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Phenotypic Information (metabolism pathway, cancer, disease, phenome) | |
Gene-Gene Network Information: Co-Expression Network, Interacting Genes & KEGG | |
Gene Summary for GUCY1A3 |
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Phenotypic Information for GUCY1A3(metabolism pathway, cancer, disease, phenome) |
Cancer Description | |
Cancer | CGAP: GUCY1A3 |
Familial Cancer Database: GUCY1A3 |
* This gene is included in those cancer gene databases. |
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Oncogene 1 | Significant driver gene in |
cf) number; DB name 1 Oncogene; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long, 2 Tumor Suppressor gene; https://bioinfo.uth.edu/TSGene/, 3 Cancer Gene Census; http://www.nature.com/nrc/journal/v4/n3/abs/nrc1299.html, 4 CancerGenes; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long, 5 Network of Cancer Gene; http://ncg.kcl.ac.uk/index.php, 1Therapeutic Vulnerabilities in Cancer; http://cbio.mskcc.org/cancergenomics/statius/ |
Metabolic Pathway Description | |
KEGG_PURINE_METABOLISM |
Mutations for GUCY1A3 |
* Under tables are showing count per each tissue to give us broad intuition about tissue specific mutation patterns.You can go to the detailed page for each mutation database's web site. |
Structural Variants in COSMIC: go to COSMIC mutation histogram |
There's no structural variation information in COSMIC data for this gene. |
Related fusion transcripts : go to Chitars2.0 |
* From mRNA Sanger sequences, Chitars2.0 arranged chimeric transcripts. This table shows GUCY1A3 related fusion information. |
ID | Head Gene | Tail Gene | Accession | Gene_a | qStart_a | qEnd_a | Chromosome_a | tStart_a | tEnd_a | Gene_a | qStart_a | qEnd_a | Chromosome_a | tStart_a | tEnd_a |
DA290840 | GUCY1A3 | 1 | 226 | 4 | 156654428 | 156654653 | GPM6A | 224 | 561 | 4 | 176594919 | 176733417 | |
AW897979 | GUCY1A3 | 12 | 488 | 4 | 156653270 | 156653746 | SEC61A1 | 478 | 636 | 3 | 127788885 | 127789044 |
Other DBs for Structural Variants |
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Copy Number Variations in COSMIC: go to COSMIC mutation CNV/Expr |
There's no copy number variation information in COSMIC data for this gene. |
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SNV Counts per Each Loci in COSMIC data: go to COSMIC point mutation |
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Somatic Mutation Counts per Tissue in COSMIC data |
Stat. for Non-Synonymous SNVs (# total SNVs=91) | (# total SNVs=29) |
(# total SNVs=0) | (# total SNVs=4) |
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Top 10 SNVs Having the Most Samples in COSMIC data |
* When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site,primary_histology,mutation(aa),pubmedID. |
GRCh37 position | Mutation(aa) | Unique sampleID count |
chr4:156631726-156631726 | p.G137S | 5 |
chr4:156632156-156632156 | p.S280W | 4 |
chr4:156643194-156643194 | p.R574Q | 3 |
chr4:156634491-156634491 | p.L443R | 3 |
chr4:156638441-156638441 | p.G568V | 3 |
chr4:156643314-156643314 | p.R614Q | 3 |
chr4:156632252-156632252 | p.R312T | 2 |
chr4:156651307-156651307 | p.S666L | 2 |
chr4:156632157-156632157 | p.S280S | 2 |
chr4:156638365-156638365 | p.D543N | 2 |
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SNV Counts per Each Loci in TCGA data |
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Point Mutation/ Tissue ID | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | 18 | 19 | 20 |
# sample | 6 | 1 |   | 30 | 1 |   | 7 |   | 1 |   |   | 12 | 10 | 2 |   |   | 32 | 16 |   | 10 |
# mutation | 6 | 1 |   | 29 | 1 |   | 7 |   | 1 |   |   | 12 | 10 | 2 |   |   | 37 | 18 |   | 12 |
nonsynonymous SNV | 5 | 1 |   | 20 |   |   | 4 |   | 1 |   |   | 11 | 7 | 2 |   |   | 27 | 16 |   | 11 |
synonymous SNV | 1 |   |   | 9 | 1 |   | 3 |   |   |   |   | 1 | 3 |   |   |   | 10 | 2 |   | 1 |
cf) Tissue ID; Tissue type (1; BLCA[Bladder Urothelial Carcinoma], 2; BRCA[Breast invasive carcinoma], 3; CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], 4; COAD[Colon adenocarcinoma], 5; GBM[Glioblastoma multiforme], 6; Glioma Low Grade, 7; HNSC[Head and Neck squamous cell carcinoma], 8; KICH[Kidney Chromophobe], 9; KIRC[Kidney renal clear cell carcinoma], 10; KIRP[Kidney renal papillary cell carcinoma], 11; LAML[Acute Myeloid Leukemia], 12; LUAD[Lung adenocarcinoma], 13; LUSC[Lung squamous cell carcinoma], 14; OV[Ovarian serous cystadenocarcinoma ], 15; PAAD[Pancreatic adenocarcinoma], 16; PRAD[Prostate adenocarcinoma], 17; SKCM[Skin Cutaneous Melanoma], 18:STAD[Stomach adenocarcinoma], 19:THCA[Thyroid carcinoma], 20:UCEC[Uterine Corpus Endometrial Carcinoma]) |
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Top 10 SNVs Having the Most Samples in TCGA data |
* We represented just top 10 SNVs. When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site, primary_histology, mutation(aa), pubmedID. |
Genomic Position | Mutation(aa) | Unique sampleID count |
chr4:156631726 | p.G137S,GUCY1A3 | 5 |
chr4:156632157 | p.S280S,GUCY1A3 | 3 |
chr4:156631770 | p.I371M,GUCY1A3 | 2 |
chr4:156634276 | p.F632F,GUCY1A3 | 2 |
chr4:156643314 | p.S384L,GUCY1A3 | 2 |
chr4:156632156 | p.D543N,GUCY1A3 | 2 |
chr4:156634314 | p.R311K,GUCY1A3 | 2 |
chr4:156638365 | p.I151I,GUCY1A3 | 2 |
chr4:156634713 | p.R574Q,GUCY1A3 | 2 |
chr4:156651206 | p.T262I,GUCY1A3 | 2 |
Other DBs for Point Mutations |
Copy Number for GUCY1A3 in TCGA |
* Copy number data were extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered on Jan-05-2015. Function ProcessCNAData in TCGA-Assembler package was used to obtain gene-level copy number value which is calculated as the average copy number of the genomic region of a gene. |
cf) Tissue ID[Tissue type]: BLCA[Bladder Urothelial Carcinoma], BRCA[Breast invasive carcinoma], CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], COAD[Colon adenocarcinoma], GBM[Glioblastoma multiforme], Glioma Low Grade, HNSC[Head and Neck squamous cell carcinoma], KICH[Kidney Chromophobe], KIRC[Kidney renal clear cell carcinoma], KIRP[Kidney renal papillary cell carcinoma], LAML[Acute Myeloid Leukemia], LUAD[Lung adenocarcinoma], LUSC[Lung squamous cell carcinoma], OV[Ovarian serous cystadenocarcinoma ], PAAD[Pancreatic adenocarcinoma], PRAD[Prostate adenocarcinoma], SKCM[Skin Cutaneous Melanoma], STAD[Stomach adenocarcinoma], THCA[Thyroid carcinoma], UCEC[Uterine Corpus Endometrial Carcinoma] |
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Gene Expression for GUCY1A3 |
Gene Expression in Cancer Cell-lines (CCLE) |
* CCLE gene expression data were extracted from CCLE_Expression_Entrez_2012-10-18.res: Gene-centric RMA-normalized mRNA expression data. |
Differential Gene Expression in Primary Tumors (TCGA) |
* Normalized gene expression data of RNASeqV2 was extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered at Jan-05-2015. Only eight cancer types have enough normal control samples for differential expression analysis. (t test, adjusted p<0.05 (using Benjamini-Hochberg FDR)) |
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CNV vs Gene Expression Plot |
* This plots show the correlation between CNV and gene expression. |
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Gene-Gene Network Information |
Co-Expressed gene's network Plot |
* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown. Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene |
ANXA1,BBOX1,PRR27,CLEC1A,DCHS2,FBXW7,GUCY1A3, GUCY1B3,IFNGR1,KCNJ2,NRP1,ODAM,PLCG2,PLRG1, RAPGEF2,RASAL2,SGMS1,SLC15A2,SLC34A2,TIGD2,TRIM2 | ANKRD13A,ARHGEF9,BTBD3,CDK6,CXADR,DSC2,EHF, EML4,GABRP,GRHL1,GUCY1A3,MBLAC2,MTAP,SPIN4, ST8SIA1,TET2,TRIM2,TRIM59,ZBTB33,ZNF286A,ZNF681 |
AMOTL1,ANKRD35,BNC2,CALD1,DZIP1,FERMT2,FILIP1, GUCY1A3,GUCY1B3,IGFBP5,JAM2,LOC399959,MEIS1,MPDZ, MRVI1,MSRB3,PRDM6,RASL12,RNF150,SPARCL1,ZEB1 | CLIP4,COPZ2,FIBIN,FXYD6,GUCY1A3,JAZF1,LOC644538, LRCH2,POPDC2,PRDM8,PRNP,PTBP2,RAB23,RHOQ, RNF180,SPG20,STX2,TTC7B,ZAK,ZCCHC24,ZEB1 |
Co-Expressed gene's Protein-protein interaction Network Plot |
* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown. Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene |
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Interacting Genes (from Pathway Commons) |
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Pharmacological Information for GUCY1A3 |
There's no related Drug. |
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Cross referenced IDs for GUCY1A3 |
* We obtained these cross-references from Uniprot database. It covers 150 different DBs, 18 categories. http://www.uniprot.org/help/cross_references_section |
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