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Phenotypic Information (metabolism pathway, cancer, disease, phenome) | |
Gene-Gene Network Information: Co-Expression Network, Interacting Genes & KEGG | |
Gene Summary for GSTM5 |
Basic gene info. | Gene symbol | GSTM5 |
Gene name | glutathione S-transferase mu 5 | |
Synonyms | GSTM5-5|GTM5 | |
Cytomap | UCSC genome browser: 1p13.3 | |
Genomic location | chr1 :110254863-110260890 | |
Type of gene | protein-coding | |
RefGenes | NM_000851.3, | |
Ensembl id | ENSG00000134201 | |
Description | GST class-mu 5S-(hydroxyalkyl)glutathione lyase M5glutathione S-alkyltransferase M5glutathione S-aralkyltransferase M5glutathione S-aryltransferase M5glutathione S-transferase M5glutathione S-transferase Mu 5 | |
Modification date | 20141207 | |
dbXrefs | MIM : 138385 | |
HGNC : HGNC | ||
Ensembl : ENSG00000134201 | ||
HPRD : 00711 | ||
Vega : OTTHUMG00000011644 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_GSTM5 | |
BioGPS: 2949 | ||
Gene Expression Atlas: ENSG00000134201 | ||
The Human Protein Atlas: ENSG00000134201 | ||
Pathway | NCI Pathway Interaction Database: GSTM5 | |
KEGG: GSTM5 | ||
REACTOME: GSTM5 | ||
ConsensusPathDB | ||
Pathway Commons: GSTM5 | ||
Metabolism | MetaCyc: GSTM5 | |
HUMANCyc: GSTM5 | ||
Regulation | Ensembl's Regulation: ENSG00000134201 | |
miRBase: chr1 :110,254,863-110,260,890 | ||
TargetScan: NM_000851 | ||
cisRED: ENSG00000134201 | ||
Context | iHOP: GSTM5 | |
cancer metabolism search in PubMed: GSTM5 | ||
UCL Cancer Institute: GSTM5 | ||
Assigned class in ccmGDB | C |
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Phenotypic Information for GSTM5(metabolism pathway, cancer, disease, phenome) |
Cancer Description | |
Cancer | CGAP: GSTM5 |
Familial Cancer Database: GSTM5 |
* This gene is included in those cancer gene databases. |
Oncogene 1 | Significant driver gene in |
cf) number; DB name 1 Oncogene; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long, 2 Tumor Suppressor gene; https://bioinfo.uth.edu/TSGene/, 3 Cancer Gene Census; http://www.nature.com/nrc/journal/v4/n3/abs/nrc1299.html, 4 CancerGenes; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long, 5 Network of Cancer Gene; http://ncg.kcl.ac.uk/index.php, 1Therapeutic Vulnerabilities in Cancer; http://cbio.mskcc.org/cancergenomics/statius/ |
Metabolic Pathway Description | |
KEGG_GLUTATHIONE_METABOLISM KEGG_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450 KEGG_DRUG_METABOLISM_CYTOCHROME_P450 |
Others | |
OMIM | |
Orphanet | |
Disease | KEGG Disease: GSTM5 |
MedGen: GSTM5 (Human Medical Genetics with Condition) | |
ClinVar: GSTM5 | |
Phenotype | MGI: GSTM5 (International Mouse Phenotyping Consortium) |
PhenomicDB: GSTM5 |
Mutations for GSTM5 |
* Under tables are showing count per each tissue to give us broad intuition about tissue specific mutation patterns.You can go to the detailed page for each mutation database's web site. |
Structural Variants in COSMIC: go to COSMIC mutation histogram |
There's no structural variation information in COSMIC data for this gene. |
Related fusion transcripts : go to Chitars2.0 |
* From mRNA Sanger sequences, Chitars2.0 arranged chimeric transcripts. This table shows GSTM5 related fusion information. |
ID | Head Gene | Tail Gene | Accession | Gene_a | qStart_a | qEnd_a | Chromosome_a | tStart_a | tEnd_a | Gene_a | qStart_a | qEnd_a | Chromosome_a | tStart_a | tEnd_a |
AV701798 | GSTM5 | 1 | 89 | 1 | 110256149 | 110256332 | GSTM4 | 84 | 401 | 1 | 110199002 | 110201648 |
Other DBs for Structural Variants |
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Copy Number Variations in COSMIC: go to COSMIC mutation CNV/Expr |
There's no copy number variation information in COSMIC data for this gene. |
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SNV Counts per Each Loci in COSMIC data: go to COSMIC point mutation |
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Somatic Mutation Counts per Tissue in COSMIC data |
Stat. for Non-Synonymous SNVs (# total SNVs=41) | (# total SNVs=34) |
(# total SNVs=0) | (# total SNVs=0) |
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Top 10 SNVs Having the Most Samples in COSMIC data |
* When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site,primary_histology,mutation(aa),pubmedID. |
GRCh37 position | Mutation(aa) | Unique sampleID count |
chr1:110257831-110257831 | p.L179P | 11 |
chr1:110255748-110255748 | p.D40D | 9 |
chr1:110257757-110257757 | p.T154T | 5 |
chr1:110257836-110257836 | p.L181L | 4 |
chr1:110257774-110257774 | p.A160V | 3 |
chr1:110256150-110256150 | p.N74N | 3 |
chr1:110257791-110257791 | p.M166V | 3 |
chr1:110257793-110257793 | p.M166I | 2 |
chr1:110256309-110256309 | p.R96C | 2 |
chr1:110255794-110255794 | p.D56Y | 2 |
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SNV Counts per Each Loci in TCGA data |
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Point Mutation/ Tissue ID | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | 18 | 19 | 20 |
# sample | 1 |   |   | 5 |   |   |   |   | 1 |   |   | 3 | 5 |   |   |   | 6 | 2 |   | 3 |
# mutation | 1 |   |   | 4 |   |   |   |   | 1 |   |   | 3 | 5 |   |   |   | 6 | 2 |   | 3 |
nonsynonymous SNV | 1 |   |   | 4 |   |   |   |   | 1 |   |   | 3 | 3 |   |   |   | 5 | 2 |   | 1 |
synonymous SNV |   |   |   |   |   |   |   |   |   |   |   |   | 2 |   |   |   | 1 |   |   | 2 |
cf) Tissue ID; Tissue type (1; BLCA[Bladder Urothelial Carcinoma], 2; BRCA[Breast invasive carcinoma], 3; CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], 4; COAD[Colon adenocarcinoma], 5; GBM[Glioblastoma multiforme], 6; Glioma Low Grade, 7; HNSC[Head and Neck squamous cell carcinoma], 8; KICH[Kidney Chromophobe], 9; KIRC[Kidney renal clear cell carcinoma], 10; KIRP[Kidney renal papillary cell carcinoma], 11; LAML[Acute Myeloid Leukemia], 12; LUAD[Lung adenocarcinoma], 13; LUSC[Lung squamous cell carcinoma], 14; OV[Ovarian serous cystadenocarcinoma ], 15; PAAD[Pancreatic adenocarcinoma], 16; PRAD[Prostate adenocarcinoma], 17; SKCM[Skin Cutaneous Melanoma], 18:STAD[Stomach adenocarcinoma], 19:THCA[Thyroid carcinoma], 20:UCEC[Uterine Corpus Endometrial Carcinoma]) |
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Top 10 SNVs Having the Most Samples in TCGA data |
* We represented just top 10 SNVs. When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site, primary_histology, mutation(aa), pubmedID. |
Genomic Position | Mutation(aa) | Unique sampleID count |
chr1:110255794 | p.D106N | 2 |
chr1:110256339 | p.E121E | 2 |
chr1:110257571 | p.T154A | 2 |
chr1:110254965 | p.R11C | 2 |
chr1:110257755 | p.D56Y | 2 |
chr1:110257831 | p.P125S | 1 |
chr1:110256121 | p.K144K | 1 |
chr1:110257850 | p.D162H | 1 |
chr1:110256125 | p.M1K | 1 |
chr1:110259984 | p.R168H | 1 |
Other DBs for Point Mutations |
Copy Number for GSTM5 in TCGA |
* Copy number data were extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered on Jan-05-2015. Function ProcessCNAData in TCGA-Assembler package was used to obtain gene-level copy number value which is calculated as the average copy number of the genomic region of a gene. |
cf) Tissue ID[Tissue type]: BLCA[Bladder Urothelial Carcinoma], BRCA[Breast invasive carcinoma], CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], COAD[Colon adenocarcinoma], GBM[Glioblastoma multiforme], Glioma Low Grade, HNSC[Head and Neck squamous cell carcinoma], KICH[Kidney Chromophobe], KIRC[Kidney renal clear cell carcinoma], KIRP[Kidney renal papillary cell carcinoma], LAML[Acute Myeloid Leukemia], LUAD[Lung adenocarcinoma], LUSC[Lung squamous cell carcinoma], OV[Ovarian serous cystadenocarcinoma ], PAAD[Pancreatic adenocarcinoma], PRAD[Prostate adenocarcinoma], SKCM[Skin Cutaneous Melanoma], STAD[Stomach adenocarcinoma], THCA[Thyroid carcinoma], UCEC[Uterine Corpus Endometrial Carcinoma] |
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Gene Expression for GSTM5 |
Gene Expression in Cancer Cell-lines (CCLE) |
* CCLE gene expression data were extracted from CCLE_Expression_Entrez_2012-10-18.res: Gene-centric RMA-normalized mRNA expression data. |
Differential Gene Expression in Primary Tumors (TCGA) |
* Normalized gene expression data of RNASeqV2 was extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered at Jan-05-2015. Only eight cancer types have enough normal control samples for differential expression analysis. (t test, adjusted p<0.05 (using Benjamini-Hochberg FDR)) |
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CNV vs Gene Expression Plot |
* This plots show the correlation between CNV and gene expression. |
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Gene-Gene Network Information |
Co-Expressed gene's network Plot |
* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown. Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene |
AACS,ACSBG1,AKR1D1,LINC01554,CLEC4C,FCN2,GSTM2P1, GSTM5,GSTT2,GUSB,HIST3H3,LOC91948,MAGEB3,MYOM2, NANOG,LINC00160,NR1H4,RNASE11,RNASE12,SLC6A3,TMPRSS9 | APOD,B4GALNT2,CCBL1,DHRS2,ENPP3,F9,GSTM2P1, GSTM5,GUSB,HIST1H2AE,HIST1H2BG,HIST1H4H,HPD,NANOG, NAT2,PPEF1,SPINK8,SPINT3,SULT1C3,TTC21A,UGT2B11 | ||||
A2M,ABCA8,BOC,C7,COL14A1,DCLK1,FBLN1, FBLN5,GSTM5,GYPC,LHFP,LIFR,MGP,PDE1A, PLAC9,PNMAL2,PODN,RBMS3,SCN4B,SLIT3,TMEM130 | AS3MT,CTSF,DCN,ZC2HC1A,FXYD1,GSTM5,LOC220930, LOC284276,MEAF6,NDNL2,NME5,PLD5,PTN,RRAGB, SNRPN,TIGD7,WASF3,ZNF470,ZNF542P,ZNF626,ZNF667 |
Co-Expressed gene's Protein-protein interaction Network Plot |
* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown. Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene |
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Interacting Genes (from Pathway Commons) |
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Pharmacological Information for GSTM5 |
Cross-referenced pharmacological DB IDs from Uniprot |
DB Category | DB Name | DB's ID and Url link |
Drug-Gene Interaction Network |
* Gene Centered Interaction Network. |
* Drug Centered Interaction Network. |
DrugBank ID | Target Name | Drug Groups | Generic Name | Drug Centered Network | Drug Structure |
DB00143 | glutathione S-transferase mu 5 | approved; nutraceutical | Glutathione | ||
DB00515 | glutathione S-transferase mu 5 | approved | Cisplatin | ||
DB01248 | glutathione S-transferase mu 5 | approved; investigational | Docetaxel |
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Cross referenced IDs for GSTM5 |
* We obtained these cross-references from Uniprot database. It covers 150 different DBs, 18 categories. http://www.uniprot.org/help/cross_references_section |
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