|
Phenotypic Information (metabolism pathway, cancer, disease, phenome) | |
Gene-Gene Network Information: Co-Expression Network, Interacting Genes & KEGG | |
Gene Summary for GCG |
Basic gene info. | Gene symbol | GCG |
Gene name | glucagon | |
Synonyms | GLP1|GLP2|GRPP | |
Cytomap | UCSC genome browser: 2q36-q37 | |
Genomic location | chr2 :162999384-163008914 | |
Type of gene | protein-coding | |
RefGenes | NM_002054.4, | |
Ensembl id | ENSG00000115263 | |
Description | glicentin-related polypeptideglucagon-like peptide 1glucagon-like peptide 2preproglucagon | |
Modification date | 20141207 | |
dbXrefs | MIM : 138030 | |
HGNC : HGNC | ||
Ensembl : ENSG00000115263 | ||
HPRD : 00676 | ||
Vega : OTTHUMG00000153892 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_GCG | |
BioGPS: 2641 | ||
Gene Expression Atlas: ENSG00000115263 | ||
The Human Protein Atlas: ENSG00000115263 | ||
Pathway | NCI Pathway Interaction Database: GCG | |
KEGG: GCG | ||
REACTOME: GCG | ||
ConsensusPathDB | ||
Pathway Commons: GCG | ||
Metabolism | MetaCyc: GCG | |
HUMANCyc: GCG | ||
Regulation | Ensembl's Regulation: ENSG00000115263 | |
miRBase: chr2 :162,999,384-163,008,914 | ||
TargetScan: NM_002054 | ||
cisRED: ENSG00000115263 | ||
Context | iHOP: GCG | |
cancer metabolism search in PubMed: GCG | ||
UCL Cancer Institute: GCG | ||
Assigned class in ccmGDB | C |
Top |
Phenotypic Information for GCG(metabolism pathway, cancer, disease, phenome) |
Cancer Description | |
Cancer | CGAP: GCG |
Familial Cancer Database: GCG |
* This gene is included in those cancer gene databases. |
Oncogene 1 | Significant driver gene in |
cf) number; DB name 1 Oncogene; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long, 2 Tumor Suppressor gene; https://bioinfo.uth.edu/TSGene/, 3 Cancer Gene Census; http://www.nature.com/nrc/journal/v4/n3/abs/nrc1299.html, 4 CancerGenes; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long, 5 Network of Cancer Gene; http://ncg.kcl.ac.uk/index.php, 1Therapeutic Vulnerabilities in Cancer; http://cbio.mskcc.org/cancergenomics/statius/ |
Metabolic Pathway Description | |
REACTOME_INTEGRATION_OF_ENERGY_METABOLISM |
Others | |
OMIM | |
Orphanet | |
Disease | KEGG Disease: GCG |
MedGen: GCG (Human Medical Genetics with Condition) | |
ClinVar: GCG | |
Phenotype | MGI: GCG (International Mouse Phenotyping Consortium) |
PhenomicDB: GCG |
Mutations for GCG |
* Under tables are showing count per each tissue to give us broad intuition about tissue specific mutation patterns.You can go to the detailed page for each mutation database's web site. |
Structural Variants in COSMIC: go to COSMIC mutation histogram |
- Statistics for Tissue and Mutation type | Top |
- For Inter-chromosomal Variations |
* Inter-chromosomal variantions includes 'interchromosomal amplicon to amplicon', 'interchromosomal amplicon to non-amplified dna', 'interchromosomal insertion', 'Interchromosomal unknown type'. |
- For Intra-chromosomal Variations |
There's no intra-chromosomal structural variation. |
Sample | Symbol_a | Chr_a | Start_a | End_a | Symbol_b | Chr_b | Start_b | End_b |
prostate | GCG | chr2 | 163001677 | 163001677 | chr7 | 115995325 | 115995325 | |
prostate | GCG | chr2 | 163001686 | 163001686 | chr7 | 124961795 | 124961795 |
cf) Tissue number; Tissue name (1;Breast, 2;Central_nervous_system, 3;Haematopoietic_and_lymphoid_tissue, 4;Large_intestine, 5;Liver, 6;Lung, 7;Ovary, 8;Pancreas, 9;Prostate, 10;Skin, 11;Soft_tissue, 12;Upper_aerodigestive_tract) |
Related fusion transcripts : go to Chitars2.0 |
* From mRNA Sanger sequences, Chitars2.0 arranged chimeric transcripts. This table shows GCG related fusion information. |
ID | Head Gene | Tail Gene | Accession | Gene_a | qStart_a | qEnd_a | Chromosome_a | tStart_a | tEnd_a | Gene_a | qStart_a | qEnd_a | Chromosome_a | tStart_a | tEnd_a |
BE969791 | GCG | 1 | 194 | 2 | 163004002 | 163008737 | CPA1 | 190 | 640 | 7 | 130023244 | 130025148 | |
AW582982 | GCG | 1 | 63 | 2 | 163000615 | 163000677 | GCG | 57 | 447 | 2 | 162999392 | 162999782 |
Other DBs for Structural Variants |
Top |
Copy Number Variations in COSMIC: go to COSMIC mutation CNV/Expr |
There's no copy number variation information in COSMIC data for this gene. |
Top |
SNV Counts per Each Loci in COSMIC data: go to COSMIC point mutation |
|
Top |
Somatic Mutation Counts per Tissue in COSMIC data |
Stat. for Non-Synonymous SNVs (# total SNVs=30) | (# total SNVs=10) |
(# total SNVs=0) | (# total SNVs=0) |
Top |
Top 10 SNVs Having the Most Samples in COSMIC data |
* When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site,primary_histology,mutation(aa),pubmedID. |
GRCh37 position | Mutation(aa) | Unique sampleID count |
chr2:163003875-163003875 | p.T81I | 2 |
chr2:163003931-163003931 | p.Y62* | 2 |
chr2:163002132-163002132 | p.T104A | 2 |
chr2:163003990-163003990 | p.D43N | 2 |
chr2:163004008-163004009 | p.S36>? | 1 |
chr2:163002043-163002043 | p.? | 1 |
chr2:163004009-163004009 | p.S36S | 1 |
chr2:163002048-163002048 | p.? | 1 |
chr2:163003880-163003880 | p.M79I | 1 |
chr2:163003939-163003939 | p.S60G | 1 |
Top |
SNV Counts per Each Loci in TCGA data |
|
Point Mutation/ Tissue ID | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | 18 | 19 | 20 |
# sample |   |   | 2 | 7 | 1 |   | 1 |   | 1 |   |   | 9 | 3 |   |   | 1 | 5 | 3 |   | 3 |
# mutation |   |   | 2 | 6 | 1 |   | 1 |   | 1 |   |   | 11 | 3 |   |   | 1 | 5 | 3 |   | 3 |
nonsynonymous SNV |   |   | 1 | 4 | 1 |   | 1 |   | 1 |   |   | 6 | 3 |   |   |   | 4 | 3 |   | 3 |
synonymous SNV |   |   | 1 | 2 |   |   |   |   |   |   |   | 5 |   |   |   | 1 | 1 |   |   |   |
cf) Tissue ID; Tissue type (1; BLCA[Bladder Urothelial Carcinoma], 2; BRCA[Breast invasive carcinoma], 3; CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], 4; COAD[Colon adenocarcinoma], 5; GBM[Glioblastoma multiforme], 6; Glioma Low Grade, 7; HNSC[Head and Neck squamous cell carcinoma], 8; KICH[Kidney Chromophobe], 9; KIRC[Kidney renal clear cell carcinoma], 10; KIRP[Kidney renal papillary cell carcinoma], 11; LAML[Acute Myeloid Leukemia], 12; LUAD[Lung adenocarcinoma], 13; LUSC[Lung squamous cell carcinoma], 14; OV[Ovarian serous cystadenocarcinoma ], 15; PAAD[Pancreatic adenocarcinoma], 16; PRAD[Prostate adenocarcinoma], 17; SKCM[Skin Cutaneous Melanoma], 18:STAD[Stomach adenocarcinoma], 19:THCA[Thyroid carcinoma], 20:UCEC[Uterine Corpus Endometrial Carcinoma]) |
Top |
Top 10 SNVs Having the Most Samples in TCGA data |
* We represented just top 10 SNVs. When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site, primary_histology, mutation(aa), pubmedID. |
Genomic Position | Mutation(aa) | Unique sampleID count |
chr2:163003950 | p.G56D | 2 |
chr2:163003990 | p.D43Y | 2 |
chr2:163002070 | p.Q37P | 1 |
chr2:163003923 | p.T104T | 1 |
chr2:163004015 | p.Q37K | 1 |
chr2:163002098 | p.E96Q | 1 |
chr2:163003939 | p.S36S | 1 |
chr2:163005628 | p.H92H | 1 |
chr2:163002103 | p.S34S | 1 |
chr2:163003945 | p.R83S | 1 |
Other DBs for Point Mutations |
Copy Number for GCG in TCGA |
* Copy number data were extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered on Jan-05-2015. Function ProcessCNAData in TCGA-Assembler package was used to obtain gene-level copy number value which is calculated as the average copy number of the genomic region of a gene. |
cf) Tissue ID[Tissue type]: BLCA[Bladder Urothelial Carcinoma], BRCA[Breast invasive carcinoma], CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], COAD[Colon adenocarcinoma], GBM[Glioblastoma multiforme], Glioma Low Grade, HNSC[Head and Neck squamous cell carcinoma], KICH[Kidney Chromophobe], KIRC[Kidney renal clear cell carcinoma], KIRP[Kidney renal papillary cell carcinoma], LAML[Acute Myeloid Leukemia], LUAD[Lung adenocarcinoma], LUSC[Lung squamous cell carcinoma], OV[Ovarian serous cystadenocarcinoma ], PAAD[Pancreatic adenocarcinoma], PRAD[Prostate adenocarcinoma], SKCM[Skin Cutaneous Melanoma], STAD[Stomach adenocarcinoma], THCA[Thyroid carcinoma], UCEC[Uterine Corpus Endometrial Carcinoma] |
Top |
Gene Expression for GCG |
Gene Expression in Cancer Cell-lines (CCLE) |
* CCLE gene expression data were extracted from CCLE_Expression_Entrez_2012-10-18.res: Gene-centric RMA-normalized mRNA expression data. |
Differential Gene Expression in Primary Tumors (TCGA) |
* Normalized gene expression data of RNASeqV2 was extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered at Jan-05-2015. Only eight cancer types have enough normal control samples for differential expression analysis. (t test, adjusted p<0.05 (using Benjamini-Hochberg FDR)) |
Top |
CNV vs Gene Expression Plot |
* This plots show the correlation between CNV and gene expression. |
Top |
Gene-Gene Network Information |
Co-Expressed gene's network Plot |
* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown. Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene |
BHLHE23,URI1,C1orf61,C1QL2,AGO2,FBXW10,GALR2, GCGR,GCNT3,GJB6,GPR12,KRT77,LOC642929,MAL, OR4B1,PCDHB17,PGLYRP3,PLEKHF1,PRB2,RHCG,SLC9A3 | AICDA,LINC00293,CACNG2,DAZL,FCAMR,GCGR,H1FOO, LOC283663,NEUROG1,OR5B3,OR8G2,OR8I2,OR8K1,PRNT, RLTPR,SERPINA9,TCL1A,TEX11,SYNDIG1L,ZC3H12D,ZNF679 |
A1BG,CCDC154,CDK3,FAM153A,FGF17,GABBR1,GCGR, HOXA2,HOXA3,HSP90AB4P,LOC146880,LOC25845,LOC339535,MAPK7, LINC00685,NXNL2,PLIN5,RNF112,SNORA11E,TMEM11,YJEFN3 | ARPP21,LINC00596,SCP2D1,CLDN6,CNGB1,CPLX2,GCGR, HELT,IFI44L,KCNK2,LINC01105,MCHR2,PEG3-AS1,PFN3, SNORA4,SNORA64,SNORA74A,tAKR,TMEM151B,USP26,VIP |
Co-Expressed gene's Protein-protein interaction Network Plot |
* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown. Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene |
Top |
Interacting Genes (from Pathway Commons) |
Top |
Pharmacological Information for GCG |
There's no related Drug. |
Top |
Cross referenced IDs for GCG |
* We obtained these cross-references from Uniprot database. It covers 150 different DBs, 18 categories. http://www.uniprot.org/help/cross_references_section |
Copyright © 2016-Present - The Univsersity of Texas Health Science Center at Houston @ |