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Phenotypic Information (metabolism pathway, cancer, disease, phenome) | |
Gene-Gene Network Information: Co-Expression Network, Interacting Genes & KEGG | |
Gene Summary for GNAI2 |
Basic gene info. | Gene symbol | GNAI2 |
Gene name | guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2 | |
Synonyms | GIP|GNAI2B|H_LUCA15.1|H_LUCA16.1 | |
Cytomap | UCSC genome browser: 3p21.31 | |
Genomic location | chr3 :50273646-50296786 | |
Type of gene | protein-coding | |
RefGenes | NM_001166425.1, NM_001282617.1,NM_001282618.1,NM_001282619.1,NM_001282620.1, NM_002070.3, | |
Ensembl id | ENSG00000263156 | |
Description | GTP-binding regulatory protein Gi alpha-2 chainadenylate cyclase-inhibiting G alpha proteinguanine nucleotide-binding protein G(i) subunit alpha-2guanine nucleotide-binding protein G(i), alpha-2 subunit | |
Modification date | 20141207 | |
dbXrefs | MIM : 139360 | |
HGNC : HGNC | ||
Ensembl : ENSG00000114353 | ||
HPRD : 00764 | ||
Vega : OTTHUMG00000156940 | ||
Protein | UniProt: P04899 go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_GNAI2 | |
BioGPS: 2771 | ||
Gene Expression Atlas: ENSG00000263156 | ||
The Human Protein Atlas: ENSG00000263156 | ||
Pathway | NCI Pathway Interaction Database: GNAI2 | |
KEGG: GNAI2 | ||
REACTOME: GNAI2 | ||
ConsensusPathDB | ||
Pathway Commons: GNAI2 | ||
Metabolism | MetaCyc: GNAI2 | |
HUMANCyc: GNAI2 | ||
Regulation | Ensembl's Regulation: ENSG00000263156 | |
miRBase: chr3 :50,273,646-50,296,786 | ||
TargetScan: NM_001166425 | ||
cisRED: ENSG00000263156 | ||
Context | iHOP: GNAI2 | |
cancer metabolism search in PubMed: GNAI2 | ||
UCL Cancer Institute: GNAI2 | ||
Assigned class in ccmGDB | B - This gene belongs to cancer gene. |
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Phenotypic Information for GNAI2(metabolism pathway, cancer, disease, phenome) |
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Cancer | CGAP: GNAI2 |
Familial Cancer Database: GNAI2 |
* This gene is included in those cancer gene databases. |
Oncogene 1 | Significant driver gene in SKCM 6, |
cf) number; DB name 1 Oncogene; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long, 2 Tumor Suppressor gene; https://bioinfo.uth.edu/TSGene/, 3 Cancer Gene Census; http://www.nature.com/nrc/journal/v4/n3/abs/nrc1299.html, 4 CancerGenes; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long, 5 Network of Cancer Gene; http://ncg.kcl.ac.uk/index.php, 6 http://www.sciencedirect.com/science/article/pii/S0092867415006340, 7Therapeutic Vulnerabilities in Cancer; http://cbio.mskcc.org/cancergenomics/statius/ |
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REACTOME_INTEGRATION_OF_ENERGY_METABOLISM |
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OMIM | 139360; gene. |
Orphanet | |
Disease | KEGG Disease: GNAI2 |
MedGen: GNAI2 (Human Medical Genetics with Condition) | |
ClinVar: GNAI2 | |
Phenotype | MGI: GNAI2 (International Mouse Phenotyping Consortium) |
PhenomicDB: GNAI2 |
Mutations for GNAI2 |
* Under tables are showing count per each tissue to give us broad intuition about tissue specific mutation patterns.You can go to the detailed page for each mutation database's web site. |
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There's no structural variation information in COSMIC data for this gene. |
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* From mRNA Sanger sequences, Chitars2.0 arranged chimeric transcripts. This table shows GNAI2 related fusion information. |
ID | Head Gene | Tail Gene | Accession | Gene_a | qStart_a | qEnd_a | Chromosome_a | tStart_a | tEnd_a | Gene_a | qStart_a | qEnd_a | Chromosome_a | tStart_a | tEnd_a |
BM931874 | MBD5 | 1 | 102 | 2 | 149024645 | 149024746 | GNAI2 | 89 | 194 | 3 | 50268507 | 50268611 | |
BM450613 | HSP90AA1 | 24 | 130 | 14 | 102549430 | 102549540 | GNAI2 | 114 | 204 | 3 | 50296695 | 50296785 | |
BY797642 | GNAI2 | 1 | 198 | 3 | 50273688 | 50273885 | NT5DC2 | 198 | 586 | 3 | 52562484 | 52563351 | |
BE707091 | GNAI2 | 20 | 206 | 3 | 50295821 | 50296003 | PSAP | 205 | 296 | 10 | 73579624 | 73580054 | |
BM684932 | GNAI2 | 19 | 123 | 3 | 50268507 | 50268611 | MBD5 | 110 | 211 | 2 | 149024645 | 149024746 | |
BI031334 | NPIPB7 | 198 | 234 | 16 | 28512657 | 28512693 | GNAI2 | 227 | 480 | 3 | 50281808 | 50282061 | |
DB337573 | LOC100128993 | 1 | 65 | 8 | 19102360 | 19102424 | GNAI2 | 59 | 552 | 3 | 50294486 | 50296040 | |
CK725123 | GNAI2 | 7 | 209 | 3 | 50296583 | 50296785 | PRKAG1 | 208 | 654 | 12 | 49396800 | 49397246 | |
BI051043 | GNAI2 | 9 | 145 | 3 | 50293693 | 50294232 | GNAI2 | 140 | 310 | 3 | 50290505 | 50293682 | |
AI377593 | GNAI2 | 1 | 195 | 3 | 50296586 | 50296780 | H19 | 185 | 414 | 11 | 2018056 | 2018286 |
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There's no copy number variation information in COSMIC data for this gene. |
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Stat. for Non-Synonymous SNVs (# total SNVs=28) | (# total SNVs=14) |
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(# total SNVs=0) | (# total SNVs=0) |
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* When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site,primary_histology,mutation(aa),pubmedID. |
GRCh37 position | Mutation(aa) | Unique sampleID count |
chr3:50293695-50293695 | p.R179H | 4 |
chr3:50293689-50293689 | p.R177Q | 3 |
chr3:50290580-50290580 | p.R143H | 3 |
chr3:50290492-50290492 | p.A114T | 2 |
chr3:50290494-50290494 | p.A114A | 2 |
chr3:50294255-50294255 | p.D232Y | 2 |
chr3:50289876-50289876 | p.R70Q | 2 |
chr3:50293694-50293694 | p.R179C | 2 |
chr3:50290615-50290615 | p.Y155H | 2 |
chr3:50294446-50294446 | p.L267L | 2 |
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Point Mutation/ Tissue ID | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | 18 | 19 | 20 |
# sample |   | 3 | 1 | 4 |   |   | 1 |   | 4 | 1 | 1 |   |   | 1 |   |   | 6 | 2 |   | 5 |
# mutation |   | 3 | 1 | 6 |   |   | 1 |   | 4 | 1 | 1 |   |   | 1 |   |   | 6 | 2 |   | 5 |
nonsynonymous SNV |   | 2 | 1 | 2 |   |   |   |   | 2 | 1 | 1 |   |   | 1 |   |   | 3 | 2 |   | 5 |
synonymous SNV |   | 1 |   | 4 |   |   | 1 |   | 2 |   |   |   |   |   |   |   | 3 |   |   |   |
cf) Tissue ID; Tissue type (1; BLCA[Bladder Urothelial Carcinoma], 2; BRCA[Breast invasive carcinoma], 3; CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], 4; COAD[Colon adenocarcinoma], 5; GBM[Glioblastoma multiforme], 6; Glioma Low Grade, 7; HNSC[Head and Neck squamous cell carcinoma], 8; KICH[Kidney Chromophobe], 9; KIRC[Kidney renal clear cell carcinoma], 10; KIRP[Kidney renal papillary cell carcinoma], 11; LAML[Acute Myeloid Leukemia], 12; LUAD[Lung adenocarcinoma], 13; LUSC[Lung squamous cell carcinoma], 14; OV[Ovarian serous cystadenocarcinoma ], 15; PAAD[Pancreatic adenocarcinoma], 16; PRAD[Prostate adenocarcinoma], 17; SKCM[Skin Cutaneous Melanoma], 18:STAD[Stomach adenocarcinoma], 19:THCA[Thyroid carcinoma], 20:UCEC[Uterine Corpus Endometrial Carcinoma]) |
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* We represented just top 10 SNVs. When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site, primary_histology, mutation(aa), pubmedID. |
Genomic Position | Mutation(aa) | Unique sampleID count |
chr3:50293694 | p.A146A,GNAI2 | 2 |
chr3:50294242 | p.D151Y,GNAI2 | 2 |
chr3:50294255 | p.R98C,GNAI2 | 2 |
chr3:50289871 | p.D13N,GNAI2 | 1 |
chr3:50293647 | p.K100K,GNAI2 | 1 |
chr3:50294280 | p.D16N,GNAI2 | 1 |
chr3:50289879 | p.T102T,GNAI2 | 1 |
chr3:50293650 | p.P17S,GNAI2 | 1 |
chr3:50294369 | p.D22D,GNAI2 | 1 |
chr3:50289947 | p.A33T,GNAI2 | 1 |
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* Copy number data were extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered on Jan-05-2015. Function ProcessCNAData in TCGA-Assembler package was used to obtain gene-level copy number value which is calculated as the average copy number of the genomic region of a gene. |
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cf) Tissue ID[Tissue type]: BLCA[Bladder Urothelial Carcinoma], BRCA[Breast invasive carcinoma], CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], COAD[Colon adenocarcinoma], GBM[Glioblastoma multiforme], Glioma Low Grade, HNSC[Head and Neck squamous cell carcinoma], KICH[Kidney Chromophobe], KIRC[Kidney renal clear cell carcinoma], KIRP[Kidney renal papillary cell carcinoma], LAML[Acute Myeloid Leukemia], LUAD[Lung adenocarcinoma], LUSC[Lung squamous cell carcinoma], OV[Ovarian serous cystadenocarcinoma ], PAAD[Pancreatic adenocarcinoma], PRAD[Prostate adenocarcinoma], SKCM[Skin Cutaneous Melanoma], STAD[Stomach adenocarcinoma], THCA[Thyroid carcinoma], UCEC[Uterine Corpus Endometrial Carcinoma] |
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Gene Expression for GNAI2 |
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* CCLE gene expression data were extracted from CCLE_Expression_Entrez_2012-10-18.res: Gene-centric RMA-normalized mRNA expression data. |
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* Normalized gene expression data of RNASeqV2 was extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered at Jan-05-2015. Only eight cancer types have enough normal control samples for differential expression analysis. (t test, adjusted p<0.05 (using Benjamini-Hochberg FDR)) |
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* This plots show the correlation between CNV and gene expression. |
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Gene-Gene Network Information |
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* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown. Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene |
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ABI3,ACVRL1,C1orf54,EMP3,ENG,TMEM255B,GNAI2, GPX1,HYAL2,IFFO1,LST1,LYL1,NCF4,PLEKHO2, PPM1M,RHOG,SPI1,TGFB1,TNFSF12,TWF2,TYROBP | ACVRL1,C10orf54,CCM2L,TOR4A,CST3,EFEMP2,ENG, GIMAP5,GMFG,GNAI2,ICAM2,ILK,MAPK3,MFNG, MGAT1,PLXND1,SYDE1,TNFRSF1A,TNFSF12,TSPAN4,VAT1 | ||||
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BASP1,C1R,CMTM3,COL6A2,EFEMP2,EHD2,EMP3, GNAI2,GYPC,LAMB2,LOXL1,MAFB,MAP7D1,MRAS, MRC2,NRP1,PLEKHO2,PTRF,TIMP2,TSPAN4,VIM | CCDC102A,CD81,CHST10,COPZ2,DOCK11,EFEMP2,FIBIN, GNAI2,GYPC,LIX1L,NAT14,PELI3,PJA1,PLSCR3, PRAF2,PRDM8,QKI,SHISA4,SNN,SULF1,TUBG2 |
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* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown. Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene |
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Pharmacological Information for GNAI2 |
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DB Category | DB Name | DB's ID and Url link |
Organism-specific databases | PharmGKB | PA24347; -. |
Organism-specific databases | CTD | 2771; -. |
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* Gene Centered Interaction Network. |
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* Drug Centered Interaction Network. |
DrugBank ID | Target Name | Drug Groups | Generic Name | Drug Centered Network | Drug Structure |
DB00125 | guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2 | approved; nutraceutical | L-Arginine | ![]() | ![]() |
DB00435 | guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2 | approved | Nitric Oxide | ![]() | ![]() |
DB00938 | guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2 | approved | Salmeterol | ![]() | ![]() |
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Cross referenced IDs for GNAI2 |
* We obtained these cross-references from Uniprot database. It covers 150 different DBs, 18 categories. http://www.uniprot.org/help/cross_references_section |
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