Cancer Cell Metabolism Database ~~ Bioinformatics and Systems Medicine Laboratory ~~

Cancer Cell Metabolism Gene Database

Cancer Cell Metabolism Gene DB

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	Gene Summary
	Phenotypic Information (metabolism pathway, cancer, disease, phenome)
	Mutations : SVs, CNVs, SNVs
	Gene expression: GE, Protein, DEGE, CNV vs GE
	Gene-Gene Network Information: Co-Expression Network, Interacting Genes & KEGG
	Pharmacological Information: Drug-Gene Network
	Cross referenced IDs

Gene Summary for HSD17B4

Basic gene info.	Gene symbol	HSD17B4
	Gene name	hydroxysteroid (17-beta) dehydrogenase 4
	Synonyms	DBP\|MFE-2\|MPF-2\|PRLTS1\|SDR8C1
	Cytomap	UCSC genome browser: 5q21
	Genomic location	chr5 :118788201-118878030
	Type of gene	protein-coding
	RefGenes	NM_001199291.2, NM_001292027.1,NM_001292028.1,NM_000414.3,NM_001199292.1,
	Ensembl id	ENSG00000133835
	Description	17-beta-HSD 417-beta-HSD IV17-beta-hydroxysteroid dehydrogenase 417beta-estradiol dehydrogenase type IV3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholest-24-enoyl-CoA hydrataseD-3-hydroxyacyl-CoA dehydrataseD-bifunctional protein, peroxisomalbeta-h
	Modification date	20141207
dbXrefs	MIM : 601860
	HGNC : HGNC
	Ensembl : ENSG00000133835
	HPRD : 03514
	Vega : OTTHUMG00000128899
Protein	UniProt: go to UniProt's Cross Reference DB Table
Expression	CleanEX: HS_HSD17B4
	BioGPS: 3295
	Gene Expression Atlas: ENSG00000133835
	The Human Protein Atlas: ENSG00000133835
Pathway	NCI Pathway Interaction Database: HSD17B4
	KEGG: HSD17B4
	REACTOME: HSD17B4
	ConsensusPathDB
	Pathway Commons: HSD17B4
Metabolism	MetaCyc: HSD17B4
	HUMANCyc: HSD17B4
Regulation	Ensembl's Regulation: ENSG00000133835
	miRBase: chr5 :118,788,201-118,878,030
	TargetScan: NM_001199291
	cisRED: ENSG00000133835
Context	iHOP: HSD17B4
	cancer metabolism search in PubMed: HSD17B4
	UCL Cancer Institute: HSD17B4
Assigned class in ccmGDB	C

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Phenotypic Information for HSD17B4(metabolism pathway, cancer, disease, phenome)

Cancer Description
Cancer	CGAP: HSD17B4
	Familial Cancer Database: HSD17B4

* This gene is included in those cancer gene databases.


Oncogene ¹	Tumor Suppressor gene ²	Cancer Gene Census ³	CancerGenes ⁴	Network of Cancer Gene ⁵	Significant driver gene in	Therapeutic Vulnerabilities in Cancer¹

cf) number; DB name
1 Oncogene; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long,
2 Tumor Suppressor gene; https://bioinfo.uth.edu/TSGene/,
3 Cancer Gene Census; http://www.nature.com/nrc/journal/v4/n3/abs/nrc1299.html,
4 CancerGenes; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long,
5 Network of Cancer Gene; http://ncg.kcl.ac.uk/index.php,
1Therapeutic Vulnerabilities in Cancer; http://cbio.mskcc.org/cancergenomics/statius/

Metabolic Pathway Description
REACTOME_PEROXISOMAL_LIPID_METABOLISM REACTOME_METABOLISM_OF_LIPIDS_AND_LIPOPROTEINS

Others
OMIM
Orphanet
Disease	KEGG Disease: HSD17B4
	MedGen: HSD17B4 (Human Medical Genetics with Condition)
	ClinVar: HSD17B4
Phenotype	MGI: HSD17B4 (International Mouse Phenotyping Consortium)
Phenotype	PhenomicDB: HSD17B4

Mutations for HSD17B4

* Under tables are showing count per each tissue to give us broad intuition about tissue specific mutation patterns.You can go to the detailed page for each mutation database's web site.

Structural Variants in COSMIC : go to COSMIC mutation histogram

- Statistics for Tissue and Mutation type

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- For Inter-chromosomal Variations

There's no inter-chromosomal structural variation.

- For Intra-chromosomal Variations

* Intra-chromosomal variantions includes 'intrachromosomal amplicon to amplicon', 'intrachromosomal amplicon to non-amplified dna', 'intrachromosomal deletion', 'intrachromosomal fold-back inversion', 'intrachromosomal inversion', 'intrachromosomal tandem duplication', 'Intrachromosomal unknown type', 'intrachromosomal with inverted orientation', 'intrachromosomal with non-inverted orientation'.

Sample	Symbol_a	Chr_a	Start_a	End_a	Symbol_b	Chr_b	Start_b	End_b
ovary	HSD17B4	chr5	118805472	118805492	HSD17B4	chr5	118808041	118808061

cf) Tissue number; Tissue name (1;Breast, 2;Central_nervous_system, 3;Haematopoietic_and_lymphoid_tissue, 4;Large_intestine, 5;Liver, 6;Lung, 7;Ovary, 8;Pancreas, 9;Prostate, 10;Skin, 11;Soft_tissue, 12;Upper_aerodigestive_tract)

Related fusion transcripts : go to Chitars2.0

* From mRNA Sanger sequences, Chitars2.0 arranged chimeric transcripts. This table shows HSD17B4 related fusion information.

Head Gene

Tail Gene

Accession

Gene_a

qStart_a

qEnd_a

Chromosome_a

tStart_a

tEnd_a

Gene_a

qStart_a

qEnd_a

Chromosome_a

tStart_a

tEnd_a

BF033554

HSD17B4

451

118844842

118865606

COPS3

444

557

17150204

17150317

Other DBs for Structural Variants

Structural Variants in Ensembl: go to Ensembl Structural variation

Structural Variants in dbVar: go to dbVar

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Copy Number Variations in COSMIC : go to COSMIC mutation CNV/Expr

There's no copy number variation information in COSMIC data for this gene.

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SNV Counts per Each Loci in COSMIC data : go to COSMIC point mutation

: Non-synonymous mutation, : Synonymous mutation, Circle size denotes number of samples.
Maximum mutation count=4

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Somatic Mutation Counts per Tissue in COSMIC data

Stat. for Non-Synonymous SNVs (# total SNVs=49)	Stat. for Synonymous SNVs (# total SNVs=14)

Stat. for Deletions (# total SNVs=2)	Stat. for Insertions (# total SNVs=0)
	There's no inserted snv.

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Top 10 SNVs Having the Most Samples in COSMIC data

* When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site,primary_histology,mutation(aa),pubmedID.

GRCh37 position	Mutation(aa)	Unique sampleID count
chr5:118861713-118861713	p.I559V	3
chr5:118813124-118813124	p.R121K	2
chr5:118865666-118865666	p.T615T	2
chr5:118835235-118835235	p.I399T	2
chr5:118860945-118860945	p.P513L	2
chr5:118810095-118810095	p.?	2
chr5:118827800-118827800	p.G240G	2
chr5:118835117-118835117	p.D360Y	2
chr5:118814698-118814698	p.Q202E	2
chr5:118824886-118824886	p.?	2

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SNV Counts per Each Loci in TCGA data

: non-synonymous mutation, : synonymous mutation, Circle size denotes number of samples.
maximum mutation count=2

Point Mutation/ Tissue ID	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20
# sample	2	6	5	9			5		2	1		6	1	1		1	5	5		9
# mutation	2	6	5	9			5		2	1		6	1	1		1	5	5		10
nonsynonymous SNV	2	5	3	7			3		2	1		4	1	1		1	5	4		10
synonymous SNV		1	2	2			2					2						1

cf) Tissue ID; Tissue type (1; BLCA[Bladder Urothelial Carcinoma], 2; BRCA[Breast invasive carcinoma], 3; CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], 4; COAD[Colon adenocarcinoma], 5; GBM[Glioblastoma multiforme], 6; Glioma Low Grade, 7; HNSC[Head and Neck squamous cell carcinoma], 8; KICH[Kidney Chromophobe], 9; KIRC[Kidney renal clear cell carcinoma], 10; KIRP[Kidney renal papillary cell carcinoma], 11; LAML[Acute Myeloid Leukemia], 12; LUAD[Lung adenocarcinoma], 13; LUSC[Lung squamous cell carcinoma], 14; OV[Ovarian serous cystadenocarcinoma ], 15; PAAD[Pancreatic adenocarcinoma], 16; PRAD[Prostate adenocarcinoma], 17; SKCM[Skin Cutaneous Melanoma], 18:STAD[Stomach adenocarcinoma], 19:THCA[Thyroid carcinoma], 20:UCEC[Uterine Corpus Endometrial Carcinoma])

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Top 10 SNVs Having the Most Samples in TCGA data

* We represented just top 10 SNVs. When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site, primary_histology, mutation(aa), pubmedID.

Genomic Position	Mutation(aa)	Unique sampleID count
chr5:118835235	p.T597T,HSD17B4	2
chr5:118813124	p.R103K,HSD17B4	2
chr5:118865666	p.I381T,HSD17B4	2
chr5:118814681	p.A178G,HSD17B4	2
chr5:118824910	p.V40A,HSD17B4	1
chr5:118862888	p.V251L,HSD17B4	1
chr5:118835179	p.G452S,HSD17B4	1
chr5:118872146	p.S591P,HSD17B4	1
chr5:118810106	p.E59E,HSD17B4	1
chr5:118844920	p.L281L,HSD17B4	1

Other DBs for Point Mutations

Point Mutation Table of Ensembl: go to Ensembl variation table

Mutation of cBioPortal: go to cBioPortal's Cross-cancer alteration summary

Copy Number for HSD17B4 in TCGA

* Copy number data were extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered on Jan-05-2015. Function ProcessCNAData in TCGA-Assembler package was used to obtain gene-level copy number value which is calculated as the average copy number of the genomic region of a gene.

cf) Tissue ID[Tissue type]: BLCA[Bladder Urothelial Carcinoma], BRCA[Breast invasive carcinoma], CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], COAD[Colon adenocarcinoma], GBM[Glioblastoma multiforme], Glioma Low Grade, HNSC[Head and Neck squamous cell carcinoma], KICH[Kidney Chromophobe], KIRC[Kidney renal clear cell carcinoma], KIRP[Kidney renal papillary cell carcinoma], LAML[Acute Myeloid Leukemia], LUAD[Lung adenocarcinoma], LUSC[Lung squamous cell carcinoma], OV[Ovarian serous cystadenocarcinoma ], PAAD[Pancreatic adenocarcinoma], PRAD[Prostate adenocarcinoma], SKCM[Skin Cutaneous Melanoma], STAD[Stomach adenocarcinoma], THCA[Thyroid carcinoma], UCEC[Uterine Corpus Endometrial Carcinoma]

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Gene Expression for HSD17B4

Gene Expression in Cancer Cell-lines (CCLE)

* CCLE gene expression data were extracted from CCLE_Expression_Entrez_2012-10-18.res: Gene-centric RMA-normalized mRNA expression data.

Differential Gene Expression in Primary Tumors (TCGA)

* Normalized gene expression data of RNASeqV2 was extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered at Jan-05-2015. Only eight cancer types have enough normal control samples for differential expression analysis.
(t test, adjusted p<0.05 (using Benjamini-Hochberg FDR))

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CNV vs Gene Expression Plot

* This plots show the correlation between CNV and gene expression.

: Open all plots for all cancer types

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Gene-Gene Network Information

Co-Expressed gene's network Plot

* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown.
Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene

: Open all plots for all cancer types


AP3B1,C5orf15,KIAA0825,TRAPPC13,COMMD10,DCTN4,DTWD2, FAM114A2,FBXL17,GIN1,HSD17B4,MATR3,MFAP3,MSH3, NUDT12,PGGT1B,PJA2,POLK,TMED7,YTHDC2,ZFYVE16	ACO1,AHCYL1,ASAH1,BTD,FAM213A,CAT,HNMT, HRASLS5,HSD17B4,OXCT1,PARVA,PEX19,PLIN1,RHOBTB3, RRAGC,RTN3,SEPT11,SLC25A16,SNX5,SORT1,VKORC1L1

ALDH7A1,AP3B1,CDC23,GLB1,HMGCR,HSD17B4,HSPA9, LARS,LYRM7,MCCC2,MRPS27,MRPS36,PAPD4,RIOK2, SKIV2L2,SLC25A46,SLC30A5,SRFBP1,TAF9,TMEM161B,UBE2D2	ALG6,ANKEF1,ATP6V1A,CCDC47,DARS2,FAM81A,FAR2, GMDS,HSD17B4,IDH1,MCCC2,MTIF2,NARS,ORC2, PHKB,SH2D4A,SRPK1,STAMBPL1,STARD7,STT3B,TM9SF2

Co-Expressed gene's Protein-protein interaction Network Plot

: Open all plots for all cancer types

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Interacting Genes (from Pathway Commons)

: Open all interacting genes' information including KEGG pathway for all interacting genes from DAVID

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Pharmacological Information for HSD17B4

Cross-referenced pharmacological DB IDs from Uniprot

DB Category

DB Name

DB's ID and Url link

Drug-Gene Interaction Network

* Gene Centered Interaction Network.

* Drug Centered Interaction Network.

DrugBank ID	Target Name	Drug Groups	Generic Name	Drug Centered Network	Drug Structure
DB00157	hydroxysteroid (17-beta) dehydrogenase 4	approved; nutraceutical	NADH
DB01907	hydroxysteroid (17-beta) dehydrogenase 4	experimental	Nicotinamide-Adenine-Dinucleotide
DB03192	hydroxysteroid (17-beta) dehydrogenase 4	experimental	3r-Hydroxydecanoyl-Coa
DB00145	hydroxysteroid (17-beta) dehydrogenase 4	approved; nutraceutical	Glycine

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Cross referenced IDs for HSD17B4

* We obtained these cross-references from Uniprot database. It covers 150 different DBs, 18 categories. http://www.uniprot.org/help/cross_references_section

: Open all cross reference information