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Phenotypic Information (metabolism pathway, cancer, disease, phenome) | |
Gene-Gene Network Information: Co-Expression Network, Interacting Genes & KEGG | |
Gene Summary for INPP5J |
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Phenotypic Information for INPP5J(metabolism pathway, cancer, disease, phenome) |
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Cancer | CGAP: INPP5J |
Familial Cancer Database: INPP5J |
* This gene is included in those cancer gene databases. |
Oncogene 1 | Significant driver gene in |
cf) number; DB name 1 Oncogene; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long, 2 Tumor Suppressor gene; https://bioinfo.uth.edu/TSGene/, 3 Cancer Gene Census; http://www.nature.com/nrc/journal/v4/n3/abs/nrc1299.html, 4 CancerGenes; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long, 5 Network of Cancer Gene; http://ncg.kcl.ac.uk/index.php, 1Therapeutic Vulnerabilities in Cancer; http://cbio.mskcc.org/cancergenomics/statius/ |
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KEGG_INOSITOL_PHOSPHATE_METABOLISM REACTOME_PHOSPHOLIPID_METABOLISM REACTOME_PI_METABOLISM REACTOME_METABOLISM_OF_LIPIDS_AND_LIPOPROTEINS |
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OMIM | |
Orphanet | |
Disease | KEGG Disease: INPP5J |
MedGen: INPP5J (Human Medical Genetics with Condition) | |
ClinVar: INPP5J | |
Phenotype | MGI: INPP5J (International Mouse Phenotyping Consortium) |
PhenomicDB: INPP5J |
Mutations for INPP5J |
* Under tables are showing count per each tissue to give us broad intuition about tissue specific mutation patterns.You can go to the detailed page for each mutation database's web site. |
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There's no structural variation information in COSMIC data for this gene. |
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* From mRNA Sanger sequences, Chitars2.0 arranged chimeric transcripts. This table shows INPP5J related fusion information. |
ID | Head Gene | Tail Gene | Accession | Gene_a | qStart_a | qEnd_a | Chromosome_a | tStart_a | tEnd_a | Gene_a | qStart_a | qEnd_a | Chromosome_a | tStart_a | tEnd_a |
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There's no copy number variation information in COSMIC data for this gene. |
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Stat. for Non-Synonymous SNVs (# total SNVs=45) | (# total SNVs=12) |
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(# total SNVs=0) | (# total SNVs=0) |
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* When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site,primary_histology,mutation(aa),pubmedID. |
GRCh37 position | Mutation(aa) | Unique sampleID count |
chr22:31522914-31522914 | p.S134L | 2 |
chr22:31524489-31524489 | p.R314H | 2 |
chr22:31529643-31529643 | p.I452I | 2 |
chr22:31523338-31523338 | p.? | 2 |
chr22:31522468-31522468 | p.A93T | 2 |
chr22:31524557-31524557 | p.Q337* | 2 |
chr22:31523368-31523368 | p.R179H | 2 |
chr22:31523373-31523373 | p.A181T | 1 |
chr22:31529401-31529401 | p.R414C | 1 |
chr22:31530047-31530047 | p.S521I | 1 |
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Point Mutation/ Tissue ID | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | 18 | 19 | 20 |
# sample | 1 | 1 |   | 7 | 2 |   | 4 |   | 2 | 2 |   | 5 | 2 |   |   |   | 8 | 4 |   | 9 |
# mutation | 1 | 1 |   | 8 | 2 |   | 4 |   | 2 | 2 |   | 5 | 3 |   |   |   | 11 | 4 |   | 11 |
nonsynonymous SNV | 1 | 1 |   | 6 | 2 |   | 4 |   | 1 | 2 |   | 3 | 2 |   |   |   | 9 | 1 |   | 9 |
synonymous SNV |   |   |   | 2 |   |   |   |   | 1 |   |   | 2 | 1 |   |   |   | 2 | 3 |   | 2 |
cf) Tissue ID; Tissue type (1; BLCA[Bladder Urothelial Carcinoma], 2; BRCA[Breast invasive carcinoma], 3; CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], 4; COAD[Colon adenocarcinoma], 5; GBM[Glioblastoma multiforme], 6; Glioma Low Grade, 7; HNSC[Head and Neck squamous cell carcinoma], 8; KICH[Kidney Chromophobe], 9; KIRC[Kidney renal clear cell carcinoma], 10; KIRP[Kidney renal papillary cell carcinoma], 11; LAML[Acute Myeloid Leukemia], 12; LUAD[Lung adenocarcinoma], 13; LUSC[Lung squamous cell carcinoma], 14; OV[Ovarian serous cystadenocarcinoma ], 15; PAAD[Pancreatic adenocarcinoma], 16; PRAD[Prostate adenocarcinoma], 17; SKCM[Skin Cutaneous Melanoma], 18:STAD[Stomach adenocarcinoma], 19:THCA[Thyroid carcinoma], 20:UCEC[Uterine Corpus Endometrial Carcinoma]) |
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* We represented just top 10 SNVs. When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site, primary_histology, mutation(aa), pubmedID. |
Genomic Position | Mutation(aa) | Unique sampleID count |
chr22:31529643 | p.I384I,INPP5J | 2 |
chr22:31523364 | p.G374V,INPP5J | 1 |
chr22:31521793 | p.V108M,INPP5J | 1 |
chr22:31524544 | p.R300G,INPP5J | 1 |
chr22:31522449 | p.S409F,INPP5J | 1 |
chr22:31529413 | p.V110M,INPP5J | 1 |
chr22:31523373 | p.A320V,INPP5J | 1 |
chr22:31521797 | p.P421P,INPP5J | 1 |
chr22:31524554 | p.A113T,INPP5J | 1 |
chr22:31522468 | p.M326V,INPP5J | 1 |
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* Copy number data were extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered on Jan-05-2015. Function ProcessCNAData in TCGA-Assembler package was used to obtain gene-level copy number value which is calculated as the average copy number of the genomic region of a gene. |
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cf) Tissue ID[Tissue type]: BLCA[Bladder Urothelial Carcinoma], BRCA[Breast invasive carcinoma], CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], COAD[Colon adenocarcinoma], GBM[Glioblastoma multiforme], Glioma Low Grade, HNSC[Head and Neck squamous cell carcinoma], KICH[Kidney Chromophobe], KIRC[Kidney renal clear cell carcinoma], KIRP[Kidney renal papillary cell carcinoma], LAML[Acute Myeloid Leukemia], LUAD[Lung adenocarcinoma], LUSC[Lung squamous cell carcinoma], OV[Ovarian serous cystadenocarcinoma ], PAAD[Pancreatic adenocarcinoma], PRAD[Prostate adenocarcinoma], SKCM[Skin Cutaneous Melanoma], STAD[Stomach adenocarcinoma], THCA[Thyroid carcinoma], UCEC[Uterine Corpus Endometrial Carcinoma] |
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Gene Expression for INPP5J |
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* CCLE gene expression data were extracted from CCLE_Expression_Entrez_2012-10-18.res: Gene-centric RMA-normalized mRNA expression data. |
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* Normalized gene expression data of RNASeqV2 was extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered at Jan-05-2015. Only eight cancer types have enough normal control samples for differential expression analysis. (t test, adjusted p<0.05 (using Benjamini-Hochberg FDR)) |
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* This plots show the correlation between CNV and gene expression. |
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Gene-Gene Network Information |
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* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown. Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene |
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CCDC157,DEGS2,FAM110B,FBP1,GALNT6,GATA3,INPP5J, KCNJ11,CCDC183,LOC284900,NHLRC4,PATZ1,PHOSPHO2,PLCD4, RAB17,RNF185,RNF215,SFI1,SLC4A8,SYNGR1,XBP1 | ARSG,BBS1,BIK,CARD14,EDARADD,ERBB4,FAM174B, GATA3,INPP5J,LOC100130093,LYPD6B,N4BP3,NAGS,PAK6, PLEKHA6,PSD4,RAP1GAP,RNF43,SALL2,TBX3,TESK2 |
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ACOT8,ANO9,NOL4L,CHN2,ENGASE,FITM2,GSS, GTF2IRD1,INPP5J,LPIN3,MAP1LC3A,NECAB3,PLAGL2,POFUT1, PXMP4,QPRT,R3HDML,RNF43,SLC5A6,STX16,ZSWIM1 | ACY1,ALPI,SOWAHA,TMEM253,CDHR5,CES2,CYP4F12, DGAT1,EDN2,INPP5J,MEP1A,MSRA,MYO1A,OIT3, PCK2,PLA2G12B,PRAP1,SEMA3B,SLC22A4,SLC3A1,TMEM120A |
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* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown. Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene |
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Pharmacological Information for INPP5J |
There's no related Drug. |
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Cross referenced IDs for INPP5J |
* We obtained these cross-references from Uniprot database. It covers 150 different DBs, 18 categories. http://www.uniprot.org/help/cross_references_section |
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