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Phenotypic Information (metabolism pathway, cancer, disease, phenome) | |
Gene-Gene Network Information: Co-Expression Network, Interacting Genes & KEGG | |
Gene Summary for GSTA2 |
Basic gene info. | Gene symbol | GSTA2 |
Gene name | glutathione S-transferase alpha 2 | |
Synonyms | GST2|GSTA2-2|GTA2|GTH2 | |
Cytomap | UCSC genome browser: 6p12.1 | |
Genomic location | chr6 :52614884-52628361 | |
Type of gene | protein-coding | |
RefGenes | NM_000846.4, | |
Ensembl id | ENSG00000244067 | |
Description | GST HA subunit 2GST class-alpha member 2GST-gammaS-(hydroxyalkyl)glutathione lyase A2glutathione S-alkyltransferase A2glutathione S-aralkyltransferase A2glutathione S-aryltransferase A2glutathione S-transferase A2liver GST2 | |
Modification date | 20141207 | |
dbXrefs | MIM : 138360 | |
HGNC : HGNC | ||
Ensembl : ENSG00000244067 | ||
HPRD : 00709 | ||
Vega : OTTHUMG00000016263 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_GSTA2 | |
BioGPS: 2939 | ||
Gene Expression Atlas: ENSG00000244067 | ||
The Human Protein Atlas: ENSG00000244067 | ||
Pathway | NCI Pathway Interaction Database: GSTA2 | |
KEGG: GSTA2 | ||
REACTOME: GSTA2 | ||
ConsensusPathDB | ||
Pathway Commons: GSTA2 | ||
Metabolism | MetaCyc: GSTA2 | |
HUMANCyc: GSTA2 | ||
Regulation | Ensembl's Regulation: ENSG00000244067 | |
miRBase: chr6 :52,614,884-52,628,361 | ||
TargetScan: NM_000846 | ||
cisRED: ENSG00000244067 | ||
Context | iHOP: GSTA2 | |
cancer metabolism search in PubMed: GSTA2 | ||
UCL Cancer Institute: GSTA2 | ||
Assigned class in ccmGDB | C |
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Phenotypic Information for GSTA2(metabolism pathway, cancer, disease, phenome) |
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Cancer | CGAP: GSTA2 |
Familial Cancer Database: GSTA2 |
* This gene is included in those cancer gene databases. |
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Oncogene 1 | Significant driver gene in |
cf) number; DB name 1 Oncogene; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long, 2 Tumor Suppressor gene; https://bioinfo.uth.edu/TSGene/, 3 Cancer Gene Census; http://www.nature.com/nrc/journal/v4/n3/abs/nrc1299.html, 4 CancerGenes; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long, 5 Network of Cancer Gene; http://ncg.kcl.ac.uk/index.php, 1Therapeutic Vulnerabilities in Cancer; http://cbio.mskcc.org/cancergenomics/statius/ |
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KEGG_GLUTATHIONE_METABOLISM KEGG_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450 KEGG_DRUG_METABOLISM_CYTOCHROME_P450 |
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OMIM | |
Orphanet | |
Disease | KEGG Disease: GSTA2 |
MedGen: GSTA2 (Human Medical Genetics with Condition) | |
ClinVar: GSTA2 | |
Phenotype | MGI: GSTA2 (International Mouse Phenotyping Consortium) |
PhenomicDB: GSTA2 |
Mutations for GSTA2 |
* Under tables are showing count per each tissue to give us broad intuition about tissue specific mutation patterns.You can go to the detailed page for each mutation database's web site. |
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There's no structural variation information in COSMIC data for this gene. |
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* From mRNA Sanger sequences, Chitars2.0 arranged chimeric transcripts. This table shows GSTA2 related fusion information. |
ID | Head Gene | Tail Gene | Accession | Gene_a | qStart_a | qEnd_a | Chromosome_a | tStart_a | tEnd_a | Gene_a | qStart_a | qEnd_a | Chromosome_a | tStart_a | tEnd_a |
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There's no copy number variation information in COSMIC data for this gene. |
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Stat. for Non-Synonymous SNVs (# total SNVs=25) | (# total SNVs=4) |
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(# total SNVs=0) | (# total SNVs=0) |
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* When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site,primary_histology,mutation(aa),pubmedID. |
GRCh37 position | Mutation(aa) | Unique sampleID count |
chr6:52619793-52619793 | p.Y74N | 2 |
chr6:52617688-52617688 | p.E126D | 2 |
chr6:52617738-52617738 | p.P110S | 2 |
chr6:52621092-52621092 | p.I35L | 2 |
chr6:52621099-52621099 | p.E32E | 2 |
chr6:52617748-52617748 | p.I106I | 2 |
chr6:52616491-52616491 | p.G144R | 2 |
chr6:52615459-52615459 | p.K195K | 2 |
chr6:52615378-52615378 | p.F222L | 1 |
chr6:52617777-52617777 | p.E97K | 1 |
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Point Mutation/ Tissue ID | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | 18 | 19 | 20 |
# sample | 2 | 1 |   | 5 |   |   | 2 |   | 2 | 1 |   | 6 | 2 | 1 |   | 1 | 4 | 1 | 1 | 5 |
# mutation | 2 | 1 |   | 5 |   |   | 1 |   | 2 | 1 |   | 6 | 2 | 1 |   | 1 | 5 | 1 | 1 | 5 |
nonsynonymous SNV | 2 | 1 |   | 3 |   |   | 1 |   |   | 1 |   | 6 | 2 | 1 |   | 1 | 2 | 1 | 1 | 5 |
synonymous SNV |   |   |   | 2 |   |   |   |   | 2 |   |   |   |   |   |   |   | 3 |   |   |   |
cf) Tissue ID; Tissue type (1; BLCA[Bladder Urothelial Carcinoma], 2; BRCA[Breast invasive carcinoma], 3; CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], 4; COAD[Colon adenocarcinoma], 5; GBM[Glioblastoma multiforme], 6; Glioma Low Grade, 7; HNSC[Head and Neck squamous cell carcinoma], 8; KICH[Kidney Chromophobe], 9; KIRC[Kidney renal clear cell carcinoma], 10; KIRP[Kidney renal papillary cell carcinoma], 11; LAML[Acute Myeloid Leukemia], 12; LUAD[Lung adenocarcinoma], 13; LUSC[Lung squamous cell carcinoma], 14; OV[Ovarian serous cystadenocarcinoma ], 15; PAAD[Pancreatic adenocarcinoma], 16; PRAD[Prostate adenocarcinoma], 17; SKCM[Skin Cutaneous Melanoma], 18:STAD[Stomach adenocarcinoma], 19:THCA[Thyroid carcinoma], 20:UCEC[Uterine Corpus Endometrial Carcinoma]) |
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* We represented just top 10 SNVs. When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site, primary_histology, mutation(aa), pubmedID. |
Genomic Position | Mutation(aa) | Unique sampleID count |
chr6:52615381 | p.R221S | 3 |
chr6:52615459 | p.K195N | 3 |
chr6:52621092 | p.I35L | 2 |
chr6:52617688 | p.E126D | 2 |
chr6:52616490 | p.R155L | 1 |
chr6:52619770 | p.D42N | 1 |
chr6:52615426 | p.K152M | 1 |
chr6:52616499 | p.G144E | 1 |
chr6:52619840 | p.E32D | 1 |
chr6:52615427 | p.K141R | 1 |
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* Copy number data were extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered on Jan-05-2015. Function ProcessCNAData in TCGA-Assembler package was used to obtain gene-level copy number value which is calculated as the average copy number of the genomic region of a gene. |
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cf) Tissue ID[Tissue type]: BLCA[Bladder Urothelial Carcinoma], BRCA[Breast invasive carcinoma], CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], COAD[Colon adenocarcinoma], GBM[Glioblastoma multiforme], Glioma Low Grade, HNSC[Head and Neck squamous cell carcinoma], KICH[Kidney Chromophobe], KIRC[Kidney renal clear cell carcinoma], KIRP[Kidney renal papillary cell carcinoma], LAML[Acute Myeloid Leukemia], LUAD[Lung adenocarcinoma], LUSC[Lung squamous cell carcinoma], OV[Ovarian serous cystadenocarcinoma ], PAAD[Pancreatic adenocarcinoma], PRAD[Prostate adenocarcinoma], SKCM[Skin Cutaneous Melanoma], STAD[Stomach adenocarcinoma], THCA[Thyroid carcinoma], UCEC[Uterine Corpus Endometrial Carcinoma] |
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Gene Expression for GSTA2 |
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* CCLE gene expression data were extracted from CCLE_Expression_Entrez_2012-10-18.res: Gene-centric RMA-normalized mRNA expression data. |
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* Normalized gene expression data of RNASeqV2 was extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered at Jan-05-2015. Only eight cancer types have enough normal control samples for differential expression analysis. (t test, adjusted p<0.05 (using Benjamini-Hochberg FDR)) |
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* This plots show the correlation between CNV and gene expression. |
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Gene-Gene Network Information |
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* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown. Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene |
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ABCB11,ART4,ATXN7L3B,CPA6,DHRS9,F5,GIF, GPER1,GSTA1,GSTA2,ICK,KIAA1377,LOC730101,LRP4, OR4P4,PMCHL1,PMCHL2,SCN1B,SLC13A4,TMEM14A,TMEM200B | ANPEP,BBOX1,PLEKHS1,CGB2,GSTA1,GSTA2,KRT23, KRT80,KRTAP1-1,KRTAP13-2,LRRC4C,OR10J5,PSG8,RNF133, STAC2,TNFRSF19,TPM4,VGLL1,VWA5A,WFDC2,ZNF365 | ||||
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AMPH,ARR3,CDH4,CNGA3,CYLC1,ELOVL2,FAM181B, GAD2,GSTA1,GSTA2,MYCN,MYCNOS,NNAT,P2RY4, PON1,SCARNA20,SERPINA12,SYNGR4,UGT2B11,UGT2B28,ZNF385B | AADAC,APOA1,APOA4,APOB,APOC3,C17orf78,CRISP1, FABP6,FAM99A,FAM99B,GSTA2,GSTA5,LCE3E,LOC388428, MOS,ONECUT3,OR10H1,OR10H5,OR4N5,PWAR4___F2RL3___PAWR,SLC2A2, SPA |
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* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown. Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene |
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Pharmacological Information for GSTA2 |
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DB Category | DB Name | DB's ID and Url link |
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* Gene Centered Interaction Network. |
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* Drug Centered Interaction Network. |
DrugBank ID | Target Name | Drug Groups | Generic Name | Drug Centered Network | Drug Structure |
DB00143 | glutathione S-transferase alpha 2 | approved; nutraceutical | Glutathione | ![]() | ![]() |
DB00608 | glutathione S-transferase alpha 2 | approved | Chloroquine | ![]() | ![]() |
DB00515 | glutathione S-transferase alpha 2 | approved | Cisplatin | ![]() | ![]() |
DB01248 | glutathione S-transferase alpha 2 | approved; investigational | Docetaxel | ![]() | ![]() |
DB00993 | glutathione S-transferase alpha 2 | approved | Azathioprine | ![]() | ![]() |
DB01033 | glutathione S-transferase alpha 2 | approved | Mercaptopurine | ![]() | ![]() |
DB01026 | glutathione S-transferase alpha 2 | approved; investigational | Ketoconazole | ![]() | ![]() |
DB01110 | glutathione S-transferase alpha 2 | approved; investigational | Miconazole | ![]() | ![]() |
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Cross referenced IDs for GSTA2 |
* We obtained these cross-references from Uniprot database. It covers 150 different DBs, 18 categories. http://www.uniprot.org/help/cross_references_section |
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