Cancer Cell Metabolism Gene Database

  Cancer Cell Metabolism Gene DB

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Gene Summary

Phenotypic Information (metabolism pathway, cancer, disease, phenome)

Mutations: SVs, CNVs, SNVs

Gene expression: GE, Protein, DEGE, CNV vs GE

Gene-Gene Network Information: Co-Expression Network, Interacting Genes & KEGG

Pharmacological Information: Drug-Gene Network

Cross referenced IDs

Gene Summary for GSTT1
Basic gene info.Gene symbolGSTT1
Gene nameglutathione S-transferase theta 1
Synonyms-
CytomapUCSC genome browser: 22q11.23
Genomic locationchr22 :24376138-24384284
Type of geneprotein-coding
RefGenesNM_000853.3,
NM_001293807.1,NM_001293808.1,NM_001293809.1,NM_001293810.1,
NM_001293811.1,NM_001293812.1,NM_001293813.1,NM_001293814.1,
Ensembl idENSG00000184674
DescriptionGST class-theta-1glutathione S-transferase theta-1glutathione transferase T1-1
Modification date20141222
dbXrefs MIM : 600436
HGNC : HGNC
HPRD : 02700
ProteinUniProt: P30711
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_GSTT1
BioGPS: 2952
Gene Expression Atlas: ENSG00000184674
The Human Protein Atlas: ENSG00000184674
PathwayNCI Pathway Interaction Database: GSTT1
KEGG: GSTT1
REACTOME: GSTT1
ConsensusPathDB
Pathway Commons: GSTT1
MetabolismMetaCyc: GSTT1
HUMANCyc: GSTT1
RegulationEnsembl's Regulation: ENSG00000184674
miRBase: chr22 :24,376,138-24,384,284
TargetScan: NM_000853
cisRED: ENSG00000184674
ContextiHOP: GSTT1
cancer metabolism search in PubMed: GSTT1
UCL Cancer Institute: GSTT1
Assigned class in ccmGDBB - This gene belongs to cancer gene.

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Phenotypic Information for GSTT1(metabolism pathway, cancer, disease, phenome)
check002.gifCancer Description
Cancer CGAP: GSTT1
Familial Cancer Database: GSTT1
* This gene is included in those cancer gene databases.

.

Oncogene 1

Tumor Suppressor gene 2

Cancer Gene Census 3

CancerGenes 4

Network of Cancer Gene 5

Significant driver gene in

Therapeutic Vulnerabilities in Cancer1

cf) number; DB name
1 Oncogene; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long,
2 Tumor Suppressor gene; https://bioinfo.uth.edu/TSGene/,
3 Cancer Gene Census; http://www.nature.com/nrc/journal/v4/n3/abs/nrc1299.html,
4 CancerGenes; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long,
5 Network of Cancer Gene; http://ncg.kcl.ac.uk/index.php,
1Therapeutic Vulnerabilities in Cancer; http://cbio.mskcc.org/cancergenomics/statius/

check002.gifMetabolic Pathway Description
KEGG_GLUTATHIONE_METABOLISM
KEGG_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450
KEGG_DRUG_METABOLISM_CYTOCHROME_P450

check002.gifOthers
OMIM 600436; gene.
Orphanet
DiseaseKEGG Disease: GSTT1
MedGen: GSTT1 (Human Medical Genetics with Condition)
ClinVar: GSTT1
PhenotypeMGI: GSTT1 (International Mouse Phenotyping Consortium)
PhenomicDB: GSTT1

Mutations for GSTT1
* Under tables are showing count per each tissue to give us broad intuition about tissue specific mutation patterns.You can go to the detailed page for each mutation database's web site.

check002.gifStructural Variants in COSMIC: go to COSMIC mutation histogram
There's no structural variation information in COSMIC data for this gene.

check002.gifRelated fusion transcripts : go to Chitars2.0
* From mRNA Sanger sequences, Chitars2.0 arranged chimeric transcripts. This table shows GSTT1 related fusion information.
IDHead GeneTail Gene
AccessionGene_aqStart_aqEnd_aChromosome_atStart_atEnd_aGene_aqStart_aqEnd_aChromosome_atStart_atEnd_a
CN352897GSTT11111222438411924384230SLC2A11108398222421730124224677

check002.gifOther DBs for Structural Variants
Structural Variants in Ensembl: go to Ensembl Structural variation
Structural Variants in dbVar: go to dbVar

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check002.gifCopy Number Variations in COSMIC: go to COSMIC mutation CNV/Expr
There's no copy number variation information in COSMIC data for this gene.

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check002.gifSNV Counts per Each Loci in COSMIC data: go to COSMIC point mutation

 : Non-synonymous mutation, : Synonymous mutation, Circle size denotes number of samples.
Maximum mutation count=3

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check002.gifSomatic Mutation Counts per Tissue in COSMIC data
Stat. for Non-Synonymous SNVs
(# total SNVs=8)
Stat. for Synonymous SNVs
(# total SNVs=3)
Stat. for Deletions
(# total SNVs=0)
Stat. for Insertions
(# total SNVs=0)
There's no deleted snv.There's no inserted snv.

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check002.gifTop 10 SNVs Having the Most Samples in COSMIC data
* When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site,primary_histology,mutation(aa),pubmedID.
GRCh37 positionMutation(aa)Unique sampleID count
chr22:24384226-24384226p.G2G1
chr22:24376964-24376964p.S129F1
chr22:24376450-24376450p.M232I1
chr22:24379409-24379409p.W101*1
chr22:24376476-24376476p.D224N1
chr22:24379451-24379451p.Q87Q1
chr22:24376501-24376501p.L215L1
chr22:24381723-24381723p.D59D1
chr22:24376503-24376503p.L215L1
chr22:24384116-24384116p.?1

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check002.gifSNV Counts per Each Loci in TCGA data

 : non-synonymous mutation, : synonymous mutation, Circle size denotes number of samples.
maximum mutation count=2

Point Mutation/ Tissue ID1234567891011121314151617181920
# sample2113  1  1   1 222 1
# mutation2114  1  1   1 222 1
nonsynonymous SNV 112  1  1     122 1
synonymous SNV2  2         1 1    
cf) Tissue ID; Tissue type (1; BLCA[Bladder Urothelial Carcinoma], 2; BRCA[Breast invasive carcinoma], 3; CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], 4; COAD[Colon adenocarcinoma], 5; GBM[Glioblastoma multiforme], 6; Glioma Low Grade, 7; HNSC[Head and Neck squamous cell carcinoma], 8; KICH[Kidney Chromophobe], 9; KIRC[Kidney renal clear cell carcinoma], 10; KIRP[Kidney renal papillary cell carcinoma], 11; LAML[Acute Myeloid Leukemia], 12; LUAD[Lung adenocarcinoma], 13; LUSC[Lung squamous cell carcinoma], 14; OV[Ovarian serous cystadenocarcinoma ], 15; PAAD[Pancreatic adenocarcinoma], 16; PRAD[Prostate adenocarcinoma], 17; SKCM[Skin Cutaneous Melanoma], 18:STAD[Stomach adenocarcinoma], 19:THCA[Thyroid carcinoma], 20:UCEC[Uterine Corpus Endometrial Carcinoma])

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check002.gifTop 10 SNVs Having the Most Samples in TCGA data
* We represented just top 10 SNVs. When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site, primary_histology, mutation(aa), pubmedID.
Genomic PositionMutation(aa)Unique sampleID count
chr22:24381723p.R96W2
chr22:24379500p.R15R,GSTT11
chr22:24376476p.L7L,GSTT11
chr22:24376501p.D106N,GSTT11
chr22:24384148p.E4Q,GSTT11
chr22:24376503p.L97L,GSTT11
chr22:24384180p.G2G,GSTT11
chr22:24376512p.L97L,GSTT11
chr22:24384187p.G2C,GSTT11
chr22:24376534p.E94K,GSTT11

check002.gifOther DBs for Point Mutations
Point Mutation Table of Ensembl: go to Ensembl variation table
Mutation of cBioPortal: go to cBioPortal's Cross-cancer alteration summary

check002.gifCopy Number for GSTT1 in TCGA
* Copy number data were extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered on Jan-05-2015. Function ProcessCNAData in TCGA-Assembler package was used to obtain gene-level copy number value which is calculated as the average copy number of the genomic region of a gene.
cf) Tissue ID[Tissue type]: BLCA[Bladder Urothelial Carcinoma], BRCA[Breast invasive carcinoma], CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], COAD[Colon adenocarcinoma], GBM[Glioblastoma multiforme], Glioma Low Grade, HNSC[Head and Neck squamous cell carcinoma], KICH[Kidney Chromophobe], KIRC[Kidney renal clear cell carcinoma], KIRP[Kidney renal papillary cell carcinoma], LAML[Acute Myeloid Leukemia], LUAD[Lung adenocarcinoma], LUSC[Lung squamous cell carcinoma], OV[Ovarian serous cystadenocarcinoma ], PAAD[Pancreatic adenocarcinoma], PRAD[Prostate adenocarcinoma], SKCM[Skin Cutaneous Melanoma], STAD[Stomach adenocarcinoma], THCA[Thyroid carcinoma], UCEC[Uterine Corpus Endometrial Carcinoma]

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Gene Expression for GSTT1

check002.gifGene Expression in Cancer Cell-lines (CCLE)
* CCLE gene expression data were extracted from CCLE_Expression_Entrez_2012-10-18.res: Gene-centric RMA-normalized mRNA expression data.

check002.gifDifferential Gene Expression in Primary Tumors (TCGA)
* Normalized gene expression data of RNASeqV2 was extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered at Jan-05-2015. Only eight cancer types have enough normal control samples for differential expression analysis.
(t test, adjusted p<0.05 (using Benjamini-Hochberg FDR))
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check002.gifCNV vs Gene Expression Plot
* This plots show the correlation between CNV and gene expression.

: Open all plots for all cancer types


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Gene-Gene Network Information
check002.gifCo-Expressed gene's network Plot
* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown.
Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene

: Open all plots for all cancer types

ALKBH7,SMDT1,CCDC157,CHCHD5,CIRBP,COQ4,DGCR6L,
DENND6B,FBXW4,GSTT1,HSCB,LOC391322,MRPL54,RAB17,
RHBDD3,RNF215,THAP7,TMEM205,TXN2,TXNRD2,WBP1
APLNR,ATG9A,NATD1,C1QTNF9,LINC00310,C22orf39,C6orf106,
TMEM246,MICU1,CDH13,GSTT1,H19,HOXA10,LINC00652,
KLHL30,LOC391322,PDE4A,ST3GAL3,SYNPO,UBE2D4,ZAK

ACY3,ALDH3A2,APOBEC1,ASL,B3GALT5,BTNL8,C1orf210,
MICU1,CIB1,CLDN7,CTSE,CYP2C18,GSTT1,LIMA1,
PIGR,PLA2G10,SDCBP2,SLC41A2,SULT1C2,TSPAN1,ZNF488
BCORP1,DNAAF2,CD9,CRYM,DCAF4,DDX43,ERI3,
EXOSC4,FAM162A,GGH,GSTT1,HAS2-AS1,DANCR,LCN15,
LOC100128822,LOC391322,RPS4Y2,TP53RK,TTTY10,ZNF544,ZNF702P
check002.gifCo-Expressed gene's Protein-protein interaction Network Plot
* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown.
Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene

: Open all plots for all cancer types

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check002.gifInteracting Genes (from Pathway Commons)

: Open all interacting genes' information including KEGG pathway for all interacting genes from DAVID

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Pharmacological Information for GSTT1
check002.gifCross-referenced pharmacological DB IDs from Uniprot
DB CategoryDB NameDB's ID and Url link
ChemistryChEMBL CHEMBL2141; -.
Organism-specific databasesPharmGKB PA183; -.
Organism-specific databasesCTD 2952; -.

check002.gifDrug-Gene Interaction Network
* Gene Centered Interaction Network.
* Drug Centered Interaction Network.
DrugBank IDTarget NameDrug GroupsGeneric NameDrug Centered NetworkDrug Structure
DB00143glutathione S-transferase theta 1approved; nutraceuticalGlutathione
DB01234glutathione S-transferase theta 1approved; investigationalDexamethasone
DB00650glutathione S-transferase theta 1approvedLeucovorin
DB00997glutathione S-transferase theta 1approved; investigationalDoxorubicin
DB04572glutathione S-transferase theta 1approvedThiotepa
DB00412glutathione S-transferase theta 1approved; investigationalRosiglitazone
DB00958glutathione S-transferase theta 1approvedCarboplatin
DB01181glutathione S-transferase theta 1approvedIfosfamide
DB00526glutathione S-transferase theta 1approved; investigationalOxaliplatin
DB00445glutathione S-transferase theta 1approvedEpirubicin
DB00515glutathione S-transferase theta 1approvedCisplatin
DB00531glutathione S-transferase theta 1approved; investigationalCyclophosphamide
DB00544glutathione S-transferase theta 1approvedFluorouracil
DB00444glutathione S-transferase theta 1approvedTeniposide
DB01042glutathione S-transferase theta 1approvedMelphalan
DB00564glutathione S-transferase theta 1approved; investigationalCarbamazepine
DB00987glutathione S-transferase theta 1approved; investigationalCytarabine
DB00694glutathione S-transferase theta 1approvedDaunorubicin
DB00773glutathione S-transferase theta 1approvedEtoposide
DB01033glutathione S-transferase theta 1approvedMercaptopurine
DB00563glutathione S-transferase theta 1approvedMethotrexate
DB00635glutathione S-transferase theta 1approvedPrednisone
DB00541glutathione S-transferase theta 1approved; investigationalVincristine
DB01008glutathione S-transferase theta 1approved; investigationalBusulfan
DB01101glutathione S-transferase theta 1approved; investigationalCapecitabine
DB00762glutathione S-transferase theta 1approved; investigationalIrinotecan
DB00382glutathione S-transferase theta 1approvedTacrine
DB01060glutathione S-transferase theta 1approvedAmoxicillin
DB00766glutathione S-transferase theta 1approvedClavulanate
DB00951glutathione S-transferase theta 1approvedIsoniazid
DB00197glutathione S-transferase theta 1withdrawnTroglitazone


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Cross referenced IDs for GSTT1
* We obtained these cross-references from Uniprot database. It covers 150 different DBs, 18 categories. http://www.uniprot.org/help/cross_references_section

: Open all cross reference information



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