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Phenotypic Information (metabolism pathway, cancer, disease, phenome) | |
Gene-Gene Network Information: Co-Expression Network, Interacting Genes & KEGG | |
Gene Summary for GOT2 |
Basic gene info. | Gene symbol | GOT2 |
Gene name | glutamic-oxaloacetic transaminase 2, mitochondrial | |
Synonyms | KAT4|KATIV|mitAAT | |
Cytomap | UCSC genome browser: 16q21 | |
Genomic location | chr16 :58741034-58768246 | |
Type of gene | protein-coding | |
RefGenes | NM_001286220.1, NM_002080.3, | |
Ensembl id | ENSG00000125166 | |
Description | FABP-1FABPpmaspartate aminotransferase 2aspartate aminotransferase, mitochondrialaspartate transaminase 2fatty acid-binding proteinglutamate oxaloacetate transaminase 2glutamic-oxaloacetic transaminase 2, mitochondrial (aspartate aminotransferase 2 | |
Modification date | 20141211 | |
dbXrefs | MIM : 138150 | |
HGNC : HGNC | ||
Ensembl : ENSG00000125166 | ||
HPRD : 00684 | ||
Vega : OTTHUMG00000133769 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_GOT2 | |
BioGPS: 2806 | ||
Gene Expression Atlas: ENSG00000125166 | ||
The Human Protein Atlas: ENSG00000125166 | ||
Pathway | NCI Pathway Interaction Database: GOT2 | |
KEGG: GOT2 | ||
REACTOME: GOT2 | ||
ConsensusPathDB | ||
Pathway Commons: GOT2 | ||
Metabolism | MetaCyc: GOT2 | |
HUMANCyc: GOT2 | ||
Regulation | Ensembl's Regulation: ENSG00000125166 | |
miRBase: chr16 :58,741,034-58,768,246 | ||
TargetScan: NM_001286220 | ||
cisRED: ENSG00000125166 | ||
Context | iHOP: GOT2 | |
cancer metabolism search in PubMed: GOT2 | ||
UCL Cancer Institute: GOT2 | ||
Assigned class in ccmGDB | C |
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Phenotypic Information for GOT2(metabolism pathway, cancer, disease, phenome) |
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Cancer | CGAP: GOT2 |
Familial Cancer Database: GOT2 |
* This gene is included in those cancer gene databases. |
Oncogene 1 | Significant driver gene in |
cf) number; DB name 1 Oncogene; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long, 2 Tumor Suppressor gene; https://bioinfo.uth.edu/TSGene/, 3 Cancer Gene Census; http://www.nature.com/nrc/journal/v4/n3/abs/nrc1299.html, 4 CancerGenes; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long, 5 Network of Cancer Gene; http://ncg.kcl.ac.uk/index.php, 1Therapeutic Vulnerabilities in Cancer; http://cbio.mskcc.org/cancergenomics/statius/ |
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KEGG_ALANINE_ASPARTATE_AND_GLUTAMATE_METABOLISM KEGG_CYSTEINE_AND_METHIONINE_METABOLISM KEGG_ARGININE_AND_PROLINE_METABOLISM KEGG_TYROSINE_METABOLISM KEGG_PHENYLALANINE_METABOLISM REACTOME_METABOLISM_OF_AMINO_ACIDS_AND_DERIVATIVES REACTOME_METABOLISM_OF_CARBOHYDRATES REACTOME_GLUCOSE_METABOLISM |
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OMIM | |
Orphanet | |
Disease | KEGG Disease: GOT2 |
MedGen: GOT2 (Human Medical Genetics with Condition) | |
ClinVar: GOT2 | |
Phenotype | MGI: GOT2 (International Mouse Phenotyping Consortium) |
PhenomicDB: GOT2 |
Mutations for GOT2 |
* Under tables are showing count per each tissue to give us broad intuition about tissue specific mutation patterns.You can go to the detailed page for each mutation database's web site. |
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There's no structural variation information in COSMIC data for this gene. |
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* From mRNA Sanger sequences, Chitars2.0 arranged chimeric transcripts. This table shows GOT2 related fusion information. |
ID | Head Gene | Tail Gene | Accession | Gene_a | qStart_a | qEnd_a | Chromosome_a | tStart_a | tEnd_a | Gene_a | qStart_a | qEnd_a | Chromosome_a | tStart_a | tEnd_a |
BQ337855 | GOT2 | 34 | 282 | 16 | 58752121 | 58752593 | HTT | 277 | 449 | 4 | 3209030 | 3210617 | |
AK129856 | MIR548N | 1 | 937 | 2 | 179437433 | 179438369 | GOT2 | 933 | 1696 | 16 | 58741037 | 58741800 | |
DA873777 | SLC38A7 | 1 | 278 | 16 | 58717859 | 58718674 | GOT2 | 276 | 565 | 16 | 58752140 | 58753162 | |
BF365549 | EML2 | 1 | 153 | 19 | 46121740 | 46121892 | GOT2 | 150 | 362 | 16 | 58753187 | 58753399 |
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There's no copy number variation information in COSMIC data for this gene. |
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Stat. for Non-Synonymous SNVs (# total SNVs=31) | (# total SNVs=7) |
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(# total SNVs=1) | (# total SNVs=0) |
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* When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site,primary_histology,mutation(aa),pubmedID. |
GRCh37 position | Mutation(aa) | Unique sampleID count |
chr16:58752192-58752192 | p.Q204K | 5 |
chr16:58743428-58743428 | p.R355G | 5 |
chr16:58768129-58768129 | p.A2S | 3 |
chr16:58749996-58749996 | p.P314L | 3 |
chr16:58750604-58750604 | p.C272C | 2 |
chr16:58750636-58750636 | p.R262C | 2 |
chr16:58757668-58757668 | p.V76V | 2 |
chr16:58749989-58749989 | p.Y316Y | 2 |
chr16:58742142-58742142 | p.S409F | 2 |
chr16:58756164-58756164 | p.A89T | 2 |
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Point Mutation/ Tissue ID | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | 18 | 19 | 20 |
# sample |   |   | 2 | 4 | 1 |   | 3 |   | 4 | 1 |   | 6 | 3 |   |   | 2 | 6 | 3 | 1 | 3 |
# mutation |   |   | 2 | 4 | 1 |   | 3 |   | 4 | 1 |   | 6 | 3 |   |   | 2 | 7 | 3 | 1 | 3 |
nonsynonymous SNV |   |   | 1 | 2 | 1 |   | 3 |   | 3 | 1 |   | 5 | 3 |   |   | 1 | 6 | 2 | 1 | 3 |
synonymous SNV |   |   | 1 | 2 |   |   |   |   | 1 |   |   | 1 |   |   |   | 1 | 1 | 1 |   |   |
cf) Tissue ID; Tissue type (1; BLCA[Bladder Urothelial Carcinoma], 2; BRCA[Breast invasive carcinoma], 3; CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], 4; COAD[Colon adenocarcinoma], 5; GBM[Glioblastoma multiforme], 6; Glioma Low Grade, 7; HNSC[Head and Neck squamous cell carcinoma], 8; KICH[Kidney Chromophobe], 9; KIRC[Kidney renal clear cell carcinoma], 10; KIRP[Kidney renal papillary cell carcinoma], 11; LAML[Acute Myeloid Leukemia], 12; LUAD[Lung adenocarcinoma], 13; LUSC[Lung squamous cell carcinoma], 14; OV[Ovarian serous cystadenocarcinoma ], 15; PAAD[Pancreatic adenocarcinoma], 16; PRAD[Prostate adenocarcinoma], 17; SKCM[Skin Cutaneous Melanoma], 18:STAD[Stomach adenocarcinoma], 19:THCA[Thyroid carcinoma], 20:UCEC[Uterine Corpus Endometrial Carcinoma]) |
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* We represented just top 10 SNVs. When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site, primary_histology, mutation(aa), pubmedID. |
Genomic Position | Mutation(aa) | Unique sampleID count |
chr16:58743428 | p.R312W,GOT2 | 7 |
chr16:58750636 | p.R219C,GOT2 | 2 |
chr16:58757714 | p.N91D | 1 |
chr16:58749996 | p.R270R,GOT2 | 1 |
chr16:58752174 | p.A89S | 1 |
chr16:58757719 | p.K236E,GOT2 | 1 |
chr16:58749998 | p.R81S,GOT2 | 1 |
chr16:58752189 | p.C229C,GOT2 | 1 |
chr16:58757769 | p.V80I,GOT2 | 1 |
chr16:58750585 | p.I222I,GOT2 | 1 |
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* Copy number data were extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered on Jan-05-2015. Function ProcessCNAData in TCGA-Assembler package was used to obtain gene-level copy number value which is calculated as the average copy number of the genomic region of a gene. |
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cf) Tissue ID[Tissue type]: BLCA[Bladder Urothelial Carcinoma], BRCA[Breast invasive carcinoma], CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], COAD[Colon adenocarcinoma], GBM[Glioblastoma multiforme], Glioma Low Grade, HNSC[Head and Neck squamous cell carcinoma], KICH[Kidney Chromophobe], KIRC[Kidney renal clear cell carcinoma], KIRP[Kidney renal papillary cell carcinoma], LAML[Acute Myeloid Leukemia], LUAD[Lung adenocarcinoma], LUSC[Lung squamous cell carcinoma], OV[Ovarian serous cystadenocarcinoma ], PAAD[Pancreatic adenocarcinoma], PRAD[Prostate adenocarcinoma], SKCM[Skin Cutaneous Melanoma], STAD[Stomach adenocarcinoma], THCA[Thyroid carcinoma], UCEC[Uterine Corpus Endometrial Carcinoma] |
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Gene Expression for GOT2 |
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* CCLE gene expression data were extracted from CCLE_Expression_Entrez_2012-10-18.res: Gene-centric RMA-normalized mRNA expression data. |
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* Normalized gene expression data of RNASeqV2 was extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered at Jan-05-2015. Only eight cancer types have enough normal control samples for differential expression analysis. (t test, adjusted p<0.05 (using Benjamini-Hochberg FDR)) |
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* This plots show the correlation between CNV and gene expression. |
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Gene-Gene Network Information |
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* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown. Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene |
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AMFR,AP1G1,C16orf70,CCDC113,CDH1,CES2,COQ9, CYB5B,ESRP2,FAM192A,GABARAPL2,GOT2,HSBP1,HSDL1, IST1,GSE1,OGFOD1,POLR2C,SETD6,SLC38A7,TERF2IP | PERM1,CACNB1,CEP85,DUSP28,EEF1A2,FEM1A,FHL3, GAMT,GOT1,GOT2,HSPA2,MYL6B,OBSCN,PDLIM3, PFKM,PHKA1,RTN2,SH3BGR,SMYD1,TPM1,TUBA4A | ||||
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FOPNL,C2orf47,CIAPIN1,COQ9,CXorf66,EARS2,EEF2KMT, GINS3,GOT2,KATNB1,LOC146481,MRPL38,NDUFAB1,NUBP1, NUP93,OGFOD1,PDF,RTN4IP1,TRAP1,TUFM,UQCRC2 | CS,DARS2,DNAJC11,E2F2,EFTUD2,ELAVL1,FAM81A, FARSA,GOT1,GOT2,HSPA9,MTA2,NARS,NOP14, PDHA1,PIGU,PPIF,PROM2,SCFD2,SLC35A4,VARS |
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* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown. Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene |
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Pharmacological Information for GOT2 |
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DB Category | DB Name | DB's ID and Url link |
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* Gene Centered Interaction Network. |
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* Drug Centered Interaction Network. |
DrugBank ID | Target Name | Drug Groups | Generic Name | Drug Centered Network | Drug Structure |
DB00114 | glutamic-oxaloacetic transaminase 2, mitochondrial | nutraceutical | Pyridoxal Phosphate | ![]() | ![]() |
DB00128 | glutamic-oxaloacetic transaminase 2, mitochondrial | approved; nutraceutical | L-Aspartic Acid | ![]() | ![]() |
DB00142 | glutamic-oxaloacetic transaminase 2, mitochondrial | approved; nutraceutical | L-Glutamic Acid | ![]() | ![]() |
DB02783 | glutamic-oxaloacetic transaminase 2, mitochondrial | experimental | 4'-Deoxy-4'-Acetylyamino-Pyridoxal-5'-Phosphate | ![]() | ![]() |
DB00121 | glutamic-oxaloacetic transaminase 2, mitochondrial | approved; nutraceutical | Biotin | ![]() | ![]() |
DB00130 | glutamic-oxaloacetic transaminase 2, mitochondrial | approved; nutraceutical; investigational | L-Glutamine | ![]() | ![]() |
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Cross referenced IDs for GOT2 |
* We obtained these cross-references from Uniprot database. It covers 150 different DBs, 18 categories. http://www.uniprot.org/help/cross_references_section |
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