Cancer Cell Metabolism Database ~~ Bioinformatics and Systems Medicine Laboratory ~~

Cancer Cell Metabolism Gene Database

Cancer Cell Metabolism Gene DB

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	Gene Summary
	Phenotypic Information (metabolism pathway, cancer, disease, phenome)
	Mutations : SVs, CNVs, SNVs
	Gene expression: GE, Protein, DEGE, CNV vs GE
	Gene-Gene Network Information: Co-Expression Network, Interacting Genes & KEGG
	Pharmacological Information: Drug-Gene Network
	Cross referenced IDs

Gene Summary for NDST1

Basic gene info.	Gene symbol	NDST1
	Gene name	N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1
	Synonyms	HSST\|MRT46\|NST1
	Cytomap	UCSC genome browser: 5q33.1
	Genomic location	chr5 :149887673-149937773
	Type of gene	protein-coding
	RefGenes	NM_001301063.1, NM_001543.4,
	Ensembl id	ENSG00000070614
	Description	HSNST 1N-HSST 1N-heparan sulfate sulfotransferase 1NDST-1[Heparan sulfate]-glucosamine N-sulfotransferase 1bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 1glucosaminyl N-deacetylase/N-sulfotransferase 1heparan sulfate-N-deacetylase/N
	Modification date	20141222
dbXrefs	MIM : 600853
	HGNC : HGNC
	Ensembl : ENSG00000070614
	HPRD : 02912
	Vega : OTTHUMG00000163572
Protein	UniProt: go to UniProt's Cross Reference DB Table
Expression	CleanEX: HS_NDST1
	BioGPS: 3340
	Gene Expression Atlas: ENSG00000070614
	The Human Protein Atlas: ENSG00000070614
Pathway	NCI Pathway Interaction Database: NDST1
	KEGG: NDST1
	REACTOME: NDST1
	ConsensusPathDB
	Pathway Commons: NDST1
Metabolism	MetaCyc: NDST1
	HUMANCyc: NDST1
Regulation	Ensembl's Regulation: ENSG00000070614
	miRBase: chr5 :149,887,673-149,937,773
	TargetScan: NM_001301063
	cisRED: ENSG00000070614
Context	iHOP: NDST1
	cancer metabolism search in PubMed: NDST1
	UCL Cancer Institute: NDST1
Assigned class in ccmGDB	C

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Phenotypic Information for NDST1(metabolism pathway, cancer, disease, phenome)

Cancer Description
Cancer	CGAP: NDST1
	Familial Cancer Database: NDST1

* This gene is included in those cancer gene databases.


Oncogene ¹	Tumor Suppressor gene ²	Cancer Gene Census ³	CancerGenes ⁴	Network of Cancer Gene ⁵	Significant driver gene in	Therapeutic Vulnerabilities in Cancer¹

cf) number; DB name
1 Oncogene; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long,
2 Tumor Suppressor gene; https://bioinfo.uth.edu/TSGene/,
3 Cancer Gene Census; http://www.nature.com/nrc/journal/v4/n3/abs/nrc1299.html,
4 CancerGenes; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long,
5 Network of Cancer Gene; http://ncg.kcl.ac.uk/index.php,
1Therapeutic Vulnerabilities in Cancer; http://cbio.mskcc.org/cancergenomics/statius/

Metabolic Pathway Description
REACTOME_METABOLISM_OF_CARBOHYDRATES

Others
OMIM
Orphanet
Disease	KEGG Disease: NDST1
	MedGen: NDST1 (Human Medical Genetics with Condition)
	ClinVar: NDST1
Phenotype	MGI: NDST1 (International Mouse Phenotyping Consortium)
Phenotype	PhenomicDB: NDST1

Mutations for NDST1

* Under tables are showing count per each tissue to give us broad intuition about tissue specific mutation patterns.You can go to the detailed page for each mutation database's web site.

Structural Variants in COSMIC : go to COSMIC mutation histogram

There's no structural variation information in COSMIC data for this gene.

Related fusion transcripts : go to Chitars2.0

* From mRNA Sanger sequences, Chitars2.0 arranged chimeric transcripts. This table shows NDST1 related fusion information.

Head Gene

Tail Gene

Accession

Gene_a

qStart_a

qEnd_a

Chromosome_a

tStart_a

tEnd_a

Gene_a

qStart_a

qEnd_a

Chromosome_a

tStart_a

tEnd_a

BU631743

FAM168B

533

131809603

131810549

NDST1

531

708

149937242

149937419

Other DBs for Structural Variants

Structural Variants in Ensembl: go to Ensembl Structural variation

Structural Variants in dbVar: go to dbVar

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Copy Number Variations in COSMIC : go to COSMIC mutation CNV/Expr

Mutation type/ Tissue ID

brca

cns

cerv

endome

haematopo

kidn

Lintest

liver

lung

ovary

pancre

prost

skin

stoma

thyro

urina

Total # sample

GAIN (# sample)

LOSS (# sample)

cf) Tissue ID; Tissue type (1; Breast, 2; Central_nervous_system, 3; Cervix, 4; Endometrium, 5; Haematopoietic_and_lymphoid_tissue, 6; Kidney, 7; Large_intestine, 8; Liver, 9; Lung, 10; NS, 11; Ovary, 12; Pancreas, 13; Prostate, 14; Skin, 15; Stomach, 16; Thyroid, 17; Urinary_tract)

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SNV Counts per Each Loci in COSMIC data : go to COSMIC point mutation

: Non-synonymous mutation, : Synonymous mutation, Circle size denotes number of samples.
Maximum mutation count=4

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Somatic Mutation Counts per Tissue in COSMIC data

Stat. for Non-Synonymous SNVs (# total SNVs=60)	Stat. for Synonymous SNVs (# total SNVs=32)

Stat. for Deletions (# total SNVs=1)	Stat. for Insertions (# total SNVs=0)
	There's no inserted snv.

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Top 10 SNVs Having the Most Samples in COSMIC data

* When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site,primary_histology,mutation(aa),pubmedID.

GRCh37 position	Mutation(aa)	Unique sampleID count
chr5:149922503-149922503	p.N647S	2
chr5:149932804-149932804	p.R853R	2
chr5:149918810-149918810	p.C486C	2
chr5:149901260-149901260	p.D148D	2
chr5:149929267-149929267	p.R782C	2
chr5:149922522-149922522	p.K653K	2
chr5:149922525-149922525	p.G654G	2
chr5:149924914-149924914	p.D671N	2
chr5:149924915-149924915	p.D671G	2
chr5:149907676-149907676	p.G275D	2

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SNV Counts per Each Loci in TCGA data

: non-synonymous mutation, : synonymous mutation, Circle size denotes number of samples.
maximum mutation count=2

Point Mutation/ Tissue ID	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20
# sample	1	3		10	2		2		2			8	4	3			10	13		16
# mutation	1	3		10	2		2		2			9	4	3			10	16		19
nonsynonymous SNV				7			1		2			6	4	1			4	11		12
synonymous SNV	1	3		3	2		1					3		2			6	5		7

cf) Tissue ID; Tissue type (1; BLCA[Bladder Urothelial Carcinoma], 2; BRCA[Breast invasive carcinoma], 3; CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], 4; COAD[Colon adenocarcinoma], 5; GBM[Glioblastoma multiforme], 6; Glioma Low Grade, 7; HNSC[Head and Neck squamous cell carcinoma], 8; KICH[Kidney Chromophobe], 9; KIRC[Kidney renal clear cell carcinoma], 10; KIRP[Kidney renal papillary cell carcinoma], 11; LAML[Acute Myeloid Leukemia], 12; LUAD[Lung adenocarcinoma], 13; LUSC[Lung squamous cell carcinoma], 14; OV[Ovarian serous cystadenocarcinoma ], 15; PAAD[Pancreatic adenocarcinoma], 16; PRAD[Prostate adenocarcinoma], 17; SKCM[Skin Cutaneous Melanoma], 18:STAD[Stomach adenocarcinoma], 19:THCA[Thyroid carcinoma], 20:UCEC[Uterine Corpus Endometrial Carcinoma])

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Top 10 SNVs Having the Most Samples in TCGA data

* We represented just top 10 SNVs. When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site, primary_histology, mutation(aa), pubmedID.

Genomic Position	Mutation(aa)	Unique sampleID count
chr5:149915419	p.D371D	2
chr5:149914445	p.R470H	2
chr5:149924914	p.D671N	2
chr5:149900988	p.R130C	1
chr5:149915300	p.E344K	1
chr5:149927918	p.E513K	1
chr5:149901282	p.R709Q	1
chr5:149919666	p.R853L	1
chr5:149932854	p.D148D	1
chr5:149907801	p.H364P	1

Other DBs for Point Mutations

Point Mutation Table of Ensembl: go to Ensembl variation table

Mutation of cBioPortal: go to cBioPortal's Cross-cancer alteration summary

Copy Number for NDST1 in TCGA

* Copy number data were extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered on Jan-05-2015. Function ProcessCNAData in TCGA-Assembler package was used to obtain gene-level copy number value which is calculated as the average copy number of the genomic region of a gene.

cf) Tissue ID[Tissue type]: BLCA[Bladder Urothelial Carcinoma], BRCA[Breast invasive carcinoma], CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], COAD[Colon adenocarcinoma], GBM[Glioblastoma multiforme], Glioma Low Grade, HNSC[Head and Neck squamous cell carcinoma], KICH[Kidney Chromophobe], KIRC[Kidney renal clear cell carcinoma], KIRP[Kidney renal papillary cell carcinoma], LAML[Acute Myeloid Leukemia], LUAD[Lung adenocarcinoma], LUSC[Lung squamous cell carcinoma], OV[Ovarian serous cystadenocarcinoma ], PAAD[Pancreatic adenocarcinoma], PRAD[Prostate adenocarcinoma], SKCM[Skin Cutaneous Melanoma], STAD[Stomach adenocarcinoma], THCA[Thyroid carcinoma], UCEC[Uterine Corpus Endometrial Carcinoma]

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Gene Expression for NDST1

Gene Expression in Cancer Cell-lines (CCLE)

* CCLE gene expression data were extracted from CCLE_Expression_Entrez_2012-10-18.res: Gene-centric RMA-normalized mRNA expression data.

Differential Gene Expression in Primary Tumors (TCGA)

* Normalized gene expression data of RNASeqV2 was extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered at Jan-05-2015. Only eight cancer types have enough normal control samples for differential expression analysis.
(t test, adjusted p<0.05 (using Benjamini-Hochberg FDR))

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CNV vs Gene Expression Plot

* This plots show the correlation between CNV and gene expression.

: Open all plots for all cancer types

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Gene-Gene Network Information

Co-Expressed gene's network Plot

* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown.
Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene

: Open all plots for all cancer types


ADCY6,ARHGEF37,PRRC2B,BTBD7,FAM13B,FAM172A,GALNT10, ARHGAP35,KDM3B,KIF13B,LOC100129034,MTHFR,NDST1,PCDH1, PDPK1,PRICKLE2,RREB1,SAP30L,TECPR2,VPS13D,ZNF106	ACVR1B,PRRC2B,DZANK1,CGNL1,CUL9,SPECC1L,ARHGAP35, IP6K1,LDOC1L,NDST1,PACSIN2,PFAS,PITPNM3,PLEKHA7, SNRNP200,SRCAP,TATDN2,TBC1D14,TECPR2,TMEM63A,TTC22

AFAP1L1,CD93,COL4A1,COL4A2,ENG,FLT4,GPR124, HEG1,HSPG2,KDR,LAMA4,MMRN2,NDST1,NID1, STAB1,STARD8,THBD,TIE1,VASH1,ZEB2,ZNF366	ELMSAN1,CCDC85C,DNAJC5,ARHGAP35,IGSF3,KSR1,LAMP1, MED15,NDST1,NFE2L1,NIPAL3,OTUD7B,PLXNB2,SORT1, STAU1,SYNPO,USP9X,VPS18,ZER1,ZFAND3,ZMIZ1

Co-Expressed gene's Protein-protein interaction Network Plot

: Open all plots for all cancer types

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Interacting Genes (from Pathway Commons)

: Open all interacting genes' information including KEGG pathway for all interacting genes from DAVID

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Pharmacological Information for NDST1

Cross-referenced pharmacological DB IDs from Uniprot

DB Category

DB Name

DB's ID and Url link

Drug-Gene Interaction Network

* Gene Centered Interaction Network.

* Drug Centered Interaction Network.

DrugBank ID	Target Name	Drug Groups	Generic Name	Drug Centered Network	Drug Structure
DB01812	N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1	experimental	Adenosine-3'-5'-Diphosphate

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Cross referenced IDs for NDST1

* We obtained these cross-references from Uniprot database. It covers 150 different DBs, 18 categories. http://www.uniprot.org/help/cross_references_section

: Open all cross reference information