|
Phenotypic Information (metabolism pathway, cancer, disease, phenome) | |
Gene-Gene Network Information: Co-Expression Network, Interacting Genes & KEGG | |
Gene Summary for GSTM3 |
Basic gene info. | Gene symbol | GSTM3 |
Gene name | glutathione S-transferase mu 3 (brain) | |
Synonyms | GST5|GSTB|GSTM3-3|GTM3 | |
Cytomap | UCSC genome browser: 1p13.3 | |
Genomic location | chr1 :110276553-110283660 | |
Type of gene | protein-coding | |
RefGenes | NM_000849.4, NR_024537.1, | |
Ensembl id | ENSG00000134202 | |
Description | GST class-mu 3S-(hydroxyalkyl)glutathione lyase M3brain GSTbrain type mu-glutathione S-transferaseglutathione S-alkyltransferase M3glutathione S-aralkyltransferase M3glutathione S-aryltransferase M3glutathione S-transferase M3 (brain)glutathione S | |
Modification date | 20141207 | |
dbXrefs | MIM : 138390 | |
HGNC : HGNC | ||
Ensembl : ENSG00000134202 | ||
HPRD : 00712 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_GSTM3 | |
BioGPS: 2947 | ||
Gene Expression Atlas: ENSG00000134202 | ||
The Human Protein Atlas: ENSG00000134202 | ||
Pathway | NCI Pathway Interaction Database: GSTM3 | |
KEGG: GSTM3 | ||
REACTOME: GSTM3 | ||
ConsensusPathDB | ||
Pathway Commons: GSTM3 | ||
Metabolism | MetaCyc: GSTM3 | |
HUMANCyc: GSTM3 | ||
Regulation | Ensembl's Regulation: ENSG00000134202 | |
miRBase: chr1 :110,276,553-110,283,660 | ||
TargetScan: NM_000849 | ||
cisRED: ENSG00000134202 | ||
Context | iHOP: GSTM3 | |
cancer metabolism search in PubMed: GSTM3 | ||
UCL Cancer Institute: GSTM3 | ||
Assigned class in ccmGDB | C |
Top |
Phenotypic Information for GSTM3(metabolism pathway, cancer, disease, phenome) |
Cancer Description | |
Cancer | CGAP: GSTM3 |
Familial Cancer Database: GSTM3 |
* This gene is included in those cancer gene databases. |
. | ||||||||||||||||||||
Oncogene 1 | Significant driver gene in |
cf) number; DB name 1 Oncogene; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long, 2 Tumor Suppressor gene; https://bioinfo.uth.edu/TSGene/, 3 Cancer Gene Census; http://www.nature.com/nrc/journal/v4/n3/abs/nrc1299.html, 4 CancerGenes; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long, 5 Network of Cancer Gene; http://ncg.kcl.ac.uk/index.php, 1Therapeutic Vulnerabilities in Cancer; http://cbio.mskcc.org/cancergenomics/statius/ |
Metabolic Pathway Description | |
KEGG_GLUTATHIONE_METABOLISM KEGG_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450 KEGG_DRUG_METABOLISM_CYTOCHROME_P450 |
Others | |
OMIM | |
Orphanet | |
Disease | KEGG Disease: GSTM3 |
MedGen: GSTM3 (Human Medical Genetics with Condition) | |
ClinVar: GSTM3 | |
Phenotype | MGI: GSTM3 (International Mouse Phenotyping Consortium) |
PhenomicDB: GSTM3 |
Mutations for GSTM3 |
* Under tables are showing count per each tissue to give us broad intuition about tissue specific mutation patterns.You can go to the detailed page for each mutation database's web site. |
Structural Variants in COSMIC: go to COSMIC mutation histogram |
There's no structural variation information in COSMIC data for this gene. |
Related fusion transcripts : go to Chitars2.0 |
* From mRNA Sanger sequences, Chitars2.0 arranged chimeric transcripts. This table shows GSTM3 related fusion information. |
ID | Head Gene | Tail Gene | Accession | Gene_a | qStart_a | qEnd_a | Chromosome_a | tStart_a | tEnd_a | Gene_a | qStart_a | qEnd_a | Chromosome_a | tStart_a | tEnd_a |
Other DBs for Structural Variants |
Top |
Copy Number Variations in COSMIC: go to COSMIC mutation CNV/Expr |
There's no copy number variation information in COSMIC data for this gene. |
Top |
SNV Counts per Each Loci in COSMIC data: go to COSMIC point mutation |
|
Top |
Somatic Mutation Counts per Tissue in COSMIC data |
Stat. for Non-Synonymous SNVs (# total SNVs=17) | (# total SNVs=5) |
(# total SNVs=1) | (# total SNVs=0) |
Top |
Top 10 SNVs Having the Most Samples in COSMIC data |
* When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site,primary_histology,mutation(aa),pubmedID. |
GRCh37 position | Mutation(aa) | Unique sampleID count |
chr1:110280786-110280786 | p.R100Q | 2 |
chr1:110279777-110279777 | p.I198I | 2 |
chr1:110280763-110280763 | p.V108I | 1 |
chr1:110282101-110282101 | p.R47* | 1 |
chr1:110280288-110280288 | p.A153V | 1 |
chr1:110280785-110280785 | p.R100R | 1 |
chr1:110282108-110282108 | p.D44D | 1 |
chr1:110280297-110280297 | p.S150L | 1 |
chr1:110282492-110282492 | p.D29D | 1 |
chr1:110280306-110280306 | p.G147E | 1 |
Top |
SNV Counts per Each Loci in TCGA data |
|
Point Mutation/ Tissue ID | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | 18 | 19 | 20 |
# sample |   | 1 |   | 4 |   |   |   |   |   |   | 1 | 1 | 1 |   | 1 |   | 4 | 3 | 1 | 3 |
# mutation |   | 1 |   | 5 |   |   |   |   |   |   | 1 | 1 | 1 |   | 1 |   | 4 | 3 | 1 | 3 |
nonsynonymous SNV |   |   |   | 3 |   |   |   |   |   |   | 1 | 1 | 1 |   | 1 |   | 2 | 2 | 1 | 3 |
synonymous SNV |   | 1 |   | 2 |   |   |   |   |   |   |   |   |   |   |   |   | 2 | 1 |   |   |
cf) Tissue ID; Tissue type (1; BLCA[Bladder Urothelial Carcinoma], 2; BRCA[Breast invasive carcinoma], 3; CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], 4; COAD[Colon adenocarcinoma], 5; GBM[Glioblastoma multiforme], 6; Glioma Low Grade, 7; HNSC[Head and Neck squamous cell carcinoma], 8; KICH[Kidney Chromophobe], 9; KIRC[Kidney renal clear cell carcinoma], 10; KIRP[Kidney renal papillary cell carcinoma], 11; LAML[Acute Myeloid Leukemia], 12; LUAD[Lung adenocarcinoma], 13; LUSC[Lung squamous cell carcinoma], 14; OV[Ovarian serous cystadenocarcinoma ], 15; PAAD[Pancreatic adenocarcinoma], 16; PRAD[Prostate adenocarcinoma], 17; SKCM[Skin Cutaneous Melanoma], 18:STAD[Stomach adenocarcinoma], 19:THCA[Thyroid carcinoma], 20:UCEC[Uterine Corpus Endometrial Carcinoma]) |
Top |
Top 10 SNVs Having the Most Samples in TCGA data |
* We represented just top 10 SNVs. When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site, primary_histology, mutation(aa), pubmedID. |
Genomic Position | Mutation(aa) | Unique sampleID count |
chr1:110282108 | p.D110D | 1 |
chr1:110280306 | p.C91F | 1 |
chr1:110282492 | p.R86C | 1 |
chr1:110280341 | p.R82H | 1 |
chr1:110282526 | p.R82C | 1 |
chr1:110280350 | p.S204A | 1 |
chr1:110279761 | p.K73K | 1 |
chr1:110280727 | p.Q203K | 1 |
chr1:110279764 | p.D44D | 1 |
chr1:110280755 | p.A199T | 1 |
Other DBs for Point Mutations |
Copy Number for GSTM3 in TCGA |
* Copy number data were extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered on Jan-05-2015. Function ProcessCNAData in TCGA-Assembler package was used to obtain gene-level copy number value which is calculated as the average copy number of the genomic region of a gene. |
cf) Tissue ID[Tissue type]: BLCA[Bladder Urothelial Carcinoma], BRCA[Breast invasive carcinoma], CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], COAD[Colon adenocarcinoma], GBM[Glioblastoma multiforme], Glioma Low Grade, HNSC[Head and Neck squamous cell carcinoma], KICH[Kidney Chromophobe], KIRC[Kidney renal clear cell carcinoma], KIRP[Kidney renal papillary cell carcinoma], LAML[Acute Myeloid Leukemia], LUAD[Lung adenocarcinoma], LUSC[Lung squamous cell carcinoma], OV[Ovarian serous cystadenocarcinoma ], PAAD[Pancreatic adenocarcinoma], PRAD[Prostate adenocarcinoma], SKCM[Skin Cutaneous Melanoma], STAD[Stomach adenocarcinoma], THCA[Thyroid carcinoma], UCEC[Uterine Corpus Endometrial Carcinoma] |
Top |
Gene Expression for GSTM3 |
Gene Expression in Cancer Cell-lines (CCLE) |
* CCLE gene expression data were extracted from CCLE_Expression_Entrez_2012-10-18.res: Gene-centric RMA-normalized mRNA expression data. |
Differential Gene Expression in Primary Tumors (TCGA) |
* Normalized gene expression data of RNASeqV2 was extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered at Jan-05-2015. Only eight cancer types have enough normal control samples for differential expression analysis. (t test, adjusted p<0.05 (using Benjamini-Hochberg FDR)) |
Top |
CNV vs Gene Expression Plot |
* This plots show the correlation between CNV and gene expression. |
Top |
Gene-Gene Network Information |
Co-Expressed gene's network Plot |
* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown. Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene |
ABCD3,ACBD4,ACOT4,C1orf64,CCDC103,CNTD1,CST9, EFHD1,GSTM2,GSTM3,GSTM4,KRT19,LOC100130581,MAGED2, ZNF205-AS1,PPT1,REEP5,RUNDC1,STC2,TMEM101,TTC39A | AAGAB,LINC00324,CAMK2N1,DNALI1,EFHD1,EIF2AK1,ERBB4, FOXA1,GLOD5,GSTM3,LYPD6B,MLPH,MYB,PPAPDC1B, PPT1,RFX6,SPA17,TMEM116,TSPAN13,TTC39A,XBP1 | ||||
ASIC1,CACNG6,CCK,DGCR5,FBXO2,GSTM3,HGFAC, LRRC42,MRTO4,PAK7,PARK7,PEX10,PPCS,PPP1R2, SLIT1,SOHLH1,SPDYC,SSU72,TCHH,TEX19,ZNF735 | ALDH1A1,ANO6,BEX1,BTC,LYRM9,C1QTNF3,C4orf3, CA11,CACNB2,DDHD2,ECM2,DENND6A,GSTM3,KRT222, CPQ,RGS5,SEC22C,STK33,TMEM64,XPA,ZNF639 |
Co-Expressed gene's Protein-protein interaction Network Plot |
* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown. Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene |
Top |
Interacting Genes (from Pathway Commons) |
Top |
Pharmacological Information for GSTM3 |
Cross-referenced pharmacological DB IDs from Uniprot |
DB Category | DB Name | DB's ID and Url link |
Drug-Gene Interaction Network |
* Gene Centered Interaction Network. |
* Drug Centered Interaction Network. |
DrugBank ID | Target Name | Drug Groups | Generic Name | Drug Centered Network | Drug Structure |
DB00143 | glutathione S-transferase mu 3 (brain) | approved; nutraceutical | Glutathione | ||
DB00958 | glutathione S-transferase mu 3 (brain) | approved | Carboplatin | ||
DB00997 | glutathione S-transferase mu 3 (brain) | approved; investigational | Doxorubicin | ||
DB01181 | glutathione S-transferase mu 3 (brain) | approved | Ifosfamide | ||
DB00515 | glutathione S-transferase mu 3 (brain) | approved | Cisplatin | ||
DB00531 | glutathione S-transferase mu 3 (brain) | approved; investigational | Cyclophosphamide |
Top |
Cross referenced IDs for GSTM3 |
* We obtained these cross-references from Uniprot database. It covers 150 different DBs, 18 categories. http://www.uniprot.org/help/cross_references_section |
Copyright © 2016-Present - The Univsersity of Texas Health Science Center at Houston @ |