Cancer Cell Metabolism Database ~~ Bioinformatics and Systems Medicine Laboratory ~~

Cancer Cell Metabolism Gene Database

Cancer Cell Metabolism Gene DB

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	Gene Summary
	Phenotypic Information (metabolism pathway, cancer, disease, phenome)
	Mutations : SVs, CNVs, SNVs
	Gene expression: GE, Protein, DEGE, CNV vs GE
	Gene-Gene Network Information: Co-Expression Network, Interacting Genes & KEGG
	Pharmacological Information: Drug-Gene Network
	Cross referenced IDs

Gene Summary for IDH3G

Basic gene info.	Gene symbol	IDH3G
	Gene name	isocitrate dehydrogenase 3 (NAD+) gamma
	Synonyms	H-IDHG
	Cytomap	UCSC genome browser: Xq28
	Genomic location	chrX :153051220-153059967
	Type of gene	protein-coding
	RefGenes	NM_004135.3, NM_174869.2,
	Ensembl id	ENSG00000267989
	Description	IDH-gammaNAD (H)-specific isocitrate dehydrogenase gamma subunitNAD(+)-specific ICDH subunit gammaNAD+-specific ICDHisocitrate dehydrogenase [NAD] subunit gamma, mitochondrialisocitrate dehydrogenase, NAD(+)-specific, mitochondrial, gamma subunitiso
	Modification date	20141207
dbXrefs	MIM : 300089
	HGNC : HGNC
	Ensembl : ENSG00000067829
	HPRD : 02100
	Vega : OTTHUMG00000024219
Protein	UniProt: go to UniProt's Cross Reference DB Table
Expression	CleanEX: HS_IDH3G
	BioGPS: 3421
	Gene Expression Atlas: ENSG00000267989
	The Human Protein Atlas: ENSG00000267989
Pathway	NCI Pathway Interaction Database: IDH3G
	KEGG: IDH3G
	REACTOME: IDH3G
	ConsensusPathDB
	Pathway Commons: IDH3G
Metabolism	MetaCyc: IDH3G
	HUMANCyc: IDH3G
Regulation	Ensembl's Regulation: ENSG00000267989
	miRBase: chrX :153,051,220-153,059,967
	TargetScan: NM_004135
	cisRED: ENSG00000267989
Context	iHOP: IDH3G
	cancer metabolism search in PubMed: IDH3G
	UCL Cancer Institute: IDH3G
Assigned class in ccmGDB	C

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Phenotypic Information for IDH3G(metabolism pathway, cancer, disease, phenome)

Cancer Description
Cancer	CGAP: IDH3G
	Familial Cancer Database: IDH3G

* This gene is included in those cancer gene databases.


Oncogene ¹	Tumor Suppressor gene ²	Cancer Gene Census ³	CancerGenes ⁴	Network of Cancer Gene ⁵	Significant driver gene in	Therapeutic Vulnerabilities in Cancer¹

cf) number; DB name
1 Oncogene; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long,
2 Tumor Suppressor gene; https://bioinfo.uth.edu/TSGene/,
3 Cancer Gene Census; http://www.nature.com/nrc/journal/v4/n3/abs/nrc1299.html,
4 CancerGenes; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long,
5 Network of Cancer Gene; http://ncg.kcl.ac.uk/index.php,
1Therapeutic Vulnerabilities in Cancer; http://cbio.mskcc.org/cancergenomics/statius/

Metabolic Pathway Description
REACTOME_PYRUVATE_METABOLISM_AND_CITRIC_ACID_TCA_CYCLE REACTOME_METABOLISM_OF_PROTEINS

Others
OMIM
Orphanet
Disease	KEGG Disease: IDH3G
	MedGen: IDH3G (Human Medical Genetics with Condition)
	ClinVar: IDH3G
Phenotype	MGI: IDH3G (International Mouse Phenotyping Consortium)
Phenotype	PhenomicDB: IDH3G

Mutations for IDH3G

* Under tables are showing count per each tissue to give us broad intuition about tissue specific mutation patterns.You can go to the detailed page for each mutation database's web site.

Structural Variants in COSMIC : go to COSMIC mutation histogram

There's no structural variation information in COSMIC data for this gene.

Related fusion transcripts : go to Chitars2.0

* From mRNA Sanger sequences, Chitars2.0 arranged chimeric transcripts. This table shows IDH3G related fusion information.

ID	Head Gene						Tail Gene
Accession	Gene_a	qStart_a	qEnd_a	Chromosome_a	tStart_a	tEnd_a	Gene_a	qStart_a	qEnd_a	Chromosome_a	tStart_a	tEnd_a
BC008758	IDH3G	1	1661	X	153051222	153059836	UBE2Q2P2	1653	2354	15	82664400	82665101
AW390706	IDH3G	1	107	X	153051322	153051428	PKP2	102	387	12	32949101	32955490
BF902554	DAZAP1	8	241	19	1419767	1420000	IDH3G	237	371	X	153052996	153053355

Other DBs for Structural Variants

Structural Variants in Ensembl: go to Ensembl Structural variation

Structural Variants in dbVar: go to dbVar

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Copy Number Variations in COSMIC : go to COSMIC mutation CNV/Expr

There's no copy number variation information in COSMIC data for this gene.

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SNV Counts per Each Loci in COSMIC data : go to COSMIC point mutation

: Non-synonymous mutation, : Synonymous mutation, Circle size denotes number of samples.
Maximum mutation count=3

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Somatic Mutation Counts per Tissue in COSMIC data

Stat. for Non-Synonymous SNVs (# total SNVs=26)	Stat. for Synonymous SNVs (# total SNVs=13)

Stat. for Deletions (# total SNVs=0)	Stat. for Insertions (# total SNVs=0)
There's no deleted snv.	There's no inserted snv.

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Top 10 SNVs Having the Most Samples in COSMIC data

* When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site,primary_histology,mutation(aa),pubmedID.

GRCh37 position	Mutation(aa)	Unique sampleID count
chr23:153053041-153053041	p.G184G	2
chr23:153053582-153053582	p.E119K	2
chr23:153051702-153051702	p.R349C	2
chr23:153052393-153052393	p.R263W	1
chr23:153055714-153055714	p.V57M	1
chr23:153051701-153051701	p.R349L	1
chr23:153052538-153052538	p.E249K	1
chr23:153055738-153055738	p.A49T	1
chr23:153053286-153053286	p.E178Q	1
chr23:153053588-153053588	p.N117Y	1

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SNV Counts per Each Loci in TCGA data

: non-synonymous mutation, : synonymous mutation, Circle size denotes number of samples.
maximum mutation count=1

Point Mutation/ Tissue ID	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20
# sample		1		5			2		2			3	2				6	2		9
# mutation		1		5			2		2			3	2				6	2		10
nonsynonymous SNV		1		4			1		2			2	2				1	2		8
synonymous SNV				1			1					1					5			2

cf) Tissue ID; Tissue type (1; BLCA[Bladder Urothelial Carcinoma], 2; BRCA[Breast invasive carcinoma], 3; CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], 4; COAD[Colon adenocarcinoma], 5; GBM[Glioblastoma multiforme], 6; Glioma Low Grade, 7; HNSC[Head and Neck squamous cell carcinoma], 8; KICH[Kidney Chromophobe], 9; KIRC[Kidney renal clear cell carcinoma], 10; KIRP[Kidney renal papillary cell carcinoma], 11; LAML[Acute Myeloid Leukemia], 12; LUAD[Lung adenocarcinoma], 13; LUSC[Lung squamous cell carcinoma], 14; OV[Ovarian serous cystadenocarcinoma ], 15; PAAD[Pancreatic adenocarcinoma], 16; PRAD[Prostate adenocarcinoma], 17; SKCM[Skin Cutaneous Melanoma], 18:STAD[Stomach adenocarcinoma], 19:THCA[Thyroid carcinoma], 20:UCEC[Uterine Corpus Endometrial Carcinoma])

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Top 10 SNVs Having the Most Samples in TCGA data

* We represented just top 10 SNVs. When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site, primary_histology, mutation(aa), pubmedID.

Genomic Position	Mutation(aa)	Unique sampleID count
chrX:153053045	p.Y303Y,IDH3G	1
chrX:153055671	p.N94N,IDH3G	1
chrX:153051811	p.N298N,IDH3G	1
chrX:153053286	p.A80T,IDH3G	1
chrX:153055697	p.E249K,IDH3G	1
chrX:153051850	p.K74M,IDH3G	1
chrX:153053319	p.R213H,IDH3G	1
chrX:153055703	p.L71P,IDH3G	1
chrX:153052271	p.A208V,IDH3G	1
chrX:153053398	p.G62G,IDH3G	1

Other DBs for Point Mutations

Point Mutation Table of Ensembl: go to Ensembl variation table

Mutation of cBioPortal: go to cBioPortal's Cross-cancer alteration summary

Copy Number for IDH3G in TCGA

* Copy number data were extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered on Jan-05-2015. Function ProcessCNAData in TCGA-Assembler package was used to obtain gene-level copy number value which is calculated as the average copy number of the genomic region of a gene.

cf) Tissue ID[Tissue type]: BLCA[Bladder Urothelial Carcinoma], BRCA[Breast invasive carcinoma], CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], COAD[Colon adenocarcinoma], GBM[Glioblastoma multiforme], Glioma Low Grade, HNSC[Head and Neck squamous cell carcinoma], KICH[Kidney Chromophobe], KIRC[Kidney renal clear cell carcinoma], KIRP[Kidney renal papillary cell carcinoma], LAML[Acute Myeloid Leukemia], LUAD[Lung adenocarcinoma], LUSC[Lung squamous cell carcinoma], OV[Ovarian serous cystadenocarcinoma ], PAAD[Pancreatic adenocarcinoma], PRAD[Prostate adenocarcinoma], SKCM[Skin Cutaneous Melanoma], STAD[Stomach adenocarcinoma], THCA[Thyroid carcinoma], UCEC[Uterine Corpus Endometrial Carcinoma]

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Gene Expression for IDH3G

Gene Expression in Cancer Cell-lines (CCLE)

* CCLE gene expression data were extracted from CCLE_Expression_Entrez_2012-10-18.res: Gene-centric RMA-normalized mRNA expression data.

Differential Gene Expression in Primary Tumors (TCGA)

* Normalized gene expression data of RNASeqV2 was extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered at Jan-05-2015. Only eight cancer types have enough normal control samples for differential expression analysis.
(t test, adjusted p<0.05 (using Benjamini-Hochberg FDR))

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CNV vs Gene Expression Plot

* This plots show the correlation between CNV and gene expression.

: Open all plots for all cancer types

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Gene-Gene Network Information

Co-Expressed gene's network Plot

* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown.
Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene

: Open all plots for all cancer types


AURKAIP1,BCAP31,CCDC124,COPE,COX4I1,CTU2,EMD, F8A1,FAM3A,FAM50A,FAM58A,GUK1,HAUS7,IDH3G, IKBKG,NAA10,NSDHL,RNF113A,SSR4,TAZ,UBL4A	ANAPC11,AURKAIP1,C19orf53,C19orf70,CLPP,COX4I1,CUEDC2, GPS1,IDH3G,MRPL28,MRPL4,MRPS18A,NAA10,NDUFA11, NDUFA13,NDUFB7,POLR2I,THAP4,UBE2M,WDR13,ZNF511

AIFM1,APEX2,BCAP31,CXorf40A,CXorf40B,EMD,FAM3A, FAM50A,FAM58A,HAUS7,IDH3G,LAGE3,MCTS1,CMC4, NAA10,NSDHL,PDZD11,RNF113A,SSR4,TIMM8A,UBL4A	ATP5D,AURKAIP1,CAPNS1,CHCHD10,COQ4,ECHS1,ENDOG, ETFB,FAM173A,GTF3C5,IDH3G,MAP2K2,MDH2,MRPL23, NDUFS7,NDUFV1,PGLS,PPAP2C,PTGES2,TALDO1,UQCRC1

Co-Expressed gene's Protein-protein interaction Network Plot

: Open all plots for all cancer types

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Interacting Genes (from Pathway Commons)

: Open all interacting genes' information including KEGG pathway for all interacting genes from DAVID

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Pharmacological Information for IDH3G

Cross-referenced pharmacological DB IDs from Uniprot

DB Category

DB Name

DB's ID and Url link

Drug-Gene Interaction Network

* Gene Centered Interaction Network.

* Drug Centered Interaction Network.

DrugBank ID	Target Name	Drug Groups	Generic Name	Drug Centered Network	Drug Structure
DB00157	isocitrate dehydrogenase 3 (NAD+) gamma	approved; nutraceutical	NADH

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Cross referenced IDs for IDH3G

* We obtained these cross-references from Uniprot database. It covers 150 different DBs, 18 categories. http://www.uniprot.org/help/cross_references_section

: Open all cross reference information