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Phenotypic Information (metabolism pathway, cancer, disease, phenome) | |
Gene-Gene Network Information: Co-Expression Network, Interacting Genes & KEGG | |
Gene Summary for ACADL |
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Phenotypic Information for ACADL(metabolism pathway, cancer, disease, phenome) |
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Cancer | CGAP: ACADL |
Familial Cancer Database: ACADL |
* This gene is included in those cancer gene databases. |
Oncogene 1 | Significant driver gene in |
cf) number; DB name 1 Oncogene; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long, 2 Tumor Suppressor gene; https://bioinfo.uth.edu/TSGene/, 3 Cancer Gene Census; http://www.nature.com/nrc/journal/v4/n3/abs/nrc1299.html, 4 CancerGenes; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long, 5 Network of Cancer Gene; http://ncg.kcl.ac.uk/index.php, 1Therapeutic Vulnerabilities in Cancer; http://cbio.mskcc.org/cancergenomics/statius/ |
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KEGG_FATTY_ACID_METABOLISM REACTOME_METABOLISM_OF_LIPIDS_AND_LIPOPROTEINS |
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OMIM | |
Orphanet | |
Disease | KEGG Disease: ACADL |
MedGen: ACADL (Human Medical Genetics with Condition) | |
ClinVar: ACADL | |
Phenotype | MGI: ACADL (International Mouse Phenotyping Consortium) |
PhenomicDB: ACADL |
Mutations for ACADL |
* Under tables are showing count per each tissue to give us broad intuition about tissue specific mutation patterns.You can go to the detailed page for each mutation database's web site. |
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- Statistics for Tissue and Mutation type | Top |
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- For Inter-chromosomal Variations |
There's no inter-chromosomal structural variation. |
- For Intra-chromosomal Variations |
* Intra-chromosomal variantions includes 'intrachromosomal amplicon to amplicon', 'intrachromosomal amplicon to non-amplified dna', 'intrachromosomal deletion', 'intrachromosomal fold-back inversion', 'intrachromosomal inversion', 'intrachromosomal tandem duplication', 'Intrachromosomal unknown type', 'intrachromosomal with inverted orientation', 'intrachromosomal with non-inverted orientation'. |
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Sample | Symbol_a | Chr_a | Start_a | End_a | Symbol_b | Chr_b | Start_b | End_b |
ovary | ACADL | chr2 | 211067574 | 211067594 | KANSL1L | chr2 | 211003627 | 211003647 |
cf) Tissue number; Tissue name (1;Breast, 2;Central_nervous_system, 3;Haematopoietic_and_lymphoid_tissue, 4;Large_intestine, 5;Liver, 6;Lung, 7;Ovary, 8;Pancreas, 9;Prostate, 10;Skin, 11;Soft_tissue, 12;Upper_aerodigestive_tract) |
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* From mRNA Sanger sequences, Chitars2.0 arranged chimeric transcripts. This table shows ACADL related fusion information. |
ID | Head Gene | Tail Gene | Accession | Gene_a | qStart_a | qEnd_a | Chromosome_a | tStart_a | tEnd_a | Gene_a | qStart_a | qEnd_a | Chromosome_a | tStart_a | tEnd_a |
BQ343589 | ACADL | 1 | 338 | 2 | 211069357 | 211070643 | MAML2 | 335 | 409 | 11 | 95805569 | 95805643 |
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Mutation type/ Tissue ID | brca | cns | cerv | endome | haematopo | kidn | Lintest | liver | lung | ns | ovary | pancre | prost | skin | stoma | thyro | urina | |||
Total # sample |   |   |   |   |   |   |   |   | 1 |   |   |   |   |   |   |   |   | |||
GAIN (# sample) |   |   |   |   |   |   |   |   | 1 |   |   |   |   |   |   |   |   | |||
LOSS (# sample) |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |
cf) Tissue ID; Tissue type (1; Breast, 2; Central_nervous_system, 3; Cervix, 4; Endometrium, 5; Haematopoietic_and_lymphoid_tissue, 6; Kidney, 7; Large_intestine, 8; Liver, 9; Lung, 10; NS, 11; Ovary, 12; Pancreas, 13; Prostate, 14; Skin, 15; Stomach, 16; Thyroid, 17; Urinary_tract) |
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Stat. for Non-Synonymous SNVs (# total SNVs=28) | (# total SNVs=11) |
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(# total SNVs=1) | (# total SNVs=0) |
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* When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site,primary_histology,mutation(aa),pubmedID. |
GRCh37 position | Mutation(aa) | Unique sampleID count |
chr2:211085456-211085456 | p.R50R | 2 |
chr2:211057599-211057599 | p.Q376Q | 2 |
chr2:211057600-211057600 | p.Q376P | 1 |
chr2:211081232-211081232 | p.A125A | 1 |
chr2:211069401-211069401 | p.T258T | 1 |
chr2:211070506-211070506 | p.N206N | 1 |
chr2:211057609-211057609 | p.S373Y | 1 |
chr2:211082716-211082716 | p.Y115F | 1 |
chr2:211069406-211069406 | p.D257N | 1 |
chr2:211085461-211085462 | p.G48K | 1 |
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Point Mutation/ Tissue ID | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | 18 | 19 | 20 |
# sample |   |   |   | 3 | 1 |   | 2 |   | 1 | 2 |   | 3 | 2 |   |   |   | 6 | 3 |   | 11 |
# mutation |   |   |   | 3 | 1 |   | 2 |   | 1 | 2 |   | 3 | 2 |   |   |   | 6 | 3 |   | 12 |
nonsynonymous SNV |   |   |   | 3 |   |   | 2 |   |   | 2 |   | 2 | 2 |   |   |   | 4 | 2 |   | 7 |
synonymous SNV |   |   |   |   | 1 |   |   |   | 1 |   |   | 1 |   |   |   |   | 2 | 1 |   | 5 |
cf) Tissue ID; Tissue type (1; BLCA[Bladder Urothelial Carcinoma], 2; BRCA[Breast invasive carcinoma], 3; CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], 4; COAD[Colon adenocarcinoma], 5; GBM[Glioblastoma multiforme], 6; Glioma Low Grade, 7; HNSC[Head and Neck squamous cell carcinoma], 8; KICH[Kidney Chromophobe], 9; KIRC[Kidney renal clear cell carcinoma], 10; KIRP[Kidney renal papillary cell carcinoma], 11; LAML[Acute Myeloid Leukemia], 12; LUAD[Lung adenocarcinoma], 13; LUSC[Lung squamous cell carcinoma], 14; OV[Ovarian serous cystadenocarcinoma ], 15; PAAD[Pancreatic adenocarcinoma], 16; PRAD[Prostate adenocarcinoma], 17; SKCM[Skin Cutaneous Melanoma], 18:STAD[Stomach adenocarcinoma], 19:THCA[Thyroid carcinoma], 20:UCEC[Uterine Corpus Endometrial Carcinoma]) |
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* We represented just top 10 SNVs. When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site, primary_histology, mutation(aa), pubmedID. |
Genomic Position | Mutation(aa) | Unique sampleID count |
chr2:211068098 | p.H221Y | 1 |
chr2:211074971 | p.Q69K | 1 |
chr2:211082805 | p.A217A | 1 |
chr2:211068111 | p.R61R | 1 |
chr2:211074977 | p.N206N | 1 |
chr2:211085399 | p.R61Q | 1 |
chr2:211069375 | p.A423V | 1 |
chr2:211081119 | p.I204I | 1 |
chr2:211085421 | p.R50Q | 1 |
chr2:211069401 | p.I410M | 1 |
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* Copy number data were extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered on Jan-05-2015. Function ProcessCNAData in TCGA-Assembler package was used to obtain gene-level copy number value which is calculated as the average copy number of the genomic region of a gene. |
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cf) Tissue ID[Tissue type]: BLCA[Bladder Urothelial Carcinoma], BRCA[Breast invasive carcinoma], CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], COAD[Colon adenocarcinoma], GBM[Glioblastoma multiforme], Glioma Low Grade, HNSC[Head and Neck squamous cell carcinoma], KICH[Kidney Chromophobe], KIRC[Kidney renal clear cell carcinoma], KIRP[Kidney renal papillary cell carcinoma], LAML[Acute Myeloid Leukemia], LUAD[Lung adenocarcinoma], LUSC[Lung squamous cell carcinoma], OV[Ovarian serous cystadenocarcinoma ], PAAD[Pancreatic adenocarcinoma], PRAD[Prostate adenocarcinoma], SKCM[Skin Cutaneous Melanoma], STAD[Stomach adenocarcinoma], THCA[Thyroid carcinoma], UCEC[Uterine Corpus Endometrial Carcinoma] |
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Gene Expression for ACADL |
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* CCLE gene expression data were extracted from CCLE_Expression_Entrez_2012-10-18.res: Gene-centric RMA-normalized mRNA expression data. |
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* Normalized gene expression data of RNASeqV2 was extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered at Jan-05-2015. Only eight cancer types have enough normal control samples for differential expression analysis. (t test, adjusted p<0.05 (using Benjamini-Hochberg FDR)) |
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* This plots show the correlation between CNV and gene expression. |
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Gene-Gene Network Information |
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* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown. Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene |
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ACADL,ADH1C,ALOX15B,C6orf223,CTNNA2,DBI,EYS, G6PD,GGTLC1,GGTLC2,HAAO,HPD,OR2W5,OXER1, PGC,RLN3,SERHL2,SLED1,SPINK8,SPINT3,UGT2B28 | ACADL,ACO1,ANO6,CAT,FAH,FERMT2,GBE1, GNAI1,GYG2,HEPACAM,KCNIP2,LOC283392,MARC1,MTHFD1, PEX19,PFKFB1,PLIN1,RHOBTB3,SIK2,SORT1,TRHDE |
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ACADL,AGBL1,ASAP1,BMP6,CCDC181,EFR3A,GLRB, GSN,IFNE,KLF15,LUZP2,NKX6-1,PHF20L1,SLITRK5, SPATA8,ST3GAL1,ST8SIA2,TG,TSPAN19,VEPH1,VWDE | ACADL,BBS5,CDO1,DCT,HOXA4,LARP6,LIMCH1, LRRN4CL,MAPK10,MOXD1,MRAS,NRSN2,OSCP1,PABPC4L, REM1,SIX4,SMARCD3,SYT14,TGFB3,TRNP1,UST |
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* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown. Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene |
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Pharmacological Information for ACADL |
There's no related Drug. |
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Cross referenced IDs for ACADL |
* We obtained these cross-references from Uniprot database. It covers 150 different DBs, 18 categories. http://www.uniprot.org/help/cross_references_section |
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