Neck squamous cell carcinoma], 8; KICH[Kidney Chromophobe], 9; KIRC[Kidney renal clear cell carcinoma], 10; KIRP[Kidney renal papillary cell carcinoma], 11; LAML[Acute Myeloid Leukemia], 12; LUAD[Lung adenocarcinoma], 13; LUSC[Lung squamous cell carcinoma], 14; OV[Ovarian serous cystadenocarcinoma ], 15; PAAD[Pancreatic adenocarcinoma], 16; PRAD[Prostate adenocarcinoma], 17; SKCM[Skin Cutaneous Melanoma], 18:STAD[Stomach adenocarcinoma], 19:THCA[Thyroid carcinoma], 20:UCEC[Uterine Corpus Endometrial Carcinoma])

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Top 10 SNVs Having the Most Samples in TCGA data

* We represented just top 10 SNVs. When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site, primary_histology, mutation(aa), pubmedID.

Genomic Position	Mutation(aa)	Unique sampleID count
chr6:111214026	p.S115L,AMD1	2
chr6:111210086	p.D46G	1
chr6:111214008	p.N138I,AMD1	1
chr6:111210137	p.R46K,AMD1	1
chr6:111214017	p.D145N,AMD1	1
chr6:111210151	p.V63A,AMD1	1
chr6:111214021	p.L147L,AMD1	1
chr6:111211528	p.L68I,AMD1	1
chr6:111211547	p.V154I,AMD1	1
chr6:111214177	p.E103D,AMD1	1

Other DBs for Point Mutations

Point Mutation Table of Ensembl: go to Ensembl variation table

Mutation of cBioPortal: go to cBioPortal's Cross-cancer alteration summary

Copy Number for AMD1 in TCGA

* Copy number data were extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered on Jan-05-2015. Function ProcessCNAData in TCGA-Assembler package was used to obtain gene-level copy number value which is calculated as the average copy number of the genomic region of a gene.

cf) Tissue ID[Tissue type]: BLCA[Bladder Urothelial Carcinoma], BRCA[Breast invasive carcinoma], CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], COAD[Colon adenocarcinoma], GBM[Glioblastoma multiforme], Glioma Low Grade, HNSC[Head and Neck squamous cell carcinoma], KICH[Kidney Chromophobe], KIRC[Kidney renal clear cell carcinoma], KIRP[Kidney renal papillary cell carcinoma], LAML[Acute Myeloid Leukemia], LUAD[Lung adenocarcinoma], LUSC[Lung squamous cell carcinoma], OV[Ovarian serous cystadenocarcinoma ], PAAD[Pancreatic adenocarcinoma], PRAD[Prostate adenocarcinoma], SKCM[Skin Cutaneous Melanoma], STAD[Stomach adenocarcinoma], THCA[Thyroid carcinoma], UCEC[Uterine Corpus Endometrial Carcinoma]

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Gene Expression for AMD1

Gene Expression in Cancer Cell-lines (CCLE)

* CCLE gene expression data were extracted from CCLE_Expression_Entrez_2012-10-18.res: Gene-centric RMA-normalized mRNA expression data.

Differential Gene Expression in Primary Tumors (TCGA)

* Normalized gene expression data of RNASeqV2 was extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered at Jan-05-2015. Only eight cancer types have enough normal control samples for differential expression analysis.
(t test, adjusted p<0.05 (using Benjamini-Hochberg FDR))

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CNV vs Gene Expression Plot

* This plots show the correlation between CNV and gene expression.

: Open all plots for all cancer types

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Gene-Gene Network Information

Co-Expressed gene's network Plot

* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown.
Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene

: Open all plots for all cancer types


AMD1,BEND3,MMS22L,CCNC,CDK19,GTF3C6,HDAC2, KIAA1804,LTV1,MTHFD1L,NDUFAF4,NUS1,PM20D2,PRKX, REV3L,RPF2,SRPK1,STK38,SYNCRIP,TTK,WDR43	ABCE1,ABHD13,ABI1,AMD1,C5orf28,CBFB,CD47, MAK16,MAPK1IP1L,MRPL42,NUS1,PPHLN1,PRKCI,RNF138, SEH1L,STXBP3,SYNCRIP,TIPRL,TMEM123,TWISTNB,ZNF267

ABCE1,AMD1,ATG5,PARPBP,CCNA2,CCNB1,CCNC, CDK1,CHEK1,DEPDC1B,FBXO5,GSTCD,MAD2L1,MRPL44, NUP37,PPIL1,SRSF3,SRSF7,TFAM,TRA2B,UBE2N	AMD1,BZW1,GSKIP,C20orf24,CHAC2,CHUK,CYB5R4, EIF4E,GTF2A2,HSPA14,MRPL47,PPP2CA,PSMC6,PTS, SLC25A46,SNRPG,TAF13,TXNDC9,UBE2N,UCHL3,USP15

Co-Expressed gene's Protein-protein interaction Network Plot

: Open all plots for all cancer types

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Interacting Genes (from Pathway Commons)

: Open all interacting genes' information including KEGG pathway for all interacting genes from DAVID

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Pharmacological Information for AMD1

Cross-referenced pharmacological DB IDs from Uniprot

DB Category

DB Name

DB's ID and Url link

Drug-Gene Interaction Network

* Gene Centered Interaction Network.

* Drug Centered Interaction Network.

DrugBank ID	Target Name	Drug Groups	Generic Name	Drug Centered Network	Drug Structure
DB00118	adenosylmethionine decarboxylase 1	approved; nutraceutical	S-Adenosylmethionine
DB01917	adenosylmethionine decarboxylase 1	experimental	Putrescine
DB03754	adenosylmethionine decarboxylase 1	experimental	Tris(Hydroxymethyl)Aminomethane
DB08163	adenosylmethionine decarboxylase 1	experimental	5'-{[4-(aminooxy)butyl](methyl)amino}-5'-deoxy-8-ethenyladenosine
DB00134	adenosylmethionine decarboxylase 1	approved; nutraceutical	L-Methionine

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Cross referenced IDs for AMD1

* We obtained these cross-references from Uniprot database. It covers 150 different DBs, 18 categories. http://www.uniprot.org/help/cross_references_section

: Open all cross reference information