Cancer Cell Metabolism Gene Database

  Cancer Cell Metabolism Gene DB

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Gene Summary

Phenotypic Information (metabolism pathway, cancer, disease, phenome)

Mutations: SVs, CNVs, SNVs

Gene expression: GE, Protein, DEGE, CNV vs GE

Gene-Gene Network Information: Co-Expression Network, Interacting Genes & KEGG

Pharmacological Information: Drug-Gene Network

Cross referenced IDs

Gene Summary for HSPA1B
Basic gene info.Gene symbolHSPA1B
Gene nameheat shock 70kDa protein 1B
SynonymsHSP70-1B|HSP70-2
CytomapUCSC genome browser: 6p21.3
Genomic locationchr6_cox_hap2 :3305093-3307616
Type of geneprotein-coding
RefGenesNM_005346.4,
Ensembl idENSG00000204388
DescriptionHSP70-1/HSP70-2HSP70.1/HSP70.2heat shock 70 kDa protein 1/2heat shock 70 kDa protein 1A/1Bheat shock 70kD protein 1B
Modification date20141207
dbXrefs MIM : 603012
HGNC : HGNC
Ensembl : ENSG00000204388
HPRD : 06784
Vega : OTTHUMG00000031202
ProteinUniProt:
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_HSPA1B
BioGPS: 3304
Gene Expression Atlas: ENSG00000204388
The Human Protein Atlas: ENSG00000204388
PathwayNCI Pathway Interaction Database: HSPA1B
KEGG: HSPA1B
REACTOME: HSPA1B
ConsensusPathDB
Pathway Commons: HSPA1B
MetabolismMetaCyc: HSPA1B
HUMANCyc: HSPA1B
RegulationEnsembl's Regulation: ENSG00000204388
miRBase: chr6_cox_hap2 :3,305,093-3,307,616
TargetScan: NM_005346
cisRED: ENSG00000204388
ContextiHOP: HSPA1B
cancer metabolism search in PubMed: HSPA1B
UCL Cancer Institute: HSPA1B
Assigned class in ccmGDBB - This gene belongs to cancer gene.

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Phenotypic Information for HSPA1B(metabolism pathway, cancer, disease, phenome)
check002.gifCancer Description
Cancer CGAP: HSPA1B
Familial Cancer Database: HSPA1B
* This gene is included in those cancer gene databases.

.

Oncogene 1

Tumor Suppressor gene 2

Cancer Gene Census 3

CancerGenes 4

Network of Cancer Gene 5

Significant driver gene in

Therapeutic Vulnerabilities in Cancer1

cf) number; DB name
1 Oncogene; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long,
2 Tumor Suppressor gene; https://bioinfo.uth.edu/TSGene/,
3 Cancer Gene Census; http://www.nature.com/nrc/journal/v4/n3/abs/nrc1299.html,
4 CancerGenes; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long,
5 Network of Cancer Gene; http://ncg.kcl.ac.uk/index.php,
1Therapeutic Vulnerabilities in Cancer; http://cbio.mskcc.org/cancergenomics/statius/

check002.gifMetabolic Pathway Description
REACTOME_METABOLISM_OF_MRNA
REACTOME_METABOLISM_OF_RNA

check002.gifOthers
OMIM
Orphanet
DiseaseKEGG Disease: HSPA1B
MedGen: HSPA1B (Human Medical Genetics with Condition)
ClinVar: HSPA1B
PhenotypeMGI: HSPA1B (International Mouse Phenotyping Consortium)
PhenomicDB: HSPA1B

Mutations for HSPA1B
* Under tables are showing count per each tissue to give us broad intuition about tissue specific mutation patterns.You can go to the detailed page for each mutation database's web site.

check002.gifStructural Variants in COSMIC: go to COSMIC mutation histogram
There's no structural variation information in COSMIC data for this gene.

check002.gifRelated fusion transcripts : go to Chitars2.0
* From mRNA Sanger sequences, Chitars2.0 arranged chimeric transcripts. This table shows HSPA1B related fusion information.
IDHead GeneTail Gene
AccessionGene_aqStart_aqEnd_aChromosome_atStart_atEnd_aGene_aqStart_aqEnd_aChromosome_atStart_atEnd_a
BF798994HSPA1B8182630911703091346HSPA1B171229630833233083381

check002.gifOther DBs for Structural Variants
Structural Variants in Ensembl: go to Ensembl Structural variation
Structural Variants in dbVar: go to dbVar

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check002.gifCopy Number Variations in COSMIC: go to COSMIC mutation CNV/Expr
There's no copy number variation information in COSMIC data for this gene.

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check002.gifSNV Counts per Each Loci in COSMIC data: go to COSMIC point mutation

 : Non-synonymous mutation, : Synonymous mutation, Circle size denotes number of samples.
Maximum mutation count=2

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check002.gifSomatic Mutation Counts per Tissue in COSMIC data
Stat. for Non-Synonymous SNVs
(# total SNVs=6)
Stat. for Synonymous SNVs
(# total SNVs=0)
There's no s-snv.
Stat. for Deletions
(# total SNVs=0)
Stat. for Insertions
(# total SNVs=1)
There's no deleted snv.

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check002.gifTop 10 SNVs Having the Most Samples in COSMIC data
* When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site,primary_histology,mutation(aa),pubmedID.
GRCh37 positionMutation(aa)Unique sampleID count
chr6:31795949-31795949p.I74I2
chr6:31797272-31797272p.I515I1
chr6:31797437-31797437p.V570V1
chr6:31797463-31797463p.S579*1
chr6:31797480-31797480p.T585P1
chr6:31797485-31797485p.L586F1
chr6:31795732-31795732p.A2V1
chr6:31797488-31797488p.A587A1
chr6:31795807-31795807p.E27G1
chr6:31797587-31797587p.G620G1

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check002.gifSNV Counts per Each Loci in TCGA data

 : non-synonymous mutation, : synonymous mutation, Circle size denotes number of samples.
maximum mutation count=1

Point Mutation/ Tissue ID1234567891011121314151617181920
# sample 1    1      1 1    
# mutation 1    1      1 1    
nonsynonymous SNV 1           1      
synonymous SNV      1        1    
cf) Tissue ID; Tissue type (1; BLCA[Bladder Urothelial Carcinoma], 2; BRCA[Breast invasive carcinoma], 3; CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], 4; COAD[Colon adenocarcinoma], 5; GBM[Glioblastoma multiforme], 6; Glioma Low Grade, 7; HNSC[Head and Neck squamous cell carcinoma], 8; KICH[Kidney Chromophobe], 9; KIRC[Kidney renal clear cell carcinoma], 10; KIRP[Kidney renal papillary cell carcinoma], 11; LAML[Acute Myeloid Leukemia], 12; LUAD[Lung adenocarcinoma], 13; LUSC[Lung squamous cell carcinoma], 14; OV[Ovarian serous cystadenocarcinoma ], 15; PAAD[Pancreatic adenocarcinoma], 16; PRAD[Prostate adenocarcinoma], 17; SKCM[Skin Cutaneous Melanoma], 18:STAD[Stomach adenocarcinoma], 19:THCA[Thyroid carcinoma], 20:UCEC[Uterine Corpus Endometrial Carcinoma])

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check002.gifTop 10 SNVs Having the Most Samples in TCGA data
* We represented just top 10 SNVs. When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site, primary_histology, mutation(aa), pubmedID.
Genomic PositionMutation(aa)Unique sampleID count
chr6:31795732p.A2V1
chr6:31797488p.A587A1
chr6:31797593p.F622F1
chr6:31797634p.T636N1
chr6:31797648p.D641Y1

check002.gifOther DBs for Point Mutations
Point Mutation Table of Ensembl: go to Ensembl variation table
Mutation of cBioPortal: go to cBioPortal's Cross-cancer alteration summary

check002.gifCopy Number for HSPA1B in TCGA
* Copy number data were extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered on Jan-05-2015. Function ProcessCNAData in TCGA-Assembler package was used to obtain gene-level copy number value which is calculated as the average copy number of the genomic region of a gene.
cf) Tissue ID[Tissue type]: BLCA[Bladder Urothelial Carcinoma], BRCA[Breast invasive carcinoma], CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], COAD[Colon adenocarcinoma], GBM[Glioblastoma multiforme], Glioma Low Grade, HNSC[Head and Neck squamous cell carcinoma], KICH[Kidney Chromophobe], KIRC[Kidney renal clear cell carcinoma], KIRP[Kidney renal papillary cell carcinoma], LAML[Acute Myeloid Leukemia], LUAD[Lung adenocarcinoma], LUSC[Lung squamous cell carcinoma], OV[Ovarian serous cystadenocarcinoma ], PAAD[Pancreatic adenocarcinoma], PRAD[Prostate adenocarcinoma], SKCM[Skin Cutaneous Melanoma], STAD[Stomach adenocarcinoma], THCA[Thyroid carcinoma], UCEC[Uterine Corpus Endometrial Carcinoma]

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Gene Expression for HSPA1B

check002.gifGene Expression in Cancer Cell-lines (CCLE)
* CCLE gene expression data were extracted from CCLE_Expression_Entrez_2012-10-18.res: Gene-centric RMA-normalized mRNA expression data.

check002.gifDifferential Gene Expression in Primary Tumors (TCGA)
* Normalized gene expression data of RNASeqV2 was extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered at Jan-05-2015. Only eight cancer types have enough normal control samples for differential expression analysis.
(t test, adjusted p<0.05 (using Benjamini-Hochberg FDR))
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check002.gifCNV vs Gene Expression Plot
* This plots show the correlation between CNV and gene expression.

: Open all plots for all cancer types


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Gene-Gene Network Information
check002.gifCo-Expressed gene's network Plot
* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown.
Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene

: Open all plots for all cancer types

BAG6,GPANK1,C6orf47,CACYBP,CUTA,DEDD2,DNAJB1,
FKBPL,HES7,HSPA1A,HSPA1B,HSPA1L,HSPA6,HSPE1,
LEMD2,NFKBIL1,PFDN6,PPP1R15A,NELFE,RNF5,ZFAND2A
AMBN,CACYBP,CPNE4,DHX40P1,DNAJB1,ULK4P3,HIST1H4L,
HSPA1A,HSPA1B,HSPA1L,HSPA6,KRTAP19-3,LOC144776,MGC14436,
OPRK1,OR6Q1,SCN1A,SSX8,TARM1,TF,TMEM95

HIST1H4K,HSPA1B,LOC653544,LOC653545,POTEE,PPIAL4B,RBMY1B,
RPL13AP20,RPL13AP6,RPL21,RPS26P11,SNORD76,TBC1D3P2,TPI1P3
ANKH,DGCR2,ECE1,EPAS1,NXPE2,FLJ35024,FLNB,
GLB1L2,HSPA1A,HSPA1B,LANCL3,MAVS,ME3,MYO1D,
PADI2,RUNDC1,SFXN5,TMEM131,TNFRSF21,UGT1A8,WSCD1
check002.gifCo-Expressed gene's Protein-protein interaction Network Plot
* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown.
Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene

: Open all plots for all cancer types

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check002.gifInteracting Genes (from Pathway Commons)

: Open all interacting genes' information including KEGG pathway for all interacting genes from DAVID

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Pharmacological Information for HSPA1B


There's no related Drug.
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Cross referenced IDs for HSPA1B
* We obtained these cross-references from Uniprot database. It covers 150 different DBs, 18 categories. http://www.uniprot.org/help/cross_references_section

: Open all cross reference information



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