Cancer Cell Metabolism Database ~~ Bioinformatics and Systems Medicine Laboratory ~~

Cancer Cell Metabolism Gene Database

Cancer Cell Metabolism Gene DB

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	Gene Summary
	Phenotypic Information (metabolism pathway, cancer, disease, phenome)
	Mutations : SVs, CNVs, SNVs
	Gene expression: GE, Protein, DEGE, CNV vs GE
	Gene-Gene Network Information: Co-Expression Network, Interacting Genes & KEGG
	Pharmacological Information: Drug-Gene Network
	Cross referenced IDs

Gene Summary for GFER

Basic gene info.	Gene symbol	GFER
	Gene name	growth factor, augmenter of liver regeneration
	Synonyms	ALR\|ERV1\|HERV1\|HPO\|HPO1\|HPO2\|HSS
	Cytomap	UCSC genome browser: 16p13.3-p13.12
	Genomic location	chr16 :2034149-2037750
	Type of gene	protein-coding
	RefGenes	NM_005262.2,
	Ensembl id	ENSG00000127554
	Description	ERV1 homologFAD-linked sulfhydryl oxidase ALRerv1-like growth factorhepatic regenerative stimulation substancehepatopoietin protein
	Modification date	20141207
dbXrefs	MIM : 600924
	HGNC : HGNC
	Ensembl : ENSG00000127554
	HPRD : 02954
	Vega : OTTHUMG00000176896
Protein	UniProt: go to UniProt's Cross Reference DB Table
Expression	CleanEX: HS_GFER
	BioGPS: 2671
	Gene Expression Atlas: ENSG00000127554
	The Human Protein Atlas: ENSG00000127554
Pathway	NCI Pathway Interaction Database: GFER
	KEGG: GFER
	REACTOME: GFER
	ConsensusPathDB
	Pathway Commons: GFER
Metabolism	MetaCyc: GFER
	HUMANCyc: GFER
Regulation	Ensembl's Regulation: ENSG00000127554
	miRBase: chr16 :2,034,149-2,037,750
	TargetScan: NM_005262
	cisRED: ENSG00000127554
Context	iHOP: GFER
	cancer metabolism search in PubMed: GFER
	UCL Cancer Institute: GFER
Assigned class in ccmGDB	C

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Phenotypic Information for GFER(metabolism pathway, cancer, disease, phenome)

Cancer Description
Cancer	CGAP: GFER
	Familial Cancer Database: GFER

* This gene is included in those cancer gene databases.

						.
Oncogene ¹	Tumor Suppressor gene ²	Cancer Gene Census ³	CancerGenes ⁴	Network of Cancer Gene ⁵	Significant driver gene in	Therapeutic Vulnerabilities in Cancer¹

cf) number; DB name
1 Oncogene; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long,
2 Tumor Suppressor gene; https://bioinfo.uth.edu/TSGene/,
3 Cancer Gene Census; http://www.nature.com/nrc/journal/v4/n3/abs/nrc1299.html,
4 CancerGenes; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long,
5 Network of Cancer Gene; http://ncg.kcl.ac.uk/index.php,
1Therapeutic Vulnerabilities in Cancer; http://cbio.mskcc.org/cancergenomics/statius/

Metabolic Pathway Description
REACTOME_METABOLISM_OF_PROTEINS

Others
OMIM
Orphanet
Disease	KEGG Disease: GFER
	MedGen: GFER (Human Medical Genetics with Condition)
	ClinVar: GFER
Phenotype	MGI: GFER (International Mouse Phenotyping Consortium)
Phenotype	PhenomicDB: GFER

Mutations for GFER

* Under tables are showing count per each tissue to give us broad intuition about tissue specific mutation patterns.You can go to the detailed page for each mutation database's web site.

Structural Variants in COSMIC : go to COSMIC mutation histogram

- Statistics for Tissue and Mutation type

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- For Inter-chromosomal Variations

There's no inter-chromosomal structural variation.

- For Intra-chromosomal Variations

There's no intra-chromosomal structural variation.

Sample

Symbol_a

Chr_a

Start_a

End_a

Symbol_b

Chr_b

Start_b

End_b

cf) Tissue number; Tissue name (1;Breast, 2;Central_nervous_system, 3;Haematopoietic_and_lymphoid_tissue, 4;Large_intestine, 5;Liver, 6;Lung, 7;Ovary, 8;Pancreas, 9;Prostate, 10;Skin, 11;Soft_tissue, 12;Upper_aerodigestive_tract)

Related fusion transcripts : go to Chitars2.0

* From mRNA Sanger sequences, Chitars2.0 arranged chimeric transcripts. This table shows GFER related fusion information.

Head Gene

Tail Gene

Accession

Gene_a

qStart_a

qEnd_a

Chromosome_a

tStart_a

tEnd_a

Gene_a

qStart_a

qEnd_a

Chromosome_a

tStart_a

tEnd_a

Other DBs for Structural Variants

Structural Variants in Ensembl: go to Ensembl Structural variation

Structural Variants in dbVar: go to dbVar

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Copy Number Variations in COSMIC : go to COSMIC mutation CNV/Expr

There's no copy number variation information in COSMIC data for this gene.

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SNV Counts per Each Loci in COSMIC data : go to COSMIC point mutation

: Non-synonymous mutation, : Synonymous mutation, Circle size denotes number of samples.
Maximum mutation count=3

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Somatic Mutation Counts per Tissue in COSMIC data

Stat. for Non-Synonymous SNVs (# total SNVs=9)	Stat. for Synonymous SNVs (# total SNVs=3)

Stat. for Deletions (# total SNVs=0)	Stat. for Insertions (# total SNVs=0)
There's no deleted snv.	There's no inserted snv.

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Top 10 SNVs Having the Most Samples in COSMIC data

* When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site,primary_histology,mutation(aa),pubmedID.

GRCh37 position	Mutation(aa)	Unique sampleID count
chr16:2035969-2035969	p.F186F	2
chr16:2035898-2035898	p.R163W	1
chr16:2035934-2035934	p.N175H	1
chr16:2035935-2035935	p.N175S	1
chr16:2035946-2035946	p.R179S	1
chr16:2035967-2035967	p.F186I	1
chr16:2034418-2034418	p.R67G	1
chr16:2034434-2034434	p.R72L	1
chr16:2036007-2036007	p.W199L	1
chr16:2034767-2034767	p.E93G	1

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SNV Counts per Each Loci in TCGA data

: non-synonymous mutation, : synonymous mutation, Circle size denotes number of samples.
maximum mutation count=3

Point Mutation/ Tissue ID	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20
# sample				1					1	1		2	1				1	1		2
# mutation				1					1	2		2	1				1	1		2
nonsynonymous SNV										2		2	1				1	1		1
synonymous SNV				1					1											1

cf) Tissue ID; Tissue type (1; BLCA[Bladder Urothelial Carcinoma], 2; BRCA[Breast invasive carcinoma], 3; CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], 4; COAD[Colon adenocarcinoma], 5; GBM[Glioblastoma multiforme], 6; Glioma Low Grade, 7; HNSC[Head and Neck squamous cell carcinoma], 8; KICH[Kidney Chromophobe], 9; KIRC[Kidney renal clear cell carcinoma], 10; KIRP[Kidney renal papillary cell carcinoma], 11; LAML[Acute Myeloid Leukemia], 12; LUAD[Lung adenocarcinoma], 13; LUSC[Lung squamous cell carcinoma], 14; OV[Ovarian serous cystadenocarcinoma ], 15; PAAD[Pancreatic adenocarcinoma], 16; PRAD[Prostate adenocarcinoma], 17; SKCM[Skin Cutaneous Melanoma], 18:STAD[Stomach adenocarcinoma], 19:THCA[Thyroid carcinoma], 20:UCEC[Uterine Corpus Endometrial Carcinoma])

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Top 10 SNVs Having the Most Samples in TCGA data

* We represented just top 10 SNVs. When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site, primary_histology, mutation(aa), pubmedID.

Genomic Position	Mutation(aa)	Unique sampleID count
chr16:2035969	p.F186F	2
chr16:2035946	p.E193A	1
chr16:2035967	p.L153L	1
chr16:2035989	p.R161S	1
chr16:2035868	p.T162I	1
chr16:2035892	p.R163W	1
chr16:2035896	p.N175H	1
chr16:2035898	p.N175S	1
chr16:2035934	p.R179S	1
chr16:2035935	p.F186I	1

Other DBs for Point Mutations

Point Mutation Table of Ensembl: go to Ensembl variation table

Mutation of cBioPortal: go to cBioPortal's Cross-cancer alteration summary

Copy Number for GFER in TCGA

* Copy number data were extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered on Jan-05-2015. Function ProcessCNAData in TCGA-Assembler package was used to obtain gene-level copy number value which is calculated as the average copy number of the genomic region of a gene.

cf) Tissue ID[Tissue type]: BLCA[Bladder Urothelial Carcinoma], BRCA[Breast invasive carcinoma], CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], COAD[Colon adenocarcinoma], GBM[Glioblastoma multiforme], Glioma Low Grade, HNSC[Head and Neck squamous cell carcinoma], KICH[Kidney Chromophobe], KIRC[Kidney renal clear cell carcinoma], KIRP[Kidney renal papillary cell carcinoma], LAML[Acute Myeloid Leukemia], LUAD[Lung adenocarcinoma], LUSC[Lung squamous cell carcinoma], OV[Ovarian serous cystadenocarcinoma ], PAAD[Pancreatic adenocarcinoma], PRAD[Prostate adenocarcinoma], SKCM[Skin Cutaneous Melanoma], STAD[Stomach adenocarcinoma], THCA[Thyroid carcinoma], UCEC[Uterine Corpus Endometrial Carcinoma]

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Gene Expression for GFER

Gene Expression in Cancer Cell-lines (CCLE)

* CCLE gene expression data were extracted from CCLE_Expression_Entrez_2012-10-18.res: Gene-centric RMA-normalized mRNA expression data.

Differential Gene Expression in Primary Tumors (TCGA)

* Normalized gene expression data of RNASeqV2 was extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered at Jan-05-2015. Only eight cancer types have enough normal control samples for differential expression analysis.
(t test, adjusted p<0.05 (using Benjamini-Hochberg FDR))

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CNV vs Gene Expression Plot

* This plots show the correlation between CNV and gene expression.

: Open all plots for all cancer types

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Gene-Gene Network Information

Co-Expressed gene's network Plot

* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown.
Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene

: Open all plots for all cancer types


TSR3,CD2BP2,ECI1,FAM173A,FAM195A,FLYWCH2,GFER, JMJD8,MLST8,MPG,MRPL28,MRPS34,NARFL,NDUFB10, NME3,NUBP2,PGP,RHOT2,STUB1,TBL3,ZNF205	ARFRP1,ARL6IP4,UQCC3,TSR3,C17orf59,NELFB,DGCR6L, EDF1,GFER,HRAS,MPG,MRPL28,MRPS34,NTHL1, NUBP2,PRPF31,RPS19BP1,SSNA1,SURF2,WDR83,ZNF688

ATP6V0C,AXIN1,C16orf13,TSR3,CHMP1A,GFER,HAGH, HMOX2,MRPS34,NARFL,NAA60,NDUFB10,NTHL1,NUBP2, RAB40C,RHOT2,RNPS1,SPSB3,STUB1,TCEB2,UBE2I	ACY1,BCL2L1,C11orf52,GUCD1,CCL14-CCL15,CES2,DCAF11, DHRS11,EPS8L2,FAM132A,GFER,GLOD5,KIAA2013,NGEF, RAB17,SLC39A5,STRADB,TMEM120A,TMEM150B,TNNC2,USH1C

Co-Expressed gene's Protein-protein interaction Network Plot

: Open all plots for all cancer types

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Interacting Genes (from Pathway Commons)

: Open all interacting genes' information including KEGG pathway for all interacting genes from DAVID

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Pharmacological Information for GFER

Cross-referenced pharmacological DB IDs from Uniprot

DB Category

DB Name

DB's ID and Url link

Drug-Gene Interaction Network

* Gene Centered Interaction Network.

* Drug Centered Interaction Network.

DrugBank ID	Target Name	Drug Groups	Generic Name	Drug Centered Network	Drug Structure
DB00260	growth factor, augmenter of liver regeneration	approved	Cycloserine
DB01993	growth factor, augmenter of liver regeneration	experimental	N-(5'-Phosphopyridoxyl)-D-Alanine
DB02142	growth factor, augmenter of liver regeneration	experimental	Pyridoxamine-5'-Phosphate
DB03097	growth factor, augmenter of liver regeneration	experimental	Pmp-Hydroxyisoxazole, Pyridoxamine-5-Phosphate-Hydroxyisoxazole
DB03327	growth factor, augmenter of liver regeneration	experimental	{1-[(3-Hydroxy-Methyl-5-Phosphonooxy-Methyl-Pyridin-4-Ylmethyl)-Amino]-Ethyl}-Phosphonic Acid
DB03579	growth factor, augmenter of liver regeneration	experimental	Pyridoxyl-N,O-Cycloserylamide-5-Monophosphate
DB03766	growth factor, augmenter of liver regeneration	experimental	Propanoic Acid
DB03801	growth factor, augmenter of liver regeneration	experimental	Lysine Nz-Carboxylic Acid
DB04467	growth factor, augmenter of liver regeneration	experimental	Pyridoxyl-Alanine-5-Phosphate

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Cross referenced IDs for GFER

* We obtained these cross-references from Uniprot database. It covers 150 different DBs, 18 categories. http://www.uniprot.org/help/cross_references_section

: Open all cross reference information