Cancer Cell Metabolism Gene Database

  Cancer Cell Metabolism Gene DB

Home

Search

Download

 Statistics

Help

About Us

Bioinformatics and Systems Medicine Laboratory Bioinformatics and Systems Medicine Laboratory

Gene Summary

Phenotypic Information (metabolism pathway, cancer, disease, phenome)

Mutations: SVs, CNVs, SNVs

Gene expression: GE, Protein, DEGE, CNV vs GE

Gene-Gene Network Information: Co-Expression Network, Interacting Genes & KEGG

Pharmacological Information: Drug-Gene Network

Cross referenced IDs

Gene Summary for ACACB
Basic gene info.Gene symbolACACB
Gene nameacetyl-CoA carboxylase beta
SynonymsACC2|ACCB|HACC275
CytomapUCSC genome browser: 12q24.11
Genomic locationchr12 :109577201-109706030
Type of geneprotein-coding
RefGenesNM_001093.3,
Ensembl idENSG00000076555
DescriptionACC-betaacetyl-CoA carboxylase 2acetyl-Coenzyme A carboxylase beta
Modification date20141207
dbXrefs MIM : 601557
HGNC : HGNC
Ensembl : ENSG00000076555
HPRD : 07044
Vega : OTTHUMG00000169250
ProteinUniProt:
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_ACACB
BioGPS: 32
Gene Expression Atlas: ENSG00000076555
The Human Protein Atlas: ENSG00000076555
PathwayNCI Pathway Interaction Database: ACACB
KEGG: ACACB
REACTOME: ACACB
ConsensusPathDB
Pathway Commons: ACACB
MetabolismMetaCyc: ACACB
HUMANCyc: ACACB
RegulationEnsembl's Regulation: ENSG00000076555
miRBase: chr12 :109,577,201-109,706,030
TargetScan: NM_001093
cisRED: ENSG00000076555
ContextiHOP: ACACB
cancer metabolism search in PubMed: ACACB
UCL Cancer Institute: ACACB
Assigned class in ccmGDBC

Top
Phenotypic Information for ACACB(metabolism pathway, cancer, disease, phenome)
check002.gifCancer Description
Cancer CGAP: ACACB
Familial Cancer Database: ACACB
* This gene is included in those cancer gene databases.

Oncogene 1

Tumor Suppressor gene 2

Cancer Gene Census 3

CancerGenes 4

Network of Cancer Gene 5

Significant driver gene in

Therapeutic Vulnerabilities in Cancer1

cf) number; DB name
1 Oncogene; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long,
2 Tumor Suppressor gene; https://bioinfo.uth.edu/TSGene/,
3 Cancer Gene Census; http://www.nature.com/nrc/journal/v4/n3/abs/nrc1299.html,
4 CancerGenes; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long,
5 Network of Cancer Gene; http://ncg.kcl.ac.uk/index.php,
1Therapeutic Vulnerabilities in Cancer; http://cbio.mskcc.org/cancergenomics/statius/

check002.gifMetabolic Pathway Description
KEGG_PYRUVATE_METABOLISM
KEGG_PROPANOATE_METABOLISM
REACTOME_INTEGRATION_OF_ENERGY_METABOLISM
REACTOME_METABOLISM_OF_LIPIDS_AND_LIPOPROTEINS

check002.gifOthers
OMIM
Orphanet
DiseaseKEGG Disease: ACACB
MedGen: ACACB (Human Medical Genetics with Condition)
ClinVar: ACACB
PhenotypeMGI: ACACB (International Mouse Phenotyping Consortium)
PhenomicDB: ACACB

Mutations for ACACB
* Under tables are showing count per each tissue to give us broad intuition about tissue specific mutation patterns.You can go to the detailed page for each mutation database's web site.

check002.gifStructural Variants in COSMIC: go to COSMIC mutation histogram

- Statistics for Tissue and Mutation typeTop
- For Inter-chromosomal Variations
* Inter-chromosomal variantions includes 'interchromosomal amplicon to amplicon', 'interchromosomal amplicon to non-amplified dna', 'interchromosomal insertion', 'Interchromosomal unknown type'.
- For Intra-chromosomal Variations
* Intra-chromosomal variantions includes 'intrachromosomal amplicon to amplicon', 'intrachromosomal amplicon to non-amplified dna', 'intrachromosomal deletion', 'intrachromosomal fold-back inversion', 'intrachromosomal inversion', 'intrachromosomal tandem duplication', 'Intrachromosomal unknown type', 'intrachromosomal with inverted orientation', 'intrachromosomal with non-inverted orientation'.
SampleSymbol_aChr_aStart_aEnd_aSymbol_bChr_bStart_bEnd_b
ovaryACACBchr12109612529109612729chr12109163338109163538
pancreasACACBchr12109605366109605386ACACBchr12109605598109605618
cf) Tissue number; Tissue name (1;Breast, 2;Central_nervous_system, 3;Haematopoietic_and_lymphoid_tissue, 4;Large_intestine, 5;Liver, 6;Lung, 7;Ovary, 8;Pancreas, 9;Prostate, 10;Skin, 11;Soft_tissue, 12;Upper_aerodigestive_tract)

check002.gifRelated fusion transcripts : go to Chitars2.0
* From mRNA Sanger sequences, Chitars2.0 arranged chimeric transcripts. This table shows ACACB related fusion information.
IDHead GeneTail Gene
AccessionGene_aqStart_aqEnd_aChromosome_atStart_atEnd_aGene_aqStart_aqEnd_aChromosome_atStart_atEnd_a
BM989099ACACB1614312109705904109706031CTDSP11444352219270373219270664
BF375856PANK21052282038734793873602ACACB21139212109625921109629547
BF822123ACACB110512109626548109626653ACACB10139812109626532109627157

check002.gifOther DBs for Structural Variants
Structural Variants in Ensembl: go to Ensembl Structural variation
Structural Variants in dbVar: go to dbVar

Top
check002.gifCopy Number Variations in COSMIC: go to COSMIC mutation CNV/Expr
 
Mutation type/ Tissue IDbrcacnscervendomehaematopokidnLintestliverlungnsovarypancreprostskinstomathyrourina
Total # sample                1
GAIN (# sample)                1
LOSS (# sample)                 
cf) Tissue ID; Tissue type (1; Breast, 2; Central_nervous_system, 3; Cervix, 4; Endometrium, 5; Haematopoietic_and_lymphoid_tissue, 6; Kidney, 7; Large_intestine, 8; Liver, 9; Lung, 10; NS, 11; Ovary, 12; Pancreas, 13; Prostate, 14; Skin, 15; Stomach, 16; Thyroid, 17; Urinary_tract)

Top
check002.gifSNV Counts per Each Loci in COSMIC data: go to COSMIC point mutation

 : Non-synonymous mutation, : Synonymous mutation, Circle size denotes number of samples.
Maximum mutation count=4

Top
check002.gifSomatic Mutation Counts per Tissue in COSMIC data
Stat. for Non-Synonymous SNVs
(# total SNVs=207)
Stat. for Synonymous SNVs
(# total SNVs=74)
Stat. for Deletions
(# total SNVs=2)
Stat. for Insertions
(# total SNVs=1)

Top
check002.gifTop 10 SNVs Having the Most Samples in COSMIC data
* When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site,primary_histology,mutation(aa),pubmedID.
GRCh37 positionMutation(aa)Unique sampleID count
chr12:109613968-109613968p.R446I4
chr12:109702924-109702924p.E2318*3
chr12:109617881-109617881p.A603T3
chr12:109625967-109625967p.S715L3
chr12:109605836-109605836p.A308P3
chr12:109687895-109687895p.V1926F2
chr12:109696853-109696853p.R2146W2
chr12:109671621-109671621p.R1403L2
chr12:109629452-109629452p.R727*2
chr12:109644522-109644522p.P974L2

Top
check002.gifSNV Counts per Each Loci in TCGA data

 : non-synonymous mutation, : synonymous mutation, Circle size denotes number of samples.
maximum mutation count=4

Point Mutation/ Tissue ID1234567891011121314151617181920
# sample792358 15 61 24117 12420228
# mutation692378 19 61 34147 12929246
nonsynonymous SNV482327 11 4  1876 11621129
synonymous SNV21 51 8 21 1671  138117
cf) Tissue ID; Tissue type (1; BLCA[Bladder Urothelial Carcinoma], 2; BRCA[Breast invasive carcinoma], 3; CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], 4; COAD[Colon adenocarcinoma], 5; GBM[Glioblastoma multiforme], 6; Glioma Low Grade, 7; HNSC[Head and Neck squamous cell carcinoma], 8; KICH[Kidney Chromophobe], 9; KIRC[Kidney renal clear cell carcinoma], 10; KIRP[Kidney renal papillary cell carcinoma], 11; LAML[Acute Myeloid Leukemia], 12; LUAD[Lung adenocarcinoma], 13; LUSC[Lung squamous cell carcinoma], 14; OV[Ovarian serous cystadenocarcinoma ], 15; PAAD[Pancreatic adenocarcinoma], 16; PRAD[Prostate adenocarcinoma], 17; SKCM[Skin Cutaneous Melanoma], 18:STAD[Stomach adenocarcinoma], 19:THCA[Thyroid carcinoma], 20:UCEC[Uterine Corpus Endometrial Carcinoma])

Top
check002.gifTop 10 SNVs Having the Most Samples in TCGA data
* We represented just top 10 SNVs. When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site, primary_histology, mutation(aa), pubmedID.
Genomic PositionMutation(aa)Unique sampleID count
chr12:109577476p.R89K3
chr12:109613968p.R446I3
chr12:109629448p.P1260R2
chr12:109660704p.S725S2
chr12:109654442p.I1789I2
chr12:109680382p.R231Q2
chr12:109631529p.D241Y2
chr12:109614053p.R1490C2
chr12:109675151p.L897L2
chr12:109623543p.E2318Q2

check002.gifOther DBs for Point Mutations
Point Mutation Table of Ensembl: go to Ensembl variation table
Mutation of cBioPortal: go to cBioPortal's Cross-cancer alteration summary

check002.gifCopy Number for ACACB in TCGA
* Copy number data were extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered on Jan-05-2015. Function ProcessCNAData in TCGA-Assembler package was used to obtain gene-level copy number value which is calculated as the average copy number of the genomic region of a gene.
cf) Tissue ID[Tissue type]: BLCA[Bladder Urothelial Carcinoma], BRCA[Breast invasive carcinoma], CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], COAD[Colon adenocarcinoma], GBM[Glioblastoma multiforme], Glioma Low Grade, HNSC[Head and Neck squamous cell carcinoma], KICH[Kidney Chromophobe], KIRC[Kidney renal clear cell carcinoma], KIRP[Kidney renal papillary cell carcinoma], LAML[Acute Myeloid Leukemia], LUAD[Lung adenocarcinoma], LUSC[Lung squamous cell carcinoma], OV[Ovarian serous cystadenocarcinoma ], PAAD[Pancreatic adenocarcinoma], PRAD[Prostate adenocarcinoma], SKCM[Skin Cutaneous Melanoma], STAD[Stomach adenocarcinoma], THCA[Thyroid carcinoma], UCEC[Uterine Corpus Endometrial Carcinoma]

Top
Gene Expression for ACACB

check002.gifGene Expression in Cancer Cell-lines (CCLE)
* CCLE gene expression data were extracted from CCLE_Expression_Entrez_2012-10-18.res: Gene-centric RMA-normalized mRNA expression data.

check002.gifDifferential Gene Expression in Primary Tumors (TCGA)
* Normalized gene expression data of RNASeqV2 was extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered at Jan-05-2015. Only eight cancer types have enough normal control samples for differential expression analysis.
(t test, adjusted p<0.05 (using Benjamini-Hochberg FDR))
Top
check002.gifCNV vs Gene Expression Plot
* This plots show the correlation between CNV and gene expression.

: Open all plots for all cancer types


Top
Gene-Gene Network Information
check002.gifCo-Expressed gene's network Plot
* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown.
Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene

: Open all plots for all cancer types

ACACB,ACVR1C,ADH1B,ADIPOQ,AOC3,AQP7,AQP7P1,
C14orf180,CD300LG,CIDEC,GPAM,GPD1,HEPACAM,KCNIP2,
KLB,LIPE,PLIN1,PLIN4,SDPR,SLC19A3,TMEM132C
ABHD15,ACAA2,ACACB,ACVR1C,AQP7,CIDEC,CNTFR,
GYG2,LGALS12,MLXIPL,MARC1,OXCT1,PC,PDE1B,
PECR,PLA2G16,PNPLA2,PPARG,SLC19A3,TJP2,TMEM132C

ABCA6,ABCA8,ABCA9,ACACB,ADH1B,AQP7,C7,
CD300LG,CIDEA,FABP4,GPIHBP1,GPX3,HEPACAM,KCNIP2,
LIFR,NGFR,PLIN1,PLIN4,SCN4A,SEMA3G,TUSC5
ABCA3,ACACB,AHNAK,COL6A2,CROCCP3,DLG5,EVC,
FYCO1,GLI2,IGHMBP2,CTIF,MTCL1,LAMA5,LAMB2,
MACF1,MECP2,PKD1,SSC5D,SYNE1,ZFYVE20,ZNF512B
check002.gifCo-Expressed gene's Protein-protein interaction Network Plot
* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown.
Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene

: Open all plots for all cancer types

Top
check002.gifInteracting Genes (from Pathway Commons)

: Open all interacting genes' information including KEGG pathway for all interacting genes from DAVID

Top
Pharmacological Information for ACACB
check002.gifCross-referenced pharmacological DB IDs from Uniprot
DB CategoryDB NameDB's ID and Url link

check002.gifDrug-Gene Interaction Network
* Gene Centered Interaction Network.
* Drug Centered Interaction Network.
DrugBank IDTarget NameDrug GroupsGeneric NameDrug Centered NetworkDrug Structure
DB00121acetyl-CoA carboxylase betaapproved; nutraceuticalBiotin
DB00173acetyl-CoA carboxylase betaapproved; nutraceuticalAdenine
DB02859acetyl-CoA carboxylase betaexperimentalSoraphen A
DB03781acetyl-CoA carboxylase betaexperimental2-[4-(2,4-Dichlorophenoxy)Phenoxy]Propanoic Acid
DB07870acetyl-CoA carboxylase betaexperimental(2S)-2-(4-{[3-CHLORO-5-(TRIFLUOROMETHYL)PYRIDIN-2-YL]OXY}PHENOXY)PROPANOIC ACID


Top
Cross referenced IDs for ACACB
* We obtained these cross-references from Uniprot database. It covers 150 different DBs, 18 categories. http://www.uniprot.org/help/cross_references_section

: Open all cross reference information



Copyright © 2016-Present - The Univsersity of Texas Health Science Center at Houston @
Site Policies | State of Texas