Cancer Cell Metabolism Gene Database

  Cancer Cell Metabolism Gene DB

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Gene Summary

Phenotypic Information (metabolism pathway, cancer, disease, phenome)

Mutations: SVs, CNVs, SNVs

Gene expression: GE, Protein, DEGE, CNV vs GE

Gene-Gene Network Information: Co-Expression Network, Interacting Genes & KEGG

Pharmacological Information: Drug-Gene Network

Cross referenced IDs

Gene Summary for GNAI1
Basic gene info.Gene symbolGNAI1
Gene nameguanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1
SynonymsGi
CytomapUCSC genome browser: 7q21
Genomic locationchr7 :79765070-79848725
Type of geneprotein-coding
RefGenesNM_001256414.1,
NM_002069.5,
Ensembl idENSG00000127955
DescriptionGi1 protein alpha subunitadenylate cyclase-inhibiting G alpha proteinguanine nucleotide-binding protein G(i) subunit alpha-1
Modification date20141207
dbXrefs MIM : 139310
HGNC : HGNC
Ensembl : ENSG00000127955
HPRD : 00756
Vega : OTTHUMG00000023523
ProteinUniProt: P63096
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_GNAI1
BioGPS: 2770
Gene Expression Atlas: ENSG00000127955
The Human Protein Atlas: ENSG00000127955
PathwayNCI Pathway Interaction Database: GNAI1
KEGG: GNAI1
REACTOME: GNAI1
ConsensusPathDB
Pathway Commons: GNAI1
MetabolismMetaCyc: GNAI1
HUMANCyc: GNAI1
RegulationEnsembl's Regulation: ENSG00000127955
miRBase: chr7 :79,765,070-79,848,725
TargetScan: NM_001256414
cisRED: ENSG00000127955
ContextiHOP: GNAI1
cancer metabolism search in PubMed: GNAI1
UCL Cancer Institute: GNAI1
Assigned class in ccmGDBB - This gene belongs to cancer gene.

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Phenotypic Information for GNAI1(metabolism pathway, cancer, disease, phenome)
check002.gifCancer Description
Cancer CGAP: GNAI1
Familial Cancer Database: GNAI1
* This gene is included in those cancer gene databases.

Oncogene 1

Tumor Suppressor gene 2

Cancer Gene Census 3

CancerGenes 4

Network of Cancer Gene 5

Significant driver gene in

Therapeutic Vulnerabilities in Cancer1

cf) number; DB name
1 Oncogene; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long,
2 Tumor Suppressor gene; https://bioinfo.uth.edu/TSGene/,
3 Cancer Gene Census; http://www.nature.com/nrc/journal/v4/n3/abs/nrc1299.html,
4 CancerGenes; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long,
5 Network of Cancer Gene; http://ncg.kcl.ac.uk/index.php,
1Therapeutic Vulnerabilities in Cancer; http://cbio.mskcc.org/cancergenomics/statius/

check002.gifMetabolic Pathway Description
REACTOME_INTEGRATION_OF_ENERGY_METABOLISM

check002.gifOthers
OMIM 139310; gene.
139310; gene.
Orphanet
DiseaseKEGG Disease: GNAI1
MedGen: GNAI1 (Human Medical Genetics with Condition)
ClinVar: GNAI1
PhenotypeMGI: GNAI1 (International Mouse Phenotyping Consortium)
PhenomicDB: GNAI1

Mutations for GNAI1
* Under tables are showing count per each tissue to give us broad intuition about tissue specific mutation patterns.You can go to the detailed page for each mutation database's web site.

check002.gifStructural Variants in COSMIC: go to COSMIC mutation histogram

- Statistics for Tissue and Mutation typeTop
- For Inter-chromosomal Variations
There's no inter-chromosomal structural variation.
- For Intra-chromosomal Variations
* Intra-chromosomal variantions includes 'intrachromosomal amplicon to amplicon', 'intrachromosomal amplicon to non-amplified dna', 'intrachromosomal deletion', 'intrachromosomal fold-back inversion', 'intrachromosomal inversion', 'intrachromosomal tandem duplication', 'Intrachromosomal unknown type', 'intrachromosomal with inverted orientation', 'intrachromosomal with non-inverted orientation'.
SampleSymbol_aChr_aStart_aEnd_aSymbol_bChr_bStart_bEnd_b
breastGNAI1chr77976705879767058GNAI1chr77977850179778501
ovaryGNAI1chr77984537579845395chr78005081980050839
cf) Tissue number; Tissue name (1;Breast, 2;Central_nervous_system, 3;Haematopoietic_and_lymphoid_tissue, 4;Large_intestine, 5;Liver, 6;Lung, 7;Ovary, 8;Pancreas, 9;Prostate, 10;Skin, 11;Soft_tissue, 12;Upper_aerodigestive_tract)

check002.gifRelated fusion transcripts : go to Chitars2.0
* From mRNA Sanger sequences, Chitars2.0 arranged chimeric transcripts. This table shows GNAI1 related fusion information.
IDHead GeneTail Gene
AccessionGene_aqStart_aqEnd_aChromosome_atStart_atEnd_aGene_aqStart_aqEnd_aChromosome_atStart_atEnd_a
AI982766GNAI1125377984834879848600MALAT1247497116526964065269890

check002.gifOther DBs for Structural Variants
Structural Variants in Ensembl: go to Ensembl Structural variation
Structural Variants in dbVar: go to dbVar

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check002.gifCopy Number Variations in COSMIC: go to COSMIC mutation CNV/Expr
 
Mutation type/ Tissue IDbrcacnscervendomehaematopokidnLintestliverlungnsovarypancreprostskinstomathyrourina
Total # sample             1   
GAIN (# sample)             1   
LOSS (# sample)                 
cf) Tissue ID; Tissue type (1; Breast, 2; Central_nervous_system, 3; Cervix, 4; Endometrium, 5; Haematopoietic_and_lymphoid_tissue, 6; Kidney, 7; Large_intestine, 8; Liver, 9; Lung, 10; NS, 11; Ovary, 12; Pancreas, 13; Prostate, 14; Skin, 15; Stomach, 16; Thyroid, 17; Urinary_tract)

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check002.gifSNV Counts per Each Loci in COSMIC data: go to COSMIC point mutation

 : Non-synonymous mutation, : Synonymous mutation, Circle size denotes number of samples.
Maximum mutation count=4

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check002.gifSomatic Mutation Counts per Tissue in COSMIC data
Stat. for Non-Synonymous SNVs
(# total SNVs=43)
Stat. for Synonymous SNVs
(# total SNVs=6)
Stat. for Deletions
(# total SNVs=0)
Stat. for Insertions
(# total SNVs=0)
There's no deleted snv.There's no inserted snv.

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check002.gifTop 10 SNVs Having the Most Samples in COSMIC data
* When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site,primary_histology,mutation(aa),pubmedID.
GRCh37 positionMutation(aa)Unique sampleID count
chr7:79818546-79818546p.A101V4
chr7:79842125-79842125p.D272Y2
chr7:79842176-79842176p.E289Q2
chr7:79833136-79833136p.D193G1
chr7:79818431-79818431p.E63*1
chr7:79842035-79842035p.R242*1
chr7:79846672-79846672p.L310V1
chr7:79828551-79828551p.R105H1
chr7:79833137-79833137p.D193D1
chr7:79818438-79818438p.E65G1

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check002.gifSNV Counts per Each Loci in TCGA data

 : non-synonymous mutation, : synonymous mutation, Circle size denotes number of samples.
maximum mutation count=1

Point Mutation/ Tissue ID1234567891011121314151617181920
# sample11 9  1 11 33   33 6
# mutation11 8  1 11 33   33 6
nonsynonymous SNV11 5  1 1  33   12 5
synonymous SNV   3     1      21 1
cf) Tissue ID; Tissue type (1; BLCA[Bladder Urothelial Carcinoma], 2; BRCA[Breast invasive carcinoma], 3; CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], 4; COAD[Colon adenocarcinoma], 5; GBM[Glioblastoma multiforme], 6; Glioma Low Grade, 7; HNSC[Head and Neck squamous cell carcinoma], 8; KICH[Kidney Chromophobe], 9; KIRC[Kidney renal clear cell carcinoma], 10; KIRP[Kidney renal papillary cell carcinoma], 11; LAML[Acute Myeloid Leukemia], 12; LUAD[Lung adenocarcinoma], 13; LUSC[Lung squamous cell carcinoma], 14; OV[Ovarian serous cystadenocarcinoma ], 15; PAAD[Pancreatic adenocarcinoma], 16; PRAD[Prostate adenocarcinoma], 17; SKCM[Skin Cutaneous Melanoma], 18:STAD[Stomach adenocarcinoma], 19:THCA[Thyroid carcinoma], 20:UCEC[Uterine Corpus Endometrial Carcinoma])

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check002.gifTop 10 SNVs Having the Most Samples in TCGA data
* We represented just top 10 SNVs. When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site, primary_histology, mutation(aa), pubmedID.
Genomic PositionMutation(aa)Unique sampleID count
chr7:79840317p.R156Q,GNAI12
chr7:79833136p.I30I,GNAI11
chr7:79842162p.A168V,GNAI11
chr7:79818279p.A35T,GNAI11
chr7:79833137p.Y178Y,GNAI11
chr7:79846625p.M36I,GNAI11
chr7:79818490p.M195I,GNAI11
chr7:79840297p.L39L,GNAI11
chr7:79846649p.K225K,GNAI11
chr7:79818503p.D45G,GNAI11

check002.gifOther DBs for Point Mutations
Point Mutation Table of Ensembl: go to Ensembl variation table
Mutation of cBioPortal: go to cBioPortal's Cross-cancer alteration summary

check002.gifCopy Number for GNAI1 in TCGA
* Copy number data were extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered on Jan-05-2015. Function ProcessCNAData in TCGA-Assembler package was used to obtain gene-level copy number value which is calculated as the average copy number of the genomic region of a gene.
cf) Tissue ID[Tissue type]: BLCA[Bladder Urothelial Carcinoma], BRCA[Breast invasive carcinoma], CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], COAD[Colon adenocarcinoma], GBM[Glioblastoma multiforme], Glioma Low Grade, HNSC[Head and Neck squamous cell carcinoma], KICH[Kidney Chromophobe], KIRC[Kidney renal clear cell carcinoma], KIRP[Kidney renal papillary cell carcinoma], LAML[Acute Myeloid Leukemia], LUAD[Lung adenocarcinoma], LUSC[Lung squamous cell carcinoma], OV[Ovarian serous cystadenocarcinoma ], PAAD[Pancreatic adenocarcinoma], PRAD[Prostate adenocarcinoma], SKCM[Skin Cutaneous Melanoma], STAD[Stomach adenocarcinoma], THCA[Thyroid carcinoma], UCEC[Uterine Corpus Endometrial Carcinoma]

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Gene Expression for GNAI1

check002.gifGene Expression in Cancer Cell-lines (CCLE)
* CCLE gene expression data were extracted from CCLE_Expression_Entrez_2012-10-18.res: Gene-centric RMA-normalized mRNA expression data.

check002.gifDifferential Gene Expression in Primary Tumors (TCGA)
* Normalized gene expression data of RNASeqV2 was extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered at Jan-05-2015. Only eight cancer types have enough normal control samples for differential expression analysis.
(t test, adjusted p<0.05 (using Benjamini-Hochberg FDR))
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check002.gifCNV vs Gene Expression Plot
* This plots show the correlation between CNV and gene expression.

: Open all plots for all cancer types


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Gene-Gene Network Information
check002.gifCo-Expressed gene's network Plot
* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown.
Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene

: Open all plots for all cancer types

B3GNT5,BMP2,BNC1,C11orf87,CAV1,CAV2,CPNE8,
CSRP2,DFNA5,EPHA2,FAM126A,FSCN1,GNAI1,KRT5,
MID1,MOB3B,MSN,PLEK2,PRNP,RBMS1,TES
ACADL,ACO1,ANO6,ANTXR2,FAM213A,PQLC2L,EIF4EBP2,
FAM89A,FBXO27,FERMT2,GHR,GNAI1,GYG2,HRASLS5,
LOC283392,MARC1,PDE8A,PEX19,PLIN1,RHOBTB3,SIK2

ABCC9,ARHGAP24,CFL2,CLIC4,DIXDC1,FERMT2,GNAI1,
HCFC2,JAZF1,MEF2A,PDE4D,PDLIM5,PJA2,PLN,
POU6F1,PPAP2A,RGS2,SECISBP2L,SETBP1,SGCE,STRN3
CNR1,ELOVL4,EPM2A,FBXO17,FGF2,GAS1,GNAI1,
GPM6A,HABP4,JAZF1,LSAMP,MARK1,MTMR9,NEGR1,
NKX3-2,NUDT10,PGR,SCD5,SOCS5,SSPN,ZDHHC15
check002.gifCo-Expressed gene's Protein-protein interaction Network Plot
* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown.
Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene

: Open all plots for all cancer types

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check002.gifInteracting Genes (from Pathway Commons)

: Open all interacting genes' information including KEGG pathway for all interacting genes from DAVID

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Pharmacological Information for GNAI1
check002.gifCross-referenced pharmacological DB IDs from Uniprot
DB CategoryDB NameDB's ID and Url link
ChemistryBindingDB P63096; -.
ChemistryChEMBL CHEMBL4741; -.
ChemistryBindingDB P63096; -.
ChemistryChEMBL CHEMBL4741; -.
Organism-specific databasesPharmGKB PA172; -.
Organism-specific databasesPharmGKB PA172; -.
Organism-specific databasesCTD 2770; -.
Organism-specific databasesCTD 2770; -.

check002.gifDrug-Gene Interaction Network
* Gene Centered Interaction Network.
* Drug Centered Interaction Network.
DrugBank IDTarget NameDrug GroupsGeneric NameDrug Centered NetworkDrug Structure
DB00945guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1approvedAcetylsalicylic acid
DB00125guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1approved; nutraceuticalL-Arginine
DB00435guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1approvedNitric Oxide
DB00396guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1approvedProgesterone
DB00171guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1approved; nutraceuticalAdenosine triphosphate
DB01064guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1approvedIsoproterenol
DB00938guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1approvedSalmeterol


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Cross referenced IDs for GNAI1
* We obtained these cross-references from Uniprot database. It covers 150 different DBs, 18 categories. http://www.uniprot.org/help/cross_references_section

: Open all cross reference information



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