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Phenotypic Information (metabolism pathway, cancer, disease, phenome) | |
Gene-Gene Network Information: Co-Expression Network, Interacting Genes & KEGG | |
Gene Summary for GNGT1 |
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Phenotypic Information for GNGT1(metabolism pathway, cancer, disease, phenome) |
Cancer Description | |
Cancer | CGAP: GNGT1 |
Familial Cancer Database: GNGT1 |
* This gene is included in those cancer gene databases. |
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Oncogene 1 | Significant driver gene in |
cf) number; DB name 1 Oncogene; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long, 2 Tumor Suppressor gene; https://bioinfo.uth.edu/TSGene/, 3 Cancer Gene Census; http://www.nature.com/nrc/journal/v4/n3/abs/nrc1299.html, 4 CancerGenes; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long, 5 Network of Cancer Gene; http://ncg.kcl.ac.uk/index.php, 1Therapeutic Vulnerabilities in Cancer; http://cbio.mskcc.org/cancergenomics/statius/ |
Metabolic Pathway Description | |
REACTOME_INTEGRATION_OF_ENERGY_METABOLISM |
Others | |
OMIM | |
Orphanet | |
Disease | KEGG Disease: GNGT1 |
MedGen: GNGT1 (Human Medical Genetics with Condition) | |
ClinVar: GNGT1 | |
Phenotype | MGI: GNGT1 (International Mouse Phenotyping Consortium) |
PhenomicDB: GNGT1 |
Mutations for GNGT1 |
* Under tables are showing count per each tissue to give us broad intuition about tissue specific mutation patterns.You can go to the detailed page for each mutation database's web site. |
Structural Variants in COSMIC: go to COSMIC mutation histogram |
There's no structural variation information in COSMIC data for this gene. |
Related fusion transcripts : go to Chitars2.0 |
* From mRNA Sanger sequences, Chitars2.0 arranged chimeric transcripts. This table shows GNGT1 related fusion information. |
ID | Head Gene | Tail Gene | Accession | Gene_a | qStart_a | qEnd_a | Chromosome_a | tStart_a | tEnd_a | Gene_a | qStart_a | qEnd_a | Chromosome_a | tStart_a | tEnd_a |
BF986197 | GNGT1 | 17 | 204 | 7 | 93516054 | 93516607 | GLG1 | 199 | 405 | 16 | 74514224 | 74519729 | |
X93851 | PSD3 | 1 | 80 | 8 | 18441287 | 18441366 | GNGT1 | 76 | 230 | 7 | 93346824 | 93346977 | |
AA303013 | TMCO3 | 1 | 226 | 13 | 114204317 | 114204542 | GNGT1 | 223 | 281 | 7 | 93516068 | 93516126 | |
BI050757 | PPP1R21 | 1 | 145 | 2 | 48725825 | 48734469 | GNGT1 | 141 | 198 | 7 | 93518478 | 93518535 | |
BM983864 | PARD3B | 2 | 21 | 2 | 205874391 | 205874410 | GNGT1 | 18 | 398 | 7 | 93515859 | 93516603 | |
AW995893 | GNGT1 | 30 | 289 | 7 | 93516673 | 93518535 | UBE2I | 272 | 437 | 16 | 1375024 | 1375189 |
Other DBs for Structural Variants |
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Copy Number Variations in COSMIC: go to COSMIC mutation CNV/Expr |
There's no copy number variation information in COSMIC data for this gene. |
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SNV Counts per Each Loci in COSMIC data: go to COSMIC point mutation |
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Somatic Mutation Counts per Tissue in COSMIC data |
Stat. for Non-Synonymous SNVs (# total SNVs=8) | (# total SNVs=4) |
(# total SNVs=0) | (# total SNVs=0) |
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Top 10 SNVs Having the Most Samples in COSMIC data |
* When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site,primary_histology,mutation(aa),pubmedID. |
GRCh37 position | Mutation(aa) | Unique sampleID count |
chr7:93540201-93540201 | p.E66Q | 1 |
chr7:93536150-93536150 | p.M31K | 1 |
chr7:93540203-93540203 | p.E66D | 1 |
chr7:93536155-93536155 | p.? | 1 |
chr7:93540213-93540213 | p.G70C | 1 |
chr7:93540125-93540125 | p.V40V | 1 |
chr7:93540228-93540228 | p.*75Q | 1 |
chr7:93536062-93536062 | p.P2T | 1 |
chr7:93540134-93540134 | p.Y43Y | 1 |
chr7:93536065-93536065 | p.V3L | 1 |
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SNV Counts per Each Loci in TCGA data |
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Point Mutation/ Tissue ID | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | 18 | 19 | 20 |
# sample |   |   |   | 1 |   |   |   |   |   |   |   | 3 | 1 |   | 1 |   | 1 | 1 | 1 | 1 |
# mutation |   |   |   | 1 |   |   |   |   |   |   |   | 3 | 1 |   | 1 |   | 1 | 1 | 1 | 1 |
nonsynonymous SNV |   |   |   | 1 |   |   |   |   |   |   |   | 3 |   |   | 1 |   |   | 1 | 1 |   |
synonymous SNV |   |   |   |   |   |   |   |   |   |   |   |   | 1 |   |   |   | 1 |   |   | 1 |
cf) Tissue ID; Tissue type (1; BLCA[Bladder Urothelial Carcinoma], 2; BRCA[Breast invasive carcinoma], 3; CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], 4; COAD[Colon adenocarcinoma], 5; GBM[Glioblastoma multiforme], 6; Glioma Low Grade, 7; HNSC[Head and Neck squamous cell carcinoma], 8; KICH[Kidney Chromophobe], 9; KIRC[Kidney renal clear cell carcinoma], 10; KIRP[Kidney renal papillary cell carcinoma], 11; LAML[Acute Myeloid Leukemia], 12; LUAD[Lung adenocarcinoma], 13; LUSC[Lung squamous cell carcinoma], 14; OV[Ovarian serous cystadenocarcinoma ], 15; PAAD[Pancreatic adenocarcinoma], 16; PRAD[Prostate adenocarcinoma], 17; SKCM[Skin Cutaneous Melanoma], 18:STAD[Stomach adenocarcinoma], 19:THCA[Thyroid carcinoma], 20:UCEC[Uterine Corpus Endometrial Carcinoma]) |
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Top 10 SNVs Having the Most Samples in TCGA data |
* We represented just top 10 SNVs. When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site, primary_histology, mutation(aa), pubmedID. |
Genomic Position | Mutation(aa) | Unique sampleID count |
chr7:93540201 | p.V3L | 1 |
chr7:93540203 | p.I4I | 1 |
chr7:93536065 | p.D8E | 1 |
chr7:93536070 | p.M31K | 1 |
chr7:93536082 | p.V40I | 1 |
chr7:93536150 | p.G56D | 1 |
chr7:93540123 | p.E59E | 1 |
chr7:93540172 | p.K65K | 1 |
chr7:93540182 | p.E66Q | 1 |
chr7:93540200 | p.E66D | 1 |
Other DBs for Point Mutations |
Copy Number for GNGT1 in TCGA |
* Copy number data were extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered on Jan-05-2015. Function ProcessCNAData in TCGA-Assembler package was used to obtain gene-level copy number value which is calculated as the average copy number of the genomic region of a gene. |
cf) Tissue ID[Tissue type]: BLCA[Bladder Urothelial Carcinoma], BRCA[Breast invasive carcinoma], CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], COAD[Colon adenocarcinoma], GBM[Glioblastoma multiforme], Glioma Low Grade, HNSC[Head and Neck squamous cell carcinoma], KICH[Kidney Chromophobe], KIRC[Kidney renal clear cell carcinoma], KIRP[Kidney renal papillary cell carcinoma], LAML[Acute Myeloid Leukemia], LUAD[Lung adenocarcinoma], LUSC[Lung squamous cell carcinoma], OV[Ovarian serous cystadenocarcinoma ], PAAD[Pancreatic adenocarcinoma], PRAD[Prostate adenocarcinoma], SKCM[Skin Cutaneous Melanoma], STAD[Stomach adenocarcinoma], THCA[Thyroid carcinoma], UCEC[Uterine Corpus Endometrial Carcinoma] |
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Gene Expression for GNGT1 |
Gene Expression in Cancer Cell-lines (CCLE) |
* CCLE gene expression data were extracted from CCLE_Expression_Entrez_2012-10-18.res: Gene-centric RMA-normalized mRNA expression data. |
Differential Gene Expression in Primary Tumors (TCGA) |
* Normalized gene expression data of RNASeqV2 was extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered at Jan-05-2015. Only eight cancer types have enough normal control samples for differential expression analysis. (t test, adjusted p<0.05 (using Benjamini-Hochberg FDR)) |
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CNV vs Gene Expression Plot |
* This plots show the correlation between CNV and gene expression. |
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Gene-Gene Network Information |
Co-Expressed gene's network Plot |
* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown. Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene |
ADAMTS20,ALG1L,C12orf56,COA1,DEFB126,COL6A4P1,SPATA31D3, GJB7,GNGT1,GRK7,H2BFWT,HTR2C,KRTAP4-1,MCHR2, OR13H1,OR8D2,SLC25A2,SLC5A12,SPDYC,SPERT,TAS2R38 | LINC01559,C7orf72,FAM151A,GNGT1,HNF1B,CEMIP,KRTAP4-1, LGSN,MAGEA4,NAPSA,NMU,OR13H1,OTOP2,SCEL, SCGB3A2,SERPINB3,SFTPB,TDRG1,TM4SF20,TR | ||||
C1orf111,RBM48,CALCR,CARD18,CGB2,GNGT1,INSM2, KRTAP27-1,LOC493754,LRCH4,NBPF6,PCLO,POLR2J4,RFPL2, RIMS2,RTP2,SBDSP1,SIM1,SLC12A9,TAS2R7,UNC5A | ABCG2,AMDHD2,KIAA1551,SH3D21,CACNA1D,COX6A2,CXADRP3, GLS,GNGT1,JMJD1C,KRT13,LOC154449,MGC27382,MIA2, OSGIN1,RSPH3,SLC16A5,SLC22A18,SLC26A1,TYW1B,UGT1A1 |
Co-Expressed gene's Protein-protein interaction Network Plot |
* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown. Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene |
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Interacting Genes (from Pathway Commons) |
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Pharmacological Information for GNGT1 |
Cross-referenced pharmacological DB IDs from Uniprot |
DB Category | DB Name | DB's ID and Url link |
Drug-Gene Interaction Network |
* Gene Centered Interaction Network. |
* Drug Centered Interaction Network. |
DrugBank ID | Target Name | Drug Groups | Generic Name | Drug Centered Network | Drug Structure |
DB07752 | guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1 | experimental | FARNESYL | ||
DB00945 | guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1 | approved | Acetylsalicylic acid | ||
DB00394 | guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1 | approved | Beclomethasone | ||
DB00443 | guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1 | approved | Betamethasone | ||
DB01222 | guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1 | approved; investigational | Budesonide | ||
DB01410 | guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1 | approved; investigational | Ciclesonide | ||
DB01260 | guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1 | approved; investigational | Desonide | ||
DB01234 | guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1 | approved; investigational | Dexamethasone | ||
DB00180 | guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1 | approved; investigational | Flunisolide | ||
DB00588 | guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1 | approved; investigational | Fluticasone Propionate | ||
DB00741 | guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1 | approved | Hydrocortisone | ||
DB00959 | guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1 | approved | Methylprednisolone | ||
DB00764 | guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1 | approved | Mometasone | ||
DB01384 | guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1 | approved | Paramethasone | ||
DB00860 | guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1 | approved | Prednisolone | ||
DB00635 | guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1 | approved | Prednisone | ||
DB00896 | guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1 | approved | Rimexolone | ||
DB00620 | guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1 | approved | Triamcinolone | ||
DB00125 | guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1 | approved; nutraceutical | L-Arginine | ||
DB00155 | guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1 | approved; nutraceutical | L-Citrulline | ||
DB00435 | guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1 | approved | Nitric Oxide | ||
DB00988 | guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1 | approved | Dopamine | ||
DB00171 | guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1 | approved; nutraceutical | Adenosine triphosphate | ||
DB00131 | guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1 | approved; nutraceutical | Adenosine monophosphate | ||
DB00396 | guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1 | approved | Progesterone |
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Cross referenced IDs for GNGT1 |
* We obtained these cross-references from Uniprot database. It covers 150 different DBs, 18 categories. http://www.uniprot.org/help/cross_references_section |
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