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Phenotypic Information (metabolism pathway, cancer, disease, phenome) | |
Gene-Gene Network Information: Co-Expression Network, Interacting Genes & KEGG | |
Gene Summary for HAS3 |
Basic gene info. | Gene symbol | HAS3 |
Gene name | hyaluronan synthase 3 | |
Synonyms | - | |
Cytomap | UCSC genome browser: 16q22.1 | |
Genomic location | chr16 :69141442-69151570 | |
Type of gene | protein-coding | |
RefGenes | NM_001199280.1, NM_005329.2,NM_138612.2, | |
Ensembl id | ENSG00000103044 | |
Description | HA synthase 3hyaluronate synthase 3hyaluronic acid synthase 3 | |
Modification date | 20141207 | |
dbXrefs | MIM : 602428 | |
HGNC : HGNC | ||
Ensembl : ENSG00000103044 | ||
HPRD : 03889 | ||
Vega : OTTHUMG00000137562 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_HAS3 | |
BioGPS: 3038 | ||
Gene Expression Atlas: ENSG00000103044 | ||
The Human Protein Atlas: ENSG00000103044 | ||
Pathway | NCI Pathway Interaction Database: HAS3 | |
KEGG: HAS3 | ||
REACTOME: HAS3 | ||
ConsensusPathDB | ||
Pathway Commons: HAS3 | ||
Metabolism | MetaCyc: HAS3 | |
HUMANCyc: HAS3 | ||
Regulation | Ensembl's Regulation: ENSG00000103044 | |
miRBase: chr16 :69,141,442-69,151,570 | ||
TargetScan: NM_001199280 | ||
cisRED: ENSG00000103044 | ||
Context | iHOP: HAS3 | |
cancer metabolism search in PubMed: HAS3 | ||
UCL Cancer Institute: HAS3 | ||
Assigned class in ccmGDB | C |
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Phenotypic Information for HAS3(metabolism pathway, cancer, disease, phenome) |
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Cancer | CGAP: HAS3 |
Familial Cancer Database: HAS3 |
* This gene is included in those cancer gene databases. |
Oncogene 1 | Significant driver gene in |
cf) number; DB name 1 Oncogene; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long, 2 Tumor Suppressor gene; https://bioinfo.uth.edu/TSGene/, 3 Cancer Gene Census; http://www.nature.com/nrc/journal/v4/n3/abs/nrc1299.html, 4 CancerGenes; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long, 5 Network of Cancer Gene; http://ncg.kcl.ac.uk/index.php, 1Therapeutic Vulnerabilities in Cancer; http://cbio.mskcc.org/cancergenomics/statius/ |
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REACTOME_HYALURONAN_METABOLISM REACTOME_METABOLISM_OF_CARBOHYDRATES |
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OMIM | |
Orphanet | |
Disease | KEGG Disease: HAS3 |
MedGen: HAS3 (Human Medical Genetics with Condition) | |
ClinVar: HAS3 | |
Phenotype | MGI: HAS3 (International Mouse Phenotyping Consortium) |
PhenomicDB: HAS3 |
Mutations for HAS3 |
* Under tables are showing count per each tissue to give us broad intuition about tissue specific mutation patterns.You can go to the detailed page for each mutation database's web site. |
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- Statistics for Tissue and Mutation type | Top |
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- For Inter-chromosomal Variations |
There's no inter-chromosomal structural variation. |
- For Intra-chromosomal Variations |
* Intra-chromosomal variantions includes 'intrachromosomal amplicon to amplicon', 'intrachromosomal amplicon to non-amplified dna', 'intrachromosomal deletion', 'intrachromosomal fold-back inversion', 'intrachromosomal inversion', 'intrachromosomal tandem duplication', 'Intrachromosomal unknown type', 'intrachromosomal with inverted orientation', 'intrachromosomal with non-inverted orientation'. |
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Sample | Symbol_a | Chr_a | Start_a | End_a | Symbol_b | Chr_b | Start_b | End_b |
ovary | HAS3 | chr16 | 69146022 | 69146042 | VPS4A | chr16 | 69353594 | 69353614 |
cf) Tissue number; Tissue name (1;Breast, 2;Central_nervous_system, 3;Haematopoietic_and_lymphoid_tissue, 4;Large_intestine, 5;Liver, 6;Lung, 7;Ovary, 8;Pancreas, 9;Prostate, 10;Skin, 11;Soft_tissue, 12;Upper_aerodigestive_tract) |
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* From mRNA Sanger sequences, Chitars2.0 arranged chimeric transcripts. This table shows HAS3 related fusion information. |
ID | Head Gene | Tail Gene | Accession | Gene_a | qStart_a | qEnd_a | Chromosome_a | tStart_a | tEnd_a | Gene_a | qStart_a | qEnd_a | Chromosome_a | tStart_a | tEnd_a |
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There's no copy number variation information in COSMIC data for this gene. |
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Stat. for Non-Synonymous SNVs (# total SNVs=27) | (# total SNVs=10) |
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(# total SNVs=1) | (# total SNVs=0) |
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* When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site,primary_histology,mutation(aa),pubmedID. |
GRCh37 position | Mutation(aa) | Unique sampleID count |
chr16:69143446-69143446 | p.A50T | 3 |
chr16:69148611-69148611 | p.N368K | 2 |
chr16:69148815-69148815 | p.M436I | 2 |
chr16:69148557-69148557 | p.W350C | 1 |
chr16:69143577-69143577 | p.A93A | 1 |
chr16:69143728-69143728 | p.E144K | 1 |
chr16:69149044-69149044 | p.L513V | 1 |
chr16:69147371-69147371 | p.P222A | 1 |
chr16:69143354-69143354 | p.L19P | 1 |
chr16:69143610-69143610 | p.C104C | 1 |
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Point Mutation/ Tissue ID | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | 18 | 19 | 20 |
# sample | 3 | 1 | 1 | 7 | 1 |   | 3 | 1 | 2 | 1 |   | 4 | 2 | 1 |   |   | 5 | 5 | 1 | 9 |
# mutation | 4 | 1 | 1 | 7 | 1 |   | 3 | 1 | 2 | 1 |   | 4 | 2 | 1 |   |   | 5 | 5 | 1 | 12 |
nonsynonymous SNV | 2 | 1 | 1 | 5 |   |   | 3 | 1 | 1 | 1 |   | 2 | 2 | 1 |   |   | 3 | 4 | 1 | 9 |
synonymous SNV | 2 |   |   | 2 | 1 |   |   |   | 1 |   |   | 2 |   |   |   |   | 2 | 1 |   | 3 |
cf) Tissue ID; Tissue type (1; BLCA[Bladder Urothelial Carcinoma], 2; BRCA[Breast invasive carcinoma], 3; CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], 4; COAD[Colon adenocarcinoma], 5; GBM[Glioblastoma multiforme], 6; Glioma Low Grade, 7; HNSC[Head and Neck squamous cell carcinoma], 8; KICH[Kidney Chromophobe], 9; KIRC[Kidney renal clear cell carcinoma], 10; KIRP[Kidney renal papillary cell carcinoma], 11; LAML[Acute Myeloid Leukemia], 12; LUAD[Lung adenocarcinoma], 13; LUSC[Lung squamous cell carcinoma], 14; OV[Ovarian serous cystadenocarcinoma ], 15; PAAD[Pancreatic adenocarcinoma], 16; PRAD[Prostate adenocarcinoma], 17; SKCM[Skin Cutaneous Melanoma], 18:STAD[Stomach adenocarcinoma], 19:THCA[Thyroid carcinoma], 20:UCEC[Uterine Corpus Endometrial Carcinoma]) |
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* We represented just top 10 SNVs. When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site, primary_histology, mutation(aa), pubmedID. |
Genomic Position | Mutation(aa) | Unique sampleID count |
chr16:69148496 | p.R330Q,HAS3 | 3 |
chr16:69148385 | p.S293T,HAS3 | 2 |
chr16:69148735 | p.I135I,HAS3 | 1 |
chr16:69143610 | p.R230Q,HAS3 | 1 |
chr16:69143820 | p.L548L,HAS3 | 1 |
chr16:69147443 | p.G142C,HAS3 | 1 |
chr16:69143315 | p.Q246K,HAS3 | 1 |
chr16:69148781 | p.G249W | 1 |
chr16:69143619 | p.T6M,HAS3 | 1 |
chr16:69143832 | p.E144K,HAS3 | 1 |
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* Copy number data were extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered on Jan-05-2015. Function ProcessCNAData in TCGA-Assembler package was used to obtain gene-level copy number value which is calculated as the average copy number of the genomic region of a gene. |
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cf) Tissue ID[Tissue type]: BLCA[Bladder Urothelial Carcinoma], BRCA[Breast invasive carcinoma], CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], COAD[Colon adenocarcinoma], GBM[Glioblastoma multiforme], Glioma Low Grade, HNSC[Head and Neck squamous cell carcinoma], KICH[Kidney Chromophobe], KIRC[Kidney renal clear cell carcinoma], KIRP[Kidney renal papillary cell carcinoma], LAML[Acute Myeloid Leukemia], LUAD[Lung adenocarcinoma], LUSC[Lung squamous cell carcinoma], OV[Ovarian serous cystadenocarcinoma ], PAAD[Pancreatic adenocarcinoma], PRAD[Prostate adenocarcinoma], SKCM[Skin Cutaneous Melanoma], STAD[Stomach adenocarcinoma], THCA[Thyroid carcinoma], UCEC[Uterine Corpus Endometrial Carcinoma] |
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Gene Expression for HAS3 |
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* CCLE gene expression data were extracted from CCLE_Expression_Entrez_2012-10-18.res: Gene-centric RMA-normalized mRNA expression data. |
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* Normalized gene expression data of RNASeqV2 was extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered at Jan-05-2015. Only eight cancer types have enough normal control samples for differential expression analysis. (t test, adjusted p<0.05 (using Benjamini-Hochberg FDR)) |
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* This plots show the correlation between CNV and gene expression. |
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Gene-Gene Network Information |
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* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown. Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene |
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BNC1,C11orf87,CDH4,COL17A1,FGFBP1,HAS3,HMGA2, HSD17B3,KRT5,KRT75,LOC150527,MIR31HG,MT4,MYO7B, OR2J3,PADI3,PCSK9,PLEK2,RPSAP52,S100A2,SOX15 | AEN,CD200,CDK2,CLDN1,DYRK3,HAS3,HEY2, HSPA4L,IFFO2,KRT23,KRT9,LAMC2,LIF,NPAS4, PLK3,SRF,STK17A,TES,TUFT1,WEE1,ZNF165 |
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CRCT1,CRNN,DEFB103B,HAS3,IL36A,KLK9,KRT14, KRT16,KRT6A,KRT6C,KRT78,LCE3D,LCE3E,LYPD3, SPRR1B,SPRR2A,SPRR2B,SPRR2C,SPRR2D,SPRR2E,TGM1 | ADRA2A,B4GALT1,FABP1,HAS3,HSD17B2,KRT12,LANCL3, LOC25845,MIER3,OSTalpha,PLOD2,PPARD,PPP1R14C,SLC20A1, SLC30A10,SLC4A9,SLC9A3,TGFA,TMEM65,WSCD1,ZNF341 |
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* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown. Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene |
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Pharmacological Information for HAS3 |
There's no related Drug. |
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Cross referenced IDs for HAS3 |
* We obtained these cross-references from Uniprot database. It covers 150 different DBs, 18 categories. http://www.uniprot.org/help/cross_references_section |
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