Cancer Cell Metabolism Gene Database

  Cancer Cell Metabolism Gene DB

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Bioinformatics and Systems Medicine Laboratory Bioinformatics and Systems Medicine Laboratory

Gene Summary

Phenotypic Information (metabolism pathway, cancer, disease, phenome)

Mutations: SVs, CNVs, SNVs

Gene expression: GE, Protein, DEGE, CNV vs GE

Gene-Gene Network Information: Co-Expression Network, Interacting Genes & KEGG

Pharmacological Information: Drug-Gene Network

Cross referenced IDs

Gene Summary for ACER2
Basic gene info.Gene symbolACER2
Gene namealkaline ceramidase 2
SynonymsALKCDase2|ASAH3L
CytomapUCSC genome browser: 9p22.1
Genomic locationchr9 :19408924-19452500
Type of geneprotein-coding
RefGenesNM_001010887.2,
Ensembl idENSG00000177076
DescriptionalkCDase 2alkaline CDase 2ceramide hydrolasehaCER2
Modification date20141207
dbXrefs MIM : 613492
HGNC : HGNC
HPRD : 16512
ProteinUniProt:
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_ACER2
BioGPS: 340485
Gene Expression Atlas: ENSG00000177076
The Human Protein Atlas: ENSG00000177076
PathwayNCI Pathway Interaction Database: ACER2
KEGG: ACER2
REACTOME: ACER2
ConsensusPathDB
Pathway Commons: ACER2
MetabolismMetaCyc: ACER2
HUMANCyc: ACER2
RegulationEnsembl's Regulation: ENSG00000177076
miRBase: chr9 :19,408,924-19,452,500
TargetScan: NM_001010887
cisRED: ENSG00000177076
ContextiHOP: ACER2
cancer metabolism search in PubMed: ACER2
UCL Cancer Institute: ACER2
Assigned class in ccmGDBC

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Phenotypic Information for ACER2(metabolism pathway, cancer, disease, phenome)
check002.gifCancer Description
Cancer CGAP: ACER2
Familial Cancer Database: ACER2
* This gene is included in those cancer gene databases.

Oncogene 1

Tumor Suppressor gene 2

Cancer Gene Census 3

CancerGenes 4

Network of Cancer Gene 5

Significant driver gene in

Therapeutic Vulnerabilities in Cancer1

cf) number; DB name
1 Oncogene; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long,
2 Tumor Suppressor gene; https://bioinfo.uth.edu/TSGene/,
3 Cancer Gene Census; http://www.nature.com/nrc/journal/v4/n3/abs/nrc1299.html,
4 CancerGenes; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long,
5 Network of Cancer Gene; http://ncg.kcl.ac.uk/index.php,
1Therapeutic Vulnerabilities in Cancer; http://cbio.mskcc.org/cancergenomics/statius/

check002.gifMetabolic Pathway Description
KEGG_SPHINGOLIPID_METABOLISM
REACTOME_PHOSPHOLIPID_METABOLISM
REACTOME_SPHINGOLIPID_METABOLISM
REACTOME_METABOLISM_OF_LIPIDS_AND_LIPOPROTEINS

check002.gifOthers
OMIM
Orphanet
DiseaseKEGG Disease: ACER2
MedGen: ACER2 (Human Medical Genetics with Condition)
ClinVar: ACER2
PhenotypeMGI: ACER2 (International Mouse Phenotyping Consortium)
PhenomicDB: ACER2

Mutations for ACER2
* Under tables are showing count per each tissue to give us broad intuition about tissue specific mutation patterns.You can go to the detailed page for each mutation database's web site.

check002.gifStructural Variants in COSMIC: go to COSMIC mutation histogram
There's no structural variation information in COSMIC data for this gene.

check002.gifRelated fusion transcripts : go to Chitars2.0
* From mRNA Sanger sequences, Chitars2.0 arranged chimeric transcripts. This table shows ACER2 related fusion information.
IDHead GeneTail Gene
AccessionGene_aqStart_aqEnd_aChromosome_atStart_atEnd_aGene_aqStart_aqEnd_aChromosome_atStart_atEnd_a
BC092487ACER21202791940901019451624CSH120192066176197227861972325

check002.gifOther DBs for Structural Variants
Structural Variants in Ensembl: go to Ensembl Structural variation
Structural Variants in dbVar: go to dbVar

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check002.gifCopy Number Variations in COSMIC: go to COSMIC mutation CNV/Expr
 
Mutation type/ Tissue IDbrcacnscervendomehaematopokidnLintestliverlungnsovarypancreprostskinstomathyrourina
Total # sample33      2 2  2  1
GAIN (# sample)2                
LOSS (# sample)13      2 2  2  1
cf) Tissue ID; Tissue type (1; Breast, 2; Central_nervous_system, 3; Cervix, 4; Endometrium, 5; Haematopoietic_and_lymphoid_tissue, 6; Kidney, 7; Large_intestine, 8; Liver, 9; Lung, 10; NS, 11; Ovary, 12; Pancreas, 13; Prostate, 14; Skin, 15; Stomach, 16; Thyroid, 17; Urinary_tract)

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check002.gifSNV Counts per Each Loci in COSMIC data: go to COSMIC point mutation

 : Non-synonymous mutation, : Synonymous mutation, Circle size denotes number of samples.
Maximum mutation count=5

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check002.gifSomatic Mutation Counts per Tissue in COSMIC data
Stat. for Non-Synonymous SNVs
(# total SNVs=21)
Stat. for Synonymous SNVs
(# total SNVs=3)
Stat. for Deletions
(# total SNVs=0)
Stat. for Insertions
(# total SNVs=0)
There's no deleted snv.There's no inserted snv.

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check002.gifTop 10 SNVs Having the Most Samples in COSMIC data
* When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site,primary_histology,mutation(aa),pubmedID.
GRCh37 positionMutation(aa)Unique sampleID count
chr9:19423911-19423911p.R54C4
chr9:19446293-19446293p.R173H2
chr9:19423917-19423917p.Y56H2
chr9:19446292-19446292p.R173C1
chr9:19409198-19409198p.?1
chr9:19424786-19424786p.A104A1
chr9:19423859-19423859p.?1
chr9:19424801-19424801p.F109F1
chr9:19446317-19446317p.S181L1
chr9:19423880-19423880p.F43F1

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check002.gifSNV Counts per Each Loci in TCGA data

 : non-synonymous mutation, : synonymous mutation, Circle size denotes number of samples.
maximum mutation count=2

Point Mutation/ Tissue ID1234567891011121314151617181920
# sample 1 31 1    42   36 4
# mutation 1 31 1    42   36 4
nonsynonymous SNV 1 21 1    32    4 2
synonymous SNV   1       1    32 2
cf) Tissue ID; Tissue type (1; BLCA[Bladder Urothelial Carcinoma], 2; BRCA[Breast invasive carcinoma], 3; CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], 4; COAD[Colon adenocarcinoma], 5; GBM[Glioblastoma multiforme], 6; Glioma Low Grade, 7; HNSC[Head and Neck squamous cell carcinoma], 8; KICH[Kidney Chromophobe], 9; KIRC[Kidney renal clear cell carcinoma], 10; KIRP[Kidney renal papillary cell carcinoma], 11; LAML[Acute Myeloid Leukemia], 12; LUAD[Lung adenocarcinoma], 13; LUSC[Lung squamous cell carcinoma], 14; OV[Ovarian serous cystadenocarcinoma ], 15; PAAD[Pancreatic adenocarcinoma], 16; PRAD[Prostate adenocarcinoma], 17; SKCM[Skin Cutaneous Melanoma], 18:STAD[Stomach adenocarcinoma], 19:THCA[Thyroid carcinoma], 20:UCEC[Uterine Corpus Endometrial Carcinoma])

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check002.gifTop 10 SNVs Having the Most Samples in TCGA data
* We represented just top 10 SNVs. When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site, primary_histology, mutation(aa), pubmedID.
Genomic PositionMutation(aa)Unique sampleID count
chr9:19424829p.R54H1
chr9:19450617p.S181L1
chr9:19423911p.N61S1
chr9:19424835p.F207F1
chr9:19450631p.Y65C1
chr9:19423912p.W214R1
chr9:19434960p.V79I1
chr9:19423933p.Y223Y1
chr9:19434994p.V79V1
chr9:19423945p.S271A1

check002.gifOther DBs for Point Mutations
Point Mutation Table of Ensembl: go to Ensembl variation table
Mutation of cBioPortal: go to cBioPortal's Cross-cancer alteration summary

check002.gifCopy Number for ACER2 in TCGA
* Copy number data were extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered on Jan-05-2015. Function ProcessCNAData in TCGA-Assembler package was used to obtain gene-level copy number value which is calculated as the average copy number of the genomic region of a gene.
cf) Tissue ID[Tissue type]: BLCA[Bladder Urothelial Carcinoma], BRCA[Breast invasive carcinoma], CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], COAD[Colon adenocarcinoma], GBM[Glioblastoma multiforme], Glioma Low Grade, HNSC[Head and Neck squamous cell carcinoma], KICH[Kidney Chromophobe], KIRC[Kidney renal clear cell carcinoma], KIRP[Kidney renal papillary cell carcinoma], LAML[Acute Myeloid Leukemia], LUAD[Lung adenocarcinoma], LUSC[Lung squamous cell carcinoma], OV[Ovarian serous cystadenocarcinoma ], PAAD[Pancreatic adenocarcinoma], PRAD[Prostate adenocarcinoma], SKCM[Skin Cutaneous Melanoma], STAD[Stomach adenocarcinoma], THCA[Thyroid carcinoma], UCEC[Uterine Corpus Endometrial Carcinoma]

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Gene Expression for ACER2

check002.gifGene Expression in Cancer Cell-lines (CCLE)
* CCLE gene expression data were extracted from CCLE_Expression_Entrez_2012-10-18.res: Gene-centric RMA-normalized mRNA expression data.

check002.gifDifferential Gene Expression in Primary Tumors (TCGA)
* Normalized gene expression data of RNASeqV2 was extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered at Jan-05-2015. Only eight cancer types have enough normal control samples for differential expression analysis.
(t test, adjusted p<0.05 (using Benjamini-Hochberg FDR))
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check002.gifCNV vs Gene Expression Plot
* This plots show the correlation between CNV and gene expression.

: Open all plots for all cancer types


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Gene-Gene Network Information
check002.gifCo-Expressed gene's network Plot
* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown.
Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene

: Open all plots for all cancer types

ACER2,ARID2,ATP7A,CCNT1,DENND4C,DMXL1,DNAJB14,
DPP8,DTWD2,FAM63B,GTF2A1,FOCAD,KLHL28,KLHL9,
LCOR,NHLRC2,RNF111,STAM2,TSTD2,UEVLD,WDFY3
ACER2,AFF1,ANO6,ARHGAP42,GPATCH11,COL4A3BP,EHHADH,
EIF4EBP2,FNIP2,MYCBP2,PDP2,PIK3CA,PREX2,PTPRG,
PVRL3,RBMS3,REEP3,RHOBTB3,SAMD8,SBF2,SOX5

ABHD3,ACER2,BCAS1,C1orf94,CCNG2,CHST5,CTSE,
FER1L6,KLF4,MARVELD3,MGLL,MMP28,PAG1,REG4,
RIOK3,SLC17A5,SMPDL3A,TSPAN1,UGT1A4,VSIG1,VSIG2
ACER2,ACVR1B,AMACR,B3GNT2,BCAS1,C12orf75,DHX32,
EIF2AK3,ENDOD1,FER1L6,GALNT12,GPR153,MINPP1,MTM1,
NEDD4L,RIMKLA,SLC17A5,SYT7,SYTL2,USP54,VIPR1
check002.gifCo-Expressed gene's Protein-protein interaction Network Plot
* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown.
Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene

: Open all plots for all cancer types

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check002.gifInteracting Genes (from Pathway Commons)

: Open all interacting genes' information including KEGG pathway for all interacting genes from DAVID

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Pharmacological Information for ACER2


There's no related Drug.
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Cross referenced IDs for ACER2
* We obtained these cross-references from Uniprot database. It covers 150 different DBs, 18 categories. http://www.uniprot.org/help/cross_references_section

: Open all cross reference information



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