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Phenotypic Information (metabolism pathway, cancer, disease, phenome) | |
Gene-Gene Network Information: Co-Expression Network, Interacting Genes & KEGG | |
Gene Summary for GLUL |
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Phenotypic Information for GLUL(metabolism pathway, cancer, disease, phenome) |
Cancer Description | |
Cancer | CGAP: GLUL |
Familial Cancer Database: GLUL |
* This gene is included in those cancer gene databases. |
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Oncogene 1 | Significant driver gene in |
cf) number; DB name 1 Oncogene; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long, 2 Tumor Suppressor gene; https://bioinfo.uth.edu/TSGene/, 3 Cancer Gene Census; http://www.nature.com/nrc/journal/v4/n3/abs/nrc1299.html, 4 CancerGenes; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long, 5 Network of Cancer Gene; http://ncg.kcl.ac.uk/index.php, 1Therapeutic Vulnerabilities in Cancer; http://cbio.mskcc.org/cancergenomics/statius/ |
Metabolic Pathway Description | |
KEGG_ALANINE_ASPARTATE_AND_GLUTAMATE_METABOLISM KEGG_ARGININE_AND_PROLINE_METABOLISM KEGG_NITROGEN_METABOLISM REACTOME_METABOLISM_OF_AMINO_ACIDS_AND_DERIVATIVES |
Others | |
OMIM | |
Orphanet | |
Disease | KEGG Disease: GLUL |
MedGen: GLUL (Human Medical Genetics with Condition) | |
ClinVar: GLUL | |
Phenotype | MGI: GLUL (International Mouse Phenotyping Consortium) |
PhenomicDB: GLUL |
Mutations for GLUL |
* Under tables are showing count per each tissue to give us broad intuition about tissue specific mutation patterns.You can go to the detailed page for each mutation database's web site. |
Structural Variants in COSMIC: go to COSMIC mutation histogram |
There's no structural variation information in COSMIC data for this gene. |
Related fusion transcripts : go to Chitars2.0 |
* From mRNA Sanger sequences, Chitars2.0 arranged chimeric transcripts. This table shows GLUL related fusion information. |
ID | Head Gene | Tail Gene | Accession | Gene_a | qStart_a | qEnd_a | Chromosome_a | tStart_a | tEnd_a | Gene_a | qStart_a | qEnd_a | Chromosome_a | tStart_a | tEnd_a |
AW352004 | GLUL | 27 | 318 | 1 | 182355437 | 182357735 | GLUL | 308 | 393 | 1 | 182353773 | 182353858 | |
CB322028 | MTIF2 | 17 | 186 | 2 | 55463756 | 55463925 | GLUL | 182 | 636 | 1 | 182353606 | 182354693 | |
DA275818 | WDR74 | 1 | 102 | 11 | 62609180 | 62609281 | GLUL | 103 | 567 | 1 | 182353265 | 182353729 | |
BF988852 | GLUL | 1 | 145 | 1 | 182353060 | 182353204 | GLUL | 137 | 244 | 1 | 182352944 | 182353051 | |
BE765952 | GLUL | 2 | 78 | 1 | 182352479 | 182352556 | SLC24A2 | 76 | 149 | 9 | 19509220 | 19509293 | |
AV650942 | SERP1 | 1 | 399 | 3 | 150299506 | 150301991 | GLUL | 389 | 598 | 1 | 182353126 | 182353336 | |
AA581184 | GLUL | 1 | 62 | 1 | 182352164 | 182352225 | GLUL | 58 | 166 | 1 | 182352045 | 182352153 | |
AW579277 | PROS1 | 1 | 237 | 3 | 93678727 | 93678963 | GLUL | 231 | 294 | 1 | 182353484 | 182353547 | |
BF932728 | RUFY1 | 8 | 65 | 5 | 178993286 | 178993345 | GLUL | 58 | 237 | 1 | 182358989 | 182359169 | |
BE765994 | GLUL | 1 | 75 | 1 | 182352482 | 182352556 | SLC24A2 | 74 | 148 | 9 | 19509220 | 19509294 | |
W27933 | GLUL | 40 | 214 | 1 | 182352976 | 182353150 | GLUL | 206 | 361 | 1 | 182357785 | 182360867 | |
BF925573 | GRAMD3 | 23 | 402 | 5 | 125827042 | 125827422 | GLUL | 388 | 481 | 1 | 182352164 | 182352256 | |
AW168573 | ART3 | 1 | 80 | 4 | 76942273 | 76942352 | GLUL | 74 | 134 | 1 | 182352031 | 182352091 |
Other DBs for Structural Variants |
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Copy Number Variations in COSMIC: go to COSMIC mutation CNV/Expr |
There's no copy number variation information in COSMIC data for this gene. |
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SNV Counts per Each Loci in COSMIC data: go to COSMIC point mutation |
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Somatic Mutation Counts per Tissue in COSMIC data |
Stat. for Non-Synonymous SNVs (# total SNVs=33) | (# total SNVs=13) |
(# total SNVs=0) | (# total SNVs=0) |
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Top 10 SNVs Having the Most Samples in COSMIC data |
* When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site,primary_histology,mutation(aa),pubmedID. |
GRCh37 position | Mutation(aa) | Unique sampleID count |
chr1:182356408-182356408 | p.F62F | 2 |
chr1:182354926-182354926 | p.A191V | 2 |
chr1:182353655-182353655 | p.Y336C | 2 |
chr1:182356278-182356278 | p.R106* | 2 |
chr1:182356326-182356326 | p.R90C | 2 |
chr1:182354584-182354584 | p.T237T | 1 |
chr1:182353624-182353624 | p.C346C | 1 |
chr1:182355457-182355457 | p.Y137H | 1 |
chr1:182353708-182353708 | p.N318N | 1 |
chr1:182354634-182354634 | p.A221T | 1 |
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SNV Counts per Each Loci in TCGA data |
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Point Mutation/ Tissue ID | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | 18 | 19 | 20 |
# sample |   | 1 |   | 7 | 1 |   | 1 |   | 1 | 1 |   | 5 | 4 | 1 | 1 |   | 3 | 6 |   | 7 |
# mutation |   | 1 |   | 6 | 1 |   | 1 |   | 1 | 1 |   | 5 | 4 | 1 | 1 |   | 3 | 7 |   | 9 |
nonsynonymous SNV |   |   |   | 4 | 1 |   | 1 |   | 1 | 1 |   | 2 | 4 | 1 |   |   | 2 | 6 |   | 5 |
synonymous SNV |   | 1 |   | 2 |   |   |   |   |   |   |   | 3 |   |   | 1 |   | 1 | 1 |   | 4 |
cf) Tissue ID; Tissue type (1; BLCA[Bladder Urothelial Carcinoma], 2; BRCA[Breast invasive carcinoma], 3; CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], 4; COAD[Colon adenocarcinoma], 5; GBM[Glioblastoma multiforme], 6; Glioma Low Grade, 7; HNSC[Head and Neck squamous cell carcinoma], 8; KICH[Kidney Chromophobe], 9; KIRC[Kidney renal clear cell carcinoma], 10; KIRP[Kidney renal papillary cell carcinoma], 11; LAML[Acute Myeloid Leukemia], 12; LUAD[Lung adenocarcinoma], 13; LUSC[Lung squamous cell carcinoma], 14; OV[Ovarian serous cystadenocarcinoma ], 15; PAAD[Pancreatic adenocarcinoma], 16; PRAD[Prostate adenocarcinoma], 17; SKCM[Skin Cutaneous Melanoma], 18:STAD[Stomach adenocarcinoma], 19:THCA[Thyroid carcinoma], 20:UCEC[Uterine Corpus Endometrial Carcinoma]) |
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Top 10 SNVs Having the Most Samples in TCGA data |
* We represented just top 10 SNVs. When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site, primary_histology, mutation(aa), pubmedID. |
Genomic Position | Mutation(aa) | Unique sampleID count |
chr1:182353767 | p.A191V,GLUL | 2 |
chr1:182354926 | p.R299C,GLUL | 2 |
chr1:182354990 | p.T2P,GLUL | 1 |
chr1:182353664 | p.P326R,GLUL | 1 |
chr1:182356423 | p.R324C,GLUL | 1 |
chr1:182353819 | p.V176M,GLUL | 1 |
chr1:182355001 | p.A321T,GLUL | 1 |
chr1:182353670 | p.A170S,GLUL | 1 |
chr1:182357774 | p.S320S,GLUL | 1 |
chr1:182354539 | p.G166E,GLUL | 1 |
Other DBs for Point Mutations |
Copy Number for GLUL in TCGA |
* Copy number data were extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered on Jan-05-2015. Function ProcessCNAData in TCGA-Assembler package was used to obtain gene-level copy number value which is calculated as the average copy number of the genomic region of a gene. |
cf) Tissue ID[Tissue type]: BLCA[Bladder Urothelial Carcinoma], BRCA[Breast invasive carcinoma], CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], COAD[Colon adenocarcinoma], GBM[Glioblastoma multiforme], Glioma Low Grade, HNSC[Head and Neck squamous cell carcinoma], KICH[Kidney Chromophobe], KIRC[Kidney renal clear cell carcinoma], KIRP[Kidney renal papillary cell carcinoma], LAML[Acute Myeloid Leukemia], LUAD[Lung adenocarcinoma], LUSC[Lung squamous cell carcinoma], OV[Ovarian serous cystadenocarcinoma ], PAAD[Pancreatic adenocarcinoma], PRAD[Prostate adenocarcinoma], SKCM[Skin Cutaneous Melanoma], STAD[Stomach adenocarcinoma], THCA[Thyroid carcinoma], UCEC[Uterine Corpus Endometrial Carcinoma] |
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Gene Expression for GLUL |
Gene Expression in Cancer Cell-lines (CCLE) |
* CCLE gene expression data were extracted from CCLE_Expression_Entrez_2012-10-18.res: Gene-centric RMA-normalized mRNA expression data. |
Differential Gene Expression in Primary Tumors (TCGA) |
* Normalized gene expression data of RNASeqV2 was extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered at Jan-05-2015. Only eight cancer types have enough normal control samples for differential expression analysis. (t test, adjusted p<0.05 (using Benjamini-Hochberg FDR)) |
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CNV vs Gene Expression Plot |
* This plots show the correlation between CNV and gene expression. |
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Gene-Gene Network Information |
Co-Expressed gene's network Plot |
* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown. Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene |
ABAT,C1orf27,KIAA0825,CD46,COG2,FAM63A,GLUL, HHAT,HNRNPH2,KIAA0040,LRG1,MAPT,MR1,NEK10, NEK11,RALGPS2,RCOR3,RUNDC1,SLC30A1,TOR1AIP1,XBP1 | ACSM2A,ACSM2B,ALDH1L1,ASS1,IZUMO4,APMAP,CALCRL, CYP1A2,ECHDC3,GLUL,GLYCTK,HRSP12,MOCS1,MOGAT1, NTSR2,PC,PMM1,RASL10B,SHMT1,TCEB3,TMEM120A | ||||
ABCB4,ARNT,C1orf198,C1orf85,CYB5R1,GLP1R,GLUL, KIAA0087,LEFTY1,LOC92973,MR1,NCSTN,OR13J1,PBXIP1, PI4KB,RNASEL,RPLP0P2,SLAMF6,STX6,TMEM204,WDR26 | APCDD1,BCAT1,CD3EAP,CP,EIF2AK4,FAM107A,FKBP5, GLUL,IRAK3,JPH1,LONRF1,LSM11,MRGPRX2,MUSK, PAPPA2,SCNN1G,SLC7A2,TBC1D8,VIT,VSIG8,ZBTB16 |
Co-Expressed gene's Protein-protein interaction Network Plot |
* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown. Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene |
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Interacting Genes (from Pathway Commons) |
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Pharmacological Information for GLUL |
Cross-referenced pharmacological DB IDs from Uniprot |
DB Category | DB Name | DB's ID and Url link |
Drug-Gene Interaction Network |
* Gene Centered Interaction Network. |
* Drug Centered Interaction Network. |
DrugBank ID | Target Name | Drug Groups | Generic Name | Drug Centered Network | Drug Structure |
DB02663 | glutamate-ammonia ligase | experimental | 2-Amino-4-(Hydroxymethyl-Phosphinyl)Butanoic Acid | ||
DB03431 | glutamate-ammonia ligase | experimental | Adenosine-5'-Diphosphate | ||
DB00130 | glutamate-ammonia ligase | approved; nutraceutical; investigational | L-Glutamine | ||
DB00142 | glutamate-ammonia ligase | approved; nutraceutical | L-Glutamic Acid |
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Cross referenced IDs for GLUL |
* We obtained these cross-references from Uniprot database. It covers 150 different DBs, 18 categories. http://www.uniprot.org/help/cross_references_section |
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