Cancer Cell Metabolism Database ~~ Bioinformatics and Systems Medicine Laboratory ~~

Cancer Cell Metabolism Gene Database

Cancer Cell Metabolism Gene DB

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	Gene Summary
	Phenotypic Information (metabolism pathway, cancer, disease, phenome)
	Mutations : SVs, CNVs, SNVs
	Gene expression: GE, Protein, DEGE, CNV vs GE
	Gene-Gene Network Information: Co-Expression Network, Interacting Genes & KEGG
	Pharmacological Information: Drug-Gene Network
	Cross referenced IDs

Gene Summary for GNG4

Basic gene info.	Gene symbol	GNG4
	Gene name	guanine nucleotide binding protein (G protein), gamma 4
	Synonyms	-
	Cytomap	UCSC genome browser: 1q42.3
	Genomic location	chr1 :235710984-235813293
	Type of gene	protein-coding
	RefGenes	NM_001098721.1, NM_001098722.1,NM_004485.3,
	Ensembl id	ENSG00000168243
	Description	guanine nucleotide binding protein 4guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4
	Modification date	20141207
dbXrefs	MIM : 604388
	HGNC : HGNC
	Ensembl : ENSG00000168243
	HPRD : 11978
Protein	UniProt: go to UniProt's Cross Reference DB Table
Expression	CleanEX: HS_GNG4
	BioGPS: 2786
	Gene Expression Atlas: ENSG00000168243
	The Human Protein Atlas: ENSG00000168243
Pathway	NCI Pathway Interaction Database: GNG4
	KEGG: GNG4
	REACTOME: GNG4
	ConsensusPathDB
	Pathway Commons: GNG4
Metabolism	MetaCyc: GNG4
	HUMANCyc: GNG4
Regulation	Ensembl's Regulation: ENSG00000168243
	miRBase: chr1 :235,710,984-235,813,293
	TargetScan: NM_001098721
	cisRED: ENSG00000168243
Context	iHOP: GNG4
	cancer metabolism search in PubMed: GNG4
	UCL Cancer Institute: GNG4
Assigned class in ccmGDB	C

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Phenotypic Information for GNG4(metabolism pathway, cancer, disease, phenome)

Cancer Description
Cancer	CGAP: GNG4
	Familial Cancer Database: GNG4

* This gene is included in those cancer gene databases.

						.
Oncogene ¹	Tumor Suppressor gene ²	Cancer Gene Census ³	CancerGenes ⁴	Network of Cancer Gene ⁵	Significant driver gene in	Therapeutic Vulnerabilities in Cancer¹

cf) number; DB name
1 Oncogene; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long,
2 Tumor Suppressor gene; https://bioinfo.uth.edu/TSGene/,
3 Cancer Gene Census; http://www.nature.com/nrc/journal/v4/n3/abs/nrc1299.html,
4 CancerGenes; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long,
5 Network of Cancer Gene; http://ncg.kcl.ac.uk/index.php,
1Therapeutic Vulnerabilities in Cancer; http://cbio.mskcc.org/cancergenomics/statius/

Metabolic Pathway Description
REACTOME_INTEGRATION_OF_ENERGY_METABOLISM

Others
OMIM
Orphanet
Disease	KEGG Disease: GNG4
	MedGen: GNG4 (Human Medical Genetics with Condition)
	ClinVar: GNG4
Phenotype	MGI: GNG4 (International Mouse Phenotyping Consortium)
Phenotype	PhenomicDB: GNG4

Mutations for GNG4

* Under tables are showing count per each tissue to give us broad intuition about tissue specific mutation patterns.You can go to the detailed page for each mutation database's web site.

Structural Variants in COSMIC : go to COSMIC mutation histogram

- Statistics for Tissue and Mutation type

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- For Inter-chromosomal Variations

* Inter-chromosomal variantions includes 'interchromosomal amplicon to amplicon', 'interchromosomal amplicon to non-amplified dna', 'interchromosomal insertion', 'Interchromosomal unknown type'.

- For Intra-chromosomal Variations

* Intra-chromosomal variantions includes 'intrachromosomal amplicon to amplicon', 'intrachromosomal amplicon to non-amplified dna', 'intrachromosomal deletion', 'intrachromosomal fold-back inversion', 'intrachromosomal inversion', 'intrachromosomal tandem duplication', 'Intrachromosomal unknown type', 'intrachromosomal with inverted orientation', 'intrachromosomal with non-inverted orientation'.

Sample	Symbol_a	Chr_a	Start_a	End_a	Symbol_b	Chr_b	Start_b	End_b
large_intestine	GNG4	chr1	235721067	235721067		chr3	3298593	3298593
large_intestine	GNG4	chr1	235796032	235796032	ZFP2	chr5	178346281	178346281
ovary	GNG4	chr1	235730555	235730575	GNG4	chr1	235730802	235730822

cf) Tissue number; Tissue name (1;Breast, 2;Central_nervous_system, 3;Haematopoietic_and_lymphoid_tissue, 4;Large_intestine, 5;Liver, 6;Lung, 7;Ovary, 8;Pancreas, 9;Prostate, 10;Skin, 11;Soft_tissue, 12;Upper_aerodigestive_tract)

Related fusion transcripts : go to Chitars2.0

* From mRNA Sanger sequences, Chitars2.0 arranged chimeric transcripts. This table shows GNG4 related fusion information.

ID	Head Gene						Tail Gene
Accession	Gene_a	qStart_a	qEnd_a	Chromosome_a	tStart_a	tEnd_a	Gene_a	qStart_a	qEnd_a	Chromosome_a	tStart_a	tEnd_a
AW888605	GNG4	14	71	1	235714929	235714990	SORBS1	66	143	10	97072737	97072814
AW880094	LOC100507412	11	48	?	117701	117739	GNG4	47	70	1	235806442	235806465
AV747616	ATF6B	1	85	6	3468011	3468095	GNG4	86	411	1	235714207	235714533
AA743558	GNG4	1	21	1	235801786	235801806	PSMD10	13	335	X	107327444	107327765

Other DBs for Structural Variants

Structural Variants in Ensembl: go to Ensembl Structural variation

Structural Variants in dbVar: go to dbVar

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Copy Number Variations in COSMIC : go to COSMIC mutation CNV/Expr

Mutation type/ Tissue ID

brca

cns

cerv

endome

haematopo

kidn

Lintest

liver

lung

ovary

pancre

prost

skin

stoma

thyro

urina

Total # sample

GAIN (# sample)

LOSS (# sample)

cf) Tissue ID; Tissue type (1; Breast, 2; Central_nervous_system, 3; Cervix, 4; Endometrium, 5; Haematopoietic_and_lymphoid_tissue, 6; Kidney, 7; Large_intestine, 8; Liver, 9; Lung, 10; NS, 11; Ovary, 12; Pancreas, 13; Prostate, 14; Skin, 15; Stomach, 16; Thyroid, 17; Urinary_tract)

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SNV Counts per Each Loci in COSMIC data : go to COSMIC point mutation

: Non-synonymous mutation, : Synonymous mutation, Circle size denotes number of samples.
Maximum mutation count=6

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Somatic Mutation Counts per Tissue in COSMIC data

Stat. for Non-Synonymous SNVs (# total SNVs=11)	Stat. for Synonymous SNVs (# total SNVs=3)

Stat. for Deletions (# total SNVs=0)	Stat. for Insertions (# total SNVs=0)
There's no deleted snv.	There's no inserted snv.

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Top 10 SNVs Having the Most Samples in COSMIC data

* When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site,primary_histology,mutation(aa),pubmedID.

GRCh37 position	Mutation(aa)	Unique sampleID count
chr1:235715441-235715441	p.R66C	4
chr1:235747067-235747067	p.K24N	2
chr1:235715489-235715489	p.R50R	2
chr1:235715439-235715439	p.R66R	1
chr1:235747058-235747058	p.A27A	1
chr1:235715440-235715440	p.R66H	1
chr1:235747064-235747064	p.M25I	1
chr1:235715446-235715446	p.P64L	1
chr1:235747078-235747078	p.E21K	1
chr1:235715474-235715474	p.I55V	1

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SNV Counts per Each Loci in TCGA data

: non-synonymous mutation, : synonymous mutation, Circle size denotes number of samples.
maximum mutation count=2

Point Mutation/ Tissue ID	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20
# sample	3			4								2	2				3	1		6
# mutation	4			4								2	2				3	1		6
nonsynonymous SNV	4			2								1	2				2	1		5
synonymous SNV				2								1					1			1

cf) Tissue ID; Tissue type (1; BLCA[Bladder Urothelial Carcinoma], 2; BRCA[Breast invasive carcinoma], 3; CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], 4; COAD[Colon adenocarcinoma], 5; GBM[Glioblastoma multiforme], 6; Glioma Low Grade, 7; HNSC[Head and Neck squamous cell carcinoma], 8; KICH[Kidney Chromophobe], 9; KIRC[Kidney renal clear cell carcinoma], 10; KIRP[Kidney renal papillary cell carcinoma], 11; LAML[Acute Myeloid Leukemia], 12; LUAD[Lung adenocarcinoma], 13; LUSC[Lung squamous cell carcinoma], 14; OV[Ovarian serous cystadenocarcinoma ], 15; PAAD[Pancreatic adenocarcinoma], 16; PRAD[Prostate adenocarcinoma], 17; SKCM[Skin Cutaneous Melanoma], 18:STAD[Stomach adenocarcinoma], 19:THCA[Thyroid carcinoma], 20:UCEC[Uterine Corpus Endometrial Carcinoma])

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Top 10 SNVs Having the Most Samples in TCGA data

* We represented just top 10 SNVs. When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site, primary_histology, mutation(aa), pubmedID.

Genomic Position	Mutation(aa)	Unique sampleID count
chr1:235715441	p.R66C,GNG4	2
chr1:235715489	p.R50R,GNG4	2
chr1:235747056	p.C28F,GNG4	2
chr1:235715436	p.S6P,GNG4	1
chr1:235747058	p.E67E,GNG4	1
chr1:235715439	p.M1I,GNG4	1
chr1:235747064	p.R66R,GNG4	1
chr1:235715440	p.R66H,GNG4	1
chr1:235747067	p.P64H,GNG4	1
chr1:235747078	p.I55V,GNG4	1

Other DBs for Point Mutations

Point Mutation Table of Ensembl: go to Ensembl variation table

Mutation of cBioPortal: go to cBioPortal's Cross-cancer alteration summary

Copy Number for GNG4 in TCGA

* Copy number data were extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered on Jan-05-2015. Function ProcessCNAData in TCGA-Assembler package was used to obtain gene-level copy number value which is calculated as the average copy number of the genomic region of a gene.

cf) Tissue ID[Tissue type]: BLCA[Bladder Urothelial Carcinoma], BRCA[Breast invasive carcinoma], CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], COAD[Colon adenocarcinoma], GBM[Glioblastoma multiforme], Glioma Low Grade, HNSC[Head and Neck squamous cell carcinoma], KICH[Kidney Chromophobe], KIRC[Kidney renal clear cell carcinoma], KIRP[Kidney renal papillary cell carcinoma], LAML[Acute Myeloid Leukemia], LUAD[Lung adenocarcinoma], LUSC[Lung squamous cell carcinoma], OV[Ovarian serous cystadenocarcinoma ], PAAD[Pancreatic adenocarcinoma], PRAD[Prostate adenocarcinoma], SKCM[Skin Cutaneous Melanoma], STAD[Stomach adenocarcinoma], THCA[Thyroid carcinoma], UCEC[Uterine Corpus Endometrial Carcinoma]

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Gene Expression for GNG4

Gene Expression in Cancer Cell-lines (CCLE)

* CCLE gene expression data were extracted from CCLE_Expression_Entrez_2012-10-18.res: Gene-centric RMA-normalized mRNA expression data.

Differential Gene Expression in Primary Tumors (TCGA)

* Normalized gene expression data of RNASeqV2 was extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered at Jan-05-2015. Only eight cancer types have enough normal control samples for differential expression analysis.
(t test, adjusted p<0.05 (using Benjamini-Hochberg FDR))

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CNV vs Gene Expression Plot

* This plots show the correlation between CNV and gene expression.

: Open all plots for all cancer types

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Gene-Gene Network Information

Co-Expressed gene's network Plot

* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown.
Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene

: Open all plots for all cancer types


ACTL6B,AP3B2,APLP1,BRSK2,BSN,CHRNB2,GNG4, HCN2,KCNH2,UNC79,LRRC16B,LRTM2,MAST1,OGDHL, PSD,RAB34___RAB39A,RUNDC3A,SCG3,SYP,TMEM145,UNC13A	ASCL2,C11orf85,C2orf50,CPA6,FADS6,GATA5,GLYATL3, GNG4,KCNF1,KRTAP10-10,MCHR1,MYT1,NTSR1,PRSS1, PSCA,SPANXA2,SPANXC,SPANXD,ABHD11-AS1,WNT3A,ZNF716

ADNP,GID8,SPATA25,FAM217B,AAR2,RTFDC1,DDX27, DPM1,GNG4,TTI1,LOC646762,MOCS3,PCMTD2,PIGU, POFUT1,PPP1R3D,RPRD1B,TAF4,TP53RK,YTHDF1,ZSWIM3	APOD,ATOH8,BCAM,CCDC184,CCDC3,CGNL1,CRABP1, CSRP2,CYP4B1,EFHD1,TMEM255A,GALNT15,GNG4,GPX3, IRX6,LOC148824,MYOC,NPTX2,PTH1R,RERGL,RHOBTB1

Co-Expressed gene's Protein-protein interaction Network Plot

: Open all plots for all cancer types

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Interacting Genes (from Pathway Commons)

: Open all interacting genes' information including KEGG pathway for all interacting genes from DAVID

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Pharmacological Information for GNG4

There's no related Drug.

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Cross referenced IDs for GNG4

* We obtained these cross-references from Uniprot database. It covers 150 different DBs, 18 categories. http://www.uniprot.org/help/cross_references_section

: Open all cross reference information