Cancer Cell Metabolism Database ~~ Bioinformatics and Systems Medicine Laboratory ~~

Cancer Cell Metabolism Gene Database

Cancer Cell Metabolism Gene DB

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	Gene Summary
	Phenotypic Information (metabolism pathway, cancer, disease, phenome)
	Mutations : SVs, CNVs, SNVs
	Gene expression: GE, Protein, DEGE, CNV vs GE
	Gene-Gene Network Information: Co-Expression Network, Interacting Genes & KEGG
	Pharmacological Information: Drug-Gene Network
	Cross referenced IDs

Gene Summary for GLA

Basic gene info.	Gene symbol	GLA
	Gene name	galactosidase, alpha
	Synonyms	GALA
	Cytomap	UCSC genome browser: Xq22
	Genomic location	chrX :100652778-100663001
	Type of gene	protein-coding
	RefGenes	NM_000169.2,
	Ensembl id	ENSG00000268815
	Description	agalsidase alfaalpha-D-galactosidase Aalpha-D-galactoside galactohydrolase 1alpha-gal Aalpha-galactosidase Amelibiase
	Modification date	20141219
dbXrefs	MIM : 300644
	HGNC : HGNC
	Ensembl : ENSG00000102393
	HPRD : 02357
	Vega : OTTHUMG00000022026
Protein	UniProt: P06280 go to UniProt's Cross Reference DB Table
Expression	CleanEX: HS_GLA
	BioGPS: 2717
	Gene Expression Atlas: ENSG00000268815
	The Human Protein Atlas: ENSG00000268815
Pathway	NCI Pathway Interaction Database: GLA
	KEGG: GLA
	REACTOME: GLA
	ConsensusPathDB
	Pathway Commons: GLA
Metabolism	MetaCyc: GLA
	HUMANCyc: GLA
Regulation	Ensembl's Regulation: ENSG00000268815
	miRBase: chrX :100,652,778-100,663,001
	TargetScan: NM_000169
	cisRED: ENSG00000268815
Context	iHOP: GLA
	cancer metabolism search in PubMed: GLA
	UCL Cancer Institute: GLA
Assigned class in ccmGDB	B - This gene belongs to cancer gene.

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Phenotypic Information for GLA(metabolism pathway, cancer, disease, phenome)

Cancer Description
Cancer	CGAP: GLA
	Familial Cancer Database: GLA

* This gene is included in those cancer gene databases.

						.
Oncogene ¹	Tumor Suppressor gene ²	Cancer Gene Census ³	CancerGenes ⁴	Network of Cancer Gene ⁵	Significant driver gene in	Therapeutic Vulnerabilities in Cancer¹

cf) number; DB name
1 Oncogene; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long,
2 Tumor Suppressor gene; https://bioinfo.uth.edu/TSGene/,
3 Cancer Gene Census; http://www.nature.com/nrc/journal/v4/n3/abs/nrc1299.html,
4 CancerGenes; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long,
5 Network of Cancer Gene; http://ncg.kcl.ac.uk/index.php,
1Therapeutic Vulnerabilities in Cancer; http://cbio.mskcc.org/cancergenomics/statius/

Metabolic Pathway Description
KEGG_GALACTOSE_METABOLISM KEGG_GLYCEROLIPID_METABOLISM KEGG_SPHINGOLIPID_METABOLISM REACTOME_GLYCOSPHINGOLIPID_METABOLISM REACTOME_PHOSPHOLIPID_METABOLISM REACTOME_SPHINGOLIPID_METABOLISM REACTOME_METABOLISM_OF_LIPIDS_AND_LIPOPROTEINS

Others
OMIM	300644; gene. 301500; phenotype.
Orphanet	324; Fabry disease.
Disease	KEGG Disease: GLA
	MedGen: GLA (Human Medical Genetics with Condition)
	ClinVar: GLA
Phenotype	MGI: GLA (International Mouse Phenotyping Consortium)
Phenotype	PhenomicDB: GLA

Mutations for GLA

* Under tables are showing count per each tissue to give us broad intuition about tissue specific mutation patterns.You can go to the detailed page for each mutation database's web site.

Structural Variants in COSMIC : go to COSMIC mutation histogram

There's no structural variation information in COSMIC data for this gene.

Related fusion transcripts : go to Chitars2.0

* From mRNA Sanger sequences, Chitars2.0 arranged chimeric transcripts. This table shows GLA related fusion information.

Head Gene

Tail Gene

Accession

Gene_a

qStart_a

qEnd_a

Chromosome_a

tStart_a

tEnd_a

Gene_a

qStart_a

qEnd_a

Chromosome_a

tStart_a

tEnd_a

Other DBs for Structural Variants

Structural Variants in Ensembl: go to Ensembl Structural variation

Structural Variants in dbVar: go to dbVar

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Copy Number Variations in COSMIC : go to COSMIC mutation CNV/Expr

There's no copy number variation information in COSMIC data for this gene.

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SNV Counts per Each Loci in COSMIC data : go to COSMIC point mutation

: Non-synonymous mutation, : Synonymous mutation, Circle size denotes number of samples.
Maximum mutation count=2

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Somatic Mutation Counts per Tissue in COSMIC data

Stat. for Non-Synonymous SNVs (# total SNVs=44)	Stat. for Synonymous SNVs (# total SNVs=5)

Stat. for Deletions (# total SNVs=0)	Stat. for Insertions (# total SNVs=0)
There's no deleted snv.	There's no inserted snv.

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Top 10 SNVs Having the Most Samples in COSMIC data

* When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site,primary_histology,mutation(aa),pubmedID.

GRCh37 position	Mutation(aa)	Unique sampleID count
chr23:100656792-100656792	p.H125Q	2
chr23:100652899-100652899	p.F396L	2
chr23:100652873-100652873	p.S405I	1
chr23:100662714-100662714	p.P60S	1
chr23:100653434-100653434	p.K308R	1
chr23:100653895-100653895	p.R227*	1
chr23:100658816-100658816	p.R118C	1
chr23:100652887-100652887	p.T400T	1
chr23:100662732-100662732	p.L54I	1
chr23:100653447-100653447	p.S304C	1

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SNV Counts per Each Loci in TCGA data

: non-synonymous mutation, : synonymous mutation, Circle size denotes number of samples.
maximum mutation count=2

Point Mutation/ Tissue ID	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20
# sample		2	1	6			2		2			6	4				1	2		8
# mutation		2	1	7			2		2			6	4				1	2		10
nonsynonymous SNV		2	1	6			2		2			5	3				1			7
synonymous SNV				1								1	1					2		3

cf) Tissue ID; Tissue type (1; BLCA[Bladder Urothelial Carcinoma], 2; BRCA[Breast invasive carcinoma], 3; CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], 4; COAD[Colon adenocarcinoma], 5; GBM[Glioblastoma multiforme], 6; Glioma Low Grade, 7; HNSC[Head and Neck squamous cell carcinoma], 8; KICH[Kidney Chromophobe], 9; KIRC[Kidney renal clear cell carcinoma], 10; KIRP[Kidney renal papillary cell carcinoma], 11; LAML[Acute Myeloid Leukemia], 12; LUAD[Lung adenocarcinoma], 13; LUSC[Lung squamous cell carcinoma], 14; OV[Ovarian serous cystadenocarcinoma ], 15; PAAD[Pancreatic adenocarcinoma], 16; PRAD[Prostate adenocarcinoma], 17; SKCM[Skin Cutaneous Melanoma], 18:STAD[Stomach adenocarcinoma], 19:THCA[Thyroid carcinoma], 20:UCEC[Uterine Corpus Endometrial Carcinoma])

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Top 10 SNVs Having the Most Samples in TCGA data

* We represented just top 10 SNVs. When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site, primary_histology, mutation(aa), pubmedID.

Genomic Position	Mutation(aa)	Unique sampleID count
chrX:100652899	p.F396L	2
chrX:100658854	p.E251E	1
chrX:100662806	p.D93H	1
chrX:100653405	p.W236C	1
chrX:100655663	p.Y88Y	1
chrX:100658859	p.Q212E	1
chrX:100662836	p.G80V	1
chrX:100653424	p.P210P	1
chrX:100655688	p.S65G	1
chrX:100658873	p.C202Y	1

Other DBs for Point Mutations

Point Mutation Table of Ensembl: go to Ensembl variation table

Mutation of cBioPortal: go to cBioPortal's Cross-cancer alteration summary

Copy Number for GLA in TCGA

* Copy number data were extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered on Jan-05-2015. Function ProcessCNAData in TCGA-Assembler package was used to obtain gene-level copy number value which is calculated as the average copy number of the genomic region of a gene.

cf) Tissue ID[Tissue type]: BLCA[Bladder Urothelial Carcinoma], BRCA[Breast invasive carcinoma], CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], COAD[Colon adenocarcinoma], GBM[Glioblastoma multiforme], Glioma Low Grade, HNSC[Head and Neck squamous cell carcinoma], KICH[Kidney Chromophobe], KIRC[Kidney renal clear cell carcinoma], KIRP[Kidney renal papillary cell carcinoma], LAML[Acute Myeloid Leukemia], LUAD[Lung adenocarcinoma], LUSC[Lung squamous cell carcinoma], OV[Ovarian serous cystadenocarcinoma ], PAAD[Pancreatic adenocarcinoma], PRAD[Prostate adenocarcinoma], SKCM[Skin Cutaneous Melanoma], STAD[Stomach adenocarcinoma], THCA[Thyroid carcinoma], UCEC[Uterine Corpus Endometrial Carcinoma]

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Gene Expression for GLA

Gene Expression in Cancer Cell-lines (CCLE)

* CCLE gene expression data were extracted from CCLE_Expression_Entrez_2012-10-18.res: Gene-centric RMA-normalized mRNA expression data.

Differential Gene Expression in Primary Tumors (TCGA)

* Normalized gene expression data of RNASeqV2 was extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered at Jan-05-2015. Only eight cancer types have enough normal control samples for differential expression analysis.
(t test, adjusted p<0.05 (using Benjamini-Hochberg FDR))

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CNV vs Gene Expression Plot

* This plots show the correlation between CNV and gene expression.

: Open all plots for all cancer types

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Gene-Gene Network Information

Co-Expressed gene's network Plot

* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown.
Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene

: Open all plots for all cancer types


ARMCX1,ARMCX3,CLIC6,CYP2C8,FUT8,GLA,GLUL, HNRNPH2,LOC645431,LRIG1,MREG,MYB,MYBPC1,NMUR2, NXNL2,PDCD4,PTHLH,RUNX1,SEMA3C,SGK223,TMEM26	ACMSD,AGR3,CLPSL2,CHST8,DEGS2,GLA,HSPA5, KCNK6,MTFP1,LINC00160,NLRP5,PVRL2,SCARNA22,SEC14L2, SERPINA11,SERPINA1,SERPINA3,SIAH2,SLC9A3R1,SNORA78,TMC3

APEX2,CXorf40B,EMD,FTSJ1,GLA,HDAC8,LAS1L, MORF4L2,NAA10,NKRF,NSDHL,PDZD11,PRPS1,RBMX2, SLC25A14,SLC25A5,SUV39H1,TIMM8A,UBE2A,UBL4A,VBP1	ABHD6,AKR1A1,ANPEP,ANXA4,APOBEC1,ARG2,FUOM, TMEM256,RTCB,IDNK,CA13,CBR1,FAM3B,GCHFR, GK,GK3P,GLA,GLRX,GOLT1A,HOXC9,MOCOS

Co-Expressed gene's Protein-protein interaction Network Plot

: Open all plots for all cancer types

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Interacting Genes (from Pathway Commons)

: Open all interacting genes' information including KEGG pathway for all interacting genes from DAVID

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Pharmacological Information for GLA

Cross-referenced pharmacological DB IDs from Uniprot

DB Category	DB Name	DB's ID and Url link
Chemistry	BindingDB	P06280; -.
Chemistry	ChEMBL	CHEMBL2524; -.
Organism-specific databases	PharmGKB	PA28707; -.
Organism-specific databases	CTD	2717; -.

Drug-Gene Interaction Network

* Gene Centered Interaction Network.

* Drug Centered Interaction Network.

DrugBank ID	Target Name	Drug Groups	Generic Name	Drug Centered Network	Drug Structure
DB02944	galactosidase, alpha	experimental	Alpha-D-Mannose

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Cross referenced IDs for GLA

* We obtained these cross-references from Uniprot database. It covers 150 different DBs, 18 categories. http://www.uniprot.org/help/cross_references_section

: Open all cross reference information