Cancer Cell Metabolism Gene Database

  Cancer Cell Metabolism Gene DB

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Bioinformatics and Systems Medicine Laboratory Bioinformatics and Systems Medicine Laboratory

Gene Summary

Phenotypic Information (metabolism pathway, cancer, disease, phenome)

Mutations: SVs, CNVs, SNVs

Gene expression: GE, Protein, DEGE, CNV vs GE

Gene-Gene Network Information: Co-Expression Network, Interacting Genes & KEGG

Pharmacological Information: Drug-Gene Network

Cross referenced IDs

Gene Summary for GOT2
Basic gene info.Gene symbolGOT2
Gene nameglutamic-oxaloacetic transaminase 2, mitochondrial
SynonymsKAT4|KATIV|mitAAT
CytomapUCSC genome browser: 16q21
Genomic locationchr16 :58741034-58768246
Type of geneprotein-coding
RefGenesNM_001286220.1,
NM_002080.3,
Ensembl idENSG00000125166
DescriptionFABP-1FABPpmaspartate aminotransferase 2aspartate aminotransferase, mitochondrialaspartate transaminase 2fatty acid-binding proteinglutamate oxaloacetate transaminase 2glutamic-oxaloacetic transaminase 2, mitochondrial (aspartate aminotransferase 2
Modification date20141211
dbXrefs MIM : 138150
HGNC : HGNC
Ensembl : ENSG00000125166
HPRD : 00684
Vega : OTTHUMG00000133769
ProteinUniProt:
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_GOT2
BioGPS: 2806
Gene Expression Atlas: ENSG00000125166
The Human Protein Atlas: ENSG00000125166
PathwayNCI Pathway Interaction Database: GOT2
KEGG: GOT2
REACTOME: GOT2
ConsensusPathDB
Pathway Commons: GOT2
MetabolismMetaCyc: GOT2
HUMANCyc: GOT2
RegulationEnsembl's Regulation: ENSG00000125166
miRBase: chr16 :58,741,034-58,768,246
TargetScan: NM_001286220
cisRED: ENSG00000125166
ContextiHOP: GOT2
cancer metabolism search in PubMed: GOT2
UCL Cancer Institute: GOT2
Assigned class in ccmGDBC

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Phenotypic Information for GOT2(metabolism pathway, cancer, disease, phenome)
check002.gifCancer Description
Cancer CGAP: GOT2
Familial Cancer Database: GOT2
* This gene is included in those cancer gene databases.

Oncogene 1

Tumor Suppressor gene 2

Cancer Gene Census 3

CancerGenes 4

Network of Cancer Gene 5

Significant driver gene in

Therapeutic Vulnerabilities in Cancer1

cf) number; DB name
1 Oncogene; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long,
2 Tumor Suppressor gene; https://bioinfo.uth.edu/TSGene/,
3 Cancer Gene Census; http://www.nature.com/nrc/journal/v4/n3/abs/nrc1299.html,
4 CancerGenes; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long,
5 Network of Cancer Gene; http://ncg.kcl.ac.uk/index.php,
1Therapeutic Vulnerabilities in Cancer; http://cbio.mskcc.org/cancergenomics/statius/

check002.gifMetabolic Pathway Description
KEGG_ALANINE_ASPARTATE_AND_GLUTAMATE_METABOLISM
KEGG_CYSTEINE_AND_METHIONINE_METABOLISM
KEGG_ARGININE_AND_PROLINE_METABOLISM
KEGG_TYROSINE_METABOLISM
KEGG_PHENYLALANINE_METABOLISM
REACTOME_METABOLISM_OF_AMINO_ACIDS_AND_DERIVATIVES
REACTOME_METABOLISM_OF_CARBOHYDRATES
REACTOME_GLUCOSE_METABOLISM

check002.gifOthers
OMIM
Orphanet
DiseaseKEGG Disease: GOT2
MedGen: GOT2 (Human Medical Genetics with Condition)
ClinVar: GOT2
PhenotypeMGI: GOT2 (International Mouse Phenotyping Consortium)
PhenomicDB: GOT2

Mutations for GOT2
* Under tables are showing count per each tissue to give us broad intuition about tissue specific mutation patterns.You can go to the detailed page for each mutation database's web site.

check002.gifStructural Variants in COSMIC: go to COSMIC mutation histogram
There's no structural variation information in COSMIC data for this gene.

check002.gifRelated fusion transcripts : go to Chitars2.0
* From mRNA Sanger sequences, Chitars2.0 arranged chimeric transcripts. This table shows GOT2 related fusion information.
IDHead GeneTail Gene
AccessionGene_aqStart_aqEnd_aChromosome_atStart_atEnd_aGene_aqStart_aqEnd_aChromosome_atStart_atEnd_a
BQ337855GOT234282165875212158752593HTT277449432090303210617
AK129856MIR548N19372179437433179438369GOT29331696165874103758741800
DA873777SLC38A71278165871785958718674GOT2276565165875214058753162
BF365549EML21153194612174046121892GOT2150362165875318758753399

check002.gifOther DBs for Structural Variants
Structural Variants in Ensembl: go to Ensembl Structural variation
Structural Variants in dbVar: go to dbVar

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check002.gifCopy Number Variations in COSMIC: go to COSMIC mutation CNV/Expr
There's no copy number variation information in COSMIC data for this gene.

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check002.gifSNV Counts per Each Loci in COSMIC data: go to COSMIC point mutation

 : Non-synonymous mutation, : Synonymous mutation, Circle size denotes number of samples.
Maximum mutation count=5

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check002.gifSomatic Mutation Counts per Tissue in COSMIC data
Stat. for Non-Synonymous SNVs
(# total SNVs=31)
Stat. for Synonymous SNVs
(# total SNVs=7)
Stat. for Deletions
(# total SNVs=1)
Stat. for Insertions
(# total SNVs=0)
There's no inserted snv.

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check002.gifTop 10 SNVs Having the Most Samples in COSMIC data
* When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site,primary_histology,mutation(aa),pubmedID.
GRCh37 positionMutation(aa)Unique sampleID count
chr16:58752192-58752192p.Q204K5
chr16:58743428-58743428p.R355G5
chr16:58768129-58768129p.A2S3
chr16:58749996-58749996p.P314L3
chr16:58750604-58750604p.C272C2
chr16:58750636-58750636p.R262C2
chr16:58757668-58757668p.V76V2
chr16:58749989-58749989p.Y316Y2
chr16:58742142-58742142p.S409F2
chr16:58756164-58756164p.A89T2

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check002.gifSNV Counts per Each Loci in TCGA data

 : non-synonymous mutation, : synonymous mutation, Circle size denotes number of samples.
maximum mutation count=6

Point Mutation/ Tissue ID1234567891011121314151617181920
# sample  241 3 41 63  26313
# mutation  241 3 41 63  27313
nonsynonymous SNV  121 3 31 53  16213
synonymous SNV  12    1  1   111  
cf) Tissue ID; Tissue type (1; BLCA[Bladder Urothelial Carcinoma], 2; BRCA[Breast invasive carcinoma], 3; CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], 4; COAD[Colon adenocarcinoma], 5; GBM[Glioblastoma multiforme], 6; Glioma Low Grade, 7; HNSC[Head and Neck squamous cell carcinoma], 8; KICH[Kidney Chromophobe], 9; KIRC[Kidney renal clear cell carcinoma], 10; KIRP[Kidney renal papillary cell carcinoma], 11; LAML[Acute Myeloid Leukemia], 12; LUAD[Lung adenocarcinoma], 13; LUSC[Lung squamous cell carcinoma], 14; OV[Ovarian serous cystadenocarcinoma ], 15; PAAD[Pancreatic adenocarcinoma], 16; PRAD[Prostate adenocarcinoma], 17; SKCM[Skin Cutaneous Melanoma], 18:STAD[Stomach adenocarcinoma], 19:THCA[Thyroid carcinoma], 20:UCEC[Uterine Corpus Endometrial Carcinoma])

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check002.gifTop 10 SNVs Having the Most Samples in TCGA data
* We represented just top 10 SNVs. When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site, primary_histology, mutation(aa), pubmedID.
Genomic PositionMutation(aa)Unique sampleID count
chr16:58743428p.R312W,GOT27
chr16:58750636p.R219C,GOT22
chr16:58757714p.N91D1
chr16:58749996p.R270R,GOT21
chr16:58752174p.A89S1
chr16:58757719p.K236E,GOT21
chr16:58749998p.R81S,GOT21
chr16:58752189p.C229C,GOT21
chr16:58757769p.V80I,GOT21
chr16:58750585p.I222I,GOT21

check002.gifOther DBs for Point Mutations
Point Mutation Table of Ensembl: go to Ensembl variation table
Mutation of cBioPortal: go to cBioPortal's Cross-cancer alteration summary

check002.gifCopy Number for GOT2 in TCGA
* Copy number data were extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered on Jan-05-2015. Function ProcessCNAData in TCGA-Assembler package was used to obtain gene-level copy number value which is calculated as the average copy number of the genomic region of a gene.
cf) Tissue ID[Tissue type]: BLCA[Bladder Urothelial Carcinoma], BRCA[Breast invasive carcinoma], CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], COAD[Colon adenocarcinoma], GBM[Glioblastoma multiforme], Glioma Low Grade, HNSC[Head and Neck squamous cell carcinoma], KICH[Kidney Chromophobe], KIRC[Kidney renal clear cell carcinoma], KIRP[Kidney renal papillary cell carcinoma], LAML[Acute Myeloid Leukemia], LUAD[Lung adenocarcinoma], LUSC[Lung squamous cell carcinoma], OV[Ovarian serous cystadenocarcinoma ], PAAD[Pancreatic adenocarcinoma], PRAD[Prostate adenocarcinoma], SKCM[Skin Cutaneous Melanoma], STAD[Stomach adenocarcinoma], THCA[Thyroid carcinoma], UCEC[Uterine Corpus Endometrial Carcinoma]

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Gene Expression for GOT2

check002.gifGene Expression in Cancer Cell-lines (CCLE)
* CCLE gene expression data were extracted from CCLE_Expression_Entrez_2012-10-18.res: Gene-centric RMA-normalized mRNA expression data.

check002.gifDifferential Gene Expression in Primary Tumors (TCGA)
* Normalized gene expression data of RNASeqV2 was extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered at Jan-05-2015. Only eight cancer types have enough normal control samples for differential expression analysis.
(t test, adjusted p<0.05 (using Benjamini-Hochberg FDR))
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check002.gifCNV vs Gene Expression Plot
* This plots show the correlation between CNV and gene expression.

: Open all plots for all cancer types


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Gene-Gene Network Information
check002.gifCo-Expressed gene's network Plot
* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown.
Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene

: Open all plots for all cancer types

AMFR,AP1G1,C16orf70,CCDC113,CDH1,CES2,COQ9,
CYB5B,ESRP2,FAM192A,GABARAPL2,GOT2,HSBP1,HSDL1,
IST1,GSE1,OGFOD1,POLR2C,SETD6,SLC38A7,TERF2IP
PERM1,CACNB1,CEP85,DUSP28,EEF1A2,FEM1A,FHL3,
GAMT,GOT1,GOT2,HSPA2,MYL6B,OBSCN,PDLIM3,
PFKM,PHKA1,RTN2,SH3BGR,SMYD1,TPM1,TUBA4A

FOPNL,C2orf47,CIAPIN1,COQ9,CXorf66,EARS2,EEF2KMT,
GINS3,GOT2,KATNB1,LOC146481,MRPL38,NDUFAB1,NUBP1,
NUP93,OGFOD1,PDF,RTN4IP1,TRAP1,TUFM,UQCRC2
CS,DARS2,DNAJC11,E2F2,EFTUD2,ELAVL1,FAM81A,
FARSA,GOT1,GOT2,HSPA9,MTA2,NARS,NOP14,
PDHA1,PIGU,PPIF,PROM2,SCFD2,SLC35A4,VARS
check002.gifCo-Expressed gene's Protein-protein interaction Network Plot
* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown.
Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene

: Open all plots for all cancer types

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check002.gifInteracting Genes (from Pathway Commons)

: Open all interacting genes' information including KEGG pathway for all interacting genes from DAVID

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Pharmacological Information for GOT2
check002.gifCross-referenced pharmacological DB IDs from Uniprot
DB CategoryDB NameDB's ID and Url link

check002.gifDrug-Gene Interaction Network
* Gene Centered Interaction Network.
* Drug Centered Interaction Network.
DrugBank IDTarget NameDrug GroupsGeneric NameDrug Centered NetworkDrug Structure
DB00114glutamic-oxaloacetic transaminase 2, mitochondrialnutraceuticalPyridoxal Phosphate
DB00128glutamic-oxaloacetic transaminase 2, mitochondrialapproved; nutraceuticalL-Aspartic Acid
DB00142glutamic-oxaloacetic transaminase 2, mitochondrialapproved; nutraceuticalL-Glutamic Acid
DB02783glutamic-oxaloacetic transaminase 2, mitochondrialexperimental4'-Deoxy-4'-Acetylyamino-Pyridoxal-5'-Phosphate
DB00121glutamic-oxaloacetic transaminase 2, mitochondrialapproved; nutraceuticalBiotin
DB00130glutamic-oxaloacetic transaminase 2, mitochondrialapproved; nutraceutical; investigationalL-Glutamine


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Cross referenced IDs for GOT2
* We obtained these cross-references from Uniprot database. It covers 150 different DBs, 18 categories. http://www.uniprot.org/help/cross_references_section

: Open all cross reference information



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