|
Phenotypic Information (metabolism pathway, cancer, disease, phenome) | |
Gene-Gene Network Information: Co-Expression Network, Interacting Genes & KEGG | |
Gene Summary for GNA11 |
Basic gene info. | Gene symbol | GNA11 |
Gene name | guanine nucleotide binding protein (G protein), alpha 11 (Gq class) | |
Synonyms | FBH|FBH2|FHH2|GNA-11|HHC2|HYPOC2 | |
Cytomap | UCSC genome browser: 19p13.3 | |
Genomic location | chr19 :3094407-3121454 | |
Type of gene | protein-coding | |
RefGenes | NM_002067.4, | |
Ensembl id | ENSG00000088256 | |
Description | G-protein subunit alpha-11g alpha-11guanine nucleotide-binding protein G(y) subunit alphaguanine nucleotide-binding protein subunit alpha-11 | |
Modification date | 20141222 | |
dbXrefs | MIM : 139313 | |
HGNC : HGNC | ||
Ensembl : ENSG00000088256 | ||
HPRD : 00759 | ||
Vega : OTTHUMG00000180631 | ||
Protein | UniProt: P29992 go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_GNA11 | |
BioGPS: 2767 | ||
Gene Expression Atlas: ENSG00000088256 | ||
The Human Protein Atlas: ENSG00000088256 | ||
Pathway | NCI Pathway Interaction Database: GNA11 | |
KEGG: GNA11 | ||
REACTOME: GNA11 | ||
ConsensusPathDB | ||
Pathway Commons: GNA11 | ||
Metabolism | MetaCyc: GNA11 | |
HUMANCyc: GNA11 | ||
Regulation | Ensembl's Regulation: ENSG00000088256 | |
miRBase: chr19 :3,094,407-3,121,454 | ||
TargetScan: NM_002067 | ||
cisRED: ENSG00000088256 | ||
Context | iHOP: GNA11 | |
cancer metabolism search in PubMed: GNA11 | ||
UCL Cancer Institute: GNA11 | ||
Assigned class in ccmGDB | B - This gene belongs to cancer gene. |
Top |
Phenotypic Information for GNA11(metabolism pathway, cancer, disease, phenome) |
![]() | |
Cancer | CGAP: GNA11 |
Familial Cancer Database: GNA11 |
* This gene is included in those cancer gene databases. |
. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Oncogene 1 | Significant driver gene in |
cf) number; DB name 1 Oncogene; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long, 2 Tumor Suppressor gene; https://bioinfo.uth.edu/TSGene/, 3 Cancer Gene Census; http://www.nature.com/nrc/journal/v4/n3/abs/nrc1299.html, 4 CancerGenes; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long, 5 Network of Cancer Gene; http://ncg.kcl.ac.uk/index.php, 1Therapeutic Vulnerabilities in Cancer; http://cbio.mskcc.org/cancergenomics/statius/ |
![]() | |
REACTOME_INTEGRATION_OF_ENERGY_METABOLISM |
![]() | |
OMIM | 139313; gene. 145981; phenotype. 615361; phenotype. |
Orphanet | 101049; Familial hypocalciuric hypercalcemia type 2. 428; Autosomal dominant hypocalcemia. |
Disease | KEGG Disease: GNA11 |
MedGen: GNA11 (Human Medical Genetics with Condition) | |
ClinVar: GNA11 | |
Phenotype | MGI: GNA11 (International Mouse Phenotyping Consortium) |
PhenomicDB: GNA11 |
Mutations for GNA11 |
* Under tables are showing count per each tissue to give us broad intuition about tissue specific mutation patterns.You can go to the detailed page for each mutation database's web site. |
![]() |
There's no structural variation information in COSMIC data for this gene. |
![]() |
* From mRNA Sanger sequences, Chitars2.0 arranged chimeric transcripts. This table shows GNA11 related fusion information. |
ID | Head Gene | Tail Gene | Accession | Gene_a | qStart_a | qEnd_a | Chromosome_a | tStart_a | tEnd_a | Gene_a | qStart_a | qEnd_a | Chromosome_a | tStart_a | tEnd_a |
CK818891 | GNA11 | 1 | 216 | 19 | 3115036 | 3119254 | REG1A | 208 | 260 | 2 | 79350483 | 79350535 | |
CK818890 | REG1A | 16 | 64 | 2 | 79350483 | 79350531 | GNA11 | 56 | 272 | 19 | 3115035 | 3119254 | |
BM126302 | GNA11 | 1 | 200 | 19 | 3115052 | 3119254 | REG1A | 192 | 244 | 2 | 79350483 | 79350535 | |
BM126025 | REG1A | 12 | 64 | 2 | 79350483 | 79350535 | GNA11 | 56 | 225 | 19 | 3118933 | 3119254 |
![]() |
Top |
![]() |
Mutation type/ Tissue ID | brca | cns | cerv | endome | haematopo | kidn | Lintest | liver | lung | ns | ovary | pancre | prost | skin | stoma | thyro | urina | |||
Total # sample |   |   |   | 1 |   | 1 |   |   |   |   |   |   |   |   |   |   |   | |||
GAIN (# sample) |   |   |   |   |   | 1 |   |   |   |   |   |   |   |   |   |   |   | |||
LOSS (# sample) |   |   |   | 1 |   |   |   |   |   |   |   |   |   |   |   |   |   |
cf) Tissue ID; Tissue type (1; Breast, 2; Central_nervous_system, 3; Cervix, 4; Endometrium, 5; Haematopoietic_and_lymphoid_tissue, 6; Kidney, 7; Large_intestine, 8; Liver, 9; Lung, 10; NS, 11; Ovary, 12; Pancreas, 13; Prostate, 14; Skin, 15; Stomach, 16; Thyroid, 17; Urinary_tract) |
Top |
![]() |
|
![]() |
Top |
![]() |
Stat. for Non-Synonymous SNVs (# total SNVs=279) | (# total SNVs=12) |
![]() | ![]() |
(# total SNVs=1) | (# total SNVs=0) |
![]() |
Top |
![]() |
* When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site,primary_histology,mutation(aa),pubmedID. |
GRCh37 position | Mutation(aa) | Unique sampleID count |
chr19:3118942-3118942 | p.Q209L | 143 |
chr19:3115012-3115012 | p.R183C | 9 |
chr19:3118942-3118943 | p.Q209L | 4 |
chr19:3118941-3118941 | p.Q209K | 4 |
chr19:3115011-3115012 | p.R183C | 3 |
chr19:3113468-3113468 | p.S154S | 2 |
chr19:3113330-3113330 | p.A108A | 2 |
chr19:3115013-3115013 | p.R183L | 2 |
chr19:3113410-3113410 | p.L135P | 1 |
chr19:3121014-3121014 | p.R306L | 1 |
Top |
![]() |
|
![]() |
Point Mutation/ Tissue ID | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | 18 | 19 | 20 |
# sample |   |   | 1 | 7 | 1 |   |   |   | 1 |   |   | 3 | 1 | 1 |   |   | 7 | 7 |   | 3 |
# mutation |   |   | 1 | 7 | 1 |   |   |   | 1 |   |   | 4 | 1 | 1 |   |   | 7 | 7 |   | 3 |
nonsynonymous SNV |   |   | 1 | 4 |   |   |   |   | 1 |   |   | 3 | 1 | 1 |   |   | 4 | 5 |   | 2 |
synonymous SNV |   |   |   | 3 | 1 |   |   |   |   |   |   | 1 |   |   |   |   | 3 | 2 |   | 1 |
cf) Tissue ID; Tissue type (1; BLCA[Bladder Urothelial Carcinoma], 2; BRCA[Breast invasive carcinoma], 3; CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], 4; COAD[Colon adenocarcinoma], 5; GBM[Glioblastoma multiforme], 6; Glioma Low Grade, 7; HNSC[Head and Neck squamous cell carcinoma], 8; KICH[Kidney Chromophobe], 9; KIRC[Kidney renal clear cell carcinoma], 10; KIRP[Kidney renal papillary cell carcinoma], 11; LAML[Acute Myeloid Leukemia], 12; LUAD[Lung adenocarcinoma], 13; LUSC[Lung squamous cell carcinoma], 14; OV[Ovarian serous cystadenocarcinoma ], 15; PAAD[Pancreatic adenocarcinoma], 16; PRAD[Prostate adenocarcinoma], 17; SKCM[Skin Cutaneous Melanoma], 18:STAD[Stomach adenocarcinoma], 19:THCA[Thyroid carcinoma], 20:UCEC[Uterine Corpus Endometrial Carcinoma]) |
Top |
![]() |
* We represented just top 10 SNVs. When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site, primary_histology, mutation(aa), pubmedID. |
Genomic Position | Mutation(aa) | Unique sampleID count |
chr19:3113330 | p.A108A | 2 |
chr19:3115013 | p.A65A | 1 |
chr19:3119342 | p.V223A | 1 |
chr19:3110205 | p.G66S | 1 |
chr19:3115036 | p.L229V | 1 |
chr19:3119345 | p.T96T | 1 |
chr19:3110206 | p.L254L | 1 |
chr19:3118923 | p.S268A | 1 |
chr19:3121014 | p.I113I | 1 |
chr19:3110298 | p.V269I | 1 |
![]() |
![]() |
* Copy number data were extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered on Jan-05-2015. Function ProcessCNAData in TCGA-Assembler package was used to obtain gene-level copy number value which is calculated as the average copy number of the genomic region of a gene. |
![]() |
cf) Tissue ID[Tissue type]: BLCA[Bladder Urothelial Carcinoma], BRCA[Breast invasive carcinoma], CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], COAD[Colon adenocarcinoma], GBM[Glioblastoma multiforme], Glioma Low Grade, HNSC[Head and Neck squamous cell carcinoma], KICH[Kidney Chromophobe], KIRC[Kidney renal clear cell carcinoma], KIRP[Kidney renal papillary cell carcinoma], LAML[Acute Myeloid Leukemia], LUAD[Lung adenocarcinoma], LUSC[Lung squamous cell carcinoma], OV[Ovarian serous cystadenocarcinoma ], PAAD[Pancreatic adenocarcinoma], PRAD[Prostate adenocarcinoma], SKCM[Skin Cutaneous Melanoma], STAD[Stomach adenocarcinoma], THCA[Thyroid carcinoma], UCEC[Uterine Corpus Endometrial Carcinoma] |
Top |
Gene Expression for GNA11 |
![]() |
* CCLE gene expression data were extracted from CCLE_Expression_Entrez_2012-10-18.res: Gene-centric RMA-normalized mRNA expression data. |
![]() |
![]() |
* Normalized gene expression data of RNASeqV2 was extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered at Jan-05-2015. Only eight cancer types have enough normal control samples for differential expression analysis. (t test, adjusted p<0.05 (using Benjamini-Hochberg FDR)) |
![]() |
Top |
![]() |
* This plots show the correlation between CNV and gene expression. |
![]() | |
![]() |
Top |
Gene-Gene Network Information |
![]() |
* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown. Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene |
![]() | |||||
AP3D1,PRRC2B,NOP9,C9orf129,CASZ1,CCNT1,DDI2, GIGYF2,GNA11,HCFC1,HERC2,LMTK2,KMT2B___KMT2D,NACC2, NFIC,PRKAR2A,RREB1,TGFBRAP1,TRIM56,YLPM1,ZNF641 | ANKRD11,ATG2A,PRRC2A,PRRC2B,GATC,GCN1L1,GLYR1, GNA11,HERC2,KHSRP,ZSWIM8,NCOR2,OTUD7A,PHF2, POLR3E,PRDM11,RNF216,RPTOR,SUPT6H,TECPR2,ZC3H7B | ||||
![]() | |||||
BTNL8,C9orf129,CNNM4,CORO2A,GNA11,GPT,GUCA2B, JOSD1,KIAA1161,LRP10,LUZP1,NBEAL1,PEX26,PHLPP2, PLEKHA7,PTPRH,RGP1,RREB1,SLC9A1,TTC22,ZZEF1 | AGPAT3,MISP,C1orf106,CARD10,COBL,GNA11,KCNK5, KIAA0247,LASP1,LPIN2,LUZP1,MALL,MAST2,MYO5B, MYO7B,PLEKHG6,SCIN,SLC9A3R1,SORT1,SPINT1,TOM1 |
![]() |
* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown. Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene |
Top |
![]() |
Top |
Pharmacological Information for GNA11 |
![]() |
DB Category | DB Name | DB's ID and Url link |
Organism-specific databases | PharmGKB | PA28764; -. |
Organism-specific databases | CTD | 2767; -. |
![]() |
* Gene Centered Interaction Network. |
![]() |
* Drug Centered Interaction Network. |
DrugBank ID | Target Name | Drug Groups | Generic Name | Drug Centered Network | Drug Structure |
DB00125 | guanine nucleotide binding protein (G protein), alpha 11 (Gq class) | approved; nutraceutical | L-Arginine | ![]() | ![]() |
DB00435 | guanine nucleotide binding protein (G protein), alpha 11 (Gq class) | approved | Nitric Oxide | ![]() | ![]() |
Top |
Cross referenced IDs for GNA11 |
* We obtained these cross-references from Uniprot database. It covers 150 different DBs, 18 categories. http://www.uniprot.org/help/cross_references_section |
Copyright © 2016-Present - The Univsersity of Texas Health Science Center at Houston @ |