Cancer Cell Metabolism Gene Database

  Cancer Cell Metabolism Gene DB

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Bioinformatics and Systems Medicine Laboratory Bioinformatics and Systems Medicine Laboratory

Gene Summary

Phenotypic Information (metabolism pathway, cancer, disease, phenome)

Mutations: SVs, CNVs, SNVs

Gene expression: GE, Protein, DEGE, CNV vs GE

Gene-Gene Network Information: Co-Expression Network, Interacting Genes & KEGG

Pharmacological Information: Drug-Gene Network

Cross referenced IDs

Gene Summary for GSTZ1
Basic gene info.Gene symbolGSTZ1
Gene nameglutathione S-transferase zeta 1
SynonymsGSTZ1-1|MAAI|MAI
CytomapUCSC genome browser: 14q24.3
Genomic locationchr14 :77787705-77797940
Type of geneprotein-coding
RefGenesNM_001513.3,
NM_145870.2,NM_145871.2,
Ensembl idENSG00000100577
DescriptionS-(hydroxyalkyl)glutathione lyaseglutathione S-alkyltransferaseglutathione S-aralkyltransferaseglutathione S-aryltransferaseglutathione transferase zeta 1maleylacetoacetate isomerasemaleylacetone isomerase
Modification date20141207
dbXrefs MIM : 603758
HGNC : HGNC
Ensembl : ENSG00000100577
HPRD : 04785
Vega : OTTHUMG00000171551
ProteinUniProt:
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_GSTZ1
BioGPS: 2954
Gene Expression Atlas: ENSG00000100577
The Human Protein Atlas: ENSG00000100577
PathwayNCI Pathway Interaction Database: GSTZ1
KEGG: GSTZ1
REACTOME: GSTZ1
ConsensusPathDB
Pathway Commons: GSTZ1
MetabolismMetaCyc: GSTZ1
HUMANCyc: GSTZ1
RegulationEnsembl's Regulation: ENSG00000100577
miRBase: chr14 :77,787,705-77,797,940
TargetScan: NM_001513
cisRED: ENSG00000100577
ContextiHOP: GSTZ1
cancer metabolism search in PubMed: GSTZ1
UCL Cancer Institute: GSTZ1
Assigned class in ccmGDBC

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Phenotypic Information for GSTZ1(metabolism pathway, cancer, disease, phenome)
check002.gifCancer Description
Cancer CGAP: GSTZ1
Familial Cancer Database: GSTZ1
* This gene is included in those cancer gene databases.

.

Oncogene 1

Tumor Suppressor gene 2

Cancer Gene Census 3

CancerGenes 4

Network of Cancer Gene 5

Significant driver gene in

Therapeutic Vulnerabilities in Cancer1

cf) number; DB name
1 Oncogene; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long,
2 Tumor Suppressor gene; https://bioinfo.uth.edu/TSGene/,
3 Cancer Gene Census; http://www.nature.com/nrc/journal/v4/n3/abs/nrc1299.html,
4 CancerGenes; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long,
5 Network of Cancer Gene; http://ncg.kcl.ac.uk/index.php,
1Therapeutic Vulnerabilities in Cancer; http://cbio.mskcc.org/cancergenomics/statius/

check002.gifMetabolic Pathway Description
KEGG_TYROSINE_METABOLISM
KEGG_GLUTATHIONE_METABOLISM
KEGG_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450
KEGG_DRUG_METABOLISM_CYTOCHROME_P450
REACTOME_METABOLISM_OF_AMINO_ACIDS_AND_DERIVATIVES

check002.gifOthers
OMIM
Orphanet
DiseaseKEGG Disease: GSTZ1
MedGen: GSTZ1 (Human Medical Genetics with Condition)
ClinVar: GSTZ1
PhenotypeMGI: GSTZ1 (International Mouse Phenotyping Consortium)
PhenomicDB: GSTZ1

Mutations for GSTZ1
* Under tables are showing count per each tissue to give us broad intuition about tissue specific mutation patterns.You can go to the detailed page for each mutation database's web site.

check002.gifStructural Variants in COSMIC: go to COSMIC mutation histogram
There's no structural variation information in COSMIC data for this gene.

check002.gifRelated fusion transcripts : go to Chitars2.0
* From mRNA Sanger sequences, Chitars2.0 arranged chimeric transcripts. This table shows GSTZ1 related fusion information.
IDHead GeneTail Gene
AccessionGene_aqStart_aqEnd_aChromosome_atStart_atEnd_aGene_aqStart_aqEnd_aChromosome_atStart_atEnd_a
BM833317PCBD21545134260240134260294GSTZ150441147779121177795526
BM820517PCBD21565134260240134260295GSTZ152609147779121177797458
AI636936ADAP21309172928492429285233GSTZ1309431147778742777791235

check002.gifOther DBs for Structural Variants
Structural Variants in Ensembl: go to Ensembl Structural variation
Structural Variants in dbVar: go to dbVar

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check002.gifCopy Number Variations in COSMIC: go to COSMIC mutation CNV/Expr
There's no copy number variation information in COSMIC data for this gene.

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check002.gifSNV Counts per Each Loci in COSMIC data: go to COSMIC point mutation

 : Non-synonymous mutation, : Synonymous mutation, Circle size denotes number of samples.
Maximum mutation count=2

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check002.gifSomatic Mutation Counts per Tissue in COSMIC data
Stat. for Non-Synonymous SNVs
(# total SNVs=9)
Stat. for Synonymous SNVs
(# total SNVs=1)
Stat. for Deletions
(# total SNVs=0)
Stat. for Insertions
(# total SNVs=0)
There's no deleted snv.There's no inserted snv.

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check002.gifTop 10 SNVs Having the Most Samples in COSMIC data
* When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site,primary_histology,mutation(aa),pubmedID.
GRCh37 positionMutation(aa)Unique sampleID count
chr14:77797425-77797425p.L125I1
chr14:77794333-77794333p.V44M1
chr14:77797454-77797454p.I134M1
chr14:77794336-77794336p.R45C1
chr14:77797487-77797487p.Q145H1
chr14:77794369-77794369p.Q56E1
chr14:77797491-77797491p.S147P1
chr14:77795495-77795495p.E69E1
chr14:77797506-77797506p.Q152*1
chr14:77795510-77795510p.T74T1

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check002.gifSNV Counts per Each Loci in TCGA data

 : non-synonymous mutation, : synonymous mutation, Circle size denotes number of samples.
maximum mutation count=2

Point Mutation/ Tissue ID1234567891011121314151617181920
# sample11 3       12   12 5
# mutation11 3       12   13 5
nonsynonymous SNV11 3       12    3 4
synonymous SNV                1  1
cf) Tissue ID; Tissue type (1; BLCA[Bladder Urothelial Carcinoma], 2; BRCA[Breast invasive carcinoma], 3; CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], 4; COAD[Colon adenocarcinoma], 5; GBM[Glioblastoma multiforme], 6; Glioma Low Grade, 7; HNSC[Head and Neck squamous cell carcinoma], 8; KICH[Kidney Chromophobe], 9; KIRC[Kidney renal clear cell carcinoma], 10; KIRP[Kidney renal papillary cell carcinoma], 11; LAML[Acute Myeloid Leukemia], 12; LUAD[Lung adenocarcinoma], 13; LUSC[Lung squamous cell carcinoma], 14; OV[Ovarian serous cystadenocarcinoma ], 15; PAAD[Pancreatic adenocarcinoma], 16; PRAD[Prostate adenocarcinoma], 17; SKCM[Skin Cutaneous Melanoma], 18:STAD[Stomach adenocarcinoma], 19:THCA[Thyroid carcinoma], 20:UCEC[Uterine Corpus Endometrial Carcinoma])

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check002.gifTop 10 SNVs Having the Most Samples in TCGA data
* We represented just top 10 SNVs. When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site, primary_histology, mutation(aa), pubmedID.
Genomic PositionMutation(aa)Unique sampleID count
chr14:77795519p.Q90H,GSTZ12
chr14:77791255p.V20I,GSTZ11
chr14:77796116p.A23S,GSTZ11
chr14:77791264p.D30N,GSTZ11
chr14:77796689p.T33M,GSTZ11
chr14:77793201p.F50I,GSTZ11
chr14:77797454p.P86S,GSTZ11
chr14:77793211p.P86P,GSTZ11
chr14:77797487p.V99M,GSTZ11
chr14:77793827p.R100C,GSTZ11

check002.gifOther DBs for Point Mutations
Point Mutation Table of Ensembl: go to Ensembl variation table
Mutation of cBioPortal: go to cBioPortal's Cross-cancer alteration summary

check002.gifCopy Number for GSTZ1 in TCGA
* Copy number data were extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered on Jan-05-2015. Function ProcessCNAData in TCGA-Assembler package was used to obtain gene-level copy number value which is calculated as the average copy number of the genomic region of a gene.
cf) Tissue ID[Tissue type]: BLCA[Bladder Urothelial Carcinoma], BRCA[Breast invasive carcinoma], CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], COAD[Colon adenocarcinoma], GBM[Glioblastoma multiforme], Glioma Low Grade, HNSC[Head and Neck squamous cell carcinoma], KICH[Kidney Chromophobe], KIRC[Kidney renal clear cell carcinoma], KIRP[Kidney renal papillary cell carcinoma], LAML[Acute Myeloid Leukemia], LUAD[Lung adenocarcinoma], LUSC[Lung squamous cell carcinoma], OV[Ovarian serous cystadenocarcinoma ], PAAD[Pancreatic adenocarcinoma], PRAD[Prostate adenocarcinoma], SKCM[Skin Cutaneous Melanoma], STAD[Stomach adenocarcinoma], THCA[Thyroid carcinoma], UCEC[Uterine Corpus Endometrial Carcinoma]

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Gene Expression for GSTZ1

check002.gifGene Expression in Cancer Cell-lines (CCLE)
* CCLE gene expression data were extracted from CCLE_Expression_Entrez_2012-10-18.res: Gene-centric RMA-normalized mRNA expression data.

check002.gifDifferential Gene Expression in Primary Tumors (TCGA)
* Normalized gene expression data of RNASeqV2 was extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered at Jan-05-2015. Only eight cancer types have enough normal control samples for differential expression analysis.
(t test, adjusted p<0.05 (using Benjamini-Hochberg FDR))
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check002.gifCNV vs Gene Expression Plot
* This plots show the correlation between CNV and gene expression.

: Open all plots for all cancer types


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Gene-Gene Network Information
check002.gifCo-Expressed gene's network Plot
* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown.
Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene

: Open all plots for all cancer types

ACAA1,SLIRP,IFT43,C14orf2,CHCHD5,COQ4,COQ6,
DCXR,DHRS4,DHRS4L2,EDF1,ENDOG,GSTZ1,ISCA2,
MRPL41,MRPL54,NDUFB1,SDSL,TEX264,TP53TG1,WDR25
ADCK2,APEH,CDK5,COQ4,DDRGK1,DUS1L,EIF3I,
GCAT,GSS,GSTZ1,MCAT,MLST8,MRPS34,NUDT16L1,
RUVBL2,STK16,STRA13,TIMM13,TMEM141,TRUB2,TUFM

SLIRP,C14orf2,C14orf80,CINP,COQ4,COQ6,DHRS4,
DHRS4L2,DLST,EMC9,GLRX5,GSTZ1,MED11,MRPL27,
NUDT8,OSGEP,PLEK2,PSMB5,PSMC1,RPL36AL,VTI1B
ARL6IP1,ATPIF1,MPC2,PTRHD1,COQ4,COX4I1,COX5A,
COX6A1,COX8A,GSTK1,GSTZ1,HARBI1,KTI12,LSM4,
MTCH2,PDSS1,RAB25,TIMM13,TP53I3,TSPAN17,UQCRC1
check002.gifCo-Expressed gene's Protein-protein interaction Network Plot
* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown.
Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene

: Open all plots for all cancer types

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check002.gifInteracting Genes (from Pathway Commons)

: Open all interacting genes' information including KEGG pathway for all interacting genes from DAVID

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Pharmacological Information for GSTZ1
check002.gifCross-referenced pharmacological DB IDs from Uniprot
DB CategoryDB NameDB's ID and Url link

check002.gifDrug-Gene Interaction Network
* Gene Centered Interaction Network.
* Drug Centered Interaction Network.
DrugBank IDTarget NameDrug GroupsGeneric NameDrug Centered NetworkDrug Structure
DB00143glutathione S-transferase zeta 1approved; nutraceuticalGlutathione
DB04447glutathione S-transferase zeta 1experimental1,4-Dithiothreitol
DB00515glutathione S-transferase zeta 1approvedCisplatin
DB00120glutathione S-transferase zeta 1approved; nutraceuticalL-Phenylalanine
DB00135glutathione S-transferase zeta 1approved; nutraceuticalL-Tyrosine
DB00360glutathione S-transferase zeta 1approved; investigationalTetrahydrobiopterin


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Cross referenced IDs for GSTZ1
* We obtained these cross-references from Uniprot database. It covers 150 different DBs, 18 categories. http://www.uniprot.org/help/cross_references_section

: Open all cross reference information



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