Cancer Cell Metabolism Gene Database

  Cancer Cell Metabolism Gene DB

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Gene Summary

Phenotypic Information (metabolism pathway, cancer, disease, phenome)

Mutations: SVs, CNVs, SNVs

Gene expression: GE, Protein, DEGE, CNV vs GE

Gene-Gene Network Information: Co-Expression Network, Interacting Genes & KEGG

Pharmacological Information: Drug-Gene Network

Cross referenced IDs

Gene Summary for HSPA8
Basic gene info.Gene symbolHSPA8
Gene nameheat shock 70kDa protein 8
SynonymsHEL-33|HEL-S-72p|HSC54|HSC70|HSC71|HSP71|HSP73|HSPA10|LAP-1|LAP1|NIP71
CytomapUCSC genome browser: 11q24.1
Genomic locationchr11 :122928199-122932901
Type of geneprotein-coding
RefGenesNM_006597.5,
NM_153201.3,
Ensembl idENSG00000109971
DescriptionLPS-associated protein 1N-myristoyltransferase inhibitor protein 71constitutive heat shock protein 70epididymis luminal protein 33epididymis secretory sperm binding protein Li 72pheat shock 70kd protein 10heat shock cognate 71 kDa proteinheat shock
Modification date20141207
dbXrefs MIM : 600816
HGNC : HGNC
Ensembl : ENSG00000109971
HPRD : 07205
Vega : OTTHUMG00000166030
ProteinUniProt: P11142
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_HSPA8
BioGPS: 3312
Gene Expression Atlas: ENSG00000109971
The Human Protein Atlas: ENSG00000109971
PathwayNCI Pathway Interaction Database: HSPA8
KEGG: HSPA8
REACTOME: HSPA8
ConsensusPathDB
Pathway Commons: HSPA8
MetabolismMetaCyc: HSPA8
HUMANCyc: HSPA8
RegulationEnsembl's Regulation: ENSG00000109971
miRBase: chr11 :122,928,199-122,932,901
TargetScan: NM_006597
cisRED: ENSG00000109971
ContextiHOP: HSPA8
cancer metabolism search in PubMed: HSPA8
UCL Cancer Institute: HSPA8
Assigned class in ccmGDBB - This gene belongs to cancer gene.

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Phenotypic Information for HSPA8(metabolism pathway, cancer, disease, phenome)
check002.gifCancer Description
Cancer CGAP: HSPA8
Familial Cancer Database: HSPA8
* This gene is included in those cancer gene databases.

.

Oncogene 1

Tumor Suppressor gene 2

Cancer Gene Census 3

CancerGenes 4

Network of Cancer Gene 5

Significant driver gene in

Therapeutic Vulnerabilities in Cancer1

cf) number; DB name
1 Oncogene; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long,
2 Tumor Suppressor gene; https://bioinfo.uth.edu/TSGene/,
3 Cancer Gene Census; http://www.nature.com/nrc/journal/v4/n3/abs/nrc1299.html,
4 CancerGenes; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long,
5 Network of Cancer Gene; http://ncg.kcl.ac.uk/index.php,
1Therapeutic Vulnerabilities in Cancer; http://cbio.mskcc.org/cancergenomics/statius/

check002.gifMetabolic Pathway Description
REACTOME_METABOLISM_OF_MRNA
REACTOME_METABOLISM_OF_RNA

check002.gifOthers
OMIM 600816; gene.
Orphanet
DiseaseKEGG Disease: HSPA8
MedGen: HSPA8 (Human Medical Genetics with Condition)
ClinVar: HSPA8
PhenotypeMGI: HSPA8 (International Mouse Phenotyping Consortium)
PhenomicDB: HSPA8

Mutations for HSPA8
* Under tables are showing count per each tissue to give us broad intuition about tissue specific mutation patterns.You can go to the detailed page for each mutation database's web site.

check002.gifStructural Variants in COSMIC: go to COSMIC mutation histogram
There's no structural variation information in COSMIC data for this gene.

check002.gifRelated fusion transcripts : go to Chitars2.0
* From mRNA Sanger sequences, Chitars2.0 arranged chimeric transcripts. This table shows HSPA8 related fusion information.
IDHead GeneTail Gene
AccessionGene_aqStart_aqEnd_aChromosome_atStart_atEnd_aGene_aqStart_aqEnd_aChromosome_atStart_atEnd_a
BQ362492HSPA8426711122930679122931356STX3263600115956921959569557
CN338266CCDC471243176184341061850869HSPA824257411122928549122929360
DA668305HSPA828911122930043122930129ALDH1A19055897553195275542085
DA378775RNU121150224301125043011399HSPA815162711122931313122932844
BP357681UTP186402174933794349340686HSPA840158211122930290122930472
DB195849HSPA818811122930042122930127HSPD1895552198361911198364590
BE812526HSPA817811122929387122929465HSPA87633511122928553122929140
BC112920HIST1H1D117762623501626235192HSPA8176124911122928205122930196
CV345070NCL12302232320299232321412HSPA821447411122929415122929903
AA063643MAP4118834791230247912490HSPA818642511122930412122930651
BF885577HSPA87833911122928553122929149HSPA833752411122930401122930588
BF154448RND38832151335355151335433HSPA88013611122928500122928556
BE771086HSPA84130511122929030122929439INADL30254616239045362391045
BF082086HSPA816711122929399122929465HSPA86542011122928553122929385
BF082156HSPA8139811122929378122929465HSPA89637111122928553122929160
CV322984C16orf7292061692079399208138HSPA820135911122929390122929776
BQ338693HSPA83038811122928960122929465SLC7A6385514166833424668334375

check002.gifOther DBs for Structural Variants
Structural Variants in Ensembl: go to Ensembl Structural variation
Structural Variants in dbVar: go to dbVar

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check002.gifCopy Number Variations in COSMIC: go to COSMIC mutation CNV/Expr
There's no copy number variation information in COSMIC data for this gene.

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check002.gifSNV Counts per Each Loci in COSMIC data: go to COSMIC point mutation

 : Non-synonymous mutation, : Synonymous mutation, Circle size denotes number of samples.
Maximum mutation count=11

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check002.gifSomatic Mutation Counts per Tissue in COSMIC data
Stat. for Non-Synonymous SNVs
(# total SNVs=107)
Stat. for Synonymous SNVs
(# total SNVs=47)
Stat. for Deletions
(# total SNVs=6)
Stat. for Insertions
(# total SNVs=0)
There's no inserted snv.

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check002.gifTop 10 SNVs Having the Most Samples in COSMIC data
* When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site,primary_histology,mutation(aa),pubmedID.
GRCh37 positionMutation(aa)Unique sampleID count
chr11:122930698-122930698p.G201G10
chr11:122930631-122930631p.G224R9
chr11:122930568-122930568p.F245L7
chr11:122930495-122930495p.R269H7
chr11:122930534-122930534p.N256S5
chr11:122930632-122930632p.A223A5
chr11:122930566-122930566p.F245F4
chr11:122930686-122930686p.F205F4
chr11:122930517-122930517p.R262C4
chr11:122930727-122930727p.E192Q3

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check002.gifSNV Counts per Each Loci in TCGA data

 : non-synonymous mutation, : synonymous mutation, Circle size denotes number of samples.
maximum mutation count=2

Point Mutation/ Tissue ID1234567891011121314151617181920
# sample51 171 5 91 83  16617
# mutation51 141 5 91 83  17619
nonsynonymous SNV31 101 3 61 72  15517
synonymous SNV2  4  2 3  11   21 2
cf) Tissue ID; Tissue type (1; BLCA[Bladder Urothelial Carcinoma], 2; BRCA[Breast invasive carcinoma], 3; CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], 4; COAD[Colon adenocarcinoma], 5; GBM[Glioblastoma multiforme], 6; Glioma Low Grade, 7; HNSC[Head and Neck squamous cell carcinoma], 8; KICH[Kidney Chromophobe], 9; KIRC[Kidney renal clear cell carcinoma], 10; KIRP[Kidney renal papillary cell carcinoma], 11; LAML[Acute Myeloid Leukemia], 12; LUAD[Lung adenocarcinoma], 13; LUSC[Lung squamous cell carcinoma], 14; OV[Ovarian serous cystadenocarcinoma ], 15; PAAD[Pancreatic adenocarcinoma], 16; PRAD[Prostate adenocarcinoma], 17; SKCM[Skin Cutaneous Melanoma], 18:STAD[Stomach adenocarcinoma], 19:THCA[Thyroid carcinoma], 20:UCEC[Uterine Corpus Endometrial Carcinoma])

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check002.gifTop 10 SNVs Having the Most Samples in TCGA data
* We represented just top 10 SNVs. When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site, primary_histology, mutation(aa), pubmedID.
Genomic PositionMutation(aa)Unique sampleID count
chr11:122930683p.L196L,HSPA82
chr11:122930685p.Y41H,HSPA82
chr11:122930692p.E110Q,HSPA82
chr11:122931384p.D206D,HSPA82
chr11:122931912p.D206Y,HSPA82
chr11:122930713p.G203G,HSPA82
chr11:122930482p.T64T,HSPA81
chr11:122931851p.K557T1
chr11:122928975p.E304K,HSPA81
chr11:122929826p.G203D,HSPA81

check002.gifOther DBs for Point Mutations
Point Mutation Table of Ensembl: go to Ensembl variation table
Mutation of cBioPortal: go to cBioPortal's Cross-cancer alteration summary

check002.gifCopy Number for HSPA8 in TCGA
* Copy number data were extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered on Jan-05-2015. Function ProcessCNAData in TCGA-Assembler package was used to obtain gene-level copy number value which is calculated as the average copy number of the genomic region of a gene.
cf) Tissue ID[Tissue type]: BLCA[Bladder Urothelial Carcinoma], BRCA[Breast invasive carcinoma], CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], COAD[Colon adenocarcinoma], GBM[Glioblastoma multiforme], Glioma Low Grade, HNSC[Head and Neck squamous cell carcinoma], KICH[Kidney Chromophobe], KIRC[Kidney renal clear cell carcinoma], KIRP[Kidney renal papillary cell carcinoma], LAML[Acute Myeloid Leukemia], LUAD[Lung adenocarcinoma], LUSC[Lung squamous cell carcinoma], OV[Ovarian serous cystadenocarcinoma ], PAAD[Pancreatic adenocarcinoma], PRAD[Prostate adenocarcinoma], SKCM[Skin Cutaneous Melanoma], STAD[Stomach adenocarcinoma], THCA[Thyroid carcinoma], UCEC[Uterine Corpus Endometrial Carcinoma]

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Gene Expression for HSPA8

check002.gifGene Expression in Cancer Cell-lines (CCLE)
* CCLE gene expression data were extracted from CCLE_Expression_Entrez_2012-10-18.res: Gene-centric RMA-normalized mRNA expression data.

check002.gifDifferential Gene Expression in Primary Tumors (TCGA)
* Normalized gene expression data of RNASeqV2 was extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered at Jan-05-2015. Only eight cancer types have enough normal control samples for differential expression analysis.
(t test, adjusted p<0.05 (using Benjamini-Hochberg FDR))
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check002.gifCNV vs Gene Expression Plot
* This plots show the correlation between CNV and gene expression.

: Open all plots for all cancer types


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Gene-Gene Network Information
check002.gifCo-Expressed gene's network Plot
* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown.
Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene

: Open all plots for all cancer types

ATP5B,CNOT1,DDX21,DHX9,DLAT,ETF1,HSPA8,
IARS,IDE,IPO7,KIF2A,LOC284441,NAA15,NLN,
PAFAH1B2,PGAM4,PRKAR2A,SBNO1,SCYL2,STT3B,ZW10
ABCF2,AIMP2,APOO,ATP5G1,COQ2,DNAJB6,EIF4E2,
EIF5AL1,GTF3C6,HN1,HSPA8,NDUFS3,PGK1,PSMA5,
PSMD14,TIMM8B,EMC6,TPI1,UTP11L,VDAC1,WDR77

ATP5B,C1QBP,CCT2,CCT4,CHTF8,CNIH1,COPS4,
G3BP1,GPN3,GTF2H3,HMMR,HSPA8,MED31,MRPL44,
MRPL49,NOC3L,PNP,RAN,RQCD1,SNRNP40,TTC5
CACYBP,CCT2,CELA3A,CHAC2,DPH2,EIF4E,HSP90AA1,
HSPA8,HSPE1,IAPP,METTL1,NOC3L,PAK1IP1,PNO1,
PSG1,RPP40,SRPRB,SSX8,TBCE,VCY,WDR12
check002.gifCo-Expressed gene's Protein-protein interaction Network Plot
* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown.
Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene

: Open all plots for all cancer types

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check002.gifInteracting Genes (from Pathway Commons)

: Open all interacting genes' information including KEGG pathway for all interacting genes from DAVID

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Pharmacological Information for HSPA8
check002.gifCross-referenced pharmacological DB IDs from Uniprot
DB CategoryDB NameDB's ID and Url link
ChemistryBindingDB P11142; -.
ChemistryChEMBL CHEMBL1275223; -.
Organism-specific databasesPharmGKB PA29507; -.
Organism-specific databasesCTD 3312; -.

check002.gifDrug-Gene Interaction Network
* Gene Centered Interaction Network.
* Drug Centered Interaction Network.
DrugBank IDTarget NameDrug GroupsGeneric NameDrug Centered NetworkDrug Structure
DB03431heat shock 70kDa protein 8experimentalAdenosine-5'-Diphosphate
DB07045heat shock 70kDa protein 8experimental(2R,3R,4S,5R)-2-[6-amino-8-[(3,4-dichlorophenyl)methylamino]purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diol
DB00458heat shock 70kDa protein 8approvedImipramine


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Cross referenced IDs for HSPA8
* We obtained these cross-references from Uniprot database. It covers 150 different DBs, 18 categories. http://www.uniprot.org/help/cross_references_section

: Open all cross reference information



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