Cancer Cell Metabolism Gene Database

  Cancer Cell Metabolism Gene DB

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Gene Summary

Phenotypic Information (metabolism pathway, cancer, disease, phenome)

Mutations: SVs, CNVs, SNVs

Gene expression: GE, Protein, DEGE, CNV vs GE

Gene-Gene Network Information: Co-Expression Network, Interacting Genes & KEGG

Pharmacological Information: Drug-Gene Network

Cross referenced IDs

Gene Summary for GUCY1A3
Basic gene info.Gene symbolGUCY1A3
Gene nameguanylate cyclase 1, soluble, alpha 3
SynonymsGC-SA3|GUC1A3|GUCA3|GUCSA3|GUCY1A1|MYMY6
CytomapUCSC genome browser: 4q31.1-q31.2
Genomic locationchr4 :156588814-156658214
Type of geneprotein-coding
RefGenesNM_000856.5,
NM_001130682.2,NM_001130683.3,NM_001130684.2,NM_001130685.2,
NM_001130687.2,NM_001256449.1,NM_001130686.1,
Ensembl idENSG00000164116
DescriptionGC-S-alpha-1GCS-alpha-3guanylate cyclase soluble subunit alpha-3soluble guanylate cyclase large subunit
Modification date20141207
dbXrefs MIM : 139396
HGNC : HGNC
Ensembl : ENSG00000164116
HPRD : 00768
Vega : OTTHUMG00000161700
ProteinUniProt:
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_GUCY1A3
BioGPS: 2982
Gene Expression Atlas: ENSG00000164116
The Human Protein Atlas: ENSG00000164116
PathwayNCI Pathway Interaction Database: GUCY1A3
KEGG: GUCY1A3
REACTOME: GUCY1A3
ConsensusPathDB
Pathway Commons: GUCY1A3
MetabolismMetaCyc: GUCY1A3
HUMANCyc: GUCY1A3
RegulationEnsembl's Regulation: ENSG00000164116
miRBase: chr4 :156,588,814-156,658,214
TargetScan: NM_000856
cisRED: ENSG00000164116
ContextiHOP: GUCY1A3
cancer metabolism search in PubMed: GUCY1A3
UCL Cancer Institute: GUCY1A3
Assigned class in ccmGDBC

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Phenotypic Information for GUCY1A3(metabolism pathway, cancer, disease, phenome)
check002.gifCancer Description
Cancer CGAP: GUCY1A3
Familial Cancer Database: GUCY1A3
* This gene is included in those cancer gene databases.

.

Oncogene 1

Tumor Suppressor gene 2

Cancer Gene Census 3

CancerGenes 4

Network of Cancer Gene 5

Significant driver gene in

Therapeutic Vulnerabilities in Cancer1

cf) number; DB name
1 Oncogene; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long,
2 Tumor Suppressor gene; https://bioinfo.uth.edu/TSGene/,
3 Cancer Gene Census; http://www.nature.com/nrc/journal/v4/n3/abs/nrc1299.html,
4 CancerGenes; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long,
5 Network of Cancer Gene; http://ncg.kcl.ac.uk/index.php,
1Therapeutic Vulnerabilities in Cancer; http://cbio.mskcc.org/cancergenomics/statius/

check002.gifMetabolic Pathway Description
KEGG_PURINE_METABOLISM

check002.gifOthers
OMIM
Orphanet
DiseaseKEGG Disease: GUCY1A3
MedGen: GUCY1A3 (Human Medical Genetics with Condition)
ClinVar: GUCY1A3
PhenotypeMGI: GUCY1A3 (International Mouse Phenotyping Consortium)
PhenomicDB: GUCY1A3

Mutations for GUCY1A3
* Under tables are showing count per each tissue to give us broad intuition about tissue specific mutation patterns.You can go to the detailed page for each mutation database's web site.

check002.gifStructural Variants in COSMIC: go to COSMIC mutation histogram
There's no structural variation information in COSMIC data for this gene.

check002.gifRelated fusion transcripts : go to Chitars2.0
* From mRNA Sanger sequences, Chitars2.0 arranged chimeric transcripts. This table shows GUCY1A3 related fusion information.
IDHead GeneTail Gene
AccessionGene_aqStart_aqEnd_aChromosome_atStart_atEnd_aGene_aqStart_aqEnd_aChromosome_atStart_atEnd_a
DA290840GUCY1A312264156654428156654653GPM6A2245614176594919176733417
AW897979GUCY1A3124884156653270156653746SEC61A14786363127788885127789044

check002.gifOther DBs for Structural Variants
Structural Variants in Ensembl: go to Ensembl Structural variation
Structural Variants in dbVar: go to dbVar

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check002.gifCopy Number Variations in COSMIC: go to COSMIC mutation CNV/Expr
There's no copy number variation information in COSMIC data for this gene.

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check002.gifSNV Counts per Each Loci in COSMIC data: go to COSMIC point mutation

 : Non-synonymous mutation, : Synonymous mutation, Circle size denotes number of samples.
Maximum mutation count=6

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check002.gifSomatic Mutation Counts per Tissue in COSMIC data
Stat. for Non-Synonymous SNVs
(# total SNVs=91)
Stat. for Synonymous SNVs
(# total SNVs=29)
Stat. for Deletions
(# total SNVs=0)
Stat. for Insertions
(# total SNVs=4)
There's no deleted snv.

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check002.gifTop 10 SNVs Having the Most Samples in COSMIC data
* When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site,primary_histology,mutation(aa),pubmedID.
GRCh37 positionMutation(aa)Unique sampleID count
chr4:156631726-156631726p.G137S5
chr4:156632156-156632156p.S280W4
chr4:156643194-156643194p.R574Q3
chr4:156634491-156634491p.L443R3
chr4:156638441-156638441p.G568V3
chr4:156643314-156643314p.R614Q3
chr4:156632157-156632157p.S280S2
chr4:156638365-156638365p.D543N2
chr4:156632084-156632084p.S256F2
chr4:156634276-156634276p.I371M2

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check002.gifSNV Counts per Each Loci in TCGA data

 : non-synonymous mutation, : synonymous mutation, Circle size denotes number of samples.
maximum mutation count=3

Point Mutation/ Tissue ID1234567891011121314151617181920
# sample61 301 7 1  12102  3216 10
# mutation61 291 7 1  12102  3718 12
nonsynonymous SNV51 20  4 1  1172  2716 11
synonymous SNV1  91 3    13   102 1
cf) Tissue ID; Tissue type (1; BLCA[Bladder Urothelial Carcinoma], 2; BRCA[Breast invasive carcinoma], 3; CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], 4; COAD[Colon adenocarcinoma], 5; GBM[Glioblastoma multiforme], 6; Glioma Low Grade, 7; HNSC[Head and Neck squamous cell carcinoma], 8; KICH[Kidney Chromophobe], 9; KIRC[Kidney renal clear cell carcinoma], 10; KIRP[Kidney renal papillary cell carcinoma], 11; LAML[Acute Myeloid Leukemia], 12; LUAD[Lung adenocarcinoma], 13; LUSC[Lung squamous cell carcinoma], 14; OV[Ovarian serous cystadenocarcinoma ], 15; PAAD[Pancreatic adenocarcinoma], 16; PRAD[Prostate adenocarcinoma], 17; SKCM[Skin Cutaneous Melanoma], 18:STAD[Stomach adenocarcinoma], 19:THCA[Thyroid carcinoma], 20:UCEC[Uterine Corpus Endometrial Carcinoma])

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check002.gifTop 10 SNVs Having the Most Samples in TCGA data
* We represented just top 10 SNVs. When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site, primary_histology, mutation(aa), pubmedID.
Genomic PositionMutation(aa)Unique sampleID count
chr4:156631726p.G137S,GUCY1A35
chr4:156632157p.S280S,GUCY1A33
chr4:156632156p.R574Q,GUCY1A32
chr4:156643314p.T262I,GUCY1A32
chr4:156634314p.C517F,GUCY1A32
chr4:156638365p.R614Q,GUCY1A32
chr4:156634713p.S280W,GUCY1A32
chr4:156651206p.I371M,GUCY1A32
chr4:156643194p.F632F,GUCY1A32
chr4:156632102p.D543N,GUCY1A32

check002.gifOther DBs for Point Mutations
Point Mutation Table of Ensembl: go to Ensembl variation table
Mutation of cBioPortal: go to cBioPortal's Cross-cancer alteration summary

check002.gifCopy Number for GUCY1A3 in TCGA
* Copy number data were extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered on Jan-05-2015. Function ProcessCNAData in TCGA-Assembler package was used to obtain gene-level copy number value which is calculated as the average copy number of the genomic region of a gene.
cf) Tissue ID[Tissue type]: BLCA[Bladder Urothelial Carcinoma], BRCA[Breast invasive carcinoma], CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], COAD[Colon adenocarcinoma], GBM[Glioblastoma multiforme], Glioma Low Grade, HNSC[Head and Neck squamous cell carcinoma], KICH[Kidney Chromophobe], KIRC[Kidney renal clear cell carcinoma], KIRP[Kidney renal papillary cell carcinoma], LAML[Acute Myeloid Leukemia], LUAD[Lung adenocarcinoma], LUSC[Lung squamous cell carcinoma], OV[Ovarian serous cystadenocarcinoma ], PAAD[Pancreatic adenocarcinoma], PRAD[Prostate adenocarcinoma], SKCM[Skin Cutaneous Melanoma], STAD[Stomach adenocarcinoma], THCA[Thyroid carcinoma], UCEC[Uterine Corpus Endometrial Carcinoma]

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Gene Expression for GUCY1A3

check002.gifGene Expression in Cancer Cell-lines (CCLE)
* CCLE gene expression data were extracted from CCLE_Expression_Entrez_2012-10-18.res: Gene-centric RMA-normalized mRNA expression data.

check002.gifDifferential Gene Expression in Primary Tumors (TCGA)
* Normalized gene expression data of RNASeqV2 was extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered at Jan-05-2015. Only eight cancer types have enough normal control samples for differential expression analysis.
(t test, adjusted p<0.05 (using Benjamini-Hochberg FDR))
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check002.gifCNV vs Gene Expression Plot
* This plots show the correlation between CNV and gene expression.

: Open all plots for all cancer types


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Gene-Gene Network Information
check002.gifCo-Expressed gene's network Plot
* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown.
Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene

: Open all plots for all cancer types

ANXA1,BBOX1,PRR27,CLEC1A,DCHS2,FBXW7,GUCY1A3,
GUCY1B3,IFNGR1,KCNJ2,NRP1,ODAM,PLCG2,PLRG1,
RAPGEF2,RASAL2,SGMS1,SLC15A2,SLC34A2,TIGD2,TRIM2
ANKRD13A,ARHGEF9,BTBD3,CDK6,CXADR,DSC2,EHF,
EML4,GABRP,GRHL1,GUCY1A3,MBLAC2,MTAP,SPIN4,
ST8SIA1,TET2,TRIM2,TRIM59,ZBTB33,ZNF286A,ZNF681

AMOTL1,ANKRD35,BNC2,CALD1,DZIP1,FERMT2,FILIP1,
GUCY1A3,GUCY1B3,IGFBP5,JAM2,LOC399959,MEIS1,MPDZ,
MRVI1,MSRB3,PRDM6,RASL12,RNF150,SPARCL1,ZEB1
CLIP4,COPZ2,FIBIN,FXYD6,GUCY1A3,JAZF1,LOC644538,
LRCH2,POPDC2,PRDM8,PRNP,PTBP2,RAB23,RHOQ,
RNF180,SPG20,STX2,TTC7B,ZAK,ZCCHC24,ZEB1
check002.gifCo-Expressed gene's Protein-protein interaction Network Plot
* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown.
Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene

: Open all plots for all cancer types

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check002.gifInteracting Genes (from Pathway Commons)

: Open all interacting genes' information including KEGG pathway for all interacting genes from DAVID

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Pharmacological Information for GUCY1A3


There's no related Drug.
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Cross referenced IDs for GUCY1A3
* We obtained these cross-references from Uniprot database. It covers 150 different DBs, 18 categories. http://www.uniprot.org/help/cross_references_section

: Open all cross reference information



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