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Phenotypic Information (metabolism pathway, cancer, disease, phenome) | |
Gene-Gene Network Information: Co-Expression Network, Interacting Genes & KEGG | |
Gene Summary for IDH3G |
Basic gene info. | Gene symbol | IDH3G |
Gene name | isocitrate dehydrogenase 3 (NAD+) gamma | |
Synonyms | H-IDHG | |
Cytomap | UCSC genome browser: Xq28 | |
Genomic location | chrX :153051220-153059967 | |
Type of gene | protein-coding | |
RefGenes | NM_004135.3, NM_174869.2, | |
Ensembl id | ENSG00000267989 | |
Description | IDH-gammaNAD (H)-specific isocitrate dehydrogenase gamma subunitNAD(+)-specific ICDH subunit gammaNAD+-specific ICDHisocitrate dehydrogenase [NAD] subunit gamma, mitochondrialisocitrate dehydrogenase, NAD(+)-specific, mitochondrial, gamma subunitiso | |
Modification date | 20141207 | |
dbXrefs | MIM : 300089 | |
HGNC : HGNC | ||
Ensembl : ENSG00000067829 | ||
HPRD : 02100 | ||
Vega : OTTHUMG00000024219 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_IDH3G | |
BioGPS: 3421 | ||
Gene Expression Atlas: ENSG00000267989 | ||
The Human Protein Atlas: ENSG00000267989 | ||
Pathway | NCI Pathway Interaction Database: IDH3G | |
KEGG: IDH3G | ||
REACTOME: IDH3G | ||
ConsensusPathDB | ||
Pathway Commons: IDH3G | ||
Metabolism | MetaCyc: IDH3G | |
HUMANCyc: IDH3G | ||
Regulation | Ensembl's Regulation: ENSG00000267989 | |
miRBase: chrX :153,051,220-153,059,967 | ||
TargetScan: NM_004135 | ||
cisRED: ENSG00000267989 | ||
Context | iHOP: IDH3G | |
cancer metabolism search in PubMed: IDH3G | ||
UCL Cancer Institute: IDH3G | ||
Assigned class in ccmGDB | C |
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Phenotypic Information for IDH3G(metabolism pathway, cancer, disease, phenome) |
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Cancer | CGAP: IDH3G |
Familial Cancer Database: IDH3G |
* This gene is included in those cancer gene databases. |
Oncogene 1 | Significant driver gene in |
cf) number; DB name 1 Oncogene; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long, 2 Tumor Suppressor gene; https://bioinfo.uth.edu/TSGene/, 3 Cancer Gene Census; http://www.nature.com/nrc/journal/v4/n3/abs/nrc1299.html, 4 CancerGenes; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long, 5 Network of Cancer Gene; http://ncg.kcl.ac.uk/index.php, 1Therapeutic Vulnerabilities in Cancer; http://cbio.mskcc.org/cancergenomics/statius/ |
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REACTOME_PYRUVATE_METABOLISM_AND_CITRIC_ACID_TCA_CYCLE REACTOME_METABOLISM_OF_PROTEINS |
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OMIM | |
Orphanet | |
Disease | KEGG Disease: IDH3G |
MedGen: IDH3G (Human Medical Genetics with Condition) | |
ClinVar: IDH3G | |
Phenotype | MGI: IDH3G (International Mouse Phenotyping Consortium) |
PhenomicDB: IDH3G |
Mutations for IDH3G |
* Under tables are showing count per each tissue to give us broad intuition about tissue specific mutation patterns.You can go to the detailed page for each mutation database's web site. |
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There's no structural variation information in COSMIC data for this gene. |
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* From mRNA Sanger sequences, Chitars2.0 arranged chimeric transcripts. This table shows IDH3G related fusion information. |
ID | Head Gene | Tail Gene | Accession | Gene_a | qStart_a | qEnd_a | Chromosome_a | tStart_a | tEnd_a | Gene_a | qStart_a | qEnd_a | Chromosome_a | tStart_a | tEnd_a |
BC008758 | IDH3G | 1 | 1661 | X | 153051222 | 153059836 | UBE2Q2P2 | 1653 | 2354 | 15 | 82664400 | 82665101 | |
AW390706 | IDH3G | 1 | 107 | X | 153051322 | 153051428 | PKP2 | 102 | 387 | 12 | 32949101 | 32955490 | |
BF902554 | DAZAP1 | 8 | 241 | 19 | 1419767 | 1420000 | IDH3G | 237 | 371 | X | 153052996 | 153053355 |
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There's no copy number variation information in COSMIC data for this gene. |
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Stat. for Non-Synonymous SNVs (# total SNVs=26) | (# total SNVs=13) |
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(# total SNVs=0) | (# total SNVs=0) |
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* When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site,primary_histology,mutation(aa),pubmedID. |
GRCh37 position | Mutation(aa) | Unique sampleID count |
chr23:153051702-153051702 | p.R349C | 2 |
chr23:153053041-153053041 | p.G184G | 2 |
chr23:153053582-153053582 | p.E119K | 2 |
chr23:153053286-153053286 | p.E178Q | 1 |
chr23:153053588-153053588 | p.N117Y | 1 |
chr23:153052927-153052927 | p.A222A | 1 |
chr23:153055739-153055739 | p.S48S | 1 |
chr23:153053287-153053287 | p.L177L | 1 |
chr23:153055231-153055231 | p.N94N | 1 |
chr23:153051711-153051711 | p.T346P | 1 |
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Point Mutation/ Tissue ID | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | 18 | 19 | 20 |
# sample |   | 1 |   | 5 |   |   | 2 |   | 2 |   |   | 3 | 2 |   |   |   | 6 | 2 |   | 9 |
# mutation |   | 1 |   | 5 |   |   | 2 |   | 2 |   |   | 3 | 2 |   |   |   | 6 | 2 |   | 10 |
nonsynonymous SNV |   | 1 |   | 4 |   |   | 1 |   | 2 |   |   | 2 | 2 |   |   |   | 1 | 2 |   | 8 |
synonymous SNV |   |   |   | 1 |   |   | 1 |   |   |   |   | 1 |   |   |   |   | 5 |   |   | 2 |
cf) Tissue ID; Tissue type (1; BLCA[Bladder Urothelial Carcinoma], 2; BRCA[Breast invasive carcinoma], 3; CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], 4; COAD[Colon adenocarcinoma], 5; GBM[Glioblastoma multiforme], 6; Glioma Low Grade, 7; HNSC[Head and Neck squamous cell carcinoma], 8; KICH[Kidney Chromophobe], 9; KIRC[Kidney renal clear cell carcinoma], 10; KIRP[Kidney renal papillary cell carcinoma], 11; LAML[Acute Myeloid Leukemia], 12; LUAD[Lung adenocarcinoma], 13; LUSC[Lung squamous cell carcinoma], 14; OV[Ovarian serous cystadenocarcinoma ], 15; PAAD[Pancreatic adenocarcinoma], 16; PRAD[Prostate adenocarcinoma], 17; SKCM[Skin Cutaneous Melanoma], 18:STAD[Stomach adenocarcinoma], 19:THCA[Thyroid carcinoma], 20:UCEC[Uterine Corpus Endometrial Carcinoma]) |
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* We represented just top 10 SNVs. When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site, primary_histology, mutation(aa), pubmedID. |
Genomic Position | Mutation(aa) | Unique sampleID count |
chrX:153053583 | p.Q377H | 1 |
chrX:153059758 | p.D140D,IDH3G | 1 |
chrX:153052970 | p.R349L,IDH3G | 1 |
chrX:153053588 | p.R136C,IDH3G | 1 |
chrX:153059774 | p.R349C,IDH3G | 1 |
chrX:153051333 | p.E119K,IDH3G | 1 |
chrX:153052989 | p.K340E,IDH3G | 1 |
chrX:153055231 | p.I118M,IDH3G | 1 |
chrX:153051378 | p.N117Y,IDH3G | 1 |
chrX:153052993 | p.A327T,IDH3G | 1 |
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* Copy number data were extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered on Jan-05-2015. Function ProcessCNAData in TCGA-Assembler package was used to obtain gene-level copy number value which is calculated as the average copy number of the genomic region of a gene. |
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cf) Tissue ID[Tissue type]: BLCA[Bladder Urothelial Carcinoma], BRCA[Breast invasive carcinoma], CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], COAD[Colon adenocarcinoma], GBM[Glioblastoma multiforme], Glioma Low Grade, HNSC[Head and Neck squamous cell carcinoma], KICH[Kidney Chromophobe], KIRC[Kidney renal clear cell carcinoma], KIRP[Kidney renal papillary cell carcinoma], LAML[Acute Myeloid Leukemia], LUAD[Lung adenocarcinoma], LUSC[Lung squamous cell carcinoma], OV[Ovarian serous cystadenocarcinoma ], PAAD[Pancreatic adenocarcinoma], PRAD[Prostate adenocarcinoma], SKCM[Skin Cutaneous Melanoma], STAD[Stomach adenocarcinoma], THCA[Thyroid carcinoma], UCEC[Uterine Corpus Endometrial Carcinoma] |
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Gene Expression for IDH3G |
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* CCLE gene expression data were extracted from CCLE_Expression_Entrez_2012-10-18.res: Gene-centric RMA-normalized mRNA expression data. |
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* Normalized gene expression data of RNASeqV2 was extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered at Jan-05-2015. Only eight cancer types have enough normal control samples for differential expression analysis. (t test, adjusted p<0.05 (using Benjamini-Hochberg FDR)) |
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* This plots show the correlation between CNV and gene expression. |
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Gene-Gene Network Information |
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* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown. Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene |
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AURKAIP1,BCAP31,CCDC124,COPE,COX4I1,CTU2,EMD, F8A1,FAM3A,FAM50A,FAM58A,GUK1,HAUS7,IDH3G, IKBKG,NAA10,NSDHL,RNF113A,SSR4,TAZ,UBL4A | ANAPC11,AURKAIP1,C19orf53,C19orf70,CLPP,COX4I1,CUEDC2, GPS1,IDH3G,MRPL28,MRPL4,MRPS18A,NAA10,NDUFA11, NDUFA13,NDUFB7,POLR2I,THAP4,UBE2M,WDR13,ZNF511 | ||||
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AIFM1,APEX2,BCAP31,CXorf40A,CXorf40B,EMD,FAM3A, FAM50A,FAM58A,HAUS7,IDH3G,LAGE3,MCTS1,CMC4, NAA10,NSDHL,PDZD11,RNF113A,SSR4,TIMM8A,UBL4A | ATP5D,AURKAIP1,CAPNS1,CHCHD10,COQ4,ECHS1,ENDOG, ETFB,FAM173A,GTF3C5,IDH3G,MAP2K2,MDH2,MRPL23, NDUFS7,NDUFV1,PGLS,PPAP2C,PTGES2,TALDO1,UQCRC1 |
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* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown. Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene |
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Pharmacological Information for IDH3G |
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DB Category | DB Name | DB's ID and Url link |
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* Gene Centered Interaction Network. |
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* Drug Centered Interaction Network. |
DrugBank ID | Target Name | Drug Groups | Generic Name | Drug Centered Network | Drug Structure |
DB00157 | isocitrate dehydrogenase 3 (NAD+) gamma | approved; nutraceutical | NADH | ![]() | ![]() |
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Cross referenced IDs for IDH3G |
* We obtained these cross-references from Uniprot database. It covers 150 different DBs, 18 categories. http://www.uniprot.org/help/cross_references_section |
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