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Phenotypic Information (metabolism pathway, cancer, disease, phenome) | |
Gene-Gene Network Information: Co-Expression Network, Interacting Genes & KEGG | |
Gene Summary for GSTT1 |
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Phenotypic Information for GSTT1(metabolism pathway, cancer, disease, phenome) |
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Cancer | CGAP: GSTT1 |
Familial Cancer Database: GSTT1 |
* This gene is included in those cancer gene databases. |
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Oncogene 1 | Significant driver gene in |
cf) number; DB name 1 Oncogene; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long, 2 Tumor Suppressor gene; https://bioinfo.uth.edu/TSGene/, 3 Cancer Gene Census; http://www.nature.com/nrc/journal/v4/n3/abs/nrc1299.html, 4 CancerGenes; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long, 5 Network of Cancer Gene; http://ncg.kcl.ac.uk/index.php, 1Therapeutic Vulnerabilities in Cancer; http://cbio.mskcc.org/cancergenomics/statius/ |
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KEGG_GLUTATHIONE_METABOLISM KEGG_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450 KEGG_DRUG_METABOLISM_CYTOCHROME_P450 |
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OMIM | 600436; gene. |
Orphanet | |
Disease | KEGG Disease: GSTT1 |
MedGen: GSTT1 (Human Medical Genetics with Condition) | |
ClinVar: GSTT1 | |
Phenotype | MGI: GSTT1 (International Mouse Phenotyping Consortium) |
PhenomicDB: GSTT1 |
Mutations for GSTT1 |
* Under tables are showing count per each tissue to give us broad intuition about tissue specific mutation patterns.You can go to the detailed page for each mutation database's web site. |
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There's no structural variation information in COSMIC data for this gene. |
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* From mRNA Sanger sequences, Chitars2.0 arranged chimeric transcripts. This table shows GSTT1 related fusion information. |
ID | Head Gene | Tail Gene | Accession | Gene_a | qStart_a | qEnd_a | Chromosome_a | tStart_a | tEnd_a | Gene_a | qStart_a | qEnd_a | Chromosome_a | tStart_a | tEnd_a |
CN352897 | GSTT1 | 1 | 111 | 22 | 24384119 | 24384230 | SLC2A11 | 108 | 398 | 22 | 24217301 | 24224677 |
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There's no copy number variation information in COSMIC data for this gene. |
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Stat. for Non-Synonymous SNVs (# total SNVs=8) | (# total SNVs=3) |
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(# total SNVs=0) | (# total SNVs=0) |
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* When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site,primary_histology,mutation(aa),pubmedID. |
GRCh37 position | Mutation(aa) | Unique sampleID count |
chr22:24376450-24376450 | p.M232I | 1 |
chr22:24379409-24379409 | p.W101* | 1 |
chr22:24376476-24376476 | p.D224N | 1 |
chr22:24379451-24379451 | p.Q87Q | 1 |
chr22:24376501-24376501 | p.L215L | 1 |
chr22:24381723-24381723 | p.D59D | 1 |
chr22:24376503-24376503 | p.L215L | 1 |
chr22:24384116-24384116 | p.? | 1 |
chr22:24376512-24376512 | p.E212K | 1 |
chr22:24384148-24384148 | p.F28L | 1 |
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Point Mutation/ Tissue ID | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | 18 | 19 | 20 |
# sample | 2 | 1 | 1 | 3 |   |   | 1 |   |   | 1 |   |   |   | 1 |   | 2 | 2 | 2 |   | 1 |
# mutation | 2 | 1 | 1 | 4 |   |   | 1 |   |   | 1 |   |   |   | 1 |   | 2 | 2 | 2 |   | 1 |
nonsynonymous SNV |   | 1 | 1 | 2 |   |   | 1 |   |   | 1 |   |   |   |   |   | 1 | 2 | 2 |   | 1 |
synonymous SNV | 2 |   |   | 2 |   |   |   |   |   |   |   |   |   | 1 |   | 1 |   |   |   |   |
cf) Tissue ID; Tissue type (1; BLCA[Bladder Urothelial Carcinoma], 2; BRCA[Breast invasive carcinoma], 3; CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], 4; COAD[Colon adenocarcinoma], 5; GBM[Glioblastoma multiforme], 6; Glioma Low Grade, 7; HNSC[Head and Neck squamous cell carcinoma], 8; KICH[Kidney Chromophobe], 9; KIRC[Kidney renal clear cell carcinoma], 10; KIRP[Kidney renal papillary cell carcinoma], 11; LAML[Acute Myeloid Leukemia], 12; LUAD[Lung adenocarcinoma], 13; LUSC[Lung squamous cell carcinoma], 14; OV[Ovarian serous cystadenocarcinoma ], 15; PAAD[Pancreatic adenocarcinoma], 16; PRAD[Prostate adenocarcinoma], 17; SKCM[Skin Cutaneous Melanoma], 18:STAD[Stomach adenocarcinoma], 19:THCA[Thyroid carcinoma], 20:UCEC[Uterine Corpus Endometrial Carcinoma]) |
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* We represented just top 10 SNVs. When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site, primary_histology, mutation(aa), pubmedID. |
Genomic Position | Mutation(aa) | Unique sampleID count |
chr22:24381723 | p.R96W | 2 |
chr22:24379500 | p.L7L,GSTT1 | 1 |
chr22:24376476 | p.E4Q,GSTT1 | 1 |
chr22:24376501 | p.D106N,GSTT1 | 1 |
chr22:24384148 | p.G2G,GSTT1 | 1 |
chr22:24376503 | p.L97L,GSTT1 | 1 |
chr22:24384180 | p.G2C,GSTT1 | 1 |
chr22:24376512 | p.L97L,GSTT1 | 1 |
chr22:24384187 | p.E94K,GSTT1 | 1 |
chr22:24376534 | p.G66R,GSTT1 | 1 |
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* Copy number data were extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered on Jan-05-2015. Function ProcessCNAData in TCGA-Assembler package was used to obtain gene-level copy number value which is calculated as the average copy number of the genomic region of a gene. |
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cf) Tissue ID[Tissue type]: BLCA[Bladder Urothelial Carcinoma], BRCA[Breast invasive carcinoma], CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], COAD[Colon adenocarcinoma], GBM[Glioblastoma multiforme], Glioma Low Grade, HNSC[Head and Neck squamous cell carcinoma], KICH[Kidney Chromophobe], KIRC[Kidney renal clear cell carcinoma], KIRP[Kidney renal papillary cell carcinoma], LAML[Acute Myeloid Leukemia], LUAD[Lung adenocarcinoma], LUSC[Lung squamous cell carcinoma], OV[Ovarian serous cystadenocarcinoma ], PAAD[Pancreatic adenocarcinoma], PRAD[Prostate adenocarcinoma], SKCM[Skin Cutaneous Melanoma], STAD[Stomach adenocarcinoma], THCA[Thyroid carcinoma], UCEC[Uterine Corpus Endometrial Carcinoma] |
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Gene Expression for GSTT1 |
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* CCLE gene expression data were extracted from CCLE_Expression_Entrez_2012-10-18.res: Gene-centric RMA-normalized mRNA expression data. |
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* Normalized gene expression data of RNASeqV2 was extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered at Jan-05-2015. Only eight cancer types have enough normal control samples for differential expression analysis. (t test, adjusted p<0.05 (using Benjamini-Hochberg FDR)) |
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* This plots show the correlation between CNV and gene expression. |
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Gene-Gene Network Information |
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* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown. Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene |
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ALKBH7,SMDT1,CCDC157,CHCHD5,CIRBP,COQ4,DGCR6L, DENND6B,FBXW4,GSTT1,HSCB,LOC391322,MRPL54,RAB17, RHBDD3,RNF215,THAP7,TMEM205,TXN2,TXNRD2,WBP1 | APLNR,ATG9A,NATD1,C1QTNF9,LINC00310,C22orf39,C6orf106, TMEM246,MICU1,CDH13,GSTT1,H19,HOXA10,LINC00652, KLHL30,LOC391322,PDE4A,ST3GAL3,SYNPO,UBE2D4,ZAK | ||||
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ACY3,ALDH3A2,APOBEC1,ASL,B3GALT5,BTNL8,C1orf210, MICU1,CIB1,CLDN7,CTSE,CYP2C18,GSTT1,LIMA1, PIGR,PLA2G10,SDCBP2,SLC41A2,SULT1C2,TSPAN1,ZNF488 | BCORP1,DNAAF2,CD9,CRYM,DCAF4,DDX43,ERI3, EXOSC4,FAM162A,GGH,GSTT1,HAS2-AS1,DANCR,LCN15, LOC100128822,LOC391322,RPS4Y2,TP53RK,TTTY10,ZNF544,ZNF702P |
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* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown. Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene |
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Pharmacological Information for GSTT1 |
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DB Category | DB Name | DB's ID and Url link |
Chemistry | ChEMBL | CHEMBL2141; -. |
Organism-specific databases | PharmGKB | PA183; -. |
Organism-specific databases | CTD | 2952; -. |
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* Gene Centered Interaction Network. |
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* Drug Centered Interaction Network. |
DrugBank ID | Target Name | Drug Groups | Generic Name | Drug Centered Network | Drug Structure |
DB00143 | glutathione S-transferase theta 1 | approved; nutraceutical | Glutathione | ![]() | ![]() |
DB01234 | glutathione S-transferase theta 1 | approved; investigational | Dexamethasone | ![]() | ![]() |
DB00650 | glutathione S-transferase theta 1 | approved | Leucovorin | ![]() | ![]() |
DB00997 | glutathione S-transferase theta 1 | approved; investigational | Doxorubicin | ![]() | ![]() |
DB04572 | glutathione S-transferase theta 1 | approved | Thiotepa | ![]() | ![]() |
DB00412 | glutathione S-transferase theta 1 | approved; investigational | Rosiglitazone | ![]() | ![]() |
DB00958 | glutathione S-transferase theta 1 | approved | Carboplatin | ![]() | ![]() |
DB01181 | glutathione S-transferase theta 1 | approved | Ifosfamide | ![]() | ![]() |
DB00526 | glutathione S-transferase theta 1 | approved; investigational | Oxaliplatin | ![]() | ![]() |
DB00445 | glutathione S-transferase theta 1 | approved | Epirubicin | ![]() | ![]() |
DB00515 | glutathione S-transferase theta 1 | approved | Cisplatin | ![]() | ![]() |
DB00531 | glutathione S-transferase theta 1 | approved; investigational | Cyclophosphamide | ![]() | ![]() |
DB00544 | glutathione S-transferase theta 1 | approved | Fluorouracil | ![]() | ![]() |
DB00444 | glutathione S-transferase theta 1 | approved | Teniposide | ![]() | ![]() |
DB01042 | glutathione S-transferase theta 1 | approved | Melphalan | ![]() | ![]() |
DB00564 | glutathione S-transferase theta 1 | approved; investigational | Carbamazepine | ![]() | ![]() |
DB00987 | glutathione S-transferase theta 1 | approved; investigational | Cytarabine | ![]() | ![]() |
DB00694 | glutathione S-transferase theta 1 | approved | Daunorubicin | ![]() | ![]() |
DB00773 | glutathione S-transferase theta 1 | approved | Etoposide | ![]() | ![]() |
DB01033 | glutathione S-transferase theta 1 | approved | Mercaptopurine | ![]() | ![]() |
DB00563 | glutathione S-transferase theta 1 | approved | Methotrexate | ![]() | ![]() |
DB00635 | glutathione S-transferase theta 1 | approved | Prednisone | ![]() | ![]() |
DB00541 | glutathione S-transferase theta 1 | approved; investigational | Vincristine | ![]() | ![]() |
DB01008 | glutathione S-transferase theta 1 | approved; investigational | Busulfan | ![]() | ![]() |
DB01101 | glutathione S-transferase theta 1 | approved; investigational | Capecitabine | ![]() | ![]() |
DB00762 | glutathione S-transferase theta 1 | approved; investigational | Irinotecan | ![]() | ![]() |
DB00382 | glutathione S-transferase theta 1 | approved | Tacrine | ![]() | ![]() |
DB01060 | glutathione S-transferase theta 1 | approved | Amoxicillin | ![]() | ![]() |
DB00766 | glutathione S-transferase theta 1 | approved | Clavulanate | ![]() | ![]() |
DB00951 | glutathione S-transferase theta 1 | approved | Isoniazid | ![]() | ![]() |
DB00197 | glutathione S-transferase theta 1 | withdrawn | Troglitazone | ![]() | ![]() |
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Cross referenced IDs for GSTT1 |
* We obtained these cross-references from Uniprot database. It covers 150 different DBs, 18 categories. http://www.uniprot.org/help/cross_references_section |
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