Cancer Cell Metabolism Gene Database

  Cancer Cell Metabolism Gene DB

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Gene Summary

Phenotypic Information (metabolism pathway, cancer, disease, phenome)

Mutations: SVs, CNVs, SNVs

Gene expression: GE, Protein, DEGE, CNV vs GE

Gene-Gene Network Information: Co-Expression Network, Interacting Genes & KEGG

Pharmacological Information: Drug-Gene Network

Cross referenced IDs

Gene Summary for ANPEP
Basic gene info.Gene symbolANPEP
Gene namealanyl (membrane) aminopeptidase
SynonymsAPN|CD13|GP150|LAP1|P150|PEPN
CytomapUCSC genome browser: 15q25-q26
Genomic locationchr15 :90328125-90358072
Type of geneprotein-coding
RefGenesNM_001150.2,
Ensembl idENSG00000166825
DescriptionAP-MAP-Nalanyl aminopeptidaseaminopeptidase Maminopeptidase NhAPNmicrosomal aminopeptidasemyeloid plasma membrane glycoprotein CD13
Modification date20141211
dbXrefs MIM : 151530
HGNC : HGNC
Ensembl : ENSG00000166825
HPRD : 01055
Vega : OTTHUMG00000149814
ProteinUniProt:
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_ANPEP
BioGPS: 290
Gene Expression Atlas: ENSG00000166825
The Human Protein Atlas: ENSG00000166825
PathwayNCI Pathway Interaction Database: ANPEP
KEGG: ANPEP
REACTOME: ANPEP
ConsensusPathDB
Pathway Commons: ANPEP
MetabolismMetaCyc: ANPEP
HUMANCyc: ANPEP
RegulationEnsembl's Regulation: ENSG00000166825
miRBase: chr15 :90,328,125-90,358,072
TargetScan: NM_001150
cisRED: ENSG00000166825
ContextiHOP: ANPEP
cancer metabolism search in PubMed: ANPEP
UCL Cancer Institute: ANPEP
Assigned class in ccmGDBC

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Phenotypic Information for ANPEP(metabolism pathway, cancer, disease, phenome)
check002.gifCancer Description
Cancer CGAP: ANPEP
Familial Cancer Database: ANPEP
* This gene is included in those cancer gene databases.

.

Oncogene 1

Tumor Suppressor gene 2

Cancer Gene Census 3

CancerGenes 4

Network of Cancer Gene 5

Significant driver gene in

Therapeutic Vulnerabilities in Cancer1

cf) number; DB name
1 Oncogene; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long,
2 Tumor Suppressor gene; https://bioinfo.uth.edu/TSGene/,
3 Cancer Gene Census; http://www.nature.com/nrc/journal/v4/n3/abs/nrc1299.html,
4 CancerGenes; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long,
5 Network of Cancer Gene; http://ncg.kcl.ac.uk/index.php,
1Therapeutic Vulnerabilities in Cancer; http://cbio.mskcc.org/cancergenomics/statius/

check002.gifMetabolic Pathway Description
KEGG_GLUTATHIONE_METABOLISM

check002.gifOthers
OMIM
Orphanet
DiseaseKEGG Disease: ANPEP
MedGen: ANPEP (Human Medical Genetics with Condition)
ClinVar: ANPEP
PhenotypeMGI: ANPEP (International Mouse Phenotyping Consortium)
PhenomicDB: ANPEP

Mutations for ANPEP
* Under tables are showing count per each tissue to give us broad intuition about tissue specific mutation patterns.You can go to the detailed page for each mutation database's web site.

check002.gifStructural Variants in COSMIC: go to COSMIC mutation histogram
There's no structural variation information in COSMIC data for this gene.

check002.gifRelated fusion transcripts : go to Chitars2.0
* From mRNA Sanger sequences, Chitars2.0 arranged chimeric transcripts. This table shows ANPEP related fusion information.
IDHead GeneTail Gene
AccessionGene_aqStart_aqEnd_aChromosome_atStart_atEnd_aGene_aqStart_aqEnd_aChromosome_atStart_atEnd_a
CB157580ANPEP1252159034650590347130ANPEP248622159034090390344722
BQ882584CUX1202167101461708101461904ANPEP206819159034712090348048

check002.gifOther DBs for Structural Variants
Structural Variants in Ensembl: go to Ensembl Structural variation
Structural Variants in dbVar: go to dbVar

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check002.gifCopy Number Variations in COSMIC: go to COSMIC mutation CNV/Expr
 
Mutation type/ Tissue IDbrcacnscervendomehaematopokidnLintestliverlungnsovarypancreprostskinstomathyrourina
Total # sample             1   
GAIN (# sample)             1   
LOSS (# sample)                 
cf) Tissue ID; Tissue type (1; Breast, 2; Central_nervous_system, 3; Cervix, 4; Endometrium, 5; Haematopoietic_and_lymphoid_tissue, 6; Kidney, 7; Large_intestine, 8; Liver, 9; Lung, 10; NS, 11; Ovary, 12; Pancreas, 13; Prostate, 14; Skin, 15; Stomach, 16; Thyroid, 17; Urinary_tract)

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check002.gifSNV Counts per Each Loci in COSMIC data: go to COSMIC point mutation

 : Non-synonymous mutation, : Synonymous mutation, Circle size denotes number of samples.
Maximum mutation count=5

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check002.gifSomatic Mutation Counts per Tissue in COSMIC data
Stat. for Non-Synonymous SNVs
(# total SNVs=98)
Stat. for Synonymous SNVs
(# total SNVs=32)
Stat. for Deletions
(# total SNVs=2)
Stat. for Insertions
(# total SNVs=3)

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check002.gifTop 10 SNVs Having the Most Samples in COSMIC data
* When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site,primary_histology,mutation(aa),pubmedID.
GRCh37 positionMutation(aa)Unique sampleID count
chr15:90344681-90344681p.R576H4
chr15:90342704-90342704p.E636K3
chr15:90349236-90349236p.F193L3
chr15:90342782-90342782p.D610N3
chr15:90349552-90349552p.T88M3
chr15:90347169-90347169p.S415F3
chr15:90347174-90347174p.F413F3
chr15:90347724-90347724p.S341L2
chr15:90349346-90349346p.E157Q2
chr15:90349632-90349632p.S61S2

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check002.gifSNV Counts per Each Loci in TCGA data

 : non-synonymous mutation, : synonymous mutation, Circle size denotes number of samples.
maximum mutation count=5

Point Mutation/ Tissue ID1234567891011121314151617181920
# sample352222 2 112 993  2310 18
# mutation452212 2 102 993  2911 20
nonsynonymous SNV351151   72 582  177 12
synonymous SNV1 161 2 3  411  124 8
cf) Tissue ID; Tissue type (1; BLCA[Bladder Urothelial Carcinoma], 2; BRCA[Breast invasive carcinoma], 3; CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], 4; COAD[Colon adenocarcinoma], 5; GBM[Glioblastoma multiforme], 6; Glioma Low Grade, 7; HNSC[Head and Neck squamous cell carcinoma], 8; KICH[Kidney Chromophobe], 9; KIRC[Kidney renal clear cell carcinoma], 10; KIRP[Kidney renal papillary cell carcinoma], 11; LAML[Acute Myeloid Leukemia], 12; LUAD[Lung adenocarcinoma], 13; LUSC[Lung squamous cell carcinoma], 14; OV[Ovarian serous cystadenocarcinoma ], 15; PAAD[Pancreatic adenocarcinoma], 16; PRAD[Prostate adenocarcinoma], 17; SKCM[Skin Cutaneous Melanoma], 18:STAD[Stomach adenocarcinoma], 19:THCA[Thyroid carcinoma], 20:UCEC[Uterine Corpus Endometrial Carcinoma])

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check002.gifTop 10 SNVs Having the Most Samples in TCGA data
* We represented just top 10 SNVs. When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site, primary_histology, mutation(aa), pubmedID.
Genomic PositionMutation(aa)Unique sampleID count
chr15:90342704p.E636K3
chr15:90349552p.A425A2
chr15:90347138p.P95P2
chr15:90328653p.P95H2
chr15:90340926p.T944M2
chr15:90342493p.T88M2
chr15:90349530p.A679A2
chr15:90349346p.A669A2
chr15:90349531p.E157Q2
chr15:90347586p.F327F1

check002.gifOther DBs for Point Mutations
Point Mutation Table of Ensembl: go to Ensembl variation table
Mutation of cBioPortal: go to cBioPortal's Cross-cancer alteration summary

check002.gifCopy Number for ANPEP in TCGA
* Copy number data were extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered on Jan-05-2015. Function ProcessCNAData in TCGA-Assembler package was used to obtain gene-level copy number value which is calculated as the average copy number of the genomic region of a gene.
cf) Tissue ID[Tissue type]: BLCA[Bladder Urothelial Carcinoma], BRCA[Breast invasive carcinoma], CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], COAD[Colon adenocarcinoma], GBM[Glioblastoma multiforme], Glioma Low Grade, HNSC[Head and Neck squamous cell carcinoma], KICH[Kidney Chromophobe], KIRC[Kidney renal clear cell carcinoma], KIRP[Kidney renal papillary cell carcinoma], LAML[Acute Myeloid Leukemia], LUAD[Lung adenocarcinoma], LUSC[Lung squamous cell carcinoma], OV[Ovarian serous cystadenocarcinoma ], PAAD[Pancreatic adenocarcinoma], PRAD[Prostate adenocarcinoma], SKCM[Skin Cutaneous Melanoma], STAD[Stomach adenocarcinoma], THCA[Thyroid carcinoma], UCEC[Uterine Corpus Endometrial Carcinoma]

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Gene Expression for ANPEP

check002.gifGene Expression in Cancer Cell-lines (CCLE)
* CCLE gene expression data were extracted from CCLE_Expression_Entrez_2012-10-18.res: Gene-centric RMA-normalized mRNA expression data.

check002.gifDifferential Gene Expression in Primary Tumors (TCGA)
* Normalized gene expression data of RNASeqV2 was extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered at Jan-05-2015. Only eight cancer types have enough normal control samples for differential expression analysis.
(t test, adjusted p<0.05 (using Benjamini-Hochberg FDR))
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check002.gifCNV vs Gene Expression Plot
* This plots show the correlation between CNV and gene expression.

: Open all plots for all cancer types


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Gene-Gene Network Information
check002.gifCo-Expressed gene's network Plot
* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown.
Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene

: Open all plots for all cancer types

ACOT11,ANKRD33,ANKRD55,ANPEP,ATP12A,CDR1,CNGA3,
TXLNGY,EIF1AY,FAM41AY1,FOXI2,KDM5D,LDHAL6A,NCRNA00185,
NETO2,PPARG,RAB40A,RGAG1,STC1,TTTY15,ZNF486
SOWAHB,ANPEP,BARX2,BBOX1,PLEKHS1,CMTM7,CXCL16,
GPR56,IL34,KLK5,KLK6,KLK8,KRT23,KRT7,
KRT80,PLD2,STAC2,TNFRSF19,TTC9,VGLL1,VPS37B

ABCG2,ACADS,ANPEP,B3GALT5,C11orf86,TMEM253,C1orf177,
C1orf94,CAPN11,CYP3A4,HSD17B2,MARVELD3,NAT8,LINC00114,
SULT1C2,TM4SF20,TM4SF4,TMEM92,TUBAL3,UGT1A4,UGT1A5
ABHD6,ACE2,ANPEP,CHN2,FLVCR1,GBA3,SLC52A1,
HEBP1,MEP1B,MYO1A,NAT8B,OIT3,OTC,PCK2,
PKLR,PRAP1,PTGR1,SLC23A1,SLC6A4,TM4SF20,AGMO
check002.gifCo-Expressed gene's Protein-protein interaction Network Plot
* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown.
Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene

: Open all plots for all cancer types

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check002.gifInteracting Genes (from Pathway Commons)

: Open all interacting genes' information including KEGG pathway for all interacting genes from DAVID

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Pharmacological Information for ANPEP
check002.gifCross-referenced pharmacological DB IDs from Uniprot
DB CategoryDB NameDB's ID and Url link

check002.gifDrug-Gene Interaction Network
* Gene Centered Interaction Network.
* Drug Centered Interaction Network.
DrugBank IDTarget NameDrug GroupsGeneric NameDrug Centered NetworkDrug Structure
DB00973alanyl (membrane) aminopeptidaseapprovedEzetimibe
DB06196alanyl (membrane) aminopeptidaseapproved; investigationalIcatibant
DB08506alanyl (membrane) aminopeptidaseexperimentalN-{(2S)-3-[(1R)-1-aminoethyl](hydroxy)phosphoryl-2-benzylpropanoyl}-L-phenylalanine
DB00563alanyl (membrane) aminopeptidaseapprovedMethotrexate
DB00987alanyl (membrane) aminopeptidaseapproved; investigationalCytarabine


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Cross referenced IDs for ANPEP
* We obtained these cross-references from Uniprot database. It covers 150 different DBs, 18 categories. http://www.uniprot.org/help/cross_references_section

: Open all cross reference information



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