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Phenotypic Information (metabolism pathway, cancer, disease, phenome) | |
Gene-Gene Network Information: Co-Expression Network, Interacting Genes & KEGG | |
Gene Summary for DCPS |
Basic gene info. | Gene symbol | DCPS |
Gene name | decapping enzyme, scavenger | |
Synonyms | DCS1|HINT-5|HINT5|HSL1 | |
Cytomap | UCSC genome browser: 11q24.2 | |
Genomic location | chr11 :126173646-126215644 | |
Type of gene | protein-coding | |
RefGenes | NM_014026.4, | |
Ensembl id | ENSG00000110063 | |
Description | decapping scavenger enzymeheat shock-like protein 1hint-related 7meGMP-directed hydrolasehistidine triad nucleotide-binding protein 5histidine triad protein member 5homolog of C. elegans 7meGMP-directed hydrolase dcs-1m7GpppX diphosphatasemRNA deca | |
Modification date | 20141222 | |
dbXrefs | MIM : 610534 | |
HGNC : HGNC | ||
Ensembl : ENSG00000110063 | ||
HPRD : 16787 | ||
Vega : OTTHUMG00000165829 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_DCPS | |
BioGPS: 28960 | ||
Gene Expression Atlas: ENSG00000110063 | ||
The Human Protein Atlas: ENSG00000110063 | ||
Pathway | NCI Pathway Interaction Database: DCPS | |
KEGG: DCPS | ||
REACTOME: DCPS | ||
ConsensusPathDB | ||
Pathway Commons: DCPS | ||
Metabolism | MetaCyc: DCPS | |
HUMANCyc: DCPS | ||
Regulation | Ensembl's Regulation: ENSG00000110063 | |
miRBase: chr11 :126,173,646-126,215,644 | ||
TargetScan: NM_014026 | ||
cisRED: ENSG00000110063 | ||
Context | iHOP: DCPS | |
cancer metabolism search in PubMed: DCPS | ||
UCL Cancer Institute: DCPS | ||
Assigned class in ccmGDB | C |
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Phenotypic Information for DCPS(metabolism pathway, cancer, disease, phenome) |
Cancer Description | |
Cancer | CGAP: DCPS |
Familial Cancer Database: DCPS |
* This gene is included in those cancer gene databases. |
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Oncogene 1 | Significant driver gene in |
cf) number; DB name 1 Oncogene; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long, 2 Tumor Suppressor gene; https://bioinfo.uth.edu/TSGene/, 3 Cancer Gene Census; http://www.nature.com/nrc/journal/v4/n3/abs/nrc1299.html, 4 CancerGenes; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long, 5 Network of Cancer Gene; http://ncg.kcl.ac.uk/index.php, 1Therapeutic Vulnerabilities in Cancer; http://cbio.mskcc.org/cancergenomics/statius/ |
Metabolic Pathway Description | |
REACTOME_METABOLISM_OF_MRNA REACTOME_METABOLISM_OF_RNA |
Others | |
OMIM | |
Orphanet | |
Disease | KEGG Disease: DCPS |
MedGen: DCPS (Human Medical Genetics with Condition) | |
ClinVar: DCPS | |
Phenotype | MGI: DCPS (International Mouse Phenotyping Consortium) |
PhenomicDB: DCPS |
Mutations for DCPS |
* Under tables are showing count per each tissue to give us broad intuition about tissue specific mutation patterns.You can go to the detailed page for each mutation database's web site. |
Structural Variants in COSMIC: go to COSMIC mutation histogram |
There's no structural variation information in COSMIC data for this gene. |
Related fusion transcripts : go to Chitars2.0 |
* From mRNA Sanger sequences, Chitars2.0 arranged chimeric transcripts. This table shows DCPS related fusion information. |
ID | Head Gene | Tail Gene | Accession | Gene_a | qStart_a | qEnd_a | Chromosome_a | tStart_a | tEnd_a | Gene_a | qStart_a | qEnd_a | Chromosome_a | tStart_a | tEnd_a |
AV705612 | DCPS | 1 | 215 | 11 | 126208319 | 126208533 | C7 | 212 | 675 | 5 | 40982513 | 40982976 |
Other DBs for Structural Variants |
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Copy Number Variations in COSMIC: go to COSMIC mutation CNV/Expr |
There's no copy number variation information in COSMIC data for this gene. |
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SNV Counts per Each Loci in COSMIC data: go to COSMIC point mutation |
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Somatic Mutation Counts per Tissue in COSMIC data |
Stat. for Non-Synonymous SNVs (# total SNVs=31) | (# total SNVs=10) |
(# total SNVs=0) | (# total SNVs=0) |
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Top 10 SNVs Having the Most Samples in COSMIC data |
* When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site,primary_histology,mutation(aa),pubmedID. |
GRCh37 position | Mutation(aa) | Unique sampleID count |
chr11:126208231-126208231 | p.F191F | 3 |
chr11:126213259-126213259 | p.D232N | 3 |
chr11:126201357-126201357 | p.R145H | 3 |
chr11:126215392-126215392 | p.E300K | 2 |
chr11:126201290-126201290 | p.? | 2 |
chr11:126176613-126176613 | p.H117R | 1 |
chr11:126176481-126176481 | p.G73V | 1 |
chr11:126213212-126213212 | p.L216S | 1 |
chr11:126215396-126215396 | p.V301A | 1 |
chr11:126176489-126176489 | p.D76Y | 1 |
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SNV Counts per Each Loci in TCGA data |
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Point Mutation/ Tissue ID | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | 18 | 19 | 20 |
# sample | 2 |   |   | 5 |   |   |   |   | 1 |   |   | 5 | 2 | 1 |   |   | 1 | 1 | 1 | 8 |
# mutation | 2 |   |   | 5 |   |   |   |   | 1 |   |   | 6 | 2 | 1 |   |   | 1 | 1 | 1 | 8 |
nonsynonymous SNV | 2 |   |   | 4 |   |   |   |   |   |   |   | 3 | 2 | 1 |   |   |   | 1 | 1 | 6 |
synonymous SNV |   |   |   | 1 |   |   |   |   | 1 |   |   | 3 |   |   |   |   | 1 |   |   | 2 |
cf) Tissue ID; Tissue type (1; BLCA[Bladder Urothelial Carcinoma], 2; BRCA[Breast invasive carcinoma], 3; CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], 4; COAD[Colon adenocarcinoma], 5; GBM[Glioblastoma multiforme], 6; Glioma Low Grade, 7; HNSC[Head and Neck squamous cell carcinoma], 8; KICH[Kidney Chromophobe], 9; KIRC[Kidney renal clear cell carcinoma], 10; KIRP[Kidney renal papillary cell carcinoma], 11; LAML[Acute Myeloid Leukemia], 12; LUAD[Lung adenocarcinoma], 13; LUSC[Lung squamous cell carcinoma], 14; OV[Ovarian serous cystadenocarcinoma ], 15; PAAD[Pancreatic adenocarcinoma], 16; PRAD[Prostate adenocarcinoma], 17; SKCM[Skin Cutaneous Melanoma], 18:STAD[Stomach adenocarcinoma], 19:THCA[Thyroid carcinoma], 20:UCEC[Uterine Corpus Endometrial Carcinoma]) |
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Top 10 SNVs Having the Most Samples in TCGA data |
* We represented just top 10 SNVs. When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site, primary_histology, mutation(aa), pubmedID. |
Genomic Position | Mutation(aa) | Unique sampleID count |
chr11:126201357 | p.R145H | 3 |
chr11:126208231 | p.F191F | 3 |
chr11:126213223 | p.A220T | 3 |
chr11:126215329 | p.T154T | 1 |
chr11:126176613 | p.R188Q | 1 |
chr11:126215338 | p.R224H | 1 |
chr11:126201304 | p.K60I | 1 |
chr11:126215349 | p.R228I | 1 |
chr11:126201331 | p.F63V | 1 |
chr11:126215396 | p.H279N | 1 |
Other DBs for Point Mutations |
Copy Number for DCPS in TCGA |
* Copy number data were extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered on Jan-05-2015. Function ProcessCNAData in TCGA-Assembler package was used to obtain gene-level copy number value which is calculated as the average copy number of the genomic region of a gene. |
cf) Tissue ID[Tissue type]: BLCA[Bladder Urothelial Carcinoma], BRCA[Breast invasive carcinoma], CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], COAD[Colon adenocarcinoma], GBM[Glioblastoma multiforme], Glioma Low Grade, HNSC[Head and Neck squamous cell carcinoma], KICH[Kidney Chromophobe], KIRC[Kidney renal clear cell carcinoma], KIRP[Kidney renal papillary cell carcinoma], LAML[Acute Myeloid Leukemia], LUAD[Lung adenocarcinoma], LUSC[Lung squamous cell carcinoma], OV[Ovarian serous cystadenocarcinoma ], PAAD[Pancreatic adenocarcinoma], PRAD[Prostate adenocarcinoma], SKCM[Skin Cutaneous Melanoma], STAD[Stomach adenocarcinoma], THCA[Thyroid carcinoma], UCEC[Uterine Corpus Endometrial Carcinoma] |
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Gene Expression for DCPS |
Gene Expression in Cancer Cell-lines (CCLE) |
* CCLE gene expression data were extracted from CCLE_Expression_Entrez_2012-10-18.res: Gene-centric RMA-normalized mRNA expression data. |
Differential Gene Expression in Primary Tumors (TCGA) |
* Normalized gene expression data of RNASeqV2 was extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered at Jan-05-2015. Only eight cancer types have enough normal control samples for differential expression analysis. (t test, adjusted p<0.05 (using Benjamini-Hochberg FDR)) |
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CNV vs Gene Expression Plot |
* This plots show the correlation between CNV and gene expression. |
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Gene-Gene Network Information |
Co-Expressed gene's network Plot |
* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown. Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene |
ATP5L,CHEK1,DCPS,FAM118B,FOXRED1,H2AFX,HMBS, HYLS1,PFN1,POLR2F,PPP1R14B,PUS3,REXO2,RPUSD4, SRPR,ST14,ST3GAL4,TIMM44,TIMM8B,UQCRH,ZPR1 | ALKBH2,APRT,CECR5,DCPS,DDX49,DEAF1,DNAJC4, DTD1,ERCC1,ETHE1,EXOSC5,GRK6,MRTO4,NHP2, NOP16,NPM3,PRCC,RPL13A,TSC22D4,VARS,ZMYND19 | ||||
ADAM15,AGR2,BACE2,C14orf80,RBFA,ECI1,DCPS, DEAF1,F12,FKBP2,HMBS,NAA38,MTX1,PIH1D1, PSMB6,PSMC3,RAC3,SLC25A22,TIMM22,TMEM134,WRAP53 | COPS7B,DCPS,DNAJC10,EXOSC7,FTSJ1,GNA14,HS6ST2, IARS,IFI16,KCTD14,MSTO1,NAP1L4,NUCB2,POLR3D, PRMT1,PRPS1,RAD51D,RUVBL1,S100A11,SLC38A5,TUBG1 |
Co-Expressed gene's Protein-protein interaction Network Plot |
* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown. Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene |
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Interacting Genes (from Pathway Commons) |
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Pharmacological Information for DCPS |
Cross-referenced pharmacological DB IDs from Uniprot |
DB Category | DB Name | DB's ID and Url link |
Drug-Gene Interaction Network |
* Gene Centered Interaction Network. |
* Drug Centered Interaction Network. |
DrugBank ID | Target Name | Drug Groups | Generic Name | Drug Centered Network | Drug Structure |
DB01649 | decapping enzyme, scavenger | experimental | 7-Methyl-Gpppa | ||
DB01960 | decapping enzyme, scavenger | experimental | 7n-Methyl-8-Hydroguanosine-5'-Diphosphate | ||
DB03593 | decapping enzyme, scavenger | experimental | N7-Methyl-Guanosine-5'-Monophosphate | ||
DB03958 | decapping enzyme, scavenger | experimental | Mrna Cap Analog N7-Methyl Gpppg | ||
DB07642 | decapping enzyme, scavenger | experimental | 5-{[1-(2-fluorobenzyl)piperidin-4-yl]methoxy}quinazoline-2,4-diamine | ||
DB07643 | decapping enzyme, scavenger | experimental | 5-{[1-(2,3-dichlorobenzyl)piperidin-4-yl]methoxy}quinazoline-2,4-diamine | ||
DB07644 | decapping enzyme, scavenger | experimental | 5-[(1S)-1-(3-chlorophenyl)ethoxy]quinazoline-2,4-diamine |
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Cross referenced IDs for DCPS |
* We obtained these cross-references from Uniprot database. It covers 150 different DBs, 18 categories. http://www.uniprot.org/help/cross_references_section |
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